Mielke, Dorothee

[["dc.bibliographiccitation.journal","Neurosurgical Review"],["dc.contributor.author","Abboud, Tammam"],["dc.contributor.author","Mader, Marius"],["dc.contributor.author","Komboz, Fares"],["dc.contributor.author","Martens, Tobias"],["dc.contributor.author","Mielke, Dorothee"],["dc.contributor.author","Rohde, Veit"],["dc.date.accessioned","2022-06-01T09:39:51Z"],["dc.date.available","2022-06-01T09:39:51Z"],["dc.date.issued","2022"],["dc.identifier.doi","10.1007/s10143-022-01803-6"],["dc.identifier.pii","1803"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/108578"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-572"],["dc.relation.eissn","1437-2320"],["dc.rights.uri","https://www.springer.com/tdm"],["dc.title","False-positive results in transcranial motor evoked potentials for outcome prognostication during surgery for supratentorial lesions"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","407"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Translational Stroke Research"],["dc.bibliographiccitation.lastpage","414"],["dc.bibliographiccitation.volume","5"],["dc.contributor.author","Malinova, Vesna"],["dc.contributor.author","Stockhammer, Florian"],["dc.contributor.author","Atangana, Etienne Ndzie"],["dc.contributor.author","Mielke, Dorothee"],["dc.contributor.author","Rohde, Veit"],["dc.date.accessioned","2018-11-07T09:39:47Z"],["dc.date.available","2018-11-07T09:39:47Z"],["dc.date.issued","2014"],["dc.description.abstract","The optimal management of spontaneous intracerebral hemorrhage (ICH), especially if deep-seated, remains a matter of discussion. Lysis of the blood clot applying recombinant tissue-type plasminogen activator (rtPA) by an intrahematomal catheter is a minimally invasive treatment option, currently being under investigation in a randomized trial. The center position of the catheter in the hematoma is believed to be crucial for an optimal clot lysis. To achieve this objective, frame-based stereotaxy and frameless stereotaxy with guidance of an articulated arm were used. Recently, a preregistered stylet for direct navigation, alleviating the need of guidance, became available. In this study, we evaluated the relative error (RE) describing the deviation of the catheter from the ideal center position in the clot and compared the accuracy of catheter placement using frameless stereotaxy or the novel preregistered stylet. The intrahematomal catheter position was evaluated in three dimensions in 89 patients with spontaneous supratentorial ICH. Frameless stereotaxy with guidance of an articulated arm was performed in 50 patients. The preregistered stylet was used in 39 patients. The catheter position was evaluated using a RE calculating the distance perpendicular to the center of the catheter in relation to the hematoma's diameter. The mean hematoma volume was 51.4 ml. Forty-four out of 89 hematomas were deep-seated. Intraventricular blood was found in 59 patients. The RE of the catheter position was lower in the stylet group in comparison to the frameless stereotaxy group (mean 0.57 vs. 0.90; p = 0.0018). There was no difference between deep-seated and lobar hematomas with regard to the accuracy of catheter placement (p = 0.62). The RE is a robust measure for describing intrahematomal catheter position. The preregistered stylet facilitates a satisfactory catheter placement and is a viable alternative to frameless stereotaxy and guidance with the articulated arm."],["dc.identifier.doi","10.1007/s12975-014-0326-1"],["dc.identifier.isi","000336336200011"],["dc.identifier.pmid","24470086"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33363"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1868-601X"],["dc.relation.issn","1868-4483"],["dc.title","Catheter Placement for Lysis of Spontaneous Intracerebral Hematomas: Is a Navigated Stylet Better Than Pointer-Guided Frameless Stereotaxy for Intrahematomal Catheter Positioning?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2753"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Acta Neurochirurgica"],["dc.bibliographiccitation.lastpage","2758"],["dc.bibliographiccitation.volume","162"],["dc.contributor.author","Wessels, Lars"],["dc.contributor.author","Fekonja, Lucius Samo"],["dc.contributor.author","Achberger, Johannes"],["dc.contributor.author","Dengler, Julius"],["dc.contributor.author","Czabanka, Marcus"],["dc.contributor.author","Hecht, Nils"],["dc.contributor.author","Schneider, Ulf"],["dc.contributor.author","Tkatschenko, Dimitri"],["dc.contributor.author","Schebesch, Karl-Michael"],["dc.contributor.author","Schmidt, Nils Ole"],["dc.contributor.author","Mielke, Dorothee"],["dc.contributor.author","Hosch, Henning"],["dc.contributor.author","Ganslandt, Oliver"],["dc.contributor.author","Gräwe, Alexander"],["dc.contributor.author","Hong, Bujung"],["dc.contributor.author","Walter, Jan"],["dc.contributor.author","Güresir, Erdem"],["dc.contributor.author","Bijlenga, Philippe"],["dc.contributor.author","Haemmerli, Julien"],["dc.contributor.author","Maldaner, Nicolai"],["dc.contributor.author","Marbacher, Serge"],["dc.contributor.author","Nurminen, Ville"],["dc.contributor.author","Zitek, Hynek"],["dc.contributor.author","Dammers, Ruben"],["dc.contributor.author","Kato, Naoki"],["dc.contributor.author","Linfante, Italo"],["dc.contributor.author","Pedro, Maria-Teresa"],["dc.contributor.author","Wrede, Karsten"],["dc.contributor.author","Wang, Wei-Te"],["dc.contributor.author","Wostrack, Maria"],["dc.contributor.author","Vajkoczy, Peter"],["dc.date.accessioned","2021-04-14T08:23:35Z"],["dc.date.available","2021-04-14T08:23:35Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1007/s00701-020-04565-6"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/80973"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","0942-0940"],["dc.relation.issn","0001-6268"],["dc.title","Diagnostic reliability of the Berlin classification for complex MCA aneurysms—usability in a series of only giant aneurysms"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Translational Stroke Research"],["dc.contributor.author","Döring, Katja"],["dc.contributor.author","Schroeder, Henning"],["dc.contributor.author","Fischer, André"],["dc.contributor.author","Sperling, Swetlana"],["dc.contributor.author","Ninkovic, Milena"],["dc.contributor.author","Stadelmann, Christine"],["dc.contributor.author","Mielke, Dorothee"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Malinova, Vesna"],["dc.date.accessioned","2022-02-01T10:31:59Z"],["dc.date.available","2022-02-01T10:31:59Z"],["dc.date.issued","2022"],["dc.description.abstract","Abstract Cerebral vasospasm is a highly investigated phenomenon in neurovascular research. Experimental vasospasm models are irreplaceable for the evaluation of new antivasospastic drugs. In this study, we assessed the reliability of in vivo vasospasm induction by ultrasound application in the chicken chorioallantoic membrane (CAM) model. After incubation of fertilized chicken eggs for four days, a fenestration was performed to enable examination of the CAM vessels. On the thirteenth day, continuous-wave ultrasound (3 MHz, 1 W/cm 2 ) was applied on the CAM vessels for 60 s. The ultrasound effect on the vessels was recorded by life imaging (5-MP HD-microscope camera, Leica®). The induced vessel diameter changes were evaluated in a defined time interval of 20 min using a Fiji macro. The vessel diameter before and after sonication was measured and the relative diameter reduction was determined. A first reduction of vessel diameter was observed after three minutes with an average vessel-diameter decrease to 77%. The maximum reduction in vessel diameter was reached eight minutes after sonication with an average vessel diameter decrease to 57% (mean relative diameter reduction of 43%, range 44–61%), ANOVA, p  = 0.0002. The vasospasm persisted for all 20 recorded minutes post induction. Vasospasm can be reliably induced by short application of 3 MHz-ultrasound to the CAM vessels. This might be a suitable in vivo model for the evaluation of drug effects on vasospasm in an experimental setting as intermediary in the transition process from in vitro to in vivo assessment using animal models."],["dc.description.abstract","Abstract Cerebral vasospasm is a highly investigated phenomenon in neurovascular research. Experimental vasospasm models are irreplaceable for the evaluation of new antivasospastic drugs. In this study, we assessed the reliability of in vivo vasospasm induction by ultrasound application in the chicken chorioallantoic membrane (CAM) model. After incubation of fertilized chicken eggs for four days, a fenestration was performed to enable examination of the CAM vessels. On the thirteenth day, continuous-wave ultrasound (3 MHz, 1 W/cm 2 ) was applied on the CAM vessels for 60 s. The ultrasound effect on the vessels was recorded by life imaging (5-MP HD-microscope camera, Leica®). The induced vessel diameter changes were evaluated in a defined time interval of 20 min using a Fiji macro. The vessel diameter before and after sonication was measured and the relative diameter reduction was determined. A first reduction of vessel diameter was observed after three minutes with an average vessel-diameter decrease to 77%. The maximum reduction in vessel diameter was reached eight minutes after sonication with an average vessel diameter decrease to 57% (mean relative diameter reduction of 43%, range 44–61%), ANOVA, p  = 0.0002. The vasospasm persisted for all 20 recorded minutes post induction. Vasospasm can be reliably induced by short application of 3 MHz-ultrasound to the CAM vessels. This might be a suitable in vivo model for the evaluation of drug effects on vasospasm in an experimental setting as intermediary in the transition process from in vitro to in vivo assessment using animal models."],["dc.identifier.doi","10.1007/s12975-021-00960-y"],["dc.identifier.pii","960"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/98997"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-517"],["dc.relation.eissn","1868-601X"],["dc.relation.issn","1868-4483"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","In Vivo Vasospasm Induction by Ultrasound Application in the Chicken Chorioallantoic Membrane Model"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.journal","Journal of Neurosurgery"],["dc.bibliographiccitation.lastpage","6"],["dc.contributor.author","Bettag, Christoph"],["dc.contributor.author","Hussein, Abdelhalim"],["dc.contributor.author","Schatlo, Bawarjan"],["dc.contributor.author","Barrantes-Freer, Alonso"],["dc.contributor.author","Abboud, Tammam"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Mielke, Dorothee"],["dc.date.accessioned","2022-06-01T09:39:47Z"],["dc.date.available","2022-06-01T09:39:47Z"],["dc.date.issued","2022"],["dc.description.abstract","OBJECTIVE Fluorescence-guided resection of cerebral metastases has been proposed as an approach to visualize residual tumor tissue and maximize the extent of resection. Critics have argued that tumor cells at the resection margins might be overlooked under microscopic visualization because of technical limitations. Therefore, an endoscope, which is capable of inducing fluorescence, has been applied with the aim of improving exposure of fluorescent tumor tissue. In this retrospective analysis, authors assessed the utility of endoscope assistance in 5-aminolevulinic acid (5-ALA) fluorescence–guided resection of brain metastases. METHODS Between June 2013 and December 2016, a standard 20-mg/kg dose of 5-ALA was administered 4 hours prior to surgery in 26 patients with suspected single brain metastases. After standard neuronavigated microsurgical tumor resection, a microscope capable of inducing fluorescence was used to examine tumor margins. The authors classified the remaining fluorescence into 3 grades (0 = none, 1 = weak, and 2 = strong). Endoscopic assistance was employed if no or only weak fluorescence was visualized at the resection margins under the microscope. Endoscopically identified fluorescent tissue at the margins was resected and evaluated separately via histological examination to prove or disprove tumor infiltration. RESULTS Under the microscope, weakly fluorescent tissue was seen at the margins of the resection cavity in 15/26 (57.7%) patients. In contrast, endoscopic inspection revealed strongly fluorescent tissue in 22/26 (84.6%) metastases. In 11/26 (42.3%) metastases no fluorescence at the tumor margins was detected by the microscope; however, strong fluorescence was visualized under the endoscope in 7 (63.6%) of these 11 metastases. In the 15 metastases with microscopically weak fluorescence, strong fluorescence was seen when using the endoscope. Neither microscopic nor endoscopic fluorescence was found in 4/26 (15.4%) cases. In the 26 patients, 96 histological specimens were obtained from the margins of the resection cavity. Findings from these specimens were in conjunction with the histopathological findings, allowing identification of metastatic infiltration with a sensitivity of 95.5% and a specificity of 75% using endoscope assistance. CONCLUSIONS Fluorescence-guided endoscope assistance may overcome the technical limitations of the conventional microscopic exposure of 5-ALA–fluorescent metastases and thereby increase visualization of fluorescent tumor tissue at the margins of the resection cavity with high sensitivity and acceptable specificity."],["dc.identifier.doi","10.3171/2022.3.JNS212301"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/108564"],["dc.notes.intern","DOI-Import GROB-572"],["dc.relation.eissn","1933-0693"],["dc.relation.issn","0022-3085"],["dc.title","Endoscope-assisted visualization of 5-aminolevulinic acid fluorescence in surgery for brain metastases"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2069"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Acta Neurochirurgica"],["dc.bibliographiccitation.lastpage","2074"],["dc.bibliographiccitation.volume","162"],["dc.contributor.author","Hernández-Durán, Silvia"],["dc.contributor.author","Zafar, Noman"],["dc.contributor.author","Behme, Daniel"],["dc.contributor.author","Momber, Matthias"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Mielke, Dorothee"],["dc.contributor.author","Fiss, Ingo"],["dc.date.accessioned","2021-06-01T10:49:15Z"],["dc.date.available","2021-06-01T10:49:15Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1007/s00701-020-04453-z"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86220"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","0942-0940"],["dc.relation.issn","0001-6268"],["dc.title","Volumetric analysis of bilateral spinal canal decompression via hemilaminectomy versus laminoplasty in cervical spondylotic myelopathy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Ophthalmology Retina"],["dc.contributor.author","Lauermann, Peer"],["dc.contributor.author","Klingelhöfer, Anthea"],["dc.contributor.author","Mielke, Dorothee"],["dc.contributor.author","van Oterendorp, Christian"],["dc.contributor.author","Hoerauf, Hans"],["dc.contributor.author","Striebe, Nina-Antonia"],["dc.contributor.author","Storch, Marcus Werner"],["dc.contributor.author","Pfeiffer, Sebastian"],["dc.contributor.author","Koscielny, Juergen"],["dc.contributor.author","Feltgen, Nicolas"],["dc.date.accessioned","2021-06-01T10:49:52Z"],["dc.date.available","2021-06-01T10:49:52Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1016/j.oret.2021.04.013"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86440"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.issn","2468-6530"],["dc.title","Risk factors for Severe Bleeding Complications in Vitreoretinal Surgery and the Role of Antiplatelet or Anticoagulant Agents"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","84"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal of Neurosurgery"],["dc.bibliographiccitation.lastpage","90"],["dc.bibliographiccitation.volume","129"],["dc.contributor.author","Malinova, Vesna"],["dc.contributor.author","Schatlo, Bawarjan"],["dc.contributor.author","Voit, Martin"],["dc.contributor.author","Suntheim, Patricia"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Mielke, Dorothee"],["dc.date.accessioned","2020-12-10T18:44:04Z"],["dc.date.available","2020-12-10T18:44:04Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.3171/2017.3.JNS162505"],["dc.identifier.eissn","1933-0693"],["dc.identifier.issn","0022-3085"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78317"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","The impact of temporary clipping during aneurysm surgery on the incidence of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Journal of Neuro-Oncology"],["dc.contributor.author","Bettag, Christoph"],["dc.contributor.author","Hussein, Abdelhalim"],["dc.contributor.author","Sachkova, Alexandra"],["dc.contributor.author","Bock, Hans Christoph"],["dc.contributor.author","Mielke, Dorothee"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Abboud, Tammam"],["dc.date.accessioned","2021-07-05T15:00:56Z"],["dc.date.available","2021-07-05T15:00:56Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1007/s11060-021-03792-w"],["dc.identifier.pii","3792"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/87939"],["dc.language.iso","en"],["dc.notes.intern","DOI Import DOI-Import GROB-441"],["dc.relation.eissn","1573-7373"],["dc.relation.issn","0167-594X"],["dc.title","Implantation of Carmustine wafers after resection of malignant glioma with and without opening of the ventricular system"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","41"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Operative Neurosurgery"],["dc.bibliographiccitation.lastpage","46"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Bettag, Christoph"],["dc.contributor.author","Hussein, Abdelhalim"],["dc.contributor.author","Behme, Daniel"],["dc.contributor.author","Maragkou, Theoni"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Mielke, Dorothee"],["dc.date.accessioned","2020-12-10T18:19:39Z"],["dc.date.available","2020-12-10T18:19:39Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1093/ons/opz082"],["dc.identifier.eissn","2332-4260"],["dc.identifier.issn","2332-4252"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/75325"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Endoscopic Fluorescence-Guided Resection Increases Radicality in Glioblastoma Surgery"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]