Bucher, Gregor

[["dc.bibliographiccitation.firstpage","1819"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Proceedings of the National Academy of Sciences"],["dc.bibliographiccitation.lastpage","1824"],["dc.bibliographiccitation.volume","115"],["dc.contributor.author","Ansari, Salim"],["dc.contributor.author","Troelenberg, Nicole"],["dc.contributor.author","Dao, Van Anh"],["dc.contributor.author","Richter, Tobias"],["dc.contributor.author","Bucher, Gregor"],["dc.contributor.author","Klingler, Martin"],["dc.date.accessioned","2020-12-10T18:12:48Z"],["dc.date.available","2020-12-10T18:12:48Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1073/pnas.1716512115"],["dc.identifier.eissn","1091-6490"],["dc.identifier.issn","0027-8424"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/74503"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Double abdomen in a short-germ insect: Zygotic control of axis formation revealed in the beetle Tribolium castaneum"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Development"],["dc.contributor.author","Garcia-Perez, Natalia Carolina"],["dc.contributor.author","Bucher, Gregor"],["dc.contributor.author","Buescher, Marita"],["dc.date.accessioned","2021-09-01T06:42:54Z"],["dc.date.available","2021-09-01T06:42:54Z"],["dc.date.issued","2021"],["dc.description.abstract","Gene regulatory mechanisms which specify subtype identity of central complex (CX) neurons are the subject of intense investigation. The CX is a compartment within the brain common to all insect species and functions as a “command center” which directs motor actions. It is made up of several thousand neurons with more than 60 morphologically distinct identities. Accordingly, transcriptional programs must effect the specification of at least as many neuronal subtypes. We demonstrate a role for the transcription factor Shaking hands (Skh) in the specification of embryonic CX neurons in Tribolium. The developmental dynamics of Tc-skh expression are characteristic for terminal selectors of subtype identity. In the embryonic brain, Tc-skh expression is restricted to a subset of neurons, many of which survive to adulthood and contribute to the mature CX. Tc-skh expression is maintained throughout the lifetime in at least some CX neurons. Tc-skh knock-down results in axon outgrowth defects thus preventing the formation of an embryonic CX primordium. The as yet unstudied Drosophila skh shows a similar embryonic expression pattern suggesting that subtype specification of CX neurons may be conserved."],["dc.description.abstract","Gene regulatory mechanisms which specify subtype identity of central complex (CX) neurons are the subject of intense investigation. The CX is a compartment within the brain common to all insect species and functions as a “command center” which directs motor actions. It is made up of several thousand neurons with more than 60 morphologically distinct identities. Accordingly, transcriptional programs must effect the specification of at least as many neuronal subtypes. We demonstrate a role for the transcription factor Shaking hands (Skh) in the specification of embryonic CX neurons in Tribolium. The developmental dynamics of Tc-skh expression are characteristic for terminal selectors of subtype identity. In the embryonic brain, Tc-skh expression is restricted to a subset of neurons, many of which survive to adulthood and contribute to the mature CX. Tc-skh expression is maintained throughout the lifetime in at least some CX neurons. Tc-skh knock-down results in axon outgrowth defects thus preventing the formation of an embryonic CX primordium. The as yet unstudied Drosophila skh shows a similar embryonic expression pattern suggesting that subtype specification of CX neurons may be conserved."],["dc.identifier.doi","10.1242/dev.199368"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/89171"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-455"],["dc.relation.eissn","1477-9129"],["dc.relation.issn","0950-1991"],["dc.title","Shaking hands is a homeodomain transcription factor that controls axon outgrowth of central complex neurons in the insect model Tribolium"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","399"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Arthropod Structure & Development"],["dc.bibliographiccitation.lastpage","410"],["dc.bibliographiccitation.volume","39"],["dc.contributor.author","Posnien, Nico"],["dc.contributor.author","Schinko, Johannes B."],["dc.contributor.author","Kittelmann, Sebastian"],["dc.contributor.author","Bucher, Gregor"],["dc.date.accessioned","2018-11-07T08:37:17Z"],["dc.date.available","2018-11-07T08:37:17Z"],["dc.date.issued","2010"],["dc.description.abstract","Many questions regarding evolution and ontogeny of the insect head remain open. Likewise, the genetic basis of insect head development is poorly understood. Recently, the investigation of gene expression data and the analysis of patterning gene function have revived interest in insect head development. Here, we argue that the red flour beetle Tribolium castaneum is a well suited model organism to spearhead research with respect to the genetic control of insect head development. We review recent molecular data and discuss its bearing on early development and morphogenesis of the head. We present a novel hypothesis on the ontogenetic origin of insect head sutures and review recent insights into the question on the origin of the labrum. Further, we argue that the study of developmental genes may identify the elusive anterior non-segmental region and present some evidence in favor of its existence. With respect to the question of evolution of patterning we show that the head Anlagen of the fruit fly Drosophila melanogaster and Tribolium differ considerably and we review profound differences of their genetic regulation. Finally, we discuss which insect model species might help us to answer the open questions concerning the genetic regulation of head development and its evolution. (C) 2010 Elsevier Ltd. All rights reserved."],["dc.identifier.doi","10.1016/j.asd.2010.08.002"],["dc.identifier.isi","000285819100002"],["dc.identifier.pmid","20800703"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18495"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Sci Ltd"],["dc.relation.issn","1467-8039"],["dc.title","Genetics, development and composition of the insect head - A beetle's view"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","107"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Developmental Biology"],["dc.bibliographiccitation.lastpage","116"],["dc.bibliographiccitation.volume","338"],["dc.contributor.author","Posnien, Nico"],["dc.contributor.author","Bucher, Gregor"],["dc.date.accessioned","2018-11-07T08:46:09Z"],["dc.date.available","2018-11-07T08:46:09Z"],["dc.date.issued","2010"],["dc.description.abstract","The insect head is composed of several segments. During embryonic development, the segments fuse to form a rigid head capsule where obvious segmental boundaries are lacking. Hence, the assignment of regions of the insect head to specific segments is hampered, especially with respect to dorsal (vertex) and lateral (gena) parts. We show that upon Tribolium labial (Tc-lab) knock down, the intercalary segment is deleted but not transformed. Furthermore, we find that the intercalary segment contributes to lateral parts of the head cuticle in Tribolium. Based on several additional mutant and RNAi phenotypes that interfere with gnathal segment development, we show that these segments do not contribute to the dorsal head capsule apart from the dorsal ridge. Opposing the classical view but in line with findings in the vinegar fly Drosophila melanogaster and the milkweed bug Oncopeltus fasciatus, we propose a \"bend and zipper\" model for insect head capsule formation. (C) 2009 Elsevier Inc, All rights reserved."],["dc.description.sponsorship","DFG [BU-1443/2]; Marie-Curie Research Training Network \"Zoonet\""],["dc.identifier.doi","10.1016/j.ydbio.2009.11.010"],["dc.identifier.isi","000274173400010"],["dc.identifier.pmid","19913530"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20618"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Inc Elsevier Science"],["dc.relation.issn","1095-564X"],["dc.relation.issn","0012-1606"],["dc.title","Formation of the insect head involves lateral contribution of the intercalary segment, which depends on Tc-labial function"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","191"],["dc.bibliographiccitation.lastpage","217"],["dc.bibliographiccitation.seriesnr","2047"],["dc.contributor.author","Farnworth, Max S."],["dc.contributor.author","Eckermann, Kolja N."],["dc.contributor.author","Ahmed, Hassan M. M."],["dc.contributor.author","Mühlen, Dominik S."],["dc.contributor.author","He, Bicheng"],["dc.contributor.author","Bucher, Gregor"],["dc.contributor.editor","Sprecher, Simon G."],["dc.date.accessioned","2021-06-02T10:44:27Z"],["dc.date.available","2021-06-02T10:44:27Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1007/978-1-4939-9732-9_11"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/87046"],["dc.notes.intern","DOI-Import GROB-425"],["dc.publisher","Springer New York"],["dc.publisher.place","New York, NY"],["dc.relation.crisseries","Methods in Molecular Biology"],["dc.relation.eisbn","978-1-4939-9732-9"],["dc.relation.isbn","978-1-4939-9731-2"],["dc.relation.ispartof","Methods in Molecular Biology"],["dc.relation.ispartof","Brain Development : Methods and Protocols"],["dc.relation.ispartofseries","Methods in Molecular Biology; 2047"],["dc.title","The Red Flour Beetle as Model for Comparative Neural Development: Genome Editing to Mark Neural Cells in Tribolium Brain Development"],["dc.type","book_chapter"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","478"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Development Genes and Evolution"],["dc.bibliographiccitation.lastpage","481"],["dc.bibliographiccitation.volume","215"],["dc.contributor.author","Bucher, G."],["dc.contributor.author","Klingler, M."],["dc.date.accessioned","2018-11-07T10:56:01Z"],["dc.date.available","2018-11-07T10:56:01Z"],["dc.date.issued","2005"],["dc.description.abstract","In Drosophila, the Mae protein (\"modulator of the activity of Ets\") regulates receptor tyrosine kinase (RTK)-dependent mitogen-activated protein kinase (MAPK) signaling. Mae has been shown to bind the Yan and Pointed-P2 transcription factors, thereby changing their ability to activate or repress target genes. In this work we show that the mae ortholog of the red flour beetle Tribolium castaneum (Tc'mae) is active at the posterior, but not the anterior pole of the blastoderm. Since MAPK signaling is known to be active at both poles, Tc'Mae could function to modulate terminal MAPK signaling to differentiate the developmental programs at the anterior and posterior poles of the Tribolium blastoderm embryo. Tc'mae is also expressed along the midline of the germband, similar as in Drosophila, where it is involved in the patterning of midline cells. Before gastrulation and in the growth zone, Tc'mae is active in mesoderm precursor cells. This suggests that in short germ embryos MAPK signaling may also be involved in the specification of mesoderm."],["dc.identifier.doi","10.1007/s00427-005-0004-0"],["dc.identifier.isi","000232056000005"],["dc.identifier.pmid","16025346"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/49919"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","0949-944X"],["dc.title","Tribolium mae expression suggests roles in terminal and midline patterning and in the specification of mesoderm"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","95"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Development Genes and Evolution"],["dc.bibliographiccitation.lastpage","104"],["dc.bibliographiccitation.volume","230"],["dc.contributor.author","Schacht, Magdalena Ines"],["dc.contributor.author","Schomburg, Christoph"],["dc.contributor.author","Bucher, Gregor"],["dc.date.accessioned","2020-12-10T14:10:36Z"],["dc.date.available","2020-12-10T14:10:36Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1007/s00427-020-00654-9"],["dc.identifier.eissn","1432-041X"],["dc.identifier.issn","0949-944X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70813"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","six3 acts upstream of foxQ2 in labrum and neural development in the spider Parasteatoda tepidariorum"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","S0048357521001012"],["dc.bibliographiccitation.firstpage","104870"],["dc.bibliographiccitation.journal","Pesticide Biochemistry and Physiology"],["dc.bibliographiccitation.volume","176"],["dc.contributor.author","Mehlhorn, Sonja"],["dc.contributor.author","Ulrich, Julia"],["dc.contributor.author","Baden, Christian U."],["dc.contributor.author","Buer, Benjamin"],["dc.contributor.author","Maiwald, Frank"],["dc.contributor.author","Lueke, Bettina"],["dc.contributor.author","Geibel, Sven"],["dc.contributor.author","Bucher, Gregor"],["dc.contributor.author","Nauen, Ralf"],["dc.date.accessioned","2021-07-05T15:00:22Z"],["dc.date.available","2021-07-05T15:00:22Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1016/j.pestbp.2021.104870"],["dc.identifier.pii","S0048357521001012"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/87808"],["dc.language.iso","en"],["dc.notes.intern","DOI Import DOI-Import GROB-441"],["dc.relation.issn","0048-3575"],["dc.title","The mustard leaf beetle, Phaedon cochleariae, as a screening model for exogenous RNAi-based control of coleopteran pests"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","104569"],["dc.bibliographiccitation.journal","Pesticide Biochemistry and Physiology"],["dc.bibliographiccitation.volume","166"],["dc.contributor.author","Mehlhorn, Sonja G."],["dc.contributor.author","Geibel, Sven"],["dc.contributor.author","Bucher, Gregor"],["dc.contributor.author","Nauen, Ralf"],["dc.date.accessioned","2021-04-14T08:25:55Z"],["dc.date.available","2021-04-14T08:25:55Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1016/j.pestbp.2020.104569"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81768"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.issn","0048-3575"],["dc.title","Profiling of RNAi sensitivity after foliar dsRNA exposure in different European populations of Colorado potato beetle reveals a robust response with minor variability"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","284"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Developmental Biology"],["dc.bibliographiccitation.lastpage","294"],["dc.bibliographiccitation.volume","321"],["dc.contributor.author","Cerny, Alexander C."],["dc.contributor.author","Grossmann, Daniela"],["dc.contributor.author","Bucher, Gregor"],["dc.contributor.author","Klingler, Martin"],["dc.date.accessioned","2018-11-07T11:11:15Z"],["dc.date.available","2018-11-07T11:11:15Z"],["dc.date.issued","2008"],["dc.description.abstract","Segment formation in the long germ insect Drosophila is dominated by overlapping gap gene domains in the syncytial blastoderm. In the short germ beetle Tribolium castaneum abdominal segments arise from a cellular growth zone. implying different patterning mechanisms. We describe here the single Tribolium ortholog of the Drosophila genes knirps and knirps-related (called Tc-knirps). Tc-knirps expression is conserved during head patterning and at later stages. However, Posterior Tc-knirps expression in the ectoderm is limited to a stripe in Al. instead of a broad abdominal domain covering segment primordia A2-A5 as in Drosophila. Tc-knirps RNAi yields only mild defects in the abdomen, at a position posterior to the abdominal Tc-knirps domain. In addition, Tc-knirps RNAi larvae lack the antennal and mandibular segments. These defects are much more severe than the head defects Caused by combined inactivation of Din-knirps and Dm-knirps-related. Our findings support the notion that the role of gap gene homologs in abdominal segmentation differs fundamentally in long and short germ insects, Moreover, the pivotal role of Tc-knirps in the head Suggests an ancestral role for knirps as head patterning gene. Based on this RNAi analysis, Tc-knirps functions neither in the head nor the abdomen as a canonical gap gene. (C) 2008 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.ydbio.2008.05.527"],["dc.identifier.isi","000258710800025"],["dc.identifier.pmid","18586236"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53389"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Inc Elsevier Science"],["dc.relation.issn","0012-1606"],["dc.title","The Tribolium ortholog of knirps and knirps-related is crucial for head segmentation but plays a minor role during abdominal patterning"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]