Stephani, Caspar

[["dc.bibliographiccitation.firstpage","724"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Brain Stimulation"],["dc.bibliographiccitation.lastpage","729"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Stephani, Caspar"],["dc.contributor.author","Koubeissi, Mohamad Z."],["dc.date.accessioned","2018-11-07T09:55:14Z"],["dc.date.available","2018-11-07T09:55:14Z"],["dc.date.issued","2015"],["dc.description.abstract","Background: The thresholds of current intensities required to evoke a clinical response during intracranial electrical stimulation mapping vary. Objective: We wanted to test if there is systematic variation of threshold currents between different brain areas. Methods: Electrode contacts of depth electrodes in a series of patients undergoing presurgical evaluation for epilepsy surgery were stimulated. The brain regions we studied included the insular cortex, the pericentral cortex, and the intervening white matter. Results: Current intensities that elicited clinical responses in central subcortical white matter tracts were significantly lower than those needed to evoke a clinical response in the cortex. Conclusion: We found systematic differences of threshold stimulation intensities between cortical and subcortical structures in the human brain. In addition to known neurophysiologic differences between white and grey matter, the systematic difference in stimulation thresholds may be due to the direction of the white matter tracts with respect to the electrode orientation and to inherent properties of specific brain regions. (C) 2015 Elsevier Inc. All rights reserved."],["dc.description.sponsorship","Stiftungsrat fur die deutsche Wissenschaft [S 134-10.044]"],["dc.identifier.doi","10.1016/j.brs.2015.02.011"],["dc.identifier.isi","000357542100006"],["dc.identifier.pmid","25842075"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36700"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.relation.issn","1876-4754"],["dc.relation.issn","1935-861X"],["dc.title","Differences of Intracranial Electrical Stimulation Thresholds in the Human Brain"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","177"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Neurology"],["dc.bibliographiccitation.lastpage","179"],["dc.bibliographiccitation.volume","86"],["dc.contributor.author","Koubeissi, Mohamad Z."],["dc.contributor.author","Vaca, Guadalupe Fernandez-Baca"],["dc.contributor.author","Maciunas, Robert"],["dc.contributor.author","Stephani, Caspar"],["dc.date.accessioned","2018-11-07T10:19:27Z"],["dc.date.available","2018-11-07T10:19:27Z"],["dc.date.issued","2016"],["dc.description.abstract","Objective:To investigate the effects of extraoperative electrical stimulation of fiber tracts connecting the language territories.Methods:We describe results of extraoperative electrical stimulation of stereotactic electrodes in 3 patients with epilepsy who underwent presurgical evaluation for epilepsy surgery. Contacts of these electrodes sampled, among other structures, the suprainsular white matter of the left hemisphere.Results:Aside from speech disturbance and speech arrest, subcortical electrical stimulation of white matter tracts directly superior to the insula representing the anterior part of the arcuate fascicle, reproducibly induced complex verbal auditory phenomena including (1) hearing one's own voice in the absence of overt speech, and (2) lack of perception of arrest or alteration in ongoing repetition of words.Conclusion:These results represent direct evidence that the anterior part of the arcuate fascicle is part of a network that is important in the mediation of speech planning and awareness likely by linking the language areas of the inferior parietal and posterior inferior frontal cortices. More specifically, our observations suggest that this structure may be relevant to the pathophysiology of thought disorders and auditory verbal hallucinations."],["dc.description.sponsorship","Stifterverband fur die Deutsche Wissenschaft [S134-10.044]"],["dc.identifier.doi","10.1212/WNL.0000000000002246"],["dc.identifier.isi","000368454800012"],["dc.identifier.pmid","26643545"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/41658"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","1526-632X"],["dc.relation.issn","0028-3878"],["dc.title","A white matter tract mediating awareness of speech"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","186"],["dc.bibliographiccitation.journal","Epilepsia"],["dc.bibliographiccitation.lastpage","187"],["dc.bibliographiccitation.volume","50"],["dc.contributor.author","Stephani, Caspar"],["dc.contributor.author","Fernandez-Baca-Vaca, G."],["dc.contributor.author","Maciunas, Robert"],["dc.contributor.author","Koubeissi, Mohamad Z."],["dc.contributor.author","Lueders, Heike"],["dc.date.accessioned","2018-11-07T11:22:31Z"],["dc.date.available","2018-11-07T11:22:31Z"],["dc.date.issued","2009"],["dc.identifier.isi","000270550500390"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56011"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell Publishing, Inc"],["dc.publisher.place","Malden"],["dc.relation.conference","63rd Annual Meeting of the American-Epilepsy-Society"],["dc.relation.eventlocation","Boston, MA"],["dc.relation.issn","0013-9580"],["dc.title","FUNCTIONAL NEUROANATOMY OF THE INSULAR CORTEX"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Epilepsia"],["dc.bibliographiccitation.volume","53"],["dc.contributor.author","Stephani, Caspar"],["dc.contributor.author","Koubeissi, Mohamad Z."],["dc.date.accessioned","2018-11-07T09:06:23Z"],["dc.date.available","2018-11-07T09:06:23Z"],["dc.date.issued","2012"],["dc.format.extent","126"],["dc.identifier.isi","000308875900432"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25547"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.conference","10th European Congress on Epileptology"],["dc.relation.eventlocation","London, ENGLAND"],["dc.relation.issn","0013-9580"],["dc.title","DIFFERENCES OF INTRACEREBRAL ELECTRICAL STIMULATION THRESHOLDS IN THE HUMAN BRAIN"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","137"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Brain Structure and Function"],["dc.bibliographiccitation.lastpage","149"],["dc.bibliographiccitation.volume","216"],["dc.contributor.author","Stephani, Caspar"],["dc.contributor.author","Vaca, Guadalupe Fernandez-Baca"],["dc.contributor.author","Maciunas, Robert"],["dc.contributor.author","Koubeissi, Mohamad Z."],["dc.contributor.author","Lueders, H. O."],["dc.date.accessioned","2018-11-07T08:55:40Z"],["dc.date.available","2018-11-07T08:55:40Z"],["dc.date.issued","2011"],["dc.description.abstract","The insula is the fifth lobe of the brain and it is the least known. Hidden under the temporal, frontal and parietal opercula, as well as under dense arterial and venous vessels, its accessibility is particularly restricted. Functional data on this region in humans, therefore, are scarce and the existing evidence makes conclusions on its functional and somatotopic organization difficult. 5 patients with intractable epilepsy underwent an invasive presurgical evaluation with implantation of diagnostic invasive-depth electrodes, including insular electrodes that were inserted using a mesiocaudodorsal to laterorostroventral approach. Altogether 113 contacts were found to be in the insula and were stimulated with alternating currents during preoperative monitoring. Different viscerosensitive and somatosensory phenomena were elicited by stimulation of these electrodes. A relatively high density of electrode contacts enabled us to delineate several functionally distinct areas within the insula. We found somatosensory symptoms to be restricted to the posterior insula and a subgroup of warmth or painful sensations in the dorsal posterior insula. Viscerosensory symptoms were elicited by more anterior electrode contacts with a subgroup of gustatory symptoms occurring after stimulation of electrode contacts in the central part of the insula. The anterior insula did not show reproducible responses to stimulation. In line with previous studies, we found evidence for somato- and viscerosensory cortex in the insula. In addition, our results suggest that there is a predominantly posterior and central distribution of these functions in the insular lobe."],["dc.description.sponsorship","Stiftungsrat fur die deutsche Wissenschaft"],["dc.identifier.doi","10.1007/s00429-010-0296-3"],["dc.identifier.isi","000290768700006"],["dc.identifier.pmid","21153903"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6626"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22961"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Heidelberg"],["dc.relation.issn","1863-2653"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Functional neuroanatomy of the insular lobe"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]