Bergau, Leonard

[["dc.bibliographiccitation.firstpage","1194"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","EP Europace"],["dc.bibliographiccitation.lastpage","1202"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Seegers, Joachim"],["dc.contributor.author","Conen, David"],["dc.contributor.author","Jung, Klaus"],["dc.contributor.author","Bergau, Leonard"],["dc.contributor.author","Dorenkamp, Marc"],["dc.contributor.author","Luethje, Lars"],["dc.contributor.author","Sohns, Christian"],["dc.contributor.author","Sossalla, Samuel"],["dc.contributor.author","Fischer, Thomas H."],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Friede, Tim"],["dc.contributor.author","Zabel, Markus"],["dc.date.accessioned","2017-09-07T11:44:47Z"],["dc.date.available","2017-09-07T11:44:47Z"],["dc.date.issued","2016"],["dc.description.abstract","Implantable cardioverter-defibrillators (ICDs) have been shown to improve survival, although a considerable number of patients never receive therapy. Implantable cardioverter-defibrillators are routinely implanted regardless of sex. There is continuing controversy whether major outcomes differ between men and women. In this retrospective single-centre study, 1151 consecutive patients (19% women) undergoing ICD implantation between 1998 and 2010 were followed for mortality and first appropriate ICD shock over 4.9 +/- 2.7 years. Sex-related differences were investigated using multivariable Cox models adjusting for potential confounders. During follow-up, 318 patients died, a rate of 5.9% per year among men and 4.6% among women (uncorrected P = 0.08); 266 patients received a first appropriate ICD shock (6.3% per year among men vs. 3.6% among women, P = 0.002). After multivariate correction, independent predictors of all-cause mortality were age (hazard ratio, HR = 1.04 per year of age, 95% confidence interval (CI) [1.03-1.06], P < 0.001), left ventricular ejection fraction (HR = 0.98 per %, 95% CI [0.97-1.00], P = 0.025), renal function (HR = 0.99 per mL/min/1.73 m(2), 95% CI [0.99-1.00], P = 0.009), use of diuretics (HR = 1.81, 95% CI [1.29-2.54], P = 0.0023), peripheral arterial disease (HR = 2.21, 95% CI [1.62-3.00], P < 0.001), and chronic obstructive pulmonary disease (HR = 1.48, 95% CI [1.13-1.94], P = 0.029), but not sex. Female sex (HR = 0.51, 95% CI [0.33-0.81], P = 0.013), older age (HR = 0.98, 95% CI [0.97-0.99], P < 0.001), and primary prophylactic ICD indication (HR = 0.69, 95% CI [0.52-0.93], P = 0.043) were independent predictors for less appropriate shocks. Women receive 50% less appropriate shocks than men having similar mortality in this large single-centre population. These data may pertain to individually improved selection of defibrillator candidates using risk factors, e.g. sex as demonstrated in this study."],["dc.identifier.doi","10.1093/europace/euv361"],["dc.identifier.gro","3141643"],["dc.identifier.isi","000383208700014"],["dc.identifier.pmid","26622054"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13747"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/4566"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.eissn","1532-2092"],["dc.relation.issn","1099-5129"],["dc.rights","CC BY-NC 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc/4.0"],["dc.title","Sex difference in appropriate shocks but not mortality during long-term follow-up in patients with implantable cardioverter-defibrillators"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]