Bergau, Leonard

[["dc.bibliographiccitation.firstpage","963"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","EP Europace"],["dc.bibliographiccitation.lastpage","970"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Sticherling, Christian"],["dc.contributor.author","Arendacka, Barbora"],["dc.contributor.author","Svendsen, Jesper Hastrup"],["dc.contributor.author","Wijers, Sofieke"],["dc.contributor.author","Friede, Tim"],["dc.contributor.author","Stockinger, Jochem"],["dc.contributor.author","Dommasch, Michael"],["dc.contributor.author","Merkely, Bela"],["dc.contributor.author","Willems, Rik"],["dc.contributor.author","Lubinski, Andrzej"],["dc.contributor.author","Scharfe, Michael"],["dc.contributor.author","Braunschweig, Frieder"],["dc.contributor.author","Svetlosak, Martin"],["dc.contributor.author","Zürn, Christine S"],["dc.contributor.author","Huikuri, Heikki"],["dc.contributor.author","Flevari, Panagiota"],["dc.contributor.author","Lund-Andersen, Caspar"],["dc.contributor.author","Schaer, Beat A"],["dc.contributor.author","Tuinenburg, Anton E"],["dc.contributor.author","Bergau, Leonard"],["dc.contributor.author","Schmidt, Georg"],["dc.contributor.author","Szeplaki, Gabor"],["dc.contributor.author","Vandenberk, Bert"],["dc.contributor.author","Kowalczyk, Emilia"],["dc.contributor.author","Eick, Christian"],["dc.contributor.author","Juntilla, Juhani"],["dc.contributor.author","Conen, David"],["dc.contributor.author","Zabel, Markus"],["dc.contributor.author","Aaboud, M. et al. (ATLAS Collaboration)"],["dc.date.accessioned","2021-11-22T14:31:38Z"],["dc.date.available","2021-11-22T14:31:38Z"],["dc.date.issued","2017"],["dc.description.abstract","Aims Therapy with an implantable cardioverter defibrillator (ICD) is established for the prevention of sudden cardiac death (SCD) in high risk patients. We aimed to determine the effectiveness of primary prevention ICD therapy by analysing registry data from 14 centres in 11 European countries compiled between 2002 and 2014, with emphasis on outcomes in women who have been underrepresented in all trials. Methods and results Retrospective data of 14 local registries of primary prevention ICD implantations between 2002 and 2014 were compiled in a central database. Predefined primary outcome measures were overall mortality and first appropriate and first inappropriate shocks. A multivariable model enforcing a common hazard ratio for sex category across the centres, but allowing for centre-specific baseline hazards and centre specific effects of other covariates, was adjusted for age, the presence of ischaemic cardiomyopathy or a CRT-D, and left ventricular ejection fraction ≤25%. Of the 5033 patients, 957 (19%) were women. During a median follow-up of 33 months (IQR 16–55 months) 129 women (13%) and 807 men (20%) died (HR 0.65; 95% CI: [0.53, 0.79], P-value < 0.0001). An appropriate ICD shock occurred in 66 women (8%) and 514 men (14%; HR 0.61; 95% CI: 0.47–0.79; P = 0.0002). Conclusion Our retrospective analysis of 14 local registries in 11 European countries demonstrates that fewer women than men undergo ICD implantation for primary prevention. After multivariate adjustment, women have a significantly lower mortality and receive fewer appropriate ICD shocks."],["dc.identifier.doi","10.1093/europace/eux176"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15529"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/93395"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.relation","info:eu-repo/grantAgreement/EC/FP7/602299/EU//EU-CERT-ICD"],["dc.relation.issn","1532-2092"],["dc.relation.issn","1099-5129"],["dc.rights","CC BY-NC 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc/4.0"],["dc.title","Sex differences in outcomes of primary prevention implantable cardioverter-defibrillator therapy: combined registry data from eleven European countries"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","182"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","ESC Heart Failure"],["dc.bibliographiccitation.lastpage","193"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","Zabel, Markus"],["dc.contributor.author","Sticherling, Christian"],["dc.contributor.author","Willems, Rik"],["dc.contributor.author","Lubinski, Andrzej"],["dc.contributor.author","Bauer, Axel"],["dc.contributor.author","Bergau, Leonard"],["dc.contributor.author","Braunschweig, Frieder"],["dc.contributor.author","Brugada, Josep"],["dc.contributor.author","Brusich, Sandro"],["dc.contributor.author","Conen, David"],["dc.contributor.author","Cygankiewicz, Iwona"],["dc.contributor.author","Flevari, Panagiota"],["dc.contributor.author","Taborsky, Milos"],["dc.contributor.author","Hansen, Jim"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Hatala, Robert"],["dc.contributor.author","Huikuri, Heikki V"],["dc.contributor.author","Iovev, Svetoslav"],["dc.contributor.author","Kääb, Stefan"],["dc.contributor.author","Kaliska, Gabriela"],["dc.contributor.author","Kasprzak, Jaroslaw D"],["dc.contributor.author","Lüthje, Lars"],["dc.contributor.author","Malik, Marek"],["dc.contributor.author","Novotny, Tomas"],["dc.contributor.author","Pavlović, Nikola"],["dc.contributor.author","Schmidt, Georg"],["dc.contributor.author","Shalganov, Tchavdar"],["dc.contributor.author","Sritharan, Rajeeva"],["dc.contributor.author","Schlögl, Simon"],["dc.contributor.author","Szavits Nossan, Janko"],["dc.contributor.author","Traykov, Vassil"],["dc.contributor.author","Tuinenburg, Anton E"],["dc.contributor.author","Velchev, Vasil"],["dc.contributor.author","Vos, Marc A"],["dc.contributor.author","Willich, Stefan N"],["dc.contributor.author","Friede, Tim"],["dc.contributor.author","Svendsen, Jesper Hastrup"],["dc.contributor.author","Merkely, Béla"],["dc.date.accessioned","2019-07-09T11:50:28Z"],["dc.date.available","2019-07-09T11:50:28Z"],["dc.date.issued","2019"],["dc.description.abstract","AIMS: The clinical effectiveness of primary prevention implantable cardioverter defibrillator (ICD) therapy is under debate. The EUropean Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter Defibrillators (EU-CERT-ICD) aims to assess its current clinical value. METHODS AND RESULTS: The EU-CERT-ICD is a prospective investigator-initiated non-randomized, controlled, multicentre observational cohort study performed in 44 centres across 15 European Union countries. We will recruit 2250 patients with ischaemic or dilated cardiomyopathy and a guideline indication for primary prophylactic ICD implantation. This sample will include 1500 patients at their first ICD implantation and 750 patients who did not receive a primary prevention ICD despite having an indication for it (non-randomized control group). The primary endpoint is all-cause mortality; the co-primary endpoint in ICD patients is time to first appropriate shock. Secondary endpoints include sudden cardiac death, first inappropriate shock, any ICD shock, arrhythmogenic syncope, revision procedures, quality of life, and cost-effectiveness. At baseline (and prior to ICD implantation if applicable), all patients undergo 12-lead electrocardiogram (ECG) and Holter ECG analysis using multiple advanced methods for risk stratification as well as detailed documentation of clinical characteristics and laboratory values. Genetic biobanking is also organized. As of August 2018, baseline data of 2265 patients are complete. All subjects will be followed for up to 4.5 years. CONCLUSIONS: The EU-CERT-ICD study will provide a necessary update about clinical effectiveness of primary prophylactic ICD implantation. This study also aims for improved risk stratification and patient selection using clinical and ECG risk markers."],["dc.identifier.doi","10.1002/ehf2.12367"],["dc.identifier.pmid","30299600"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15947"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59780"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation","info:eu-repo/grantAgreement/EC/FP7/602299/EU//EU-CERT-ICD"],["dc.relation.issn","2055-5822"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/4.0"],["dc.subject.ddc","610"],["dc.subject.mesh","Cardiomyopathy, Dilated"],["dc.subject.mesh","Death, Sudden, Cardiac"],["dc.subject.mesh","Defibrillators, Implantable"],["dc.subject.mesh","Electrocardiography"],["dc.subject.mesh","Europe"],["dc.subject.mesh","Follow-Up Studies"],["dc.subject.mesh","Humans"],["dc.subject.mesh","Patient Selection"],["dc.subject.mesh","Primary Prevention"],["dc.subject.mesh","Prospective Studies"],["dc.subject.mesh","Quality of Life"],["dc.subject.mesh","Risk Assessment"],["dc.subject.mesh","Survival Rate"],["dc.subject.mesh","Treatment Outcome"],["dc.title","Rationale and design of the EU-CERT-ICD prospective study: comparative effectiveness of prophylactic ICD implantation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","196"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Diabetes Care"],["dc.bibliographiccitation.lastpage","200"],["dc.bibliographiccitation.volume","43"],["dc.contributor.author","Junttila, M. Juhani"],["dc.contributor.author","Pelli, Ari"],["dc.contributor.author","Kenttä, Tuomas V."],["dc.contributor.author","Friede, Tim"],["dc.contributor.author","Willems, Rik"],["dc.contributor.author","Bergau, Leonard"],["dc.contributor.author","Malik, Marek"],["dc.contributor.author","Vandenberk, Bert"],["dc.contributor.author","Vos, Marc A."],["dc.contributor.author","Schmidt, Georg"],["dc.contributor.author","Merkely, Bela"],["dc.contributor.author","Lubinski, Andrzej"],["dc.contributor.author","Svetlosak, Martin"],["dc.contributor.author","Braunschweig, Frieder"],["dc.contributor.author","Harden, Markus"],["dc.contributor.author","Zabel, Markus"],["dc.contributor.author","Huikuri, Heikki V."],["dc.contributor.author","Sticherling, Christian"],["dc.date.accessioned","2020-12-10T18:43:45Z"],["dc.date.available","2020-12-10T18:43:45Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.2337/dc19-1014"],["dc.identifier.eissn","1935-5548"],["dc.identifier.issn","0149-5992"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78224"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Appropriate Shocks and Mortality in Patients With Versus Without Diabetes With Prophylactic Implantable Cardioverter Defibrillators"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]