Reuß, Bernhard M.

[["dc.bibliographiccitation.firstpage","1110"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Immunologic Research"],["dc.bibliographiccitation.lastpage","1123"],["dc.bibliographiccitation.volume","65"],["dc.contributor.author","Almamy, Abdullah"],["dc.contributor.author","Schwerk, Christian"],["dc.contributor.author","Schroten, Horst"],["dc.contributor.author","Ishikawa, Hiroshi"],["dc.contributor.author","Asif, Abdul Rahman"],["dc.contributor.author","Reuss, Bernhard"],["dc.date.accessioned","2020-12-10T14:14:22Z"],["dc.date.available","2020-12-10T14:14:22Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1007/s12026-017-8952-9"],["dc.identifier.eissn","1559-0755"],["dc.identifier.issn","0257-277X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/71336"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Interactions of antisera to different Chlamydia and Chlamydophila species with the ribosomal protein RPS27a correlate with impaired protein synthesis in a human choroid plexus papilloma cell line"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","163"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Molecular Neuroscience"],["dc.bibliographiccitation.lastpage","180"],["dc.bibliographiccitation.volume","62"],["dc.contributor.author","Almamy, Abdullah"],["dc.contributor.author","Schwerk, C."],["dc.contributor.author","Schroten, Horst"],["dc.contributor.author","Ishikawa, Hiroshi"],["dc.contributor.author","Asif, Abdul Rahman"],["dc.contributor.author","Reuss, Bernhard"],["dc.date.accessioned","2018-11-07T10:23:14Z"],["dc.date.available","2018-11-07T10:23:14Z"],["dc.date.issued","2017"],["dc.description.abstract","Early maternal infections with Neisseria gonorrhoeae (NG) correlate to an increased lifetime schizophrenia risk for the offspring, which might be due to an immune-mediated mechanism. Here, we investigated the interactions of polyclonal antisera to NG (alpha-NG) with a first trimester prenatal brain multiprotein array, revealing among others the SNARE-complex protein Snap23 as a target antigen for alpha-NG. This interaction was confirmed by Western blot analysis with a recombinant Snap23 protein, whereas the closely related Snap25 failed to interact with alpha-NG. Furthermore, a polyclonal antiserum to the closely related bacterium Neisseria meningitidis (alpha-NM) failed to interact with both proteins. Functionally, in SH-SY5Y cells, alpha-NG pretreatment interfered with both insulin-induced vesicle recycling, as revealed by uptake of the fluorescent endocytosis marker FM1-43, and insulin-dependent membrane translocation of the glucose transporter GluT4. Similar effects could be observed for an antiserum raised directly to Snap23, whereas a serum to Snap25 failed to do so. In conclusion, Snap23 seems to be a possible immune target for anti-gonococcal antibodies, the interactions of which seem at least in vitro to interfere with vesicle-associated exocytosis. Whether these changes contribute to the correlation between maternal gonococcal infections and psychosis in vivo remains still to be clarified."],["dc.description.sponsorship","University Medicine Gottingen (UMG)"],["dc.identifier.doi","10.1007/s12031-017-0920-2"],["dc.identifier.isi","000402981900004"],["dc.identifier.pmid","28462458"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42420"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Humana Press Inc"],["dc.relation.issn","1559-1166"],["dc.relation.issn","0895-8696"],["dc.title","Crossreactivity of an Antiserum Directed to the Gram-Negative Bacterium Neisseria gonorrhoeae with the SNARE-Complex Protein Snap23 Correlates to Impaired Exocytosis in SH-SY5Y Cells"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","23"],["dc.bibliographiccitation.journal","Brain Research"],["dc.bibliographiccitation.lastpage","38"],["dc.bibliographiccitation.volume","1653"],["dc.contributor.author","Reuss, Bernhard"],["dc.contributor.author","Asif, Abdul R."],["dc.contributor.author","Almamy, Abdullah"],["dc.contributor.author","Schwerk, Christian"],["dc.contributor.author","Schroten, Horst"],["dc.contributor.author","Ishikawa, Hiroshi"],["dc.contributor.author","Drummer, Charis"],["dc.contributor.author","Behr, Ruediger"],["dc.date.accessioned","2018-11-07T10:04:31Z"],["dc.date.available","2018-11-07T10:04:31Z"],["dc.date.issued","2016"],["dc.description.abstract","Prenatal maternal infections with Neisseria gonorrhoeae (NG) correlate with an increased lifetime probability for the offspring to develop psychosis. We could previously demonstrate that in human choroid plexus papilloma cells, anti-NG antibodies (alpha-NG) bind to mitochondrial proteins HSP60 and ATPB, and interfere with cellular energy metabolism. To assess the in vivo relevance for this, especially during prenatal neural development, we investigated here interactions of NG-specific antisera (alpha-NG1, alpha-NG2) with brain, choroid plexus and other non -neural tissues in pre-and perinatal samples of the nonhuman primate (NHP) Callithrix jacchus (C1), a NHP model for preclinical research. In histological sections at embryonic day E75, immunohistochemistry revealed alpha-NG1 and -2-staining in choroid plexus, ganglionic hill, optic cup, heart, and liver. Within the cells, organelle -like structures were labeled, which could be identified by immunohistochemical double -labeling as mitochondria. Both one-and two-dimensional Western blot analysis revealed tissue specific patterns of alpha-NG1 immunoreactive bands and spots, respectively, which were subsequently characterized by mass spectrometry. Thereby we could confirm the interactions of alpha-NG1 with human HSP60 and ATPB also in CJ choroid plexus and liver. Even more important, in the CJ brain, several new targets, including NCAM1, CRMP2, and SYT1, were identified, which by unrelated studies have been previously suggested to correlate with an increased schizophrenia risk. These findings support the idea that the marmoset monkey is a useful NHP model to investigate the role of maternal bacterial infections during prenatal brain development, and thereby might improve the understanding of this important aspect of schizophrenia pathology."],["dc.identifier.doi","10.1016/j.brainres.2016.10.012"],["dc.identifier.isi","000389730100004"],["dc.identifier.pmid","27765579"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38709"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","1872-6240"],["dc.relation.issn","0006-8993"],["dc.title","Antisera against Neisseria gonorrhoeae cross-react with specific brain proteins of the common marmoset monkey and other nonhuman primate species"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]