Gruber, Oliver

[["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Pharmacopsychiatry"],["dc.bibliographiccitation.volume","40"],["dc.contributor.author","Gruber, Oliver"],["dc.contributor.author","Meyer, J."],["dc.contributor.author","Zilles, David"],["dc.contributor.author","Gruber, Eva"],["dc.contributor.author","Falkai, Peter Gaston"],["dc.date.accessioned","2018-11-07T10:59:21Z"],["dc.date.available","2018-11-07T10:59:21Z"],["dc.date.issued","2007"],["dc.format.extent","221"],["dc.identifier.isi","000249873600085"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50679"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.publisher.place","Stuttgart"],["dc.relation.conference","25th Symposium of the Arbeitsgemeinschaft-Neuropsychopharmakologie-und-Pharmakopsychiatrie"],["dc.relation.eventlocation","Munich, GERMANY"],["dc.relation.issn","0176-3679"],["dc.title","Genetic polymorphisms of serotonergic and dopaminergic neurotransmission differentially affect neurofunctional subsystems of working memory"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","229"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Pharmacopsychiatry"],["dc.bibliographiccitation.lastpage","230"],["dc.bibliographiccitation.volume","40"],["dc.contributor.author","Zilles, David"],["dc.contributor.author","Gruber, Oliver"],["dc.contributor.author","Burke, Sarah"],["dc.contributor.author","Falkai, Peter Gaston"],["dc.date.accessioned","2018-11-07T10:59:22Z"],["dc.date.available","2018-11-07T10:59:22Z"],["dc.date.issued","2007"],["dc.identifier.isi","000249873600125"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50683"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.publisher.place","Stuttgart"],["dc.relation.conference","25th Symposium of the Arbeitsgemeinschaft-Neuropsychopharmakologie-und-Pharmakopsychiatrie"],["dc.relation.eventlocation","Munich, GERMANY"],["dc.relation.issn","0176-3679"],["dc.title","The influence of genetic loading on working memory performance in schizophrenia"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","100"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","European Neuropsychopharmacology"],["dc.bibliographiccitation.lastpage","113"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Delvecchio, Giuseppe"],["dc.contributor.author","Fossati, Philippe"],["dc.contributor.author","Boyer, Patrice"],["dc.contributor.author","Brambilla, Paolo"],["dc.contributor.author","Falkai, Peter"],["dc.contributor.author","Gruber, Oliver"],["dc.contributor.author","Hietala, Jarmo"],["dc.contributor.author","Lawrie, Stephen M."],["dc.contributor.author","Martinot, Jean-Luc"],["dc.contributor.author","McIntosh, Andrew M."],["dc.contributor.author","Meisenzahl, Eva"],["dc.contributor.author","Frangou, Sophia"],["dc.date.accessioned","2018-11-07T09:13:58Z"],["dc.date.available","2018-11-07T09:13:58Z"],["dc.date.issued","2012"],["dc.description.abstract","Neuroimaging studies have consistently shown functional brain abnormalities in patients with Bipolar Disorder (BD) and Major Depressive Disorder (MDD). However, the extent to which these two disorders are associated with similar or distinct neural changes remains unclear. We conducted a systematic review of functional magnetic resonance imaging studies comparing BD and MDD patients to healthy participants using facial affect processing paradigms. Relevant spatial coordinates from twenty original studies were subjected to quantitative Activation Likelihood Estimation meta-analyses based on 168 BD and 189 MDD patients and 344 healthy controls. We identified common and distinct patterns of neural engagement for BD and MDD within the facial affect processing network. Both disorders were associated with increased engagement of limbic regions. Diagnosis-specific differences were observed in cortical, thalamic and striatal regions. Decreased ventrolateral prefrontal cortical engagement was associated with BD while relative hypoactivation of the sensorimotor cortices was seen in MDD. Increased responsiveness in the thalamus and basal ganglia were associated with BD. These findings were modulated by stimulus valence. These data suggest that whereas limbic overactivation is reported consistently in patients with mood disorders, future research should consider the relevance of a wider network of regions in formulating conceptual models of BD and MDD. (c) 2011 Elsevier B.V. and ECNP. All rights reserved."],["dc.description.sponsorship","ECNP networks Initiative"],["dc.identifier.doi","10.1016/j.euroneuro.2011.07.003"],["dc.identifier.isi","000299720700003"],["dc.identifier.pmid","21820878"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/27291"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","0924-977X"],["dc.title","Common and distinct neural correlates of emotional processing in Bipolar Disorder and Major Depressive Disorder: A voxel-based meta-analysis of functional magnetic resonance imaging studies"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","The International Journal of Neuropsychopharmacology"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Gruber, Oliver"],["dc.contributor.author","Burkhardt, S."],["dc.contributor.author","Gruber, Eva"],["dc.contributor.author","Falkai, Peter Gaston"],["dc.date.accessioned","2018-11-07T11:13:33Z"],["dc.date.available","2018-11-07T11:13:33Z"],["dc.date.issued","2008"],["dc.format.extent","271"],["dc.identifier.isi","000258855501400"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53922"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Cambridge Univ Press"],["dc.publisher.place","New york"],["dc.relation.conference","26th Collegium Internationale Neuro-Psychopharmacologicum Congress (CINP)"],["dc.relation.eventlocation","Munich, GERMANY"],["dc.relation.issn","1461-1457"],["dc.title","Common and disease-specific dysfunctions of brain systems underlying attentional and executive control in schizophrenia and bipolar disorder"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","126"],["dc.bibliographiccitation.journal","Brain Research"],["dc.bibliographiccitation.lastpage","134"],["dc.bibliographiccitation.volume","1301"],["dc.contributor.author","Parlapani, Eleni"],["dc.contributor.author","Schmitt, Andrea"],["dc.contributor.author","Erdmann, Andrea"],["dc.contributor.author","Bernstein, Hans-Gert"],["dc.contributor.author","Breunig, Barbara"],["dc.contributor.author","Gruber, Oliver"],["dc.contributor.author","Petroianu, Georg A."],["dc.contributor.author","von Wilmsdorff, Martina"],["dc.contributor.author","Schneider-Axmann, Thomas"],["dc.contributor.author","Honer, William G."],["dc.contributor.author","Falkai, Peter"],["dc.date.accessioned","2018-11-07T11:22:01Z"],["dc.date.available","2018-11-07T11:22:01Z"],["dc.date.issued","2009"],["dc.description.abstract","There is evidence for migrational disturbances in the entorhinal cortex (ERC) in schizophrenia that supports a neurodevelopmental origin of the disorder. Since impaired myelin basic protein (MBP) gene expression during the migration phase could lead to abnormalities in final laminar position, we performed layer specific measurements of MBP expression in the ERC and hypothesised that migrational disturbances of pre-alpha-cell clusters relate to decreased MBP expression. Paraffin embedded sections of the left entorhinal cortex of 16 schizophrenia patients and 10 control subjects were stained for MBP using routine immunohistochemistry. on each section representative regions of interest were scanned to attain optimal quality images of the gray matter. Results were correlated to previous published disturbed dispersion of pre-alpha-cell clusters in adjacent brain sections. Mean MBP stain-intensity was significantly reduced in schizophrenia patients. Absolute MBP stain-intensity was significantly reduced in layers III and IV in patients. A significant correlation of MBP stain-intensity with the distance of the deep pole of the pre-alpha-cell cluster from the gray white matter junction was observed in the ERC of schizophrenia patients. The present data provide evidence for reduced MBP expression in the ERC in schizophrenia, which implies deficits in axonal myelination and disturbed connectivity. MBP gene is expressed in oligodendrocytes and neuronal populations during embryonic development, which are important in establishing the structure of the cerebral cortex. Correlation between reduced MBP as a sign of down-regulated MBP gene expression and disorganization of pre-alpha-cell clusters supports a neurodevelopmental origin of pathological processes in schizophrenia. (C) 2009 Elsevier B.V. All rights reserved."],["dc.identifier.doi","10.1016/j.brainres.2009.09.007"],["dc.identifier.isi","000272100200014"],["dc.identifier.pmid","19747901"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55908"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","0006-8993"],["dc.title","Association between myelin basic protein expression and left entorhinal cortex pre-alpha cell layer disorganization in schizophrenia"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","127"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","European Archives of Psychiatry and Clinical Neuroscience"],["dc.bibliographiccitation.lastpage","136"],["dc.bibliographiccitation.volume","265"],["dc.contributor.author","Kittel-Schneider, Sarah"],["dc.contributor.author","Wobrock, Thomas"],["dc.contributor.author","Scherk, Harald"],["dc.contributor.author","Schneider-Axmann, Thomas"],["dc.contributor.author","Trost, Sarah"],["dc.contributor.author","Zilles, David"],["dc.contributor.author","Wolf, C."],["dc.contributor.author","Schmitt, A."],["dc.contributor.author","Malchow, Berend"],["dc.contributor.author","Hasan, Alkomiet"],["dc.contributor.author","Backens, Martin"],["dc.contributor.author","Reith, W."],["dc.contributor.author","Falkai, Peter Gaston"],["dc.contributor.author","Gruber, Oliver"],["dc.contributor.author","Reif, A."],["dc.date.accessioned","2018-11-07T10:00:31Z"],["dc.date.available","2018-11-07T10:00:31Z"],["dc.date.issued","2015"],["dc.description.abstract","The diacylglycerol kinase eta (DGKH) gene, first identified in a genome-wide association study, is one of the few replicated risk genes of bipolar affective disorder (BD). Following initial positive studies, it not only was found to be associated with BD but also implicated in the etiology of other psychiatric disorders featuring affective symptoms, rendering DGKH a cross-disorder risk gene. However, the (patho-)physiological role of the encoded enzyme is still elusive. In the present study, we investigated primarily the influence of a risk haplotype on amygdala volume in patients suffering from schizophrenia or BD as well as healthy controls and four single nucleotide polymorphisms conveying risk. There was a significant association of the DGKH risk haplotype with increased amygdala volume in BD, but not in schizophrenia or healthy controls. These findings add to the notion of a role of DGKH in the pathogenesis of BD."],["dc.description.sponsorship","DFG [RTG 1253/1, RE1632/5-1]; BMBF (DZHI) [01EO1004]; IZKF [Z3-24]"],["dc.identifier.doi","10.1007/s00406-014-0513-9"],["dc.identifier.isi","000350305500005"],["dc.identifier.pmid","24958494"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37825"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Heidelberg"],["dc.relation.issn","1433-8491"],["dc.relation.issn","0940-1334"],["dc.title","Influence of DGKH variants on amygdala volume in patients with bipolar affective disorder and schizophrenia"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3325"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Human Brain Mapping"],["dc.bibliographiccitation.lastpage","3331"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","Diekhof, Esther Kristina"],["dc.contributor.author","Falkai, Peter"],["dc.contributor.author","Gruber, Oliver"],["dc.date.accessioned","2018-11-07T11:23:43Z"],["dc.date.available","2018-11-07T11:23:43Z"],["dc.date.issued","2009"],["dc.description.abstract","The ability to quickly decide on the nature of unexpected environmental changes is vital for adaptive behavior. Converging evidence suggests that the orbitofrontal cortex plays an important role in the rapid assignment of motivational significance and goal relevance to environmental stimuli. However, its putative role as a central part of a network involved in the prioritization of attentional selection, particulary when significant environmental changes Occur unexpectedly or outside of attentional focus, remains to be established. Therefore, we used functional magnetic resonance imaging with a subsequent psychophysiological interaction analysis to reveal the functional connectivity of the right posterior orbitofrontal cortex (pOFC) in a context, in which subjects had to adjust goal-directed behavior to behaviorally relevant events presented outside of the current attentional focus. As expected, an increased functional interaction between pOFC and regions involved in the modulation of selective attention (pulvinar nucleus and inferior parietal lobule) and processing of \"bottom-up\" salience (substantia nigra) could be observed when unattended, but significant changes were relevant for behavior. Moreover, a positive correlation between level of accuracy and an increased functional connectivity between pOFC and extrastriate cortex Suggested that a motivationally-triggered signal from pOFC may have increased visual processing of the relevant but currently unattended stimulus attribute. These data provide evidence that the interplay between the pOFC and these regions underlies a mechanism by which organisms rapidly achieve voluntary control of attentional resources to deal with behaviorally significant changes that occur outside of current attentional focus. Hum Brain Mapp 30:3325-3331, 2009. (C) 2009 Wiley-Liss, Inc."],["dc.identifier.doi","10.1002/hbm.20754"],["dc.identifier.isi","000270853700020"],["dc.identifier.pmid","19288466"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56251"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1065-9471"],["dc.title","Functional Interactions Guiding Adaptive Processing of Behavioral Significance"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Pharmacopsychiatry"],["dc.bibliographiccitation.volume","40"],["dc.contributor.author","Henseler, Ilona"],["dc.contributor.author","Gruber, Oliver"],["dc.contributor.author","Krick, Christoph"],["dc.contributor.author","Reith, W."],["dc.contributor.author","Falkai, Peter Gaston"],["dc.date.accessioned","2018-11-07T10:59:21Z"],["dc.date.available","2018-11-07T10:59:21Z"],["dc.date.issued","2007"],["dc.format.extent","222"],["dc.identifier.isi","000249873600089"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50680"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.publisher.place","Stuttgart"],["dc.relation.conference","25th Symposium of the Arbeitsgemeinschaft-Neuropsychopharmakologie-und-Pharmakopsychiatrie"],["dc.relation.eventlocation","Munich, GERMANY"],["dc.relation.issn","0176-3679"],["dc.title","Schizophrenia patients present aberrant brain activation patterns during verbal and spatial working memory tasks: an fMRI study"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","693"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","European Journal of Neuroscience"],["dc.bibliographiccitation.lastpage","702"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","Henseler, Ilona"],["dc.contributor.author","Falkai, Peter Gaston"],["dc.contributor.author","Gruber, Oliver"],["dc.date.accessioned","2018-11-07T11:25:59Z"],["dc.date.available","2018-11-07T11:25:59Z"],["dc.date.issued","2009"],["dc.description.abstract","Working memory impairment is one of the cardinal cognitive disturbances in schizophrenia and considerable evidence suggests that it can be traced to functional alterations in the brain. The exact allocation of specific deficits to regional specific dysfunctions, however, remains elusive. The aim of this study was to examine the functional integrity of three distinguishable brain systems underlying maintenance-related subprocesses of working memory (articulatory rehearsal, non-articulatory maintenance of phonological information, maintenance of visuospatial information) in patients with schizophrenia. Using an experimental paradigm, which had been designed to selectively activate these different brain systems, we assessed the brain activation of patients and controls with functional magnetic resonance imaging. Compared with controls, patients showed reduced activation of the fronto-opercular, intraparietal and anterior cingulate cortex during the non-articulatory maintenance of phonological information, as well as attenuated deactivation of the hippocampus. Additionally, we found prefrontal activation to depend critically on the patients' current symptom status. During visuospatial maintenance, patients showed impaired activation of the superior parietal, temporal and occipital cortex, combined with enhanced activation of the frontal eye field and the inferior parietal cortex. No abnormal activations were observed during the articulatory rehearsal task. All activation differences were independent of group differences in task performance. Our fine-grained analysis of dysfunctions in particular aspects of working memory circuitry provides evidence for a differential impairment of the brain systems supporting working memory subcomponents in schizophrenia and extends knowledge of the relationship between cognitive deficits, brain activation abnormalities and symptoms in schizophrenia."],["dc.identifier.doi","10.1111/j.1460-9568.2009.06850.x"],["dc.identifier.isi","000269263500016"],["dc.identifier.pmid","19686473"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56753"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell Publishing, Inc"],["dc.relation.issn","0953-816X"],["dc.title","A systematic fMRI investigation of the brain systems subserving different working memory components in schizophrenia"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","254S"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Biological Psychiatry"],["dc.bibliographiccitation.lastpage","255S"],["dc.bibliographiccitation.volume","63"],["dc.contributor.author","Gruber, Oliver"],["dc.contributor.author","Henseler, Ilona"],["dc.contributor.author","Tost, Heike"],["dc.contributor.author","Scherk, Harald"],["dc.contributor.author","Wobrock, Thomas"],["dc.contributor.author","Rietschel, Marcella"],["dc.contributor.author","Falkai, Peter"],["dc.date.accessioned","2018-11-07T11:16:21Z"],["dc.date.available","2018-11-07T11:16:21Z"],["dc.date.issued","2008"],["dc.identifier.isi","254163700809"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54565"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.publisher.place","New york"],["dc.relation.conference","63rd Annual Convention of the Society-of-Biological-Psychiatry"],["dc.relation.eventlocation","Washington, DC"],["dc.relation.issn","0006-3223"],["dc.title","Working memory dysfunction as phenotypic marker of schizophrenic and bipolar affective psychoses: Common and differential abnormalities in brain activation"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]