Hummers, Eva

[["dc.bibliographiccitation.firstpage","448"],["dc.bibliographiccitation.lastpage","452"],["dc.contributor.author","Schmiemann, Guido"],["dc.contributor.author","Bleidorn, Jutta"],["dc.contributor.author","Hummers-Pradier, Eva"],["dc.contributor.author","Gágyor, Ildikó"],["dc.contributor.author","Kochen, Michael M."],["dc.contributor.editor","Kochen, Michael M."],["dc.date.accessioned","2021-09-06T10:13:22Z"],["dc.date.available","2021-09-06T10:13:22Z"],["dc.date.issued","2017"],["dc.description.edition","5"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/89284"],["dc.publisher","Thieme"],["dc.publisher.place","Stuttgart"],["dc.relation.isbn","978-3-13-141385-7"],["dc.relation.ispartof","Allgemeinmedizin und Familienmedizin"],["dc.relation.orgunit","Institut für Allgemeinmedizin"],["dc.title","Schmerzen beim Wasserlassen"],["dc.type","book_chapter"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","54"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Patient Education and Counseling"],["dc.bibliographiccitation.lastpage","60"],["dc.bibliographiccitation.volume","90"],["dc.contributor.author","Wrede, Jennifer"],["dc.contributor.author","Voigt, Isabel"],["dc.contributor.author","Bleidorn, Jutta"],["dc.contributor.author","Hummers-Pradier, Eva"],["dc.contributor.author","Dierks, Marie-Luise"],["dc.contributor.author","Junius-Walker, Ulrike"],["dc.date.accessioned","2021-08-26T13:15:55Z"],["dc.date.available","2021-08-26T13:15:55Z"],["dc.date.issued","2013-01"],["dc.description.abstract","To examine to what extent general practitioners in consultations after a geriatric assessment set shared health priorities with older patients experiencing multimorbidity and to what extent this was facilitated through patient-centered behavior."],["dc.identifier.doi","10.1016/j.pec.2012.07.015"],["dc.identifier.pmid","22884411"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/88824"],["dc.language.iso","en"],["dc.relation.eissn","1873-5134"],["dc.relation.issn","0738-3991"],["dc.relation.orgunit","Institut für Allgemeinmedizin"],["dc.title","Complex health care decisions with older patients in general practice: patient-centeredness and prioritization in consultations following a geriatric assessment"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","30"],["dc.bibliographiccitation.journal","BMC Medicine"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Bleidorn, Jutta"],["dc.contributor.author","Gagyor, Ildiko"],["dc.contributor.author","Kochen, Michael M."],["dc.contributor.author","Wegscheider, Karl"],["dc.contributor.author","Hummers-Pradier, Eva"],["dc.date.accessioned","2018-11-07T08:43:08Z"],["dc.date.available","2018-11-07T08:43:08Z"],["dc.date.issued","2010"],["dc.description.abstract","Background: Uncomplicated lower urinary tract infections (UTI) are usually treated with antibiotics. However, there is little evidence for alternative therapeutic options. This pilot study was set out 1) to make a rough estimate of the equivalence of ibuprofen and ciprofloxacin for uncomplicated urinary tract infection with regard to symptom resolution, and 2) to demonstrate the feasibility of a double-blind, randomized controlled drug trial in German general practices. Methods: We performed a double-blind, randomized controlled pilot trial in 29 German general practices. Eighty otherwise healthy women aged 18 to 85 years, presenting with at least one of the main UTI symptoms dysuria and frequency and without any complicating factors, were randomly assigned to receive either ibuprofen 3 x 400 mg oral or ciprofloxacin 2 x 250 mg (+1 placebo) oral, both for three days. Intensity of main symptoms-dysuria, frequency, low abdominal pain-was recorded at inclusion and after 4, 7 and 28 days, scoring each symptom from 0 (none) to 4 (very strong). The primary endpoint was symptom resolution on Day 4. Secondary outcomes were the burden of symptoms on Days 4 and 7 (based on the sum score of all symptoms), symptom resolution on Day 7 and frequency of relapses. Equivalence margins for symptom burden on Day 4 were pre-specified as +/-0.5 sum score points. Data analysis was done by intention to treat and per protocol. Randomization was carried out on patient level by computer programme in blocks of six. Results: Seventy-nine patients were analyzed (ibuprofen n = 40, ciprofloxacin n = 39). On Day 4, 21/36 (58.3%) of patients in the ibuprofen-group were symptom-free versus 17/33 (51.5%) in the ciprofloxacin-group. On Day 4, ibuprofen patients reported fewer symptoms in terms of total sum score (1; SD 1,42) than ciprofloxacin patients (1,3; SD 1,9), difference-0,33 (95% CI (-1,13 to + 0,47)), PP (per protocol) analysis. During Days 0 and 9, 12/36 (33%) of patients in the ibuprofen-group received secondary antibiotic treatment due to ongoing or worsening symptoms, compared to 6/33 (18%) in the ciprofloxacin-group (non significant). A total of 58 non-serious adverse events were reported, 32 in the ibuprofen group versus 26 in the ciprofloxacin group (non significant). Conclusions: Our results support the assumption of non-inferiority of ibuprofen compared to ciprofloxacin for treatment of symptomatic uncomplicated UTI, but need confirmation by further trials."],["dc.identifier.doi","10.1186/1741-7015-8-30"],["dc.identifier.isi","000279916700001"],["dc.identifier.pmid","20504298"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/5676"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19886"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","1741-7015"],["dc.relation.orgunit","Institut für Allgemeinmedizin"],["dc.rights","CC BY 2.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.0"],["dc.title","Symptomatic treatment (ibuprofen) or antibiotics (ciprofloxacin) for uncomplicated urinary tract infection? - Results of a randomized controlled pilot trial"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","E234"],["dc.bibliographiccitation.issue","645"],["dc.bibliographiccitation.journal","British Journal of General Practice"],["dc.bibliographiccitation.lastpage","E240"],["dc.bibliographiccitation.volume","66"],["dc.contributor.author","Gágyor, Ildikó"],["dc.contributor.author","Haasenritter, Jörg"],["dc.contributor.author","Bleidorn, Jutta"],["dc.contributor.author","McIsaac, Warren"],["dc.contributor.author","Schmiemann, Guido"],["dc.contributor.author","Hummers-Pradier, Eva"],["dc.contributor.author","Himmel, Wolfgang"],["dc.date.accessioned","2020-12-10T18:47:26Z"],["dc.date.available","2020-12-10T18:47:26Z"],["dc.date.issued","2016"],["dc.description.abstract","Background Uncomplicated urinary tract infection (UTI) is often treated with antibiotics, resulting in increasing resistance levels. A randomised controlled trial showed that two-thirds of females with UTI treated symptomatically recovered without subsequent antibiotic treatment. Aim To investigate whether there are differences between females with a UTI who were subsequently prescribed antibiotics and those who recovered with symptomatic treatment only, and to develop a model to predict those who can safely and effectively be treated symptomatically. Design and setting This is a subgroup analysis of females assigned to ibuprofen in a UTI trial in general practices. Method Multiple logistic regression analysis was used to select variables for a prediction model, The discriminative value of the model was estimated by the area under the receiver operator curve (AUC) and the effects of different thresholds were calculated within the model predicting antibiotic prescription and need for follow-up visits. Results Of the 235 females in the ibuprofen group, 79 were subsequently prescribed antibiotics within 28 days of follow-up. The final model included five predictors: urgency/frequency, impaired daily activities, and positive dipstick test results for erythrocytes, leucocytes, and nitrite. The AUC was 0.73 (95% CI = 0.67 to 0.80). A reasonable threshold for antibiotic initiation would result in 58% of females presenting with UTI being treated with antibiotics. Of the remaining females, only 6% would return to the practice because of symptomatic treatment failure. Conclusion The present model revealed moderately good accuracy and could be the basis for a decision aid for GPs and females to find the treatment option that fits best."],["dc.identifier.doi","10.3399/bjgp16X684361"],["dc.identifier.isi","000376585200002"],["dc.identifier.pmid","26965031"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14110"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78763"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","1478-5242"],["dc.relation.issn","0960-1643"],["dc.relation.orgunit","Institut für Allgemeinmedizin"],["dc.rights","CC BY-NC 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc/3.0"],["dc.title","Predicting antibiotic prescription after symptomatic treatment for urinary tract infection: development of a model using data from an RCT in general practice"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","87"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Zeitschrift für Evidenz, Fortbildung und Qualität im Gesundheitswesen"],["dc.bibliographiccitation.lastpage","92"],["dc.bibliographiccitation.volume","107"],["dc.contributor.author","Joos, Stefanie"],["dc.contributor.author","Bleidorn, Jutta"],["dc.contributor.author","Haasenritter, Jörg"],["dc.contributor.author","Hummers-Pradier, Eva"],["dc.contributor.author","Peters-Klimm, Frank"],["dc.contributor.author","Gágyor, Ildikó"],["dc.date.accessioned","2021-08-26T13:16:03Z"],["dc.date.available","2021-08-26T13:16:03Z"],["dc.date.issued","2013"],["dc.description.abstract","In recent years studies not falling under the German Pharmaceutical Law (\"non-drug trials\") have also been increasingly expected to be conducted according to Good Clinical Practice (GCP) in order to ensure that uniform standards are maintained for data quality and patient safety. However, simple transfer of the GCP criteria is not always possible and often not useful. Given the fact that research questions regarding non-drug interventions are common in primary care (e.g., general practice), the \"Network for Clinical Studies in General Practice\" has developed a manual for planning and conducting non-drug trials. This manual is based on the GCP guideline, taking account of the conditions and circumstances in primary care settings. Both structure and relevant content of the manual are presented in the article. (As supplied by the authors)."],["dc.identifier.doi","10.1016/j.zefq.2012.12.019"],["dc.identifier.pmid","23415348"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/88826"],["dc.language.iso","other"],["dc.relation.eissn","2212-0289"],["dc.relation.issn","1865-9217"],["dc.relation.orgunit","Institut für Allgemeinmedizin"],["dc.title","Ein Leitfaden zur Planung Nichtmedikamentöser klinischer Studien in der Primärversorgung unter Berücksichtigung der Kriterien der Guten Klinischen Praxis (GCP)"],["dc.title.alternative","Manual for the design of non-drug trials in primary care, taking account of Good Clinical Practice (GCP) criteria"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","125"],["dc.bibliographiccitation.journal","Zeitschrift für Allgemeinmedizin"],["dc.bibliographiccitation.lastpage","130"],["dc.bibliographiccitation.volume","93"],["dc.contributor.author","Kruschinski, Carsten"],["dc.contributor.author","Schneider, Nils"],["dc.contributor.author","Hummers-Pradier, Eva"],["dc.contributor.author","Bleidorn, Jutta"],["dc.date.accessioned","2021-09-06T09:40:29Z"],["dc.date.available","2021-09-06T09:40:29Z"],["dc.date.issued","2017"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/89277"],["dc.relation.orgunit","Institut für Allgemeinmedizin"],["dc.title","Begleitung eines chronisch kranken Patienten in der Hausarztpraxis"],["dc.title.alternative","The Chronically Ill Patient in Family Medicine. Curriculum and Experiences with a Longitudinal Elective"],["dc.title.subtitle","Curriculum und Erfahrungen mit einem Wahlfach"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Family medicine & medical science research"],["dc.bibliographiccitation.volume","3"],["dc.contributor.author","Bleidorn, Jutta"],["dc.contributor.author","Költzsch, C."],["dc.contributor.author","Hummers-Pradier, Eva"],["dc.contributor.author","Gágyor, Ildikó"],["dc.contributor.author","Theile, G."],["dc.date.accessioned","2021-09-07T13:12:45Z"],["dc.date.available","2021-09-07T13:12:45Z"],["dc.date.issued","2014"],["dc.identifier.doi","10.4172/2327-4972.1000122"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/89304"],["dc.relation.orgunit","Institut für Allgemeinmedizin"],["dc.title","Family Physicians as Clinical Trial Investigators? - A Qualitative Study of Physicians’ Experiences with a Double-Blind Clinical Trial"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","Doc17"],["dc.bibliographiccitation.journal","GMS German Medical Science"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Bleidorn, Jutta"],["dc.contributor.author","Bucak, Sermin"],["dc.contributor.author","Gágyor, Ildikó"],["dc.contributor.author","Hummers-Pradier, Eva"],["dc.contributor.author","Dierks, Marie-Luise"],["dc.date.accessioned","2021-06-02T14:47:55Z"],["dc.date.available","2021-06-02T14:47:55Z"],["dc.date.issued","2015"],["dc.description.abstract","Insufficient patient recruitment can impair the conduct of clinical trials substantially, not least because a significant number of eligible patients decline trial participation. Though barriers and motivational factors have been worked out for patients with cancer or chronic diseases, little is known about primary care patients' perceptions towards trial participation when visiting their family practitioner (FP) with acute uncomplicated conditions. This study aims to assess primary care patients' motivation and barriers to participate in trials, and to identify factors that optimize patient recruitment in future trials."],["dc.identifier.doi","10.3205/000221"],["dc.identifier.pmid","26512232"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/87100"],["dc.language.iso","en"],["dc.relation.eissn","1612-3174"],["dc.relation.orgunit","Institut für Allgemeinmedizin"],["dc.rights","CC BY 4.0"],["dc.title","Why do - or don't - patients with urinary tract infection participate in a clinical trial? A qualitative study in German family medicine"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1441"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Clinical Microbiology and Infection"],["dc.bibliographiccitation.lastpage","1447"],["dc.bibliographiccitation.volume","27"],["dc.contributor.author","Gágyor, Ildikó"],["dc.contributor.author","Hummers, Eva"],["dc.contributor.author","Schmiemann, Guido"],["dc.contributor.author","Friede, Tim"],["dc.contributor.author","Pfeiffer, Sebastian"],["dc.contributor.author","Afshar, Kambiz"],["dc.contributor.author","Bleidorn, Jutta"],["dc.date.accessioned","2021-08-16T09:08:13Z"],["dc.date.available","2021-08-16T09:08:13Z"],["dc.date.issued","2021-10"],["dc.description.abstract","Objective\r\n\r\nWe explored whether initial treatment with the herbal drug uva ursi (UU) reduces antibiotic use in women with uncomplicated urinary tract infection (UTI) without increasing symptom burden and complication frequency compared with antibiotic treatment.\r\nMethods\r\n\r\nA double-blind randomized controlled trial was conducted in 42 family practices in Germany. The participants were adult women with suspected uncomplicated UTIs receiving either UU 105 mg 3 × 2 tablets for 5 days (intervention) or fosfomycin a 3-g single dose (control), and their respective placebos. Participants and investigators were blinded. The primary outcome included (1) antibiotic courses day 0–28 as superiority, and (2) symptom burden (sum of daily symptom scores) day 0–7, as non-inferiority outcome (margin 125%). Clinicaltrials.gov: NCT03151603.\r\nResults\r\n\r\nOverall, 398 patients were randomly allocated to groups receiving UU (n = 207) and fosfomycin (n = 191). The number of antibiotic courses was 63.6% lower (95% CI 53.6%–71.4%; p < 0.0001) in the UU group than in the fosfomycin group. The ratio of total symptom burden in the UU group compared with control was 136.5% (95% CI 122.7–151.9; p 0.95), failing non-inferiority. Eight women developed pyelonephritis in the UU group compared with two in the fosfomycin group (mean difference 2.8; 95% CI 0.2–5.9; p 0.067). Adverse events were similar between the groups.\r\nDiscussion\r\n\r\nIn women with uncomplicated UTIs, initial treatment with UU reduced antibiotic use but led to a higher symptom burden and more safety concerns than fosfomycin."],["dc.identifier.doi","10.1016/j.cmi.2021.05.032"],["dc.identifier.pmid","34111592"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/88709"],["dc.language.iso","en"],["dc.relation.eissn","1469-0691"],["dc.relation.issn","1198-743X"],["dc.relation.orgunit","Institut für Allgemeinmedizin"],["dc.relation.orgunit","Institut für Medizinische Statistik"],["dc.title","Herbal treatment with uva ursi extract versus fosfomycin in women with uncomplicated urinary tract infection in primary care: a randomized controlled trial"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","73"],["dc.bibliographiccitation.journal","Zeitschrift für Allgemeinmedizin"],["dc.bibliographiccitation.lastpage","77"],["dc.bibliographiccitation.volume","91"],["dc.contributor.author","Bleidorn, Jutta"],["dc.contributor.author","Költzsch, Christina"],["dc.contributor.author","Hummers-Pradier, Eva"],["dc.contributor.author","Gágyor, Ildikó"],["dc.contributor.author","Theile, Gudrun"],["dc.date.accessioned","2021-09-06T14:53:00Z"],["dc.date.available","2021-09-06T14:53:00Z"],["dc.date.issued","2015"],["dc.identifier.doi","10.3238/zfa.2015.0073–0077"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/89294"],["dc.relation.orgunit","Institut für Allgemeinmedizin"],["dc.title","Forschungsprojekte in der Hausarztpraxis- und wie sieht's die MFA?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]