Koch, Philipp

[["dc.bibliographiccitation.firstpage","384"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","International Archives of Occupational and Environmental Health"],["dc.bibliographiccitation.lastpage","388"],["dc.bibliographiccitation.volume","73"],["dc.contributor.author","Westphal, Goetz Alexander"],["dc.contributor.author","Schnuch, Axel"],["dc.contributor.author","Schulz, Thomas G."],["dc.contributor.author","Reich, Kristian"],["dc.contributor.author","Aberer, Werner"],["dc.contributor.author","Brasch, Jochen"],["dc.contributor.author","Koch, P."],["dc.contributor.author","Wessbecher, R."],["dc.contributor.author","Szliska, Christiane"],["dc.contributor.author","Bauer, A."],["dc.contributor.author","Hallier, Ernst"],["dc.date.accessioned","2018-11-07T10:37:14Z"],["dc.date.available","2018-11-07T10:37:14Z"],["dc.date.issued","2000"],["dc.description.abstract","Objective: Thimerosal is an important preservative in vaccines and ophthalmologic preparations. The substance is known to be a type IV sensitizing agent. High sensitization rates were observed in contact-allergic patients and in health care workers who had been exposed to thimerosal-preserved vaccines. There is evidence for the involvement of the glutathione system in the metabolism of thimerosal or its decomposition products (organomercury alkyl compounds). Thus detoxification by polymorphically expressed glutathione S-transferases such as GSTT1 and GSTM1 might have a protective effect against sensitization by these substances. Methods: To address this question, a case control study was conducted, including 91 Central European individuals with a positive patch-test reaction to thimerosal. This population was compared with 169 healthy controls and additionally with 114 individuals affected by an allergy against para-substituted aryl compounds. The latter population was included in order to test whether possible associations were due to substance-specific effects, or were a general feature connected with type IV immunological diseases. Homozygous deletions of GSTT1 and GSTM1 were determined by polymerase chain reaction. Results: Glutathione S-transferase M1 deficiency was significantly more frequent among patients sensitized to thimerosal (65.9%, P = 0.013) compared with the healthy control group (49.1%) and the \"para-compound\" group (48%, P = 0.034). Glutathione S-transferase T1 deficiency in the thimerosal/mercury group (19.8%) was barely elevated versus healthy controls (16.0%) and the \"para-compound\" group (14.0%). The combined deletion (GSTT1-/GSTM1-) was markedly more frequent among thimerosal-sensitized patients than in healthy controls (17.6% vs. 6.5%, P = 0.0093) and in the \"para-compound\" group (17.6% vs. 6.1%; P = 0.014), revealing a synergistic effect of these enzyme deficiencies (healthy controls vs. thimerosal GSTM1 negative individuals, OR = 2.0 [CI = 1.2-3.4], GSTT1-, OR = 1.2 [CI = 0.70-2.1], GSTM1/T1-, OR = 3.1 [CI = 1.4-6.5]). Conclusions: Since the glutathione-dependent system was repeatedly shown to be involved in the metabolism of thimerosal decomposition products, the observed association may be of functional relevance."],["dc.identifier.doi","10.1007/s004200000159"],["dc.identifier.isi","000089088300005"],["dc.identifier.pmid","11007341"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/45516"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0340-0131"],["dc.title","Homozygous gene deletions of the glutathione S-transferases M1, and T1 are associated with thimerosal sensitization"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","118"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Contact Dermatitis"],["dc.bibliographiccitation.lastpage","130"],["dc.bibliographiccitation.volume","51"],["dc.contributor.author","Geier, Johannes"],["dc.contributor.author","Lessmann, Holger"],["dc.contributor.author","Dickel, Heinrich"],["dc.contributor.author","Frosch, Peter J."],["dc.contributor.author","Koch, P."],["dc.contributor.author","Becker, D."],["dc.contributor.author","Jappe, Uta"],["dc.contributor.author","Aberer, Werner"],["dc.contributor.author","Schnuch, Axel"],["dc.contributor.author","Uter, Wolfgang"],["dc.date.accessioned","2018-11-07T10:45:53Z"],["dc.date.available","2018-11-07T10:45:53Z"],["dc.date.issued","2004"],["dc.description.abstract","Based on the information of the interdisciplinary task force on allergy diagnostics in the metal branch, in 2001, the German Contact Dermatitis Research Group (DKG) compiled two metalworking fluid (MWF) test series with currently and previously used components, respectively. After 2 years of patch testing, we present results obtained with these series, based on data of the Information Network of Departments of Dermatology (IVDK). 251 metalworkers who were patch tested because of suspected MWF dermatitis in 2002 and 2003 were included in this retrospective data analysis. Of these, 206 were tested with the current MWF series and 155 with the historical MWF series. Among the current MWF allergens, monoethanolamine ranked 1st with 11.6% positive reactions. Diethanolamine (3.0%), triethanolamine (1.1%), and diglycolamine (1.9%) elicited positive reactions far less frequently. Allergic reactions to p-aminoazobenzene were frequently observed (6.0%), but the relevance of these reactions is still obscure. Positive reactions to biocides ranged from 4.5% for Bioban((R)) CS 1135 to 0.5% for iodopropynyl butylcarbamate and 2-phenoxyethanol. Concomitant reactions to formaldehyde, which caused positive reactions in 3.3%, and formaldehyde releasers occurred to varying extents without conclusive pattern. No positive reactions were seen to dibutyl phthalate, di-2-ethylhexyl phthalate, tricresyl phosphate, isopropyl myristate or benzotriazole. With the historical MWF test series, positive reactions to methyldibromo glutaronitrile (MDBGN) were observed most frequently. However, sensitization via allergen sources other than MWF seems likely, as MDBGN, during the study period, has been one of the most frequent preservative allergens in cosmetics and body care products. Other historical MWF allergens comprised morpholinyl mercaptobenzothiazole (3.3%), benzisothiazolinone (BIT; 2.0%) and Bioban((R)) P 1487(1.3%). BIT is currently used in MWF again, so it was shifted to the current MWF test series. As decreasing reaction frequencies to former MWF allergens that are no longer used can be expected, the historical series should be re-evaluated after some years. The test series with current MWF allergens has to be kept up-to-date based on information from industry and to be kept concise by eliminating test substances which never cause positive reactions."],["dc.identifier.doi","10.1111/j.0105-1873.2004.00416.x"],["dc.identifier.isi","000224434600003"],["dc.identifier.pmid","15479200"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/47608"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley"],["dc.relation.issn","1600-0536"],["dc.relation.issn","0105-1873"],["dc.title","Patch test results with the metalworking fluid series of the German Contact Dermatitis Research Group (DKG)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","85"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Contact Dermatitis"],["dc.bibliographiccitation.lastpage","90"],["dc.bibliographiccitation.volume","49"],["dc.contributor.author","Geier, Johannes"],["dc.contributor.author","Lessmann, Holger"],["dc.contributor.author","Frosch, Peter J."],["dc.contributor.author","Pirker, C."],["dc.contributor.author","Koch, P."],["dc.contributor.author","Aschoff, R."],["dc.contributor.author","Richter, G."],["dc.contributor.author","Becker, D."],["dc.contributor.author","Eckert, C."],["dc.contributor.author","Uter, Wolfgang"],["dc.contributor.author","Schnuch, Axel"],["dc.contributor.author","Fuchs, Tina"],["dc.date.accessioned","2018-11-07T10:37:10Z"],["dc.date.available","2018-11-07T10:37:10Z"],["dc.date.issued","2003"],["dc.description.abstract","Water-based metalworking fluids (MWFs) may cause both irritant and allergic contact dermatitis. Several well-known MWF allergens are available for patch testing, but considering the wide variety of possible components used in MWF, our diagnostic arsenal covers only a small part of potential allergens. We therefore selected 13 frequently used MWF components that might be sensitizers and had not yet been tested routinely. In 5 centres, 233 dermatitis patients with present or past occupational exposure to MWF were patch tested with this and other panels. Only 7 patients showed positive reactions to the study panel. Allergic reactions to the emulsifier diglycolamine [syn. 2-(2-aminoethoxy) ethanol] were seen in 5 patients, and 1 patient each reacted positively to 2-amino-2-ethyl-1,3-propanediol (AEPD) and methyldiethanolamine (MDEA). Clinical relevance of the reactions to diglycolamine was unequivocally proven by its presence in the MWF from the patients' workplace in 3 cases. Diglycolamine seems to be an important MWF allergen, independently from monoethanolamine and diethanolamine. A test concentration of 1% petrolatum (pet.) appears to be appropriate. The importance of AEPD and MDEA as MWF allergens still remains to be established. The lack of positive test reactions to the other MWF components tested may be due to their low-sensitizing potential or too low a patch test concentration being used."],["dc.identifier.doi","10.1111/j.0105-1873.2003.00187.x"],["dc.identifier.isi","000186892100005"],["dc.identifier.pmid","14641356"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/45500"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Munksgaard"],["dc.relation.issn","0105-1873"],["dc.title","Patch testing with components of water-based metalworking fluids"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","263"],["dc.bibliographiccitation.issue","5-6"],["dc.bibliographiccitation.journal","Contact Dermatitis"],["dc.bibliographiccitation.lastpage","272"],["dc.bibliographiccitation.volume","51"],["dc.contributor.author","Geier, Johannes"],["dc.contributor.author","Lessmann, Holger"],["dc.contributor.author","Hillen, Uwe"],["dc.contributor.author","Jappe, Uta"],["dc.contributor.author","Dickel, Heinrich"],["dc.contributor.author","Koch, P."],["dc.contributor.author","Frosch, Peter J."],["dc.contributor.author","Schnuch, Axel"],["dc.contributor.author","Uter, Wolfgang"],["dc.date.accessioned","2018-11-07T10:44:08Z"],["dc.date.available","2018-11-07T10:44:08Z"],["dc.date.issued","2004"],["dc.description.abstract","Epoxy resin systems (ERSs) are a frequent cause of occupational allergic contact dermatitis. Sensitization occurs not only to the resins, but also to hardeners and reactive diluents. However, only a fraction of the ERS components currently in use are available for patch testing. With the multicentre study EPOX 2002, we attempted to improve diagnostics in this field by patch testing with components currently used in ERSs. During the first study period (October 2002 to July 2003), in addition to commercially available ERS patch test substances, 16 study substances (1 resin, 9 hardeners and 6 reactive diluents) were patch tested in 70 patients with suspected contact allergy due to ERSs and 22 patients with a prior positive patch test reaction to epoxy resin (ER) in the standard series. Most frequently, allergic reactions to ER based on diglycidyl ether of bisphenol A and F were observed (55.2% and 43.7%, respectively). Agreement between positive reactions to both resins, which can be explained by immunological cross-sensitization and/or coexposure, was substantial [Cohen's kappa 0.65 (95% CI: 0.49-0.80)]. Among the reactive diluents, 1,6-hexanediol diglycidyl ether (1,6-HDDGE) and 1,4-butanediol diglycidyl ether (1,4-BDDGE) were the most frequent allergens, with 19.5% and 18.4% positive reactions, respectively. Although agreement between positive reactions to 1,6-HDDGE and 1,4-BDDGE was even better than with the 2 resins, the sample size is considered too small to decide reliably whether 1,6-HDDGE alone could serve as a marker allergen for both. Allergic reactions to p-tert-butylphenyl glycidyl ether and to phenyl glycidyl ether (PGE) occurred in 11.5% of the patients tested, with only moderate agreement. All patients positive to cresyl glycidyl ether (6.8%) also reacted to PGE. Of the hardeners tested, m-xylylene diamine was the most frequent allergen (13.8%), followed by isophorone diamine (5.7%). No reactions were observed to several substances, the test concentration of which may have been too low and will be increased in the future."],["dc.identifier.doi","10.1111/j.0105-1873.2004.00465.x"],["dc.identifier.isi","000225629900008"],["dc.identifier.pmid","15606651"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/47207"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Munksgaard"],["dc.relation.issn","0105-1873"],["dc.title","An attempt to improve diagnostics of contact allergy due to epoxy resin systems. First results of the multicentre study EPOX 2002"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","197"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Contact Dermatitis"],["dc.bibliographiccitation.lastpage","206"],["dc.bibliographiccitation.volume","52"],["dc.contributor.author","Schnuch, Axel"],["dc.contributor.author","Kelterer, D."],["dc.contributor.author","Bauer, A."],["dc.contributor.author","Schuster, C."],["dc.contributor.author","Aberer, Werner"],["dc.contributor.author","Mahler, Vera"],["dc.contributor.author","Katzer, K."],["dc.contributor.author","Rakoski, J."],["dc.contributor.author","Jappe, Uta"],["dc.contributor.author","Krautheim, Andrea"],["dc.contributor.author","Bircher, A."],["dc.contributor.author","Koch, P."],["dc.contributor.author","Worm, Margitta"],["dc.contributor.author","Loffler, H."],["dc.contributor.author","Hillen, Uwe"],["dc.contributor.author","Frosch, Peter J."],["dc.contributor.author","Uter, Wolfgang"],["dc.date.accessioned","2018-11-07T11:10:17Z"],["dc.date.available","2018-11-07T11:10:17Z"],["dc.date.issued","2005"],["dc.description.abstract","Contact allergy to methyldibromo glutaronitrile (MDBGN), often combined with phenoxyethanol (PE) (e.g., Euxyl K 400((R))), increased throughout the 1990s in Europe. Consequently, in 2003, the European Commission banned its use in leave-on products, where its use concentration was considered too high and the non-sensitizing use concentration as yet unknown. The 2 objectives of the study are (a) to find a maximum non-eliciting concentration in a leave-on product in MDBGN/PE-sensitized patients, which could possibly also be considered safe regarding induction and (b) to find the best patch test concentration for MDBGN. We, therefore, performed a use-related test (ROAT) in patients sensitized to MDBGN/PE (n = 39) with 3 concentrations of MDBGN/PE (50, 100 and 250 p.p.m. MDBGN, respectively). A subset of these patients (n = 24) was later patch-tested with various concentrations (0.1, 0.2, 0.3 and 0.5% MDBGN, respectively). 15 patients (38%, 95% confidence interval (CI) = 23-55%) had a negative and 24 (62%; 95% CI = 45-77%) a positive overall repeated open application test (ROAT) result. 13 reacted to the lowest (50 p.p.m.), 8 to the middle (100 p.p.m.) and 3 to the highest concentration (250 p.p.m.) only. In those 13 reacting to the lowest ROAT concentration, dermatitis developed within a few days (1-7). The strength of the initial and the confirmatory patch test result, respectively, and the outcome of the ROAT were positively associated. Of the 24 patients with a use and confirmatory patch test, 15 reacted to 0.1% MDBGN, 16 to 0.2%, 17 to 0.3% and 22 to 0.5%. With the patch test concentration of 0.5%, the number of ROAT-negative patients but patch-test-positive patients increases considerably, particularly due to + reactions. A maximum sensitivity of 94% (95% CI = 70-100%) is reached with a patch test concentration of 0.2%, and is not further improved by increasing the concentration. However, the specificity decreases dramatically from 88 (95% CI = 47-100%) with 0.2% to a mere 12.5% (95% CI = 0-53%) with 0.5%. It can be concluded (a) that for MDBGN 0.2% is very likely the best patch test concentration and (b) that 50 p.p.m. in a leave-on product can elicit contact dermatitis in sensitized persons. We were, therefore, unable to find a safe, still microbicidal, concentration for leave-on products. By contrast, with other contact allergens, dose-response use tests may be able to identify a non-eliciting concentration, which could give valuable clues to a non-inducing (i.e., safe) concentration in products."],["dc.identifier.doi","10.1111/j.0105-1873.2005.00529.x"],["dc.identifier.isi","000228744700005"],["dc.identifier.pmid","15859992"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53181"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Munksgaard"],["dc.relation.issn","0105-1873"],["dc.title","Quantitative patch and repeated open application testing in methyldibromo glutaronitrile-sensitive patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]