Gröning, Stephanie

[["dc.bibliographiccitation.firstpage","605"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","BJU International"],["dc.bibliographiccitation.lastpage","605"],["dc.bibliographiccitation.volume","82"],["dc.contributor.author","Zöller, G."],["dc.contributor.author","Gröne, H.-J."],["dc.contributor.author","Seseke, F."],["dc.contributor.author","Ringert, R.-H."],["dc.date.accessioned","2021-12-08T12:27:36Z"],["dc.date.available","2021-12-08T12:27:36Z"],["dc.date.issued","1998"],["dc.identifier.doi","10.1046/j.1464-410X.1998.00781.x"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/95398"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-476"],["dc.relation.eissn","1464-410X"],["dc.relation.issn","1464-4096"],["dc.rights.uri","http://doi.wiley.com/10.1002/tdm_license_1.1"],["dc.title","Development of a testicular tumour after negative biopsy for carcinoma in situ"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e2003315"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","PLOS Biology"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Yan, Shuling"],["dc.contributor.author","Acharya, Sreemukta"],["dc.contributor.author","Gröning, Stephanie"],["dc.contributor.author","Großhans, Jörg"],["dc.date.accessioned","2019-02-13T12:35:26Z"],["dc.date.available","2019-02-13T12:35:26Z"],["dc.date.issued","2017"],["dc.description.abstract","Many mRNAs specifically localize within the cytoplasm and are present in RNA-protein complexes. It is generally assumed that localization and complex formation of these RNAs are controlled by trans-acting proteins encoded by genes different than the RNAs themselves. Here, we analyze slow as molasses (slam) mRNA that prominently colocalizes with its encoded protein at the basal cortical compartment during cellularization. The functional implications of this striking colocalization have been unknown. Here, we show that slam mRNA translation is spatiotemporally controlled. We found that translation was largely restricted to the onset of cellularization when Slam protein levels at the basal domain sharply increase. slam mRNA was translated locally, at least partially, as not yet translated mRNA transiently accumulated at the basal region. Slam RNA accumulated at the basal domain only if Slam protein was present. Furthermore, a slam RNA with impaired localization but full coding capacity was only weakly translated. We detected a biochemical interaction of slam mRNA and protein as demonstrated by specific co-immunoprecipitation from embryonic lysate. The intimate relationship of slam mRNA and protein may constitute a positive feedback loop that facilitates and controls timely and rapid accumulation of Slam protein at the prospective basal region."],["dc.identifier.doi","10.1371/journal.pbio.2003315"],["dc.identifier.pmid","29206227"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15662"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/57558"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.relation.eissn","1545-7885"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Slam protein dictates subcellular localization and translation of its own mRNA"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2305"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","G3 (Bethesda, Md.)"],["dc.bibliographiccitation.lastpage","2314"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Winkler, Franziska"],["dc.contributor.author","Kriebel, Maria"],["dc.contributor.author","Clever, Michaela"],["dc.contributor.author","Gröning, Stephanie"],["dc.contributor.author","Großhans, Jörg"],["dc.date.accessioned","2019-07-09T11:43:38Z"],["dc.date.available","2019-07-09T11:43:38Z"],["dc.date.issued","2017-07-05"],["dc.description.abstract","Many metabolic enzymes are evolutionarily highly conserved and serve a central function in the catabolism and anabolism of cells. The serine hydroxymethyl transferase (SHMT) catalyzing the conversion of serine and glycine and vice versa feeds into tetrahydrofolate (THF)-mediated C1 metabolism. We identified a Drosophila mutation in SHMT (CG3011) in a screen for blastoderm mutants. Embryos from SHMT mutant germline clones specifically arrest the cell cycle in interphase 13 at the time of the midblastula transition (MBT) and prior to cellularization. The phenotype is due to a loss of enzymatic activity as it cannot be rescued by an allele with a point mutation in the catalytic center but by an allele based on the SHMT coding sequence from Escherichia coli The onset of zygotic gene expression and degradation of maternal RNAs in SHMT mutant embryos are largely similar to that in wild-type embryos. The specific timing of the defects in SHMT mutants indicates that at least one of the SHMT-dependent metabolites becomes limiting in interphase 13, if it is not produced by the embryo. Our data suggest that mutant eggs contain maternally-provided and SHMT-dependent metabolites in amounts that suffice for early development until interphase 13."],["dc.identifier.doi","10.1534/g3.117.043133"],["dc.identifier.pmid","28515048"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14608"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58933"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","2160-1836"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","610"],["dc.title","Essential Function of the Serine Hydroxymethyl Transferase (SHMT) Gene During Rapid Syncytial Cell Cycles in Drosophila."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]