Mielke, Dorothee

[["dc.bibliographiccitation.journal","Neurosurgical Review"],["dc.contributor.author","Abboud, Tammam"],["dc.contributor.author","Mader, Marius"],["dc.contributor.author","Komboz, Fares"],["dc.contributor.author","Martens, Tobias"],["dc.contributor.author","Mielke, Dorothee"],["dc.contributor.author","Rohde, Veit"],["dc.date.accessioned","2022-06-01T09:39:51Z"],["dc.date.available","2022-06-01T09:39:51Z"],["dc.date.issued","2022"],["dc.identifier.doi","10.1007/s10143-022-01803-6"],["dc.identifier.pii","1803"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/108578"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-572"],["dc.relation.eissn","1437-2320"],["dc.rights.uri","https://www.springer.com/tdm"],["dc.title","False-positive results in transcranial motor evoked potentials for outcome prognostication during surgery for supratentorial lesions"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.journal","Journal of Neurosurgery"],["dc.bibliographiccitation.lastpage","6"],["dc.contributor.author","Bettag, Christoph"],["dc.contributor.author","Hussein, Abdelhalim"],["dc.contributor.author","Schatlo, Bawarjan"],["dc.contributor.author","Barrantes-Freer, Alonso"],["dc.contributor.author","Abboud, Tammam"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Mielke, Dorothee"],["dc.date.accessioned","2022-06-01T09:39:47Z"],["dc.date.available","2022-06-01T09:39:47Z"],["dc.date.issued","2022"],["dc.description.abstract","OBJECTIVE Fluorescence-guided resection of cerebral metastases has been proposed as an approach to visualize residual tumor tissue and maximize the extent of resection. Critics have argued that tumor cells at the resection margins might be overlooked under microscopic visualization because of technical limitations. Therefore, an endoscope, which is capable of inducing fluorescence, has been applied with the aim of improving exposure of fluorescent tumor tissue. In this retrospective analysis, authors assessed the utility of endoscope assistance in 5-aminolevulinic acid (5-ALA) fluorescence–guided resection of brain metastases. METHODS Between June 2013 and December 2016, a standard 20-mg/kg dose of 5-ALA was administered 4 hours prior to surgery in 26 patients with suspected single brain metastases. After standard neuronavigated microsurgical tumor resection, a microscope capable of inducing fluorescence was used to examine tumor margins. The authors classified the remaining fluorescence into 3 grades (0 = none, 1 = weak, and 2 = strong). Endoscopic assistance was employed if no or only weak fluorescence was visualized at the resection margins under the microscope. Endoscopically identified fluorescent tissue at the margins was resected and evaluated separately via histological examination to prove or disprove tumor infiltration. RESULTS Under the microscope, weakly fluorescent tissue was seen at the margins of the resection cavity in 15/26 (57.7%) patients. In contrast, endoscopic inspection revealed strongly fluorescent tissue in 22/26 (84.6%) metastases. In 11/26 (42.3%) metastases no fluorescence at the tumor margins was detected by the microscope; however, strong fluorescence was visualized under the endoscope in 7 (63.6%) of these 11 metastases. In the 15 metastases with microscopically weak fluorescence, strong fluorescence was seen when using the endoscope. Neither microscopic nor endoscopic fluorescence was found in 4/26 (15.4%) cases. In the 26 patients, 96 histological specimens were obtained from the margins of the resection cavity. Findings from these specimens were in conjunction with the histopathological findings, allowing identification of metastatic infiltration with a sensitivity of 95.5% and a specificity of 75% using endoscope assistance. CONCLUSIONS Fluorescence-guided endoscope assistance may overcome the technical limitations of the conventional microscopic exposure of 5-ALA–fluorescent metastases and thereby increase visualization of fluorescent tumor tissue at the margins of the resection cavity with high sensitivity and acceptable specificity."],["dc.identifier.doi","10.3171/2022.3.JNS212301"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/108564"],["dc.notes.intern","DOI-Import GROB-572"],["dc.relation.eissn","1933-0693"],["dc.relation.issn","0022-3085"],["dc.title","Endoscope-assisted visualization of 5-aminolevulinic acid fluorescence in surgery for brain metastases"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Frontiers in Neurology"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Abboud, Tammam"],["dc.contributor.author","Mielke, Dorothee"],["dc.contributor.author","Rohde, Veit"],["dc.date.accessioned","2022-04-01T10:03:16Z"],["dc.date.available","2022-04-01T10:03:16Z"],["dc.date.issued","2022"],["dc.description.abstract","Impedance measurement of human tissue can be performed either in vivo or ex vivo . The majority of the in-vivo approaches are non-invasive, and few are invasive. To date, there is no gold standard for impedance measurement of intracranial tissue. In addition, most of the techniques addressing this topic are still experimental and have not found their way into clinical practice. This review covers available impedance measurement approaches in the neuroscience in general and specifically addresses recent advances made in the application of impedance measurement in the field of surgical neurooncology. It will provide an understandable picture on impedance measurement and give an overview of limitations that currently hinders clinical application and require future technical and conceptual solutions."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2022"],["dc.identifier.doi","10.3389/fneur.2021.825012"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/106126"],["dc.notes.intern","DOI-Import GROB-530"],["dc.relation.eissn","1664-2295"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0/"],["dc.title","Mini Review: Impedance Measurement in Neuroscience and Its Prospective Application in the Field of Surgical Neurooncology"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Journal of Neuro-Oncology"],["dc.contributor.author","Bettag, Christoph"],["dc.contributor.author","Hussein, Abdelhalim"],["dc.contributor.author","Sachkova, Alexandra"],["dc.contributor.author","Bock, Hans Christoph"],["dc.contributor.author","Mielke, Dorothee"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Abboud, Tammam"],["dc.date.accessioned","2021-07-05T15:00:56Z"],["dc.date.available","2021-07-05T15:00:56Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1007/s11060-021-03792-w"],["dc.identifier.pii","3792"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/87939"],["dc.language.iso","en"],["dc.notes.intern","DOI Import DOI-Import GROB-441"],["dc.relation.eissn","1573-7373"],["dc.relation.issn","0167-594X"],["dc.title","Implantation of Carmustine wafers after resection of malignant glioma with and without opening of the ventricular system"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Scientific Reports"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Hazaymeh, Mohammad"],["dc.contributor.author","Löber-Handwerker, Ronja"],["dc.contributor.author","Döring, Katja"],["dc.contributor.author","Abboud, Tammam"],["dc.contributor.author","Mielke, Dorothee"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Malinova, Vesna"],["dc.date.accessioned","2022-12-01T08:30:57Z"],["dc.date.available","2022-12-01T08:30:57Z"],["dc.date.issued","2022"],["dc.description.abstract","Abstract\n \n Approximately 25% of glioblastomas show at diagnosis a corpus callosum infiltration, which is associated with poor prognosis. The extent of corpus callosum involvement, however, ranges from partial unilateral to complete bilateral infiltration. The role of surgery in glioblastoma with corpus callosum involvement is controversial. In this study, we aimed to examine prognostic differences between glioblastoma with unilateral and glioblastoma with bilateral corpus callosum infiltration, and to evaluate possible treatment strategy implications. Patients with newly diagnosed glioblastoma from 2010 to 2019 were included. Corpus callosum infiltration was assessed in contrast-enhanced T1-weighted preoperative magnetic resonance imaging. Extent of resection, adjuvant treatments and overall survival were evaluated. Corpus callosum involvement was found in 96 (26.4%) out of 363 patients with newly diagnosed glioblastoma. Bilateral corpus callosum infiltration was found in 27 out of 96 patients (28%), and 69 patients had unilateral corpus callosum infiltration. Glioblastoma with corpus callosum affection had significantly lower median overall survival compared to glioblastoma without corpus callosum involvement (9 vs. 11 months,\n p\n  = 0.02). A subgroup analysis of glioblastoma with unilateral corpus callosum infiltration revealed a significant difference in median overall survival dependent on extent of resection (6.5 without gross total resection vs. 11 months with gross total resection, Log-rank test\n p\n  = 0.02). Our data confirms a shorter overall survival in glioblastoma subpopulation with corpus callosum involvement, especially for glioblastoma with bilateral corpus callosum infiltration. However, patients with partial corpus callosum infiltration undergoing gross total resection exhibited a significant survival benefit compared to their counterparts without gross total resection. Whenever reasonably achievable gross total resection should be considered as an integral part of the treatment strategy in glioblastoma with partial corpus callosum infiltration."],["dc.identifier.doi","10.1038/s41598-022-23794-6"],["dc.identifier.pii","23794"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/118028"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-621"],["dc.relation.eissn","2045-2322"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Prognostic differences and implications on treatment strategies between butterfly glioblastoma and glioblastoma with unilateral corpus callosum infiltration"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Brain Pathology"],["dc.bibliographiccitation.volume","31"],["dc.contributor.affiliation","Stork, Lidia; 2Institute of Neuropathology University Medical Center Göttingen Göttingen Germany"],["dc.contributor.affiliation","Schildhaus, Hans‐Ulrich; 3Institute of Pathology University Medical Center Göttingen Göttingen Germany"],["dc.contributor.affiliation","Stadelmann, Christine; 2Institute of Neuropathology University Medical Center Göttingen Göttingen Germany"],["dc.contributor.affiliation","Rohde, Veit; 1Department of Neurosurgery University Medical Center Göttingen Göttingen Germany"],["dc.contributor.affiliation","Mielke, Dorothee; 1Department of Neurosurgery University Medical Center Göttingen Göttingen Germany"],["dc.contributor.author","Abboud, Tammam"],["dc.contributor.author","Stork, Lidia"],["dc.contributor.author","Schildhaus, Hans‐Ulrich"],["dc.contributor.author","Stadelmann, Christine"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Mielke, Dorothee"],["dc.date.accessioned","2021-08-12T07:45:21Z"],["dc.date.available","2021-08-12T07:45:21Z"],["dc.date.issued","2021"],["dc.date.updated","2022-03-21T14:18:32Z"],["dc.description.abstract","image"],["dc.description.sponsorship","Open-Access-Finanzierung durch die Universitätsmedizin Göttingen 2021"],["dc.identifier.doi","10.1111/bpa.12995"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/88437"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-448"],["dc.relation.eissn","1750-3639"],["dc.relation.issn","1015-6305"],["dc.relation.orgunit","Klinik für Neurochirurgie"],["dc.rights","CC BY 4.0"],["dc.title","An unusual lymphoid lesion mimicking meningioma"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.journal","International Journal of Neuroscience"],["dc.bibliographiccitation.lastpage","6"],["dc.contributor.author","Komboz, Fares"],["dc.contributor.author","Zechel, Sabrina"],["dc.contributor.author","Malinova, Vesna"],["dc.contributor.author","Mielke, Dorothee"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Abboud, Tammam"],["dc.date.accessioned","2022-06-01T09:39:17Z"],["dc.date.available","2022-06-01T09:39:17Z"],["dc.date.issued","2022"],["dc.identifier.doi","10.1080/00207454.2022.2082965"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/108430"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-572"],["dc.relation.eissn","1543-5245"],["dc.relation.issn","0020-7454"],["dc.title","Infratentorial Ganglioglioma Mimicking a Cerebellar Metastasis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1307"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Brain Stimulation"],["dc.bibliographiccitation.lastpage","1316"],["dc.bibliographiccitation.volume","14"],["dc.contributor.author","Abboud, Tammam"],["dc.contributor.author","Hahn, Günter"],["dc.contributor.author","Just, Anita"],["dc.contributor.author","Paidhungat, Mihika"],["dc.contributor.author","Nazarenus, Angelina"],["dc.contributor.author","Mielke, Dorothee"],["dc.contributor.author","Rohde, Veit"],["dc.date.accessioned","2021-10-01T09:57:48Z"],["dc.date.available","2021-10-01T09:57:48Z"],["dc.date.issued","2021"],["dc.description.sponsorship","Open-Access-Publikationsfonds 2021"],["dc.identifier.doi","10.1016/j.brs.2021.08.023"],["dc.identifier.pii","S1935861X21002254"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/89918"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-469"],["dc.relation.issn","1935-861X"],["dc.relation.orgunit","Klinik für Neurochirurgie"],["dc.rights","CC BY-NC-ND 4.0"],["dc.title","An insight into electrical resistivity of white matter and brain tumors"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","World Neurosurgery"],["dc.contributor.author","Sachkova, Alexandra"],["dc.contributor.author","Khadhraoui, Eya"],["dc.contributor.author","Goryaynov, Sergey"],["dc.contributor.author","Batalov, Artem"],["dc.contributor.author","Solozhentseva, Kristina D."],["dc.contributor.author","Pronin, Igor"],["dc.contributor.author","Mielke, Dorothee"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Abboud, Tammam"],["dc.date.accessioned","2022-12-01T08:30:45Z"],["dc.date.available","2022-12-01T08:30:45Z"],["dc.date.issued","2022"],["dc.identifier.doi","10.1016/j.wneu.2022.10.102"],["dc.identifier.pii","S1878875022015145"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/117968"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-621"],["dc.relation.issn","1878-8750"],["dc.rights.uri","https://www.elsevier.com/tdm/userlicense/1.0/"],["dc.title","Meningeosis Neoplastica in Patients with Glioblastoma: Analysis of 36 Cases"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1490"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Biomedicines"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Abboud, Tammam"],["dc.contributor.author","Asendorf, Thomas"],["dc.contributor.author","Heinrich, Jutta"],["dc.contributor.author","Faust, Katharina"],["dc.contributor.author","Krieg, Sandro M."],["dc.contributor.author","Seidel, Kathleen"],["dc.contributor.author","Mielke, Dorothee"],["dc.contributor.author","Matthies, Cordola"],["dc.contributor.author","Ringel, Florian"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Szelényi, Andrea"],["dc.date.accessioned","2021-12-01T09:22:46Z"],["dc.date.available","2021-12-01T09:22:46Z"],["dc.date.issued","2021"],["dc.description.abstract","Background: Monitoring of motor function during surgery for supratentorial tumors under general anesthesia applies either transcranial electrical stimulation (TES) or direct cortical stimulation (DCS) to elicit motor-evoked potentials. To date, there is no guideline that favor one method over the other. Therefore, we designed this randomized study to compare between both methods regarding the prediction of postoperative motor deficits and extent of tumor resection. Methods: This is a multicenter (six centers in Germany and one in Switzerland), double blind, parallel group, exploratory, randomized controlled clinical trial. Patients without or with mild paresis, who are scheduled for surgical resection of motor-eloquent brain tumors under general anesthesia will be randomized to surgical resection under TES or surgical resection under DCS. The primary endpoint is sensitivity and specificity in prognosis of motor function 7 days after surgery. The main secondary endpoint is the extent of tumor resection. The study is planned to include 120 patients within 2 years. Discussion: The present exploratory study should compare TES and DCS regarding sensitivity and specificity in predicting postoperative motor deficit and extent of tumor resection to calculate the required number of patients in a confirmatory trial to test the superiority of one method over the other."],["dc.description.abstract","Background: Monitoring of motor function during surgery for supratentorial tumors under general anesthesia applies either transcranial electrical stimulation (TES) or direct cortical stimulation (DCS) to elicit motor-evoked potentials. To date, there is no guideline that favor one method over the other. Therefore, we designed this randomized study to compare between both methods regarding the prediction of postoperative motor deficits and extent of tumor resection. Methods: This is a multicenter (six centers in Germany and one in Switzerland), double blind, parallel group, exploratory, randomized controlled clinical trial. Patients without or with mild paresis, who are scheduled for surgical resection of motor-eloquent brain tumors under general anesthesia will be randomized to surgical resection under TES or surgical resection under DCS. The primary endpoint is sensitivity and specificity in prognosis of motor function 7 days after surgery. The main secondary endpoint is the extent of tumor resection. The study is planned to include 120 patients within 2 years. Discussion: The present exploratory study should compare TES and DCS regarding sensitivity and specificity in predicting postoperative motor deficit and extent of tumor resection to calculate the required number of patients in a confirmatory trial to test the superiority of one method over the other."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2021"],["dc.identifier.doi","10.3390/biomedicines9101490"],["dc.identifier.pii","biomedicines9101490"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/94481"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-478"],["dc.relation.eissn","2227-9059"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0/"],["dc.title","Transcranial versus Direct Cortical Stimulation for Motor-Evoked Potentials during Resection of Supratentorial Tumors under General Anesthesia (The TRANSEKT-Trial): Study Protocol for a Randomized Controlled Trial"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]