Felmerer, Gunther

[["dc.bibliographiccitation.artnumber","e0164964"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","PLoS ONE"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Hasselhof, Viktoria"],["dc.contributor.author","Sperling, Anastasia"],["dc.contributor.author","Buttler, Kerstin"],["dc.contributor.author","Strobel, Philipp"],["dc.contributor.author","Becker, Juergen"],["dc.contributor.author","Aung, Thiha"],["dc.contributor.author","Felmerer, Gunther"],["dc.contributor.author","Wilting, Joerg"],["dc.date.accessioned","2018-11-07T10:06:56Z"],["dc.date.available","2018-11-07T10:06:56Z"],["dc.date.issued","2016"],["dc.description.abstract","Millions of patients suffer from lymphedema worldwide. Supporting the contractility of lymphatic collectors is an attractive target for pharmacological therapy of lymphedema. However, lymphatics have mostly been studied in animals, while the cellular and molecular characteristics of human lymphatic collectors are largely unknown. We studied epifascial lymphatic collectors of the thigh, which were isolated for autologous transplantations. Our immunohistological studies identify additional markers for LECs (vimentin, CCBE1). We show and confirm differences between initial and collecting lymphatics concerning the markers ESAM1, D2-40 and LYVE-1. Our transmission electron microscopic studies reveal two types of smooth muscle cells (SMCs) in the media of the collectors with dark and light cytoplasm. We observed vasa vasorum in the media of the largest collectors, as well as interstitial Cajal-like cells, which are highly ramified cells with long processes, caveolae, and lacking a basal lamina. They are in close contact with SMCs, which possess multiple caveolae at the contact sites. Immunohistologically we identified such cells with antibodies against vimentin and PDGFR alpha, but not CD34 and cKIT. With Next Generation Sequencing we searched for highly expressed genes in the media of lymphatic collectors, and found therapeutic targets, suitable for acceleration of lymphatic contractility, such as neuropeptide Y receptors 1, and 5; tachykinin receptors 1, and 2; purinergic receptors P2RX1, and 6, P2RY12, 13, and 14; 5-hydroxytryptamine receptors HTR2B, and 3C; and adrenoceptors alpha(2A),(B),(C). Our studies represent the first comprehensive characterization of human epifascial lymphatic collectors, as a prerequisite for diagnosis and therapy."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2016"],["dc.identifier.doi","10.1371/journal.pone.0164964"],["dc.identifier.isi","000386204500086"],["dc.identifier.pmid","27764183"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13797"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39190"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Public Library Science"],["dc.relation.issn","1932-6203"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Morphological and Molecular Characterization of Human Dermal Lymphatic Collectors"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","e12399"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Microcirculation"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Borchardt, Thomas"],["dc.contributor.author","Ernst, Jennifer"],["dc.contributor.author","Helmke, Andreas"],["dc.contributor.author","Tanyeli, Murat"],["dc.contributor.author","Schilling, Arndt F."],["dc.contributor.author","Felmerer, Gunther"],["dc.contributor.author","Viöl, Wolfgang"],["dc.date.accessioned","2020-12-10T18:29:11Z"],["dc.date.available","2020-12-10T18:29:11Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1111/micc.12399"],["dc.identifier.issn","1073-9688"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16970"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/76550"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Effect of direct cold atmospheric plasma (diCAP) on microcirculation of intact skin in a controlled mechanical environment"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3313"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","International Journal of Molecular Sciences"],["dc.bibliographiccitation.volume","22"],["dc.contributor.affiliation","Wolf, Stefan; \t\t \r\n\t\t Department of Plastic Surgery and Hand Surgery, University Hospital Zurich, 8091 Zurich, Switzerland, stefan.wolf2@usz.ch"],["dc.contributor.affiliation","Deuel, Jeremy W.; \t\t \r\n\t\t Division of Internal Medicine, University Hospital of Zurich, 8091 Zurich, Switzerland, jd862@cam.ac.uk"],["dc.contributor.affiliation","Hollmén, Maija; \t\t \r\n\t\t MediCity Research Laboratory, University of Turku, 20520 Turku, Finland, maijal@utu.fi"],["dc.contributor.affiliation","Felmerer, Gunther; \t\t \r\n\t\t Division of Plastic Surgery, Department of Trauma Surgery, Orthopaedics and Plastic Surgery, University Medical Center Göttingen, Georg-August-University, 37099 Göttingen, Germany, gunther.felmerer@med.uni-goettingen.de"],["dc.contributor.affiliation","Kim, Bong-Sung; \t\t \r\n\t\t Department of Plastic Surgery and Hand Surgery, University Hospital Zurich, 8091 Zurich, Switzerland, bong-sung.kim@usz.ch"],["dc.contributor.affiliation","Vasella, Mauro; \t\t \r\n\t\t Department of Plastic Surgery and Hand Surgery, University Hospital Zurich, 8091 Zurich, Switzerland, Mauro.Vasella@usz.ch"],["dc.contributor.affiliation","Grünherz, Lisanne; \t\t \r\n\t\t Department of Plastic Surgery and Hand Surgery, University Hospital Zurich, 8091 Zurich, Switzerland, Lisanne.Gruenherz@usz.ch"],["dc.contributor.affiliation","Giovanoli, Pietro; \t\t \r\n\t\t Department of Plastic Surgery and Hand Surgery, University Hospital Zurich, 8091 Zurich, Switzerland, Pietro.Giovanoli@usz.ch"],["dc.contributor.affiliation","Lindenblatt, Nicole; \t\t \r\n\t\t Department of Plastic Surgery and Hand Surgery, University Hospital Zurich, 8091 Zurich, Switzerland, Nicole.Lindenblatt@usz.ch"],["dc.contributor.affiliation","Gousopoulos, Epameinondas; \t\t \r\n\t\t Department of Plastic Surgery and Hand Surgery, University Hospital Zurich, 8091 Zurich, Switzerland, epameinondas.gousopoulos@usz.ch"],["dc.contributor.author","Wolf, Stefan"],["dc.contributor.author","Deuel, Jeremy W."],["dc.contributor.author","Hollmén, Maija"],["dc.contributor.author","Felmerer, Gunther"],["dc.contributor.author","Kim, Bong-Sung"],["dc.contributor.author","Vasella, Mauro"],["dc.contributor.author","Grünherz, Lisanne"],["dc.contributor.author","Giovanoli, Pietro"],["dc.contributor.author","Lindenblatt, Nicole"],["dc.contributor.author","Gousopoulos, Epameinondas"],["dc.date.accessioned","2021-06-01T09:42:36Z"],["dc.date.available","2021-06-01T09:42:36Z"],["dc.date.issued","2021"],["dc.date.updated","2022-09-05T10:23:01Z"],["dc.description.abstract","Lipedema is an adipose tissue disorder characterized by the disproportionate increase of subcutaneous fat tissue in the lower and/or upper extremities. The underlying pathomechanism remains unclear and no molecular biomarkers to distinguish the disease exist, leading to a large number of undiagnosed and misdiagnosed patients. To unravel the distinct molecular characteristic of lipedema we performed lipidomic analysis of the adipose tissue and serum of lipedema versus anatomically- and body mass index (BMI)-matched control patients. Both tissue groups showed no significant changes regarding lipid composition. As hyperplastic adipose tissue represents low-grade inflammation, the potential systemic effects on circulating cytokines were evaluated in lipedema and control patients using the Multiplex immunoassay system. Interestingly, increased systemic levels of interleukin 11 (p = 0.03), interleukin 28A (p = 0.04) and interleukin 29 (p = 0.04) were observed. As cytokines can influence metabolic activity, the metabolic phenotype of the stromal vascular fraction was examined, revealing significantly increased mitochondrial respiration in lipedema. In conclusion, despite sharing a comparable lipid profile with healthy adipose tissue, lipedema is characterized by a distinct systemic cytokine profile and metabolic activity of the stromal vascular fraction."],["dc.description.sponsorship","Lipedema Foundation"],["dc.description.sponsorship","Universität Zürich"],["dc.identifier.doi","10.3390/ijms22073313"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85296"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","1422-0067"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0/"],["dc.title","A Distinct Cytokine Profile and Stromal Vascular Fraction Metabolic Status without Significant Changes in the Lipid Composition Characterizes Lipedema"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]