Felmerer, Gunther

[["dc.bibliographiccitation.firstpage","904"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Journal of Wound Care"],["dc.bibliographiccitation.lastpage","914"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","Ernst, Jennifer"],["dc.contributor.author","Tanyeli, Murat"],["dc.contributor.author","Borchardt, Thomas"],["dc.contributor.author","Ojugo, Moses"],["dc.contributor.author","Helmke, Andreas"],["dc.contributor.author","Viöl, Wolfgang"],["dc.contributor.author","Schilling, Arndt F"],["dc.contributor.author","Felmerer, Gunther"],["dc.date.accessioned","2021-12-01T09:22:31Z"],["dc.date.available","2021-12-01T09:22:31Z"],["dc.date.issued","2021"],["dc.description.abstract","Objective: The response of different critical acute and hard-to-heal wounds to an innovative wound care modality—direct application of cold atmospheric plasma (CAP)—was investigated in this clinical case series. Method: Over an observation period of two years, acute wounds with at least one risk factor for chronification, as well as hard-to-heal wounds were treated for 180 seconds three times per week with CAP. CAP treatment was additional to standard wound care. Photographs were taken for wound documentation. The wound sizes before the first CAP treatment, after four weeks, after 12 weeks and at wound closure/end of observation time were determined using image processing software, and analysed longitudinally for the development of wound size. Results: A total of 27 wounds (19 hard-to-heal and eight acute wounds) with a mean wound area of 15cm 2 and a mean wound age of 49 months were treated with CAP and analysed. All (100%) of the acute wounds and 68% of the hard-to-heal wounds healed after an average treatment duration of 14.2 weeks. At the end of the observation period, 21% of hard-to-heal wounds were not yet closed but were reduced in size by >80%. In 11% of the hard-to-heal wounds (n=2) therapy failed. Conclusion: The results suggested a beneficial effect of additional CAP therapy on wound healing. Declaration of interest: This work was carried out within the research projects \\‘Plasma for Life\\’ (funding reference no. 13FH6I04IA) with financial support from the German Federal Ministry of Education and Research (BMBF). In the past seven years AFS has provided consulting services to Evonik and has received institutional support by Heraeus, Johnson & Johnson and Evonik. There are no royalties to disclose. The Department for Trauma Surgery, Orthopaedics and Plastic Surgery received charitable donations by CINOGY GmbH. CINOGY GmbH released the di_CAP devices and electrodes for the study. WV and AH were involved in the development of the used di_CAP device (Plasmaderm, CINOGY GmbH). WV is shareholder of the outsourced start-up company CINOGY GmbH."],["dc.identifier.doi","10.12968/jowc.2021.30.11.904"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/94420"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-478"],["dc.relation.eissn","2052-2916"],["dc.relation.issn","0969-0700"],["dc.title","Effect on healing rates of wounds treated with direct cold atmospheric plasma: a case series"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Skin Pharmacology and Physiology"],["dc.contributor.author","Borchardt, Thomas"],["dc.contributor.author","Helmke, Andreas"],["dc.contributor.author","Ernst, Jennifer"],["dc.contributor.author","Emmert, Steffen"],["dc.contributor.author","Schilling, Arndt F."],["dc.contributor.author","Felmerer, Gunther"],["dc.contributor.author","Viöl, Wolfgang"],["dc.date.accessioned","2022-12-01T08:31:18Z"],["dc.date.available","2022-12-01T08:31:18Z"],["dc.date.issued","2022"],["dc.description.abstract","Introduction:\r\nWe aim to explore potentials and modalities of cold atmospheric pressure plasma (CAP) for the subsequent development of therapies targeting an increased perfusion of the lower leg skin tissue. In this study, we addressed the question whether the microcirculation enhancement is restricted to the tissue in direct contact with plasma or if adjacent tissue might also benefit.\r\n\r\nMethods:\r\nA dielectric barrier discharge (DBD)-generated CAP device exhibiting an electrode area of 27.5 cm² was used to treat the anterior lower leg of ten healthy subjects for 4.5 minutes. Subsequently, hyperspectral imaging (HIS) was performed to measure tempo-spatially resolved characteristics of microcirculation parameters in superficial (up to 1 mm) and deeper (up to 5 mm) skin layers.\r\n\r\nResults:\r\nIn the tissue area covered by the plasma electrode, DBD-CAP treatment enhances most of the perfusion parameters. The maximum oxygen saturation (StO2) increase reached 8 %, the near infrared perfusion index (NIR) increases by a maximum of 4 %, and the maximum tissue hemoglobin (THI) increase equaled 14 %. Tissue water index (TWI) was lower in both the control and the plasma group thus not affected by the DBD-CAP treatment. Yet, our study reveals that adjacent tissue is hardly affected by the enhancements in the electrode area and the effects are locally confined. \r\n\r\nConclusion:\r\nApplication of DBD-CAP to the lower leg resulted in enhancement of cutaneous microcirculation that extended 1 h beyond the treatment period with localization to the tissue area in direct contact with the cold plasma. This suggests the possibility of tailoring application schemes for topically confined enhancement of skin microcirculation, e.g. in the treatment of chronic wounds."],["dc.identifier.doi","10.1159/000527700"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/118137"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-621"],["dc.relation.eissn","1660-5535"],["dc.relation.issn","1660-5527"],["dc.title","Topically confined enhancement of cutaneous microcirculation by cold plasma"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","e12399"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Microcirculation"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Borchardt, Thomas"],["dc.contributor.author","Ernst, Jennifer"],["dc.contributor.author","Helmke, Andreas"],["dc.contributor.author","Tanyeli, Murat"],["dc.contributor.author","Schilling, Arndt F."],["dc.contributor.author","Felmerer, Gunther"],["dc.contributor.author","Viöl, Wolfgang"],["dc.date.accessioned","2020-12-10T18:29:11Z"],["dc.date.available","2020-12-10T18:29:11Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1111/micc.12399"],["dc.identifier.issn","1073-9688"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16970"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/76550"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Effect of direct cold atmospheric plasma (diCAP) on microcirculation of intact skin in a controlled mechanical environment"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]