Bucher, Gregor

[["dc.bibliographiccitation.firstpage","1819"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Proceedings of the National Academy of Sciences"],["dc.bibliographiccitation.lastpage","1824"],["dc.bibliographiccitation.volume","115"],["dc.contributor.author","Ansari, Salim"],["dc.contributor.author","Troelenberg, Nicole"],["dc.contributor.author","Dao, Van Anh"],["dc.contributor.author","Richter, Tobias"],["dc.contributor.author","Bucher, Gregor"],["dc.contributor.author","Klingler, Martin"],["dc.date.accessioned","2020-12-10T18:12:48Z"],["dc.date.available","2020-12-10T18:12:48Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1073/pnas.1716512115"],["dc.identifier.eissn","1091-6490"],["dc.identifier.issn","0027-8424"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/74503"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Double abdomen in a short-germ insect: Zygotic control of axis formation revealed in the beetle Tribolium castaneum"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","284"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Developmental Biology"],["dc.bibliographiccitation.lastpage","294"],["dc.bibliographiccitation.volume","321"],["dc.contributor.author","Cerny, Alexander C."],["dc.contributor.author","Grossmann, Daniela"],["dc.contributor.author","Bucher, Gregor"],["dc.contributor.author","Klingler, Martin"],["dc.date.accessioned","2018-11-07T11:11:15Z"],["dc.date.available","2018-11-07T11:11:15Z"],["dc.date.issued","2008"],["dc.description.abstract","Segment formation in the long germ insect Drosophila is dominated by overlapping gap gene domains in the syncytial blastoderm. In the short germ beetle Tribolium castaneum abdominal segments arise from a cellular growth zone. implying different patterning mechanisms. We describe here the single Tribolium ortholog of the Drosophila genes knirps and knirps-related (called Tc-knirps). Tc-knirps expression is conserved during head patterning and at later stages. However, Posterior Tc-knirps expression in the ectoderm is limited to a stripe in Al. instead of a broad abdominal domain covering segment primordia A2-A5 as in Drosophila. Tc-knirps RNAi yields only mild defects in the abdomen, at a position posterior to the abdominal Tc-knirps domain. In addition, Tc-knirps RNAi larvae lack the antennal and mandibular segments. These defects are much more severe than the head defects Caused by combined inactivation of Din-knirps and Dm-knirps-related. Our findings support the notion that the role of gap gene homologs in abdominal segmentation differs fundamentally in long and short germ insects, Moreover, the pivotal role of Tc-knirps in the head Suggests an ancestral role for knirps as head patterning gene. Based on this RNAi analysis, Tc-knirps functions neither in the head nor the abdomen as a canonical gap gene. (C) 2008 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.ydbio.2008.05.527"],["dc.identifier.isi","000258710800025"],["dc.identifier.pmid","18586236"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53389"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Inc Elsevier Science"],["dc.relation.issn","0012-1606"],["dc.title","The Tribolium ortholog of knirps and knirps-related is crucial for head segmentation but plays a minor role during abdominal patterning"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","215"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Developmental Biology"],["dc.bibliographiccitation.lastpage","227"],["dc.bibliographiccitation.volume","333"],["dc.contributor.author","Yang, Xiaoyun"],["dc.contributor.author","Weber, Markus"],["dc.contributor.author","ZarinKamar, Nazanin"],["dc.contributor.author","Posnien, Nico"],["dc.contributor.author","Friedrich, Frank"],["dc.contributor.author","Wigand, Barbara"],["dc.contributor.author","Beutel, Rolf"],["dc.contributor.author","Damen, Wim G. M."],["dc.contributor.author","Bucher, Gregor"],["dc.contributor.author","Klingler, Martin"],["dc.contributor.author","Friedrich, Markus"],["dc.date.accessioned","2018-11-07T11:24:39Z"],["dc.date.available","2018-11-07T11:24:39Z"],["dc.date.issued","2009"],["dc.description.abstract","The Pax6 genes eyeless (ey) and twin of eyeless (toy) are upstream regulators in the retinal determination gene network (RDGN), which instructs the formation of the adult eye primordium in Drosophila. Most animals possess a singleton Pax6 ortholog, but the dependence of eye development on Pax6 is widely conserved. A rare exception is given by the larval eyes of Drosophila, which develop independently of ey and toy. To obtain insight into the origin of differential larval and adult eye regulation, we studied the function of toy and ey in the red. our beetle Tribolium castaneum. We find that single and combinatorial knockdown of toy and ey affect larval eye development strongly but adult eye development only mildly in this primitive hemimetabolous species. Compound eye-loss, however, was provoked when ey and toy were RNAi-silenced in combination with the early retinal gene dachshund (dac). We propose that these data reflect a role of Pax6 during regional specification in the developing head and that the subsequent maintenance and growth of the adult eye primordium is regulated partly by redundant and partly by specific functions of toy, ey and dac in Tribolium. The results from embryonic knockdown and comparative protein sequence analysis lead us further to conclude that Tribolium represents an ancestral state of redundant control by ey and toy. Published by Elsevier Inc."],["dc.identifier.doi","10.1016/j.ydbio.2009.06.013"],["dc.identifier.isi","000272260100018"],["dc.identifier.pmid","19527703"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56454"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Inc Elsevier Science"],["dc.relation.issn","0012-1606"],["dc.title","Probing the Drosophila retinal determination gene network in Tribolium (II): The Pax6 genes eyeless and twin of eyeless"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","430"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Mechanisms of Development"],["dc.bibliographiccitation.lastpage","439"],["dc.bibliographiccitation.volume","123"],["dc.contributor.author","Wohfrom, Hilde"],["dc.contributor.author","Schinko, Johannes Benno"],["dc.contributor.author","Klingler, Martin"],["dc.contributor.author","Bucher, Gregor"],["dc.date.accessioned","2018-11-07T09:46:32Z"],["dc.date.available","2018-11-07T09:46:32Z"],["dc.date.issued","2006"],["dc.description.abstract","For homeotic and segment-polarity genes in Drosophila, a switch in gene regulation has been described that distinguishes patterning and maintenance phases. Maintenance of segment and organ primordia involves secondary patterning and differentiation steps, as well as survival factors regulating proliferation and organ size. In a screen for embryonic lethal mutations in the flour beetle Tribolium castaneum, we have recovered two alleles of the knodel gene, which result in short, bag-like embryos. These embryos have severely reduced appendages and differentiate a cuticle that lacks most overt signs of segmentation. In addition, they lack bristles and display defects in the nervous system. Early patterning in knodel mutant embryos is normal up to the extended germ band stage, as indicated by the formation of regular even-skipped (Tc'eve) and wingless (Tc'wg) stripes. Afterwards, however, these patterns degenerate. Similarly, proximo-distal growth and patterning of limbs are nearly normal initially, but limb primordia shrink, and proximo-distal patterns degenerate, during subsequent stages. knodel could be a segment polarity gene required for segment border maintenance in both trunk and appendages. Alternatively, it may have a more general role in tissue or organ maintenance. (c) 2006 Elsevier Ireland Ltd. All rights reserved."],["dc.identifier.doi","10.1016/j.mod.2006.04.003"],["dc.identifier.isi","000241001700002"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/34890"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","0925-4773"],["dc.title","Maintenance of segment and appendage primordia by the Tribolium gene knodel"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]