Junker, Andreas

[["dc.bibliographiccitation.issue","1-2"],["dc.bibliographiccitation.journal","Journal of Neuroimmunology"],["dc.bibliographiccitation.volume","275"],["dc.contributor.author","Schultz, Verena"],["dc.contributor.author","Scheidt, Uta"],["dc.contributor.author","Paap, Franziska"],["dc.contributor.author","Brueck, Wolfgang"],["dc.contributor.author","Junker, Andreas"],["dc.date.accessioned","2018-11-07T09:33:35Z"],["dc.date.available","2018-11-07T09:33:35Z"],["dc.date.issued","2014"],["dc.format.extent","129"],["dc.identifier.doi","10.1016/j.jneuroim.2014.08.346"],["dc.identifier.isi","000345192100336"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/31999"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.publisher.place","Amsterdam"],["dc.relation.conference","12th International Congress of Neuroimmunology (ISNI)"],["dc.relation.eventlocation","Mainz, GERMANY"],["dc.relation.issn","1872-8421"],["dc.relation.issn","0165-5728"],["dc.title","Axonal damage and protection during early remyelination in multiple sclerosis and an animal model"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","796"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Macromolecular Rapid Communications"],["dc.bibliographiccitation.lastpage","802"],["dc.bibliographiccitation.volume","26"],["dc.contributor.author","Buback, M."],["dc.contributor.author","Junkers, T."],["dc.contributor.author","Vana, P."],["dc.date.accessioned","2018-11-07T11:00:23Z"],["dc.date.available","2018-11-07T11:00:23Z"],["dc.date.issued","2005"],["dc.description.abstract","A novel method combining RAFT polymerization with pulsed-laser initiation for determining chain-length dependent termination rate coefficients, k(t), is presented. Degenerative chain-transfer in RAFT enables single-pulse pulsed-laser polymerization (SP-PLP) traces to be measured on systems with a narrow radical distribution that remains essentially unchanged during the experiment. SP-PLP-RAFT experiments at different polymerization times allow for determining kt as a function of chain length via classical kinetics assuming chain-length independent k(t)."],["dc.identifier.doi","10.1002/marc.200500067"],["dc.identifier.isi","000229424200005"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50904"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-v C H Verlag Gmbh"],["dc.relation.issn","1022-1336"],["dc.title","Laser single pulse initiated RAFT polymerization for assessing chain-length dependent radical termination kinetics"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Acta Neuropathologica Communications"],["dc.bibliographiccitation.volume","2"],["dc.contributor.author","Mohan, Hema"],["dc.contributor.author","Friese, Anita"],["dc.contributor.author","Albrecht, Stefanie"],["dc.contributor.author","Krumbholz, Markus"],["dc.contributor.author","Elliott, Christina L"],["dc.contributor.author","Arthur, Ariel"],["dc.contributor.author","Menon, Ramesh"],["dc.contributor.author","Farina, Cinthia"],["dc.contributor.author","Junker, Andreas"],["dc.contributor.author","Meinl, Edgar"],["dc.date.accessioned","2021-06-01T10:48:07Z"],["dc.date.available","2021-06-01T10:48:07Z"],["dc.date.issued","2014"],["dc.identifier.doi","10.1186/s40478-014-0168-9"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85831"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","2051-5960"],["dc.title","Transcript profiling of different types of multiple sclerosis lesions yields FGF1 as a promoter of remyelination"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","56"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Nature Reviews Neurology"],["dc.bibliographiccitation.lastpage","59"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Junker, Andreas"],["dc.contributor.author","Hohlfeld, Reinhard"],["dc.contributor.author","Meinl, Edgar"],["dc.date.accessioned","2018-11-07T09:01:45Z"],["dc.date.available","2018-11-07T09:01:45Z"],["dc.date.issued","2011"],["dc.description.abstract","Several hundred microRNAs (miRNAs) fine-tune the expression of approximately half of all human genes. Recent studies have revealed that miRNA profiles in blood cells become altered in multiple sclerosis (MS), and that active and inactive MS lesions have distinct miRNA expression patterns. The dysregulated miRNAs in MS lesions seem to be associated with astrocytes and infiltrating immune cells, and might unleash local macrophages through downregulation of the self-recognition signal CD47. The expression of miRNA-326 in blood cells has been reported to increase during relapses. This miRNA promotes T helper 17 cell differentiation and is highly abundant in active MS lesions. miRNAs are needed for maintenance of the myelin sheath, and the absence of such molecules results in axonal damage in mice. miRNA-219 and other miRNAs promote oligodendrocyte differentiation. Here, we discuss the possible contribution of miRNAs to MS pathogenesis. An improved understanding of this contribution should help to identify novel therapeutic targets and biomarkers for this disease."],["dc.identifier.doi","10.1038/nrneurol.2010.179"],["dc.identifier.isi","000286099300012"],["dc.identifier.pmid","21151203"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24509"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","1759-4758"],["dc.title","The emerging role of microRNAs in multiple sclerosis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","27"],["dc.bibliographiccitation.issue","1-2"],["dc.bibliographiccitation.journal","Journal of Neuroimmunology"],["dc.bibliographiccitation.lastpage","33"],["dc.bibliographiccitation.volume","246"],["dc.contributor.author","Lescher, Juliane"],["dc.contributor.author","Paap, Franziska"],["dc.contributor.author","Schultz, Verena"],["dc.contributor.author","Redenbach, Laura"],["dc.contributor.author","Scheidt, Uta"],["dc.contributor.author","Rosewich, Hendrik"],["dc.contributor.author","Nessler, Stefan"],["dc.contributor.author","Fuchs, Eberhard"],["dc.contributor.author","Gärtner, Jutta"],["dc.contributor.author","Brueck, Wolfgang"],["dc.contributor.author","Junker, Andreas"],["dc.date.accessioned","2017-09-07T11:48:52Z"],["dc.date.available","2017-09-07T11:48:52Z"],["dc.date.issued","2012"],["dc.description.abstract","Here we demonstrate that miRNA regulation in marmoset (Callithrix jacchus) and C57/BL6 mouse EAE lesions largely resembles miRNA regulation in active human MS lesions. Detailed quantitative PCR analyses of the most up- and downregulated miRNAs of active human MS lesions in dissected lesions from marmoset EAE brains and inflamed spinal cords of EAE mice revealed that the conserved and highly regulated miRNAs, miRNA-155, miRNA-142-3p, miRNA-146a, miRNA-146b and miRNA-21, turned out to be similarly upregulated in marmoset and mouse EAE lesions. (C) 2012 Elsevier B.V. All rights reserved."],["dc.identifier.doi","10.1016/j.jneuroim.2012.02.012"],["dc.identifier.gro","3142535"],["dc.identifier.isi","000304026900004"],["dc.identifier.pmid","22445295"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/8897"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","0165-5728"],["dc.title","MicroRNA regulation in experimental autoimmune encephalomyelitis in mice and marmosets resembles regulation in human multiple sclerosis lesions"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","523"],["dc.bibliographiccitation.lastpage","537"],["dc.contributor.author","Junker, Andreas"],["dc.contributor.editor","Lawrie, Charles H."],["dc.date.accessioned","2021-12-08T12:28:28Z"],["dc.date.available","2021-12-08T12:28:28Z"],["dc.date.issued","2013"],["dc.identifier.doi","10.1002/9781118300312.ch32"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/95710"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-476"],["dc.publisher","John Wiley & Sons, Inc."],["dc.publisher.place","Hoboken, NJ, USA"],["dc.relation.eisbn","9781118300312"],["dc.relation.isbn","9781118300398"],["dc.relation.ispartof","MicroRNAs in Medicine"],["dc.title","MicroRNA Regulation in Multiple Sclerosis"],["dc.type","book_chapter"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","9497"],["dc.bibliographiccitation.issue","23"],["dc.bibliographiccitation.journal","Macromolecules"],["dc.bibliographiccitation.lastpage","9508"],["dc.bibliographiccitation.volume","38"],["dc.contributor.author","Junkers, T."],["dc.contributor.author","Theis, A."],["dc.contributor.author","Buback, M."],["dc.contributor.author","Davis, T. P."],["dc.contributor.author","Stenzel, M. H."],["dc.contributor.author","Vana, P."],["dc.contributor.author","Barner-Kowollik, C."],["dc.date.accessioned","2018-11-07T10:54:20Z"],["dc.date.available","2018-11-07T10:54:20Z"],["dc.date.issued","2005"],["dc.description.abstract","The chain-length dependence of the termination rate coefficient, k(t), in butyl acrylate free-radical polymerization has been determined by two independent methods, RAFT-SP-PLP and RAFT-CLD-T, both employing control of radical chain length by reversible addition fragmentation chain transfer (RAFT) polymerization. Within RAFT-SP-PLP, the polymerization induced by a laser single pulse is monitored via near-IR spectroscopy with a time resolution of microseconds. In RAFT-CLD-T, isothermal reaction rate measurements are carried out via DSC under stationary polymerization conditions. The resulting k(t) data refer to the situation of living/controlled radical polymerization, where both radical chain length and monomer conversion increase during the course of the reaction. The RAFT-SP-PLP measurements were carried out at 60 degrees C and two pressures, 5 and 1000 bar. The RAFT-CLD-T experiments were run at ambient pressure and at two temperatures, 60 and 80 degrees C, respectively. In absolute value, the termination rate coefficients for identical pressure and temperature deduced from the two methods differ by less than a factor of 2. For the dependence of k(t) on chain length, i, almost identical information is provided by the two techniques. The chain-length dependence of kt may be described by the power-law expression k(t)(i) = k(t)(1,1)i(-alpha) with, however, a being different for short-chain and long-chain radicals. RAFT-SP-PLP yields alpha(1) = 1.25 for the short-chain regime from 1 < i < 30, and alpha(2) = 0.22 for chain lengths above i = 50. RAFT-CLD-T results in alpha(1) = 1.04 and alpha(2) = 0.20 in identical chain length regimes. kt(1,1) values are found to be close to 1 x 10(9) L mol(-1) s(-1)."],["dc.identifier.doi","10.1021/ma051485k"],["dc.identifier.isi","000233225600015"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/49541"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Chemical Soc"],["dc.relation.issn","0024-9297"],["dc.title","Chain length dependent termination in butyl acrylate free-radical polymerization studied via stationary and pulsed laser initiated RAFT polymerization"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1004"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Macromolecular Rapid Communications"],["dc.bibliographiccitation.lastpage","1009"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Buback, M."],["dc.contributor.author","Egorov, M."],["dc.contributor.author","Junkers, T."],["dc.contributor.author","Panchenko, E."],["dc.date.accessioned","2018-11-07T10:48:53Z"],["dc.date.available","2018-11-07T10:48:53Z"],["dc.date.issued","2004"],["dc.description.abstract","A novel method for measuring termination rate coefficients, k(t), in free-radical polymerization is presented. A single laser pulse is used to instantaneously produce photoinitiator-derived radicals. During subsequent polmerization, radical concentration is monitored by time-resolved electron spin resonance (ESR) spectroscopy. The size of the free radicals, which exhibits a narrow distribution increases linearly with time t, which allows the chain-length dependence of k(t), to be deduced. The method will be illustrated using dodecyl methacrylate polymerization as an example."],["dc.identifier.doi","10.1002/marc.200400050"],["dc.identifier.isi","000221724000005"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/48306"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-v C H Verlag Gmbh"],["dc.relation.issn","1022-1336"],["dc.title","Free-radical termination kinetics studied using a novel SP-PLP-ESR technique"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2073"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Brain: A Journal of Neurology"],["dc.bibliographiccitation.lastpage","2088"],["dc.bibliographiccitation.volume","143"],["dc.contributor.author","Jäckle, Katharina"],["dc.contributor.author","Zeis, Thomas"],["dc.contributor.author","Schaeren-Wiemers, Nicole"],["dc.contributor.author","Junker, Andreas"],["dc.contributor.author","van der Meer, Franziska"],["dc.contributor.author","Kramann, Nadine"],["dc.contributor.author","Stadelmann, Christine"],["dc.contributor.author","Brück, Wolfgang"],["dc.date.accessioned","2021-04-14T08:24:16Z"],["dc.date.available","2021-04-14T08:24:16Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1093/brain/awaa158"],["dc.identifier.pmid","32577755"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81225"],["dc.identifier.url","https://mbexc.uni-goettingen.de/literature/publications/283"],["dc.identifier.url","https://rdp.sfb274.de/literature/publications/29"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation","EXC 2067: Multiscale Bioimaging"],["dc.relation","TRR 274: Checkpoints of Central Nervous System Recovery"],["dc.relation","TRR 274 | B02: Inflammatory neurodegeneration and repair mechanisms in childhood onset autoimmune and neurometabolic demyelinating CNS disease"],["dc.relation.eissn","1460-2156"],["dc.relation.issn","0006-8950"],["dc.relation.workinggroup","RG Stadelmann-Nessler"],["dc.relation.workinggroup","RG Brück"],["dc.title","Molecular signature of slowly expanding lesions in progressive multiple sclerosis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","333"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Macromolecular Chemistry and Physics"],["dc.bibliographiccitation.lastpage","341"],["dc.bibliographiccitation.volume","206"],["dc.contributor.author","Buback, M."],["dc.contributor.author","Egorov, M."],["dc.contributor.author","Junkers, T."],["dc.contributor.author","Panchenko, E."],["dc.date.accessioned","2018-11-07T11:24:11Z"],["dc.date.available","2018-11-07T11:24:11Z"],["dc.date.issued","2005"],["dc.description.abstract","The termination kinetics of dibutyl itaconate(DBI) bulk polymerization was studied via SP-PLP-ESR single pulse-pulsed laser polymerization with time-resolved detection of free-radical concentration by electron-spin resonace, at temperature of PLP experiments,termination rate coefficients,k(1)(i,i), are measured for radicals of (almost) identical chain length (CL)i. CL-averaged , for chain lenghts up to 200 monomer units, and also k(t)(0) referring to termination of very small-size radicals are directly deduced from measured DBI radical concentration vs time traces. At 45degreesC, is (3.4 +/-0.6) (.) 10(5) L (.) mol(-1 .) s(-1) and k(t)(0) is (7.2 +/- 1.0) (.) 10(5) L (.) mol(-1) (.) s(-1). Both rate coefficients are independent of monomer conversion up to the highest experimental conversion of 18%. The associated activation energies are E-A() = 23.0 +/- 3.2 kJ (.) mol(-1) and E-A(k(0)(t)) = 27.6 +/- 2.8 kJ (.) mol(-1), respectively. \"Model-dependent\" and \"model-free\" analyses of radical concentration vs time profiles indicate a pronouced CL dependence of k(t)(i,i) for DBI radicals of moderate size, 5 < i < 50. The lowering of k(t)(i,i) for DBI radicals of moderate size, 5 < i < 50. The lowering of k(t)(i,i) with CL corresponds to an exponent alpha close to an exponent alpha close to 0.5 in a power-law expression k(t)(i,i)=k(t)(0 .) i(-a). At higher chain lengths, the variation of k(t)(i,i) with CL becomes weaker and may be represented by an alpha(1) value of 0.16 or even below. These results are consistent with models according to which alpha varies to a larger extent at low CL and to a smaller extent at high CL with the crossover region between the two ranges being located somewhere around i=100. [GRAPHIC] Conversion dependence of and k(t)(0) from laser-induced photopolymerization of DBI."],["dc.identifier.doi","10.1002/macp.200400358"],["dc.identifier.isi","000227008000002"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56348"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-v C H Verlag Gmbh"],["dc.relation.issn","1022-1352"],["dc.title","Termination kinetics of dibutyl itaconate free-radical polymerization studied via the SP-PLP-ESRTechnique"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]