Fischer, André

[["dc.bibliographiccitation.journal","Molecular Neurobiology"],["dc.contributor.author","Epple, Robert"],["dc.contributor.author","Krüger, Dennis"],["dc.contributor.author","Berulava, Tea"],["dc.contributor.author","Brehm, Gerrit"],["dc.contributor.author","Ninov, Momchil"],["dc.contributor.author","Islam, Rezaul"],["dc.contributor.author","Köster, Sarah"],["dc.contributor.author","Fischer, Andre"],["dc.date.accessioned","2021-04-14T08:29:06Z"],["dc.date.available","2021-04-14T08:29:06Z"],["dc.date.issued","2021"],["dc.description.abstract","Neurons are highly compartmentalized cells that depend on local protein synthesis. Messenger RNAs (mRNAs) have thus been detected in neuronal dendrites, and more recently in the pre- and postsynaptic compartments as well. Other RNA species such as microRNAs have also been described at synapses where they are believed to control mRNA availability for local translation. A combined dataset analyzing the synaptic coding and non-coding RNAome via next-generation sequencing approaches is, however, still lacking. Here, we isolate synaptosomes from the hippocampus of young wild-type mice and provide the coding and non-coding synaptic RNAome. These data are complemented by a novel approach for analyzing the synaptic RNAome from primary hippocampal neurons grown in microfluidic chambers. Our data show that synaptic microRNAs control almost the entire synaptic mRNAome, and we identified several hub microRNAs. By combining the in vivo synaptosomal data with our novel microfluidic chamber system, our findings also support the hypothesis that part of the synaptic microRNAome may be supplied to neurons via astrocytes. Moreover, the microfluidic system is suitable for studying the dynamics of the synaptic RNAome in response to stimulation. In conclusion, our data provide a valuable resource and point to several important targets for further research."],["dc.identifier.doi","10.1007/s12035-021-02296-y"],["dc.identifier.pmid","33569760"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/82797"],["dc.identifier.url","https://mbexc.uni-goettingen.de/literature/publications/228"],["dc.identifier.url","https://sfb1286.uni-goettingen.de/literature/publications/110"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation","EXC 2067: Multiscale Bioimaging"],["dc.relation","SFB 1286: Quantitative Synaptologie"],["dc.relation","SFB 1286 | B06: Die Rolle von RNA in Synapsenphysiologie und Neurodegeneration"],["dc.relation.eissn","1559-1182"],["dc.relation.haserratum","/handle/2/82796"],["dc.relation.issn","0893-7648"],["dc.relation.workinggroup","RG A. Fischer (Epigenetics and Systems Medicine in Neurodegenerative Diseases)"],["dc.relation.workinggroup","RG Köster (Cellular Biophysics)"],["dc.rights","CC BY 4.0"],["dc.title","The Coding and Small Non-coding Hippocampal Synaptic RNAome"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Molecular Neurobiology"],["dc.contributor.author","Epple, Robert"],["dc.contributor.author","Krüger, Dennis"],["dc.contributor.author","Berulava, Tea"],["dc.contributor.author","Brehm, Gerrit"],["dc.contributor.author","Ninov, Momchil"],["dc.contributor.author","Islam, Rezaul"],["dc.contributor.author","Köster, Sarah"],["dc.contributor.author","Fischer, Andre"],["dc.date.accessioned","2021-04-14T08:29:05Z"],["dc.date.available","2021-04-14T08:29:05Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1007/s12035-021-02349-2"],["dc.identifier.pmid","33710584"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/82796"],["dc.identifier.url","https://mbexc.uni-goettingen.de/literature/publications/273"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation","EXC 2067: Multiscale Bioimaging"],["dc.relation.eissn","1559-1182"],["dc.relation.isdataof","/handle/2/82797"],["dc.relation.issn","0893-7648"],["dc.relation.workinggroup","RG A. Fischer (Epigenetics and Systems Medicine in Neurodegenerative Diseases)"],["dc.relation.workinggroup","RG Köster (Cellular Biophysics)"],["dc.rights","CC BY 4.0"],["dc.title","Correction to: The Coding and Small Non-coding Hippocampal Synaptic RNAome"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","erratum_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.contributor.author","Epple, Robert"],["dc.contributor.author","Krüger, Dennis"],["dc.contributor.author","Berulava, Tea"],["dc.contributor.author","Brehm, Gerrit"],["dc.contributor.author","Islam, Rezaul"],["dc.contributor.author","Köster, Sarah"],["dc.contributor.author","Fischer, André"],["dc.date.accessioned","2022-02-16T13:26:06Z"],["dc.date.available","2022-02-16T13:26:06Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1101/2020.11.27.401901"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/99925"],["dc.identifier.url","https://mbexc.uni-goettingen.de/literature/publications/138"],["dc.identifier.url","https://sfb1286.uni-goettingen.de/literature/publications/92"],["dc.relation","EXC 2067: Multiscale Bioimaging"],["dc.relation","SFB 1286: Quantitative Synaptologie"],["dc.relation","SFB 1286 | B01: Der Verteilung struktureller Lipide in synaptischen Membranen"],["dc.relation.orgunit","Institut für Röntgenphysik"],["dc.relation.workinggroup","RG Köster (Cellular Biophysics)"],["dc.relation.workinggroup","RG A. Fischer (Epigenetics and Systems Medicine in Neurodegenerative Diseases)"],["dc.subject.gro","other"],["dc.title","The Coding And Small-Non-Coding Hippocampal Synaptic RNAome"],["dc.type","preprint"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]