Dresing, Klaus

[["dc.bibliographiccitation.firstpage","521"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Der Unfallchirurg"],["dc.bibliographiccitation.lastpage","527"],["dc.bibliographiccitation.volume","110"],["dc.contributor.author","Frosch, Karl-Heinz"],["dc.contributor.author","Hingelbaum, S."],["dc.contributor.author","Dresing, Klaus"],["dc.contributor.author","Roessler, M."],["dc.contributor.author","Stuermer, Klaus-Michael"],["dc.date.accessioned","2018-11-07T11:02:18Z"],["dc.date.available","2018-11-07T11:02:18Z"],["dc.date.issued","2007"],["dc.description.abstract","Background. The anatomic region on the lateral cortex of the ileum, where a palpable \"groove\" is formed by angulations of the lateral cortex of the iliac wing, is recommended as the insertion point for the pelvic emergency clamp by many authors. In our opinion this technique often leads to an incomplete closure of the anterior pelvic ring as well as to bacterial contamination of the access for the sacroiliac joint screw fixation and is accompanied by a risk for nerve and vessel injuries. To reduce these risks the pelvic clamp was placed at a supra-acetabular location. The goal of our study was to report on our experiences with the supra-acetabular position of the pelvic emergency clamp and to compare our results with the current literature. Material and method. From September 1998 to February 2006 the pelvic emergency clamp was applied in 15 polytraumatized patients (9 male, 6 female), with a mean age of 46 years (19-93) and a mean injury severity score (ISS) of 40 points (25-66) with mechanically and hemodynamically unstable pelvic ring fractures. According to the AO classification the injury pattern was type B2 in four cases, type B3 in one case, type C1 in seven cases, type C2 in two cases and type C3 in one case. The pelvic clamp was percutaneously applied 2-3 cm cranial to the acetabular roof. The duration from hospital admission until the pelvic emergency clamp was applied amounted to an average of 54 min (15-150); the procedure itself was performed in all cases in less than 15 min. The mean Hb at arrival in the emergency department was 7.4 (2.4-13.8) mg/dl and the mean systolic blood pressure 69 (0-130) mmHg. Results. In 14 patients a complete closure of the anterior and posterior pelvic ring could be achieved; in 1 patient an overcompression of the anterior pelvic ring was observed. Four patients died due to massive bleeding. Three patients with isolated pelvic ring fractures became hemodynamically stable within 20 min after treatment with the supra-acetabular pelvic clamp. Nine patients needed additional emergency surgery because of intracerebral, intrathoracic or intra-abdominal injuries. On average in the first 6 h, 36.7 (9-175) units of erythrocyte concentrates and 34.5 (4-200) units of fresh frozen plasma were transfused. Conclusions. The supra-acetabular pelvic clamp leads to a homogeneous force distribution to the pelvic ring and enables complete closure of the anterior and posterior pelvic ring in unstable pelvic fractures. Reduction of the intrapelvic volume and compression of the posterior pelvic ring can thus be achieved. Risks for intrapelvic perforation or injuries of vessels and nerves are low. No bacterial contamination of the access for the sacroiliac screw fixation occurs. To avoid overcompression of the unstable pelvic ring, manual or radiological control of the closure of the ventral pelvic ring is necessary."],["dc.identifier.doi","10.1007/s00113-007-1228-4"],["dc.identifier.isi","000247257500005"],["dc.identifier.pmid","17318312"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/51348"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0177-5537"],["dc.title","The supra-acetabular pelvic clamp. Emergency treatment for unstable pelvic ring fractures"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1026"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Der Chirurg"],["dc.bibliographiccitation.lastpage","1033"],["dc.bibliographiccitation.volume","74"],["dc.contributor.author","Dresing, Klaus"],["dc.contributor.author","Pouwels, Claudia"],["dc.contributor.author","Bonsack, S."],["dc.contributor.author","Oellerich, M."],["dc.contributor.author","Schworer, H."],["dc.contributor.author","Uy, Angela"],["dc.contributor.author","Sturmer, K. M."],["dc.date.accessioned","2018-11-07T10:34:55Z"],["dc.date.available","2018-11-07T10:34:55Z"],["dc.date.issued","2003"],["dc.description.abstract","Background. Trauma and emergency surgeons (S) are in contact with high-risk patients (P) infected with HBV, HCV, and HIV without knowing which P is and which is not infected. The aim of this paper was to analyze routine screening (SCR) in trauma care. Method. Microparticle enzyme immunoassays (MEIA) (Abbott Axym system) were analyzed from routine blood samples: HBsAg (Q), HCV version 3.0, HIV 1/2gO. All positive or uncertain samples were confirmed with ELISA/PCR. Results. From January 2002 to October 2002 a total of 1074 emergency P were examined. The results were available within 50 min after admittance to the emergency room. In 53 of 1074 (4.9%) the MEIA was positive or in threshold margins (LV): HBV 15 P plus 3 LV (9 secured by ELISA/PCR), prevalence (PV) 0.84%. HCV 34 P plus I LV (31 secured with ELISA/PCR), PV 2.9%. HIV 2 P, PV 1.86parts per thousand, 1 in co-infection with HCV, I with HBV. Of 42 infections, 21 were unknown before screening, and in 5 P the S suspected an infection. After screening, nine surgical procedures were changed to safer procedures. Conclusion. MEIA is a good tool for quick SCR of HCV, HBV, and HIV in emergency surgery (ES). When the infection is known the S is more aware to perform only safe procedures during surgery (no touch technique) or to use more protective devices (e.g., fluid shield, double gloves). Our results indicate that surgeons and nurses in ES are exposed four to six times more often to infection with HCV, HBV, and HIV than represented by officially published data. We recommend routine SCR of HBV, HCV, and HIV for all P in ES. Prevention procedures are discussed."],["dc.identifier.doi","10.1007/s00104-003-0741-4"],["dc.identifier.isi","000187002800008"],["dc.identifier.pmid","14605720"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/44981"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0009-4722"],["dc.title","HCV, HBV, and HIV infection: risk for surgeon and staff. Results and consequences of routine screening in emergency patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","GMS Medizinische Informatik, Biometrie und Epidemiologie"],["dc.bibliographiccitation.lastpage","7"],["dc.contributor.author","Stürmer, Klaus Michael"],["dc.contributor.author","Wagner, Markus"],["dc.contributor.author","Duwenkamp, Christopher"],["dc.contributor.author","Ahrens, Christoph Alexander"],["dc.contributor.author","Plischke, Maik"],["dc.contributor.author","Dresing, Klaus"],["dc.contributor.author","Bott, Oliver Johannes"],["dc.date.accessioned","2019-07-09T11:52:48Z"],["dc.date.available","2019-07-09T11:52:48Z"],["dc.date.issued","2009"],["dc.description.abstract","Hintergrund und Fragestellung: Die durch röntgentechnische Diagnoseverfahren in der Medizin entstehende Strahlenbelastung für Patient und Personal soll laut Strahlenschutzverordnung so gering wie möglich gehalten werden. Um dieses zu erreichen ist ein professioneller und bedachter Umgang mit den Röntgengeräten unabdingbar. Dieses Verhalten kann derzeit jedoch nur theoretisch vermittelt werden, da sich ein Üben mit realer Strahlung von selbst verbietet. Daher stellt sich die Frage wie man die Strahlenschutzausbildung durch eine verbesserte Vermittlung der komplexen Thematik unterstützen kann. Methoden: Das CBT-System (Computer Based Training) virtX, welches das Erlernen der korrekten Handhabung mobiler Röntgengeräte unterstützt, wurde um Aspekte aus dem Bereich des Strahlenschutzes erweitert. Es wurde eine prototypische Visualisierung der entstehenden Streustrahlung sowie die Darstellung des Nutzstrahlenganges integriert. Des Weiteren wurde die Berechnung und Anzeige der virtuellen Einfallsdosis für das durchstrahlte Volumen sowie für den Bereich des Bildverstärkers hinzugefügt. Für die Berechnung und Visualisierung all dieser Komponenten werden die in virtX parametrisierbaren C-Bogen-Einstellungen, z.B. Stellung der Blenden, Positionierung des Röntgengerätes zum durchstrahlten Volumen und Strahlenintensität, herangezogen. Das so erweiterte System wurde auf einem dreitägigen Kurs für OP-Personal mit über 120 Teilnehmern eingesetzt und auf der Basis von Fragebögen evaluiert. Ergebnisse: Von den Teilnehmern gaben 55 einen ausgefüllten Evaluations-Fragebogen ab (Responserate 82%). Das Durchschnittsalter der 39 weiblichen und 15 männlichen Teilnehmer (einer o.A.) lag bei 33±8 Jahren, die Berufserfahrung bei 9,37±7 Jahren. Die Erfahrung mit dem C-Bogen wurde von einem Teilnehmer (2%) mit „Keine oder bisher nur Einführung erhalten“, von acht Teilnehmern (14%) mit „bediene einen C-Bogen gelegentlich“ und von 46 (84%) mit „bediene einen C-Bogen regelmäßig“ angegeben. 45 (92%) der Teilnehmer gaben an, durch die Visualisierung der Streustrahlung etwas Neues zur Vermeidung unnötiger Strahlenbelastung dazugelernt zu haben. Schlussfolgerung: Trotz einer bislang nur prototypischen Visualisierung der Streustrahlung können mit virtX zentrale Aspekte und Verhaltensweisen zur Vermeidung unnötiger Strahlenbelastung erfolgreich vermittelt werden und so Lücken der traditionellen Strahlenschutzausbildung geschlossen werden."],["dc.identifier.doi","10.3205/mibe000081"],["dc.identifier.fs","568165"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/5967"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/60279"],["dc.language.iso","de"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1860-9171"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.ddc","610"],["dc.title","virtX: ein Lehr- und Lernsystem für mobile Röntgengeräte zur Verbesserung der Ausbildung im Strahlenschutz"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","214"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Cells Tissues Organs"],["dc.bibliographiccitation.lastpage","227"],["dc.bibliographiccitation.volume","170"],["dc.contributor.author","Frosch, Karl-Heinz"],["dc.contributor.author","Barvencik, F."],["dc.contributor.author","Lohmann, Christoph H."],["dc.contributor.author","Viereck, Volker"],["dc.contributor.author","Siggelkow, Heide"],["dc.contributor.author","Breme, J."],["dc.contributor.author","Dresing, Klaus"],["dc.contributor.author","Sturmer, K. M."],["dc.date.accessioned","2018-11-07T10:32:53Z"],["dc.date.available","2018-11-07T10:32:53Z"],["dc.date.issued","2002"],["dc.description.abstract","The goal of this study was to characterize growth, mineralization and bone formation of osteoblast-like cells in titanium pore channels of defined diameter. Titanium implants with continuous drill channels of diameters of 300, 400, 500, 600 and 1,000 mum were inserted into human osteoblast-like cell cultures. The ingrowth of the cells into the drill channels was investigated by transmitted-light microscopy and scanning electron microscopy. Immunofluorescence and histological analysis of 15-channel sections of each diameter were used to investigate the growth behavior and the matrix protein patterns. Mineralization was evidenced by Alizarin red staining and high-resolution microradiography. The ingrowth of human osteoblast-like cells in the drill channels occurred in a sequence of four characteristic stages. In stage 1, osteoblast precursor cells adhered to the wall of the channel and migrated three-dimensionally into the channel by forming foot-like protoplasmic processes. For all 15 sample drill channels that were investigated, the cell ingrowth over 20 days amounted on average to 793 mum (+/- 179) into 600-mum-diameter channels, where they migrated significantly faster than in all the other channels. In stage 2, approximately on day 5-7, the osteoblast-like cells began to anchor on the substrate wall by matrix proteins and to build up a dense network of matrix proteins in the drill channel. The mineralization of the extracellular matrix, while depending on cell stimulation, was initiated in stage 3, on average after 4 weeks. In drill channels of a diameter of 1,000 mum the cell growth was incomplete and no mineralization was found by radiological assessment. Starting in week 6, in the drill channels of diameters ranging from 300 to 600 mum, the network of extracellular matrix proteins and osteoblast-like cells began to form an osteon-like structure. Neither the highly developed migration behavior of osteoblastic cells nor the reorganization from a fiber-like matrix to a lamellar structure have so far been described for cell cultures."],["dc.identifier.doi","10.1159/000047925"],["dc.identifier.isi","000174840400002"],["dc.identifier.pmid","11919409"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/44464"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.relation.issn","1422-6405"],["dc.title","Migration, matrix production and lamellar bone formation of human osteoblast-like cells in porous titanium implants"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","101"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Sportverletzung · Sportschaden"],["dc.bibliographiccitation.lastpage","107"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Losch, Andreas"],["dc.contributor.author","Meybohm, Patrick"],["dc.contributor.author","Schmalz, T."],["dc.contributor.author","Fuchs, M."],["dc.contributor.author","Vamvukakis, F."],["dc.contributor.author","Dresing, Klaus"],["dc.contributor.author","Blumentritt, S."],["dc.contributor.author","Sturmer, K. M."],["dc.date.accessioned","2018-11-07T10:08:45Z"],["dc.date.available","2018-11-07T10:08:45Z"],["dc.date.issued","2002"],["dc.description.abstract","Retrospectively 20 patients with a surgically treated ankle fracture caused by hobby-accidents were examined clinically and radiologically by a score modified to Phillips after 12 months postoperatively. Further they have taken part in a dynamical gait analysis at the same time. A group of 20 healthy adults was used as a control group comparable to age, sex, height and weight. Although 19 patients out of 20 have achieved a good result at the score evaluation and none of them was clinically noticed with any pathological gait, gait analysis has shown a significant slowed gait speed and a decreased stride lenght. The reduction of the plantarflexor moment at the injured ankle joint immediately following heel contact was yet the most remarkable result of the gait analysis. The changes of gait pattern are interpreted as an adapted and internalized motion pattern caused by pain and behaviour of rest at any time while the mobilisation-phase was going on. It could not document any significant correlation between subjective and clinical parameters and parameters registered by gait analysis. However, a significant correlation of gait-analysed parameters was found between the injured and uninjured side. By dynamical gait analysis it is possible to quantify remarkable gait changes, to obtain objektive data, but also to demonstrate asymmetrical loading and motion that were not clinically detectable previously. It follows that it can be relevant to patients with complaints by leading them to specific physiotherapeutical treatment and gait training so that they would be able to carry on their sports-activities again."],["dc.identifier.doi","10.1055/s-2002-34750"],["dc.identifier.isi","000178978300001"],["dc.identifier.pmid","12382182"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39530"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","0932-0555"],["dc.title","Functional results of dynamical gait analysis after 1 year of hobby-athletes with a surgically treated ankle fracture"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","602"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Der Unfallchirurg"],["dc.bibliographiccitation.lastpage","606"],["dc.bibliographiccitation.volume","103"],["dc.contributor.author","Fuchs, M."],["dc.contributor.author","Burchhardt, H."],["dc.contributor.author","Dresing, Klaus"],["dc.contributor.author","Radebold, T."],["dc.contributor.author","Sturmer, K. M."],["dc.date.accessioned","2018-11-07T10:43:14Z"],["dc.date.available","2018-11-07T10:43:14Z"],["dc.date.issued","2000"],["dc.description.abstract","Surgical treatment of calcaneal fractures is demanding due to the poor musculocutaneous coverage. Infection with osteitis is a severe complication with open fractures. The appearance of osteitis requires aggressive surgical treatment including amputation in case of persistence, leading to considerable invalidism. We report the case of an 37-year-old mason with an grade III open calcaneal fracture caused by a fall. Osteitis appeared after primary osteosynthesis with open reduction and eventually - after several revisions required a calcanectomy. By preservation of the forefoot and midfoot and thanks to sufficient orthesis treatment the patient was able to return to his profession after eigth months."],["dc.identifier.doi","10.1007/s001130050589"],["dc.identifier.isi","000088319800013"],["dc.identifier.pmid","10969549"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/46997"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0177-5537"],["dc.title","Resection of the calcaneus as a treatment option in osteitis at following an open calcaneal fracture"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","331"],["dc.bibliographiccitation.issue","5-6"],["dc.bibliographiccitation.journal","Journal of Molecular Histology"],["dc.bibliographiccitation.lastpage","341"],["dc.bibliographiccitation.volume","40"],["dc.contributor.author","Tezval, Mohammad"],["dc.contributor.author","Tezval, Hossein"],["dc.contributor.author","Dresing, Klaus"],["dc.contributor.author","Stuermer, Ewa Klara"],["dc.contributor.author","Blaschke, Martina"],["dc.contributor.author","Stuermer, Klaus Michael"],["dc.contributor.author","Siggelkow, Heide"],["dc.date.accessioned","2018-11-07T11:23:52Z"],["dc.date.available","2018-11-07T11:23:52Z"],["dc.date.issued","2009"],["dc.description.abstract","Urocortin-1 (UCN) a corticotropin releasing-factor (CRF) related peptide, has been found to be expressed in many different tissues like the central nervous system, the cardiovascular system, adipose tissue, and skeletal muscle. The effects of UCN are mediated via stimulation of CRF-receptors 1 and 2 (CRFR1 and 2, CRFR's) with a high affinity for CRFR2. It has been shown that the CRF-related peptides and CRFR's are involved in the regulation of stress-related endocrine, autonomic and behavioural responses. Using immunocytochemistry, immunohistochemistry and RT-PCR, we now can show the differentiation dependent expression of UCN mRNA and peptide in human mesenchymal progenitor cells (MSCs) directed to the osteoblastic phenotype for the first time. UCN expression was down regulated by TGF-beta and BMP-2 in the early proliferation phase of osteoblast development, whereas dexamethasone (dex) minimally induced UCN gene expression during matrix maturation after 24 h stimulation. Stimulation of MSCs for 28 days with ascorbate/beta-glycerophosphate (asc/bGp) induced UCN gene expression at day 14. This effect was prevented when using 1,25-vitamin D3 or dex in addition. There was no obvious correlation to osteocalcin (OCN) gene expression in these experiments. In MSCs from patients with metabolic bone disease (n = 9) UCN gene expression was significantly higher compared to MSCs from normal controls (n = 6). Human MSCs did not express any of the CRFR's during differentiation to osteoblasts. Our results indicate that UCN is produced during the development of MSCs to osteoblasts and differentially regulated during culture as well as by differentiation factors. The expression is maximal between proliferation and matrix maturation phase. However, UCN does not seem to act on the osteoblast itself as shown by the missing CRFR's. Our results suggest new perspectives on the role of urocortin in human skeletal tissue in health and disease."],["dc.identifier.doi","10.1007/s10735-009-9244-z"],["dc.identifier.isi","000275443300002"],["dc.identifier.pmid","19949969"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?goescholar/4160"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56279"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1567-2379"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Differentiation dependent expression of urocortin's mRNA and peptide in human osteoprogenitor cells: influence of BMP-2, TGF-beta-1 and dexamethasone"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1194"],["dc.bibliographiccitation.issue","16-17"],["dc.bibliographiccitation.journal","Clinical Biochemistry"],["dc.bibliographiccitation.lastpage","1200"],["dc.bibliographiccitation.volume","40"],["dc.contributor.author","Dresing, Klaus"],["dc.contributor.author","Armstrong, Victor William"],["dc.contributor.author","Leip, Casper-Lennart"],["dc.contributor.author","Streit, Frank"],["dc.contributor.author","Burchardi, Hilmar"],["dc.contributor.author","Stuermer, Klaus-Michael"],["dc.contributor.author","Oellerich, Michael"],["dc.date.accessioned","2018-11-07T10:55:48Z"],["dc.date.available","2018-11-07T10:55:48Z"],["dc.date.issued","2007"],["dc.description.abstract","Objectives: The aim was to investigate the outcome MODS/MOF in critically ill patients with regard to early hepatic dysfunction. Methods: Thirty adult polytrauma patients admitted to the ICU, with ISS >= 16 were prospectively investigated. Real-time liver function was assessed using the MEGX test and arterial ketone body ratio (AKBR) 12-24 h after admittance to ICU, and on days 3, 5, 8, 12. Results: Six patients (19%) died between days 4 and 29. Non-survivors were older (64.2 vs. 31.5 years), had a significantly higher ISS (40.5 vs. 30; p=0.002) and MODS score (9.5 vs. 5; p=0.001) on admittance to the ICU than survivors. On day 3 MEGX values (31 vs. 71.3 mu g/L; p=0.001) and the AKBRs (0.6 vs. 1.3; p=0.001) were significantly lower in non-survivors than in survivors whereas IL-6 levels were significantly higher in the former group (519 vs. 61 mu g/L; p = 0.05). Conclusions: The MEGX test and AKBR are sensitive early indicators of hepatic dysfunction in severely injured polytrauma patients at risk for developing MODS/MOF. (C) 2007 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.clinbiochem.2007.06.013"],["dc.identifier.isi","000250605200004"],["dc.identifier.pmid","17707362"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/49869"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Pergamon-elsevier Science Ltd"],["dc.relation.issn","0009-9120"],["dc.title","Real-time assessment of hepatic function is related to clinical outcome in critically ill patients after polytrauma"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","367"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Der Unfallchirurg"],["dc.bibliographiccitation.lastpage","+"],["dc.bibliographiccitation.volume","106"],["dc.contributor.author","Frosch, Karl-Heinz"],["dc.contributor.author","Knopp, W."],["dc.contributor.author","Dresing, Klaus"],["dc.contributor.author","Langer, C."],["dc.contributor.author","Sturmer, K. M."],["dc.date.accessioned","2018-11-07T10:39:29Z"],["dc.date.available","2018-11-07T10:39:29Z"],["dc.date.issued","2003"],["dc.description.abstract","The treatment of comminuted fractures of the radial head with concomitant injuries of the ulnar complex by resection of the radial head usually does not provide satisfactory long-term results. Other than joint instability in the elbow and a limited range of motion, radius proximalisation in the sense of ulnocarpal impingement, osteoarthritis and pain in the elbow have been described. Between 1995 and 1997, 11 radial head prostheses were implanted in ten patients who had sustained a comminuted fracture of the radial head with concomitant injury to the ulnar complex. A follow-up survey was conducted with the patients on average 5 years after the injury. Eight patients with nine implants participated in the follow-up, one patient had died and another refused to participate but declared that he did not suffer from any impairment. According to the Morrey score, two of the results were found to be very good,five to be good, one to be fair and one to be poor. Despite the severe injuries sustained by the elbow, neither joint instability in the elbow nor proximalisation of the radius, cubitus valgus, ulnar nerve syndrome, nor loosening of the prosthesis were found in any of the patients. In the event of comminuted fractures of the radial head which are impossible to reconstruct by osteosynthesis and which occur with concomitant ulnar ligamentous or osseous injury, the implantation of a prosthesis is preferred over the resection of the head of the radius."],["dc.identifier.doi","10.1007/s00113-003-0573-1"],["dc.identifier.isi","000183518200002"],["dc.identifier.pmid","12750809"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/46061"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0177-5537"],["dc.title","A bipolar radial head prosthesis after comminuted radial head fractures: indications, treatment and outcome after 5 years"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","325"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Biomedical Materials Research Part A"],["dc.bibliographiccitation.lastpage","334"],["dc.bibliographiccitation.volume","68A"],["dc.contributor.author","Frosch, Karl-Heinz"],["dc.contributor.author","Barvencik, F."],["dc.contributor.author","Viereck, Volker"],["dc.contributor.author","Lohmann, Christoph H."],["dc.contributor.author","Dresing, Klaus"],["dc.contributor.author","Breme, J."],["dc.contributor.author","Brunner, E."],["dc.contributor.author","Sturmer, K. M."],["dc.date.accessioned","2018-11-07T10:51:26Z"],["dc.date.available","2018-11-07T10:51:26Z"],["dc.date.issued","2004"],["dc.description.abstract","The purpose of the current study was to investigate the effect of different diameters of cylindrical titanium channels on human osteoblasts. Titanium samples having continuous drill channels with diameters of 300, 400, 500, 600, and 1000 mum were put into osteoblast cell cultures that were isolated from 12 adult human trauma patients. Cell migration into the drill channels was investigated by transmitted-light microscopy. The DNA content in the drill channels was measured photometrically, collagen type I production was analyzed by enzyme-linked immunosorbent assay (ELISA) and osteocalcin gene expression by reverse transcriptase-polymerase chain reaction (RT-PCR). Formation of mineralized tissue was assessed by microradiographs of histological sections. Within 20 days, cells grew an average of 838 mum (+/-128 mum) into the drill channels with a diameter of 600 mum and were significantly faster (p < 0.05) than in all other channels. Cells produced significantly more osteocalcin messenger RNA (mRNA) in 600-mum channels (p < 0.05) than they did in 1000-mum channels and demonstrated the highest osteogenic differentiation. The channel diameter did not influence collagen type I production. The highest cell density was found in 300-mum channels (p < 0.05). The DNA content of the channels linearly decreased with increasing channel diameters. After 40 days of culture, the proportion of mineralized tissue at the mouth section amounted to 6% in 300-mum channels and to 9-11% in 400-600-mum channels. In 1000-mum channels, only traces of mineralization were detected. Our data suggest that the diameter of cylindrical titanium channels has a significant effect on migration, gene expression, and mineralization of human osteoblasts. (C) 2003 Wiley Periodicals, Inc."],["dc.identifier.doi","10.1002/jbm.a.20010"],["dc.identifier.isi","000188710000014"],["dc.identifier.pmid","14704974"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/48894"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-liss"],["dc.relation.issn","0021-9304"],["dc.title","Growth behavior, matrix production, and gene expression of human osteoblasts in defined cylindrical titanium channels"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]