Junker, Andreas

[["dc.bibliographiccitation.firstpage","17565"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","International Journal of Molecular Sciences"],["dc.bibliographiccitation.lastpage","17588"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Abdelhak, Ahmed"],["dc.contributor.author","Junker, Andreas"],["dc.contributor.author","Brettschneider, Johannes"],["dc.contributor.author","Kassubek, Jan"],["dc.contributor.author","Ludolph, Albert C."],["dc.contributor.author","Otto, Markus"],["dc.contributor.author","Tumani, Hayrettin"],["dc.date.accessioned","2018-11-07T09:53:26Z"],["dc.date.available","2018-11-07T09:53:26Z"],["dc.date.issued","2015"],["dc.description.abstract","Many neurodegenerative disorders share a common pathophysiological pathway involving axonal degeneration despite different etiological triggers. Analysis of cytoskeletal markers such as neurofilaments, protein tau and tubulin in cerebrospinal fluid (CSF) may be a useful approach to detect the process of axonal damage and its severity during disease course. In this article, we review the published literature regarding brain-specific CSF markers for cytoskeletal damage in primary progressive multiple sclerosis and amyotrophic lateral sclerosis in order to evaluate their utility as a biomarker for disease progression in conjunction with imaging and histological markers which might also be useful in other neurodegenerative diseases associated with affection of the upper motor neurons. A long-term benefit of such an approach could be facilitating early diagnostic and prognostic tools and assessment of treatment efficacy of disease modifying drugs."],["dc.description.sponsorship","BMBF-funded competence network multiple sclerosis (KKNMS)"],["dc.identifier.doi","10.3390/ijms160817565"],["dc.identifier.isi","000366826100046"],["dc.identifier.pmid","26263977"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/12759"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36329"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Mdpi Ag"],["dc.relation.issn","1422-0067"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Brain-Specific Cytoskeletal Damage Markers in Cerebrospinal Fluid: Is There a Common Pattern between Amyotrophic Lateral Sclerosis and Primary Progressive Multiple Sclerosis?"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]