Banaschewski, Tobias

[["dc.bibliographiccitation.firstpage","1680"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Autism Research"],["dc.bibliographiccitation.lastpage","1692"],["dc.bibliographiccitation.volume","12"],["dc.contributor.affiliation","Banaschewski, Tobias; 2\r\nDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim\r\nHeidelberg University\r\nMannheim Germany"],["dc.contributor.affiliation","Dziobek, Isabel; 3\r\nBerlin School of Mind and Brain and Institute of Psychology\r\nHumboldt‐Universität zu Berlin\r\nBerlin Germany"],["dc.contributor.affiliation","Brandeis, Daniel; 2\r\nDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim\r\nHeidelberg University\r\nMannheim Germany"],["dc.contributor.affiliation","Poustka, Luise; 2\r\nDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim\r\nHeidelberg University\r\nMannheim Germany"],["dc.contributor.affiliation","Freitag, Christine M.; 1\r\nDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy\r\nUniversity Hospital, Goethe University Frankfurt am Main\r\nFrankfurt Germany"],["dc.contributor.author","Bast, Nico"],["dc.contributor.author","Banaschewski, Tobias"],["dc.contributor.author","Dziobek, Isabel"],["dc.contributor.author","Brandeis, Daniel"],["dc.contributor.author","Poustka, Luise"],["dc.contributor.author","Freitag, Christine M."],["dc.date.accessioned","2019-11-25T15:27:33Z"],["dc.date.accessioned","2021-10-27T13:21:35Z"],["dc.date.available","2019-11-25T15:27:33Z"],["dc.date.available","2021-10-27T13:21:35Z"],["dc.date.issued","2019"],["dc.date.updated","2022-02-09T13:22:08Z"],["dc.description.abstract","Progression of pupil dilation (PD) in response to visual stimuli may indicate distinct internal processes. No study has been performed on PD progression during a social cognition task. Here, we describe PD progression during the Movie for the Assessment of Social Cognition (MASC) test in n = 23 adolescents with Autism Spectrum Disorder (ASD) and n = 24 age, IQ and sex-matched neurotypical controls (NTC). The MASC consists of 43 video sequences depicting human social interactions, each followed by a multiple-choice question concerning characters' mental states. PD progression data were extracted by eye tracking and controlled for fixation behavior. Segmenting PD progression during video sequences by principal component analysis, three sequential PD components were unveiled. In ASD compared with NTC, a distinct PD progression was observed with increased constriction amplitude, increased dilation latency, and increased dilation amplitude that correlated with PD progression components. These components predicted social cognition performance. The first and second PD components correlated positively with MASC behavioral performance in ASD but negatively in NTC. These PD components may be interpreted as indicators of sensory-perceptual processing and attention function. In ASD, aberrant sensory-perceptual processing and attention function could contribute to attenuated social cognition performance. This needs to be tested by additional studies combining the respective cognitive tests and the outlined PD progression analysis. Phasic activity of the locus coeruleus-norepinephrine system is discussed as putatively shared underlying mechanism. Autism Res2019. © 2019 The Authors. Autism Research published by International Society for Autism Research published by Wiley Periodicals, Inc. LAY SUMMARY: In adolescents with autism, we found an altered pupil dilation during watching scenes of human interactions. Early pupil dilation correlated positively with the number of correct answers to questions about the shown human interactions. Our findings suggest that aberrant sensory processing and attention function may contribute to altered social cognition in autism."],["dc.description.sponsorship","Innovative Medicines Initiative Joint Undertaking"],["dc.identifier.doi","10.1002/aur.2178"],["dc.identifier.eissn","1939-3806"],["dc.identifier.issn","1939-3792"],["dc.identifier.pmid","31347301"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16726"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/92033"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.publisher","John Wiley & Sons, Inc."],["dc.relation.eissn","1939-3806"],["dc.relation.issn","1939-3806"],["dc.relation.issn","1939-3792"],["dc.relation.orgunit","Universitätsmedizin Göttingen"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","610"],["dc.title","Pupil Dilation Progression Modulates Aberrant Social Cognition in Autism Spectrum Disorder"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","435"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","JAMA Psychiatry"],["dc.bibliographiccitation.volume","76"],["dc.contributor.author","Luo, Qiang"],["dc.contributor.author","Chen, Qiang"],["dc.contributor.author","Wang, Wenjia"],["dc.contributor.author","Desrivières, Sylvane"],["dc.contributor.author","Quinlan, Erin Burke"],["dc.contributor.author","Jia, Tianye"],["dc.contributor.author","Macare, Christine"],["dc.contributor.author","Robert, Gabriel H."],["dc.contributor.author","Cui, Jing"],["dc.contributor.author","Guedj, Mickaël"],["dc.contributor.author","Palaniyappan, Lena"],["dc.contributor.author","Kherif, Ferath"],["dc.contributor.author","Banaschewski, Tobias"],["dc.contributor.author","Bokde, Arun L. W."],["dc.contributor.author","Büchel, Christian"],["dc.contributor.author","Flor, Herta"],["dc.contributor.author","Frouin, Vincent"],["dc.contributor.author","Garavan, Hugh"],["dc.contributor.author","Gowland, Penny"],["dc.contributor.author","Heinz, Andreas"],["dc.contributor.author","Ittermann, Bernd"],["dc.contributor.author","Martinot, Jean-Luc"],["dc.contributor.author","Artiges, Eric"],["dc.contributor.author","Paillère-Martinot, Marie-Laure"],["dc.contributor.author","Nees, Frauke"],["dc.contributor.author","Orfanos, Dimitri Papadopoulos"],["dc.contributor.author","Poustka, Luise"],["dc.contributor.author","Fröhner, Juliane H."],["dc.contributor.author","Smolka, Michael N."],["dc.contributor.author","Walter, Henrik"],["dc.contributor.author","Whelan, Robert"],["dc.contributor.author","Callicott, Joseph H."],["dc.contributor.author","Mattay, Venkata S."],["dc.contributor.author","Pausova, Zdenka"],["dc.contributor.author","Dartigues, Jean-François"],["dc.contributor.author","Tzourio, Christophe"],["dc.contributor.author","Crivello, Fabrice"],["dc.contributor.author","Berman, Karen F."],["dc.contributor.author","Li, Fei"],["dc.contributor.author","Paus, Tomáš"],["dc.contributor.author","Weinberger, Daniel R."],["dc.contributor.author","Murray, Robin M."],["dc.contributor.author","Schumann, Gunter"],["dc.contributor.author","Feng, Jianfeng"],["dc.date.accessioned","2019-07-09T11:51:24Z"],["dc.date.available","2019-07-09T11:51:24Z"],["dc.date.issued","2019"],["dc.description.abstract","Importance: Deviation from normal adolescent brain development precedes manifestations of many major psychiatric symptoms. Such altered developmental trajectories in adolescents may be linked to genetic risk for psychopathology. Objective: To identify genetic variants associated with adolescent brain structure and explore psychopathologic relevance of such associations. Design, Setting, and Participants: Voxelwise genome-wide association study in a cohort of healthy adolescents aged 14 years and validation of the findings using 4 independent samples across the life span with allele-specific expression analysis of top hits. Group comparison of the identified gene-brain association among patients with schizophrenia, unaffected siblings, and healthy control individuals. This was a population-based, multicenter study combined with a clinical sample that included participants from the IMAGEN cohort, Saguenay Youth Study, Three-City Study, and Lieber Institute for Brain Development sample cohorts and UK biobank who were assessed for both brain imaging and genetic sequencing. Clinical samples included patients with schizophrenia and unaffected siblings of patients from the Lieber Institute for Brain Development study. Data were analyzed between October 2015 and April 2018. Main Outcomes and Measures: Gray matter volume was assessed by neuroimaging and genetic variants were genotyped by Illumina BeadChip. Results: The discovery sample included 1721 adolescents (873 girls [50.7%]), with a mean (SD) age of 14.44 (0.41) years. The replication samples consisted of 8690 healthy adults (4497 women [51.8%]) from 4 independent studies across the life span. A nonsynonymous genetic variant (minor T allele of rs13107325 in SLC39A8, a gene implicated in schizophrenia) was associated with greater gray matter volume of the putamen (variance explained of 4.21% in the left hemisphere; 8.66; 95% CI, 6.59-10.81; P = 5.35 × 10-18; and 4.44% in the right hemisphere; t = 8.90; 95% CI, 6.75-11.19; P = 6.80 × 10-19) and also with a lower gene expression of SLC39A8 specifically in the putamen (t127 = -3.87; P = 1.70 × 10-4). The identified association was validated in samples across the life span but was significantly weakened in both patients with schizophrenia (z = -3.05; P = .002; n = 157) and unaffected siblings (z = -2.08; P = .04; n = 149). Conclusions and Relevance: Our results show that a missense mutation in gene SLC39A8 is associated with larger gray matter volume in the putamen and that this association is significantly weakened in schizophrenia. These results may suggest a role for aberrant ion transport in the etiology of psychosis and provide a target for preemptive developmental interventions aimed at restoring the functional effect of this mutation."],["dc.identifier.doi","10.1001/jamapsychiatry.2018.4126"],["dc.identifier.pmid","30649180"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16122"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59943"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation","info:eu-repo/grantAgreement/EC/H2020/720270/EU//HBP SGA1"],["dc.relation","info:eu-repo/grantAgreement/EC/H2020/695313/EU//STRATIFY"],["dc.relation","info:eu-repo/grantAgreement/EC/FP7/602450/EU//IMAGEMEND"],["dc.relation","info:eu-repo/grantAgreement/EC/FP7/603016/EU//MATRICS"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.ddc","610"],["dc.title","Association of a Schizophrenia-Risk Nonsynonymous Variant With Putamen Volume in Adolescents"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","214"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Brain Sciences"],["dc.bibliographiccitation.volume","11"],["dc.contributor.affiliation","Kaiser, Anna; \t\t \r\n\t\t Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, 68159 Mannheim, Germany, anna.kaiser@zi-mannheim.de"],["dc.contributor.affiliation","Aggensteiner, Pascal-M.; \t\t \r\n\t\t Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, 68159 Mannheim, Germany, Pascal.Aggensteiner@zi-mannheim.de"],["dc.contributor.affiliation","Holtmann, Martin; \t\t \r\n\t\t LWL-University Hospital for Child and Adolescent Psychiatry, Psychotherapy, and Psychosomatics, Ruhr University Bochum, 59071 Hamm, Germany, martin.holtmann@lwl.org"],["dc.contributor.affiliation","Fallgatter, Andreas; \t\t \r\n\t\t Tübingen University Hospital for Psychiatry and Psychotherapy, 72076 Tübingen, Germany, Andreas.Fallgatter@med.uni-tuebingen.de"],["dc.contributor.affiliation","Romanos, Marcel; \t\t \r\n\t\t Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, 97080 Würzburg, Germany, Romanos_M@ukw.de"],["dc.contributor.affiliation","Abenova, Karina; \t\t \r\n\t\t Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, 68159 Mannheim, Germany, Karina.Abenova@zi-mannheim.de"],["dc.contributor.affiliation","Alm, Barbara; \t\t \r\n\t\t Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, 68159 Mannheim, Germany, Barbara.Alm@zi-mannheim.de"],["dc.contributor.affiliation","Becker, Katja; \t\t \r\n\t\t Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Medical Faculty Philipps-University Marburg and University Hospital Marburg, 35039 Marburg, Germany, katja.becker@med.uni-marburg.de\t\t \r\n\t\t Center for Mind, Brain and Behavior (CMBB), University of Marburg and Justus Liebig University Giessen, 35032 Marburg, Germany, katja.becker@med.uni-marburg.de"],["dc.contributor.affiliation","Döpfner, Manfred; \t\t \r\n\t\t Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany, manfred.doepfner@uk-koeln.de"],["dc.contributor.affiliation","Ethofer, Thomas; \t\t \r\n\t\t Tübingen University Hospital for Psychiatry and Psychotherapy, 72076 Tübingen, Germany, Thomas.Ethofer@med.uni-tuebingen.de"],["dc.contributor.affiliation","Freitag, Christine; \t\t \r\n\t\t Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Frankfurt, Goethe University, 60323 Frankfurt am Main, Germany, C.Freitag@em.uni-frankfurt.de"],["dc.contributor.affiliation","Geissler, Julia; \t\t \r\n\t\t Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, 97080 Würzburg, Germany, Geissler_J@ukw.de"],["dc.contributor.affiliation","Hebebrand, Johannes; \t\t \r\n\t\t Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany, johannes.hebebrand@lvr.de"],["dc.contributor.affiliation","Huss, Michael; \t\t \r\n\t\t Department of Child and Adolescent Psychiatry, University Medical Center of the Johannes Gutenberg-University Mainz, 55131 Mainz, Germany, m.huss@rfk.landeskrankenhaus.de"],["dc.contributor.affiliation","Jans, Thomas; \t\t \r\n\t\t Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, 97080 Würzburg, Germany, Jans_T@ukw.de"],["dc.contributor.affiliation","Jendreizik, Lea; \t\t \r\n\t\t Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany, lea.jendreizik@uk-koeln.de"],["dc.contributor.affiliation","Ketter, Johanna; \t\t \r\n\t\t Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Medical Faculty Philipps-University Marburg and University Hospital Marburg, 35039 Marburg, Germany, ketterj@med.uni-marburg.de"],["dc.contributor.affiliation","Legenbauer, Tanja; \t\t \r\n\t\t LWL-University Hospital for Child and Adolescent Psychiatry, Psychotherapy, and Psychosomatics, Ruhr University Bochum, 59071 Hamm, Germany, tanja.legenbauer@lwl.org"],["dc.contributor.affiliation","Philipsen, Alexandra; \t\t \r\n\t\t Department of Psychiatry and Psychotherapy, University of Bonn, 53127 Bonn, Germany, Alexandra.Philipsen@ukbonn.de"],["dc.contributor.affiliation","Poustka, Luise; \t\t \r\n\t\t Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, 37075 Göttingen, Germany, luise.poustka@med.uni-goettingen.de"],["dc.contributor.affiliation","Renner, Tobias; \t\t \r\n\t\t Department of Child and Adolescence Psychiatry and Psychotherapy, University of Tübingen, 72076 Tübingen, Germany, tobias.renner@med.uni-tuebingen.de"],["dc.contributor.affiliation","Retz, Wolfgang; \t\t \r\n\t\t Department of Psychiatry and Psychotherapy, University Medical Center Mainz, 55131 Mainz, Germany, wolfgang.retz@unimedizin-mainz.de\t\t \r\n\t\t Institute for Forensic Psychology and Psychiatry, Saarland University, 66424 Homburg, Germany, wolfgang.retz@unimedizin-mainz.de"],["dc.contributor.affiliation","Rösler, Michael; \t\t \r\n\t\t Institute for Forensic Psychology and Psychiatry, Saarland University, 66424 Homburg, Germany, Michael.Roesler@uks.eu"],["dc.contributor.affiliation","Thome, Johannes; \t\t \r\n\t\t Department of Psychiatry and Psychotherapy, University Medical Center Rostock, 18055 Rostock, Germany, johannes.thome@med.uni-rostock.de"],["dc.contributor.affiliation","Uebel-von Sandersleben, Henrik; \t\t \r\n\t\t Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, 37075 Göttingen, Germany, huebel@gwdg.de"],["dc.contributor.affiliation","von Wirth, Elena; \t\t \r\n\t\t Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany, elena.von-wirth@uk-koeln.de"],["dc.contributor.affiliation","Zinnow, Toivo; \t\t \r\n\t\t Institute for Forensic Psychology and Psychiatry, Saarland University, 66424 Homburg, Germany, Toivo.Zinnow@uks.eu"],["dc.contributor.affiliation","Hohmann, Sarah; \t\t \r\n\t\t Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, 68159 Mannheim, Germany, Sarah.Hohmann@zi-mannheim.de"],["dc.contributor.affiliation","Millenet, Sabina; \t\t \r\n\t\t Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, 68159 Mannheim, Germany, Sabina.Millenet@zi-mannheim.de"],["dc.contributor.affiliation","Holz, Nathalie; \t\t \r\n\t\t Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, 68159 Mannheim, Germany, Nathalie.Holz@zi-mannheim.de"],["dc.contributor.affiliation","Banaschewski, Tobias; \t\t \r\n\t\t Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, 68159 Mannheim, Germany, tobias.banaschewski@zi-mannheim.de"],["dc.contributor.affiliation","Brandeis, Daniel; \t\t \r\n\t\t Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, 68159 Mannheim, Germany, Daniel.Brandeis@zi-mannheim.de\t\t \r\n\t\t Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry, University of Zürich, 8032 Zürich, Switzerland, Daniel.Brandeis@zi-mannheim.de\t\t \r\n\t\t Center for Integrative Human Physiology, University of Zürich, 8057 Zürich, Switzerland, Daniel.Brandeis@zi-mannheim.de\t\t \r\n\t\t Neuroscience Center Zürich, Swiss Federal Institute of Technology and University of Zürich, 8057 Zürich, Switzerland, Daniel.Brandeis@zi-mannheim.de"],["dc.contributor.author","Kaiser, Anna"],["dc.contributor.author","Aggensteiner, Pascal-M."],["dc.contributor.author","Holtmann, Martin"],["dc.contributor.author","Fallgatter, Andreas"],["dc.contributor.author","Romanos, Marcel"],["dc.contributor.author","Abenova, Karina"],["dc.contributor.author","Alm, Barbara"],["dc.contributor.author","Becker, Katja"],["dc.contributor.author","Döpfner, Manfred"],["dc.contributor.author","Ethofer, Thomas"],["dc.contributor.author","Freitag, Christine"],["dc.contributor.author","Geissler, Julia"],["dc.contributor.author","Hebebrand, Johannes"],["dc.contributor.author","Huss, Michael"],["dc.contributor.author","Jans, Thomas"],["dc.contributor.author","Jendreizik, Lea"],["dc.contributor.author","Ketter, Johanna"],["dc.contributor.author","Legenbauer, Tanja"],["dc.contributor.author","Philipsen, Alexandra"],["dc.contributor.author","Poustka, Luise"],["dc.contributor.author","Renner, Tobias"],["dc.contributor.author","Retz, Wolfgang"],["dc.contributor.author","Rösler, Michael"],["dc.contributor.author","Thome, Johannes"],["dc.contributor.author","Uebel-von Sandersleben, Henrik"],["dc.contributor.author","von Wirth, Elena"],["dc.contributor.author","Zinnow, Toivo"],["dc.contributor.author","Hohmann, Sarah"],["dc.contributor.author","Millenet, Sabina"],["dc.contributor.author","Holz, Nathalie"],["dc.contributor.author","Banaschewski, Tobias"],["dc.contributor.author","Brandeis, Daniel"],["dc.contributor.editorcorporation","ESCAlife-Consortium"],["dc.date.accessioned","2021-04-14T08:29:47Z"],["dc.date.available","2021-04-14T08:29:47Z"],["dc.date.issued","2021"],["dc.date.updated","2022-02-09T13:21:21Z"],["dc.description.sponsorship","German Federal Ministry of Education and Research"],["dc.identifier.doi","10.3390/brainsci11020214"],["dc.identifier.eissn","2076-3425"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/82987"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.publisher","MDPI"],["dc.relation.eissn","2076-3425"],["dc.rights","https://creativecommons.org/licenses/by/4.0/"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0/"],["dc.title","EEG Data Quality: Determinants and Impact in a Multicenter Study of Children, Adolescents, and Adults with Attention-Deficit/Hyperactivity Disorder (ADHD)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Frontiers in Genetics"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Millenet, Sabina K."],["dc.contributor.author","Nees, Frauke"],["dc.contributor.author","Heintz, Stefan"],["dc.contributor.author","Bach, Christiane"],["dc.contributor.author","Frank, Josef"],["dc.contributor.author","Vollstädt-Klein, Sabine"],["dc.contributor.author","Bokde, Arun"],["dc.contributor.author","Bromberg, Uli"],["dc.contributor.author","Büchel, Christian"],["dc.contributor.author","Quinlan, Erin B."],["dc.contributor.author","Desrivières, Sylvane"],["dc.contributor.author","Fröhner, Juliane"],["dc.contributor.author","Flor, Herta"],["dc.contributor.author","Frouin, Vincent"],["dc.contributor.author","Garavan, Hugh"],["dc.contributor.author","Gowland, Penny"],["dc.contributor.author","Heinz, Andreas"],["dc.contributor.author","Ittermann, Bernd"],["dc.contributor.author","Lemaire, Herve"],["dc.contributor.author","Martinot, Jean-Luc"],["dc.contributor.author","Martinot, Marie-Laure P."],["dc.contributor.author","Papadoulos, Dimitri O."],["dc.contributor.author","Paus, Tomáš"],["dc.contributor.author","Poustka, Luise"],["dc.contributor.author","Rietschel, Marcella"],["dc.contributor.author","Smolka, Michael N."],["dc.contributor.author","Walter, Henrik"],["dc.contributor.author","Whelan, Rob"],["dc.contributor.author","Schumann, Gunter"],["dc.contributor.author","Banaschewski, Tobias"],["dc.contributor.author","Hohmann, Sarah"],["dc.date.accessioned","2020-12-10T18:44:23Z"],["dc.date.available","2020-12-10T18:44:23Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.3389/fgene.2018.00284"],["dc.identifier.eissn","1664-8021"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15711"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78431"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","COMT Val158Met Polymorphism and Social Impairment Interactively Affect Attention-Deficit Hyperactivity Symptoms in Healthy Adolescents"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Child and adolescent psychiatry and mental health"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Aebi, Marcel"],["dc.contributor.author","Kuhn, Christine"],["dc.contributor.author","Banaschewski, Tobias"],["dc.contributor.author","Grimmer, Yvonne"],["dc.contributor.author","Poustka, Luise"],["dc.contributor.author","Steinhausen, Hans-Christoph"],["dc.contributor.author","Goodman, Robert"],["dc.date.accessioned","2017-09-07T11:46:25Z"],["dc.date.available","2017-09-07T11:46:25Z"],["dc.date.issued","2017"],["dc.description.abstract","BACKGROUND: Discrepancies between multiple informants often create considerable uncertainties in delivering services to youth. The present study assessed the ability of the parent and youth scales of the Strength and Difficulties Questionnaire (SDQ) to predict mental health problems/disorders across several mental health domains as validated against two contrasting indices of validity for psychopathology derived from the Development and Well Being Assessment (DAWBA): (1) an empirically derived computer algorithm and (2) expert based ICD-10 diagnoses.; METHODS: Ordinal and logistic regressions were used to predict any problems/disorders, emotional problems/disorders and behavioural problems/disorders in a community sample (n=252) and in a clinic sample (n=95).; RESULTS: The findings were strikingly similar in both samples. Parent and youth SDQ scales were related to any problem/disorder. Youth SDQ symptom and impact had the strongest association with emotional problems/disorder and parent SDQ symptom score were most strongly related to behavioural problems/disorders. Both the SDQ total and the impact scores significantly predicted emotional problems/disorders in males whereas this was the case only for the total SDQ score in females.; CONCLUSION: The present study confirms and expands previous findings on parent and youth informant validity. Clinicians should include both parent and youth for identifying any mental health problems/disorders, youth information for detecting emotional problems/disorders, and parent information to detect behavioural problems/disorders. Not only symptom scores but also impact measures may be useful to detect emotional problems/disorders, particularly in male youth."],["dc.identifier.doi","10.1186/s13034-017-0160-9"],["dc.identifier.gro","3151915"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14437"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/8749"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-07-25"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","The contribution of parent and youth information to identify mental health disorders or problems in adolescents"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","737"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","European Child & Adolescent Psychiatry"],["dc.bibliographiccitation.lastpage","739"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Sergeant, Joseph A."],["dc.contributor.author","Banaschewski, Tobias"],["dc.contributor.author","Buitelar, Jan"],["dc.contributor.author","Coghill, David"],["dc.contributor.author","Danckaerts, Marina"],["dc.contributor.author","Doepfner, Manfred"],["dc.contributor.author","Rothenberger, A."],["dc.contributor.author","Santosh, Paramala"],["dc.contributor.author","Sonuga-Barke, Edmund J."],["dc.contributor.author","Steinhausen, Hans-Christoph"],["dc.contributor.author","Taylor, Eric A."],["dc.contributor.author","Zuddas, Alessandro"],["dc.date.accessioned","2018-11-07T08:39:39Z"],["dc.date.available","2018-11-07T08:39:39Z"],["dc.date.issued","2010"],["dc.description.abstract","The Eunethydis ADHD Guidelines group set out here the ethical principles governing the relationship between the group and industry. The principles set out here are provided to ensure that this is both done and seen to be done. The impetus for these guidelines comes from within the Group and is linked to the recognition for the need for an open and transparent basis for Group-industry relations, especially in the light of the present concern that the pharmaceutical industry may be exerting a growing influence on the actions of researchers and clinicians in the ADHD field."],["dc.identifier.doi","10.1007/s00787-010-0114-8"],["dc.identifier.isi","000281162600006"],["dc.identifier.pmid","20549526"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6776"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19048"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.haserratum","/handle/2/91541"],["dc.relation.issn","1018-8827"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Eunethydis: a statement of the ethical principles governing the relationship between the European group for ADHD guidelines, and its members, with commercial for-profit organisations"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","2059"],["dc.bibliographiccitation.journal","Frontiers in Psychology"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Kirov, Roumen"],["dc.contributor.author","Brand, Serge"],["dc.contributor.author","Banaschewski, Tobias"],["dc.contributor.author","Rothenberger, Aribert"],["dc.date.accessioned","2018-11-07T10:28:27Z"],["dc.date.available","2018-11-07T10:28:27Z"],["dc.date.issued","2017"],["dc.description.abstract","Rapid eye movement (REM) sleep has been shown to be related to many adaptive cognitive and behavioral functions. However, its precise functions are still elusive, particularly in developmental psychiatric disorders. The present study aims at investigating associations between polysomnographic (PSG) REM sleep measurements and neurobehavioral functions in children with common developmental psychiatric conditions compared to typically developing children (TDC). Twenty-four children with attention-deficit/hyperactivity disorder (ADHD), 21 with Tourette syndrome/tic disorder (TD), 21 with ADHD/TD comorbidity, and 22 TDC, matched for age and gender, underwent a two-night PSG, and their psychopathological scores and intelligence quotient (IQ) were assessed. Major PSG findings showed more REM sleep and shorter REM latency in the children with psychiatric disorders than in the TDC. Multiple regression analyses revealed that in groups with developmental psychopathology, REM sleep proportion correlated positively with scores of inattention and negatively with performance IQ. In contrast, in the group of TDC, REM sleep proportion correlated negatively with scores of inattention and positively with performance IQ. Whilst shorter REM latency was associated with greater inattention scores in children with psychopathology, no such an association existed in the group of TDC. Altogether, these results indicate an opposite impact of REM sleep on neurobehavioral functioning, related to presence or absence of developmental psychiatric disorders. Our findings suggest that during development, REM sleep functions may interact dissimilarly with different pathways of brain maturation."],["dc.description.sponsorship","University Medical Center of Goettingen, Goettingen, Germany"],["dc.identifier.doi","10.3389/fpsyg.2016.02059"],["dc.identifier.isi","000391399200002"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14229"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43422"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Frontiers Media Sa"],["dc.relation.issn","1664-1078"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Opposite Impact of REM Sleep on Neurobehavioral Functioning in Children with Common Psychiatric Disorders Compared toTypically Developing Children"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","eLife"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Kühn, Simone"],["dc.contributor.author","Mascharek, Anna"],["dc.contributor.author","Banaschewski, Tobias"],["dc.contributor.author","Bodke, Arun"],["dc.contributor.author","Bromberg, Uli"],["dc.contributor.author","Büchel, Christian"],["dc.contributor.author","Quinlan, Erin Burke"],["dc.contributor.author","Desrivieres, Sylvane"],["dc.contributor.author","Flor, Herta"],["dc.contributor.author","Grigis, Antoine"],["dc.contributor.author","Garavan, Hugh"],["dc.contributor.author","Gowland, Penny A"],["dc.contributor.author","Heinz, Andreas"],["dc.contributor.author","Ittermann, Bernd"],["dc.contributor.author","Martinot, Jean-Luc"],["dc.contributor.author","Nees, Frauke"],["dc.contributor.author","Papadopoulos Orfanos, Dimitri"],["dc.contributor.author","Paus, Tomas"],["dc.contributor.author","Poustka, Luise"],["dc.contributor.author","Millenet, Sabina"],["dc.contributor.author","Fröhner, Juliane H"],["dc.contributor.author","Smolka, Michael N"],["dc.contributor.author","Walter, Henrik"],["dc.contributor.author","Whelan, Robert"],["dc.contributor.author","Schumann, Gunter"],["dc.contributor.author","Lindenberger, Ulman"],["dc.contributor.author","Gallinat, Jürgen"],["dc.date.accessioned","2020-12-10T18:48:07Z"],["dc.date.available","2020-12-10T18:48:07Z"],["dc.date.issued","2019"],["dc.description.abstract","Adolescence is a common time for initiation of alcohol use and development of alcohol use disorders. The present study investigates neuroanatomical predictors for trajectories of future alcohol use based on a novel voxel-wise whole-brain structural equation modeling framework. In 1814 healthy adolescents of the IMAGEN sample, the Alcohol Use Disorder Identification Test (AUDIT) was acquired at three measurement occasions across five years. Based on a two-part latent growth curve model, we conducted whole-brain analyses on structural MRI data at age 14, predicting change in alcohol use score over time. Higher grey-matter volumes in the caudate nucleus and the left cerebellum at age 14 years were predictive of stronger increase in alcohol use score over 5 years. The study is the first to demonstrate the feasibility of running separate voxel-wise structural equation models thereby opening new avenues for data analysis in brain imaging."],["dc.identifier.doi","10.7554/eLife.44056"],["dc.identifier.eissn","2050-084X"],["dc.identifier.pmid","31262402"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16292"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/79024"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.relation.eissn","2050-084X"],["dc.relation.issn","2050-084X"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Predicting development of adolescent drinking behaviour from whole brain structure at 14 years of age"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e0216152"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","PLOS ONE"],["dc.bibliographiccitation.volume","14"],["dc.contributor.author","Albaugh, Matthew D."],["dc.contributor.author","Hudziak, James. J."],["dc.contributor.author","Orr, Catherine"],["dc.contributor.author","Spechler, Philip A."],["dc.contributor.author","Chaarani, Bader"],["dc.contributor.author","Mackey, Scott"],["dc.contributor.author","Lepage, Claude"],["dc.contributor.author","Fonov, Vladimir"],["dc.contributor.author","Rioux, Pierre"],["dc.contributor.author","Evans, Alan C."],["dc.contributor.author","Banaschewski, Tobias"],["dc.contributor.author","Bokde, Arun L. W."],["dc.contributor.author","Bromberg, Uli"],["dc.contributor.author","Büchel, Christian"],["dc.contributor.author","Quinlan, Erin Burke"],["dc.contributor.author","Desrivières, Sylvane"],["dc.contributor.author","Flor, Herta"],["dc.contributor.author","Grigis, Antoine"],["dc.contributor.author","Gowland, Penny"],["dc.contributor.author","Heinz, Andreas"],["dc.contributor.author","Ittermann, Bernd"],["dc.contributor.author","Martinot, Jean-Luc"],["dc.contributor.author","Martinot, Marie-Laure Paillère"],["dc.contributor.author","Nees, Frauke"],["dc.contributor.author","Orfanos, Dimitri Papadopoulos"],["dc.contributor.author","Paus, Tomáš"],["dc.contributor.author","Poustka, Luise"],["dc.contributor.author","Millenet, Sabina"],["dc.contributor.author","Fröhner, Juliane H."],["dc.contributor.author","Smolka, Michael N."],["dc.contributor.author","Walter, Henrik"],["dc.contributor.author","Whelan, Robert"],["dc.contributor.author","Schumann, Gunter"],["dc.contributor.author","Potter, Alexandra S."],["dc.contributor.author","Garavan, Hugh"],["dc.date.accessioned","2019-07-09T11:51:17Z"],["dc.date.available","2019-07-09T11:51:17Z"],["dc.date.issued","2019"],["dc.description.abstract","In structural neuroimaging studies, reduced cerebral cortical thickness in orbital and ventromedial prefrontal regions is frequently interpreted as reflecting an impaired ability to downregulate neuronal activity in the amygdalae. Unfortunately, little research has been conducted in order to test this conjecture. We examine the extent to which amygdalar reactivity is associated with cortical thickness in a population-based sample of adolescents. Data were obtained from the IMAGEN study, which includes 2,223 adolescents. While undergoing functional neuroimaging, participants passively viewed video clips of a face that started from a neutral expression and progressively turned angry, or, instead, turned to a second neutral expression. Left and right amygdala ROIs were used to extract mean BOLD signal change for the angry minus neutral face contrast for all subjects. T1-weighted images were processed through the CIVET pipeline (version 2.1.0). In variable-centered analyses, local cortical thickness was regressed against amygdalar reactivity using first and second-order linear models. In a follow-up person-centered analysis, we defined a \"high reactive\" group of participants based on mean amygdalar BOLD signal change for the angry minus neutral face contrast. Between-group differences in cortical thickness were examined (\"high reactive\" versus all other participants). A significant association was revealed between the continuous measure of amygdalar reactivity and bilateral ventromedial prefrontal cortical thickness in a second-order linear model (p < 0.05, corrected). The \"high reactive\" group, in comparison to all other participants, possessed reduced cortical thickness in bilateral orbital and ventromedial prefrontal cortices, bilateral anterior temporal cortices, left caudal middle temporal gyrus, and the left inferior and middle frontal gyri (p < 0.05, corrected). Results are consistent with non-human primate studies, and provide empirical support for an association between reduced prefrontal cortical thickness and amygdalar reactivity. Future research will likely benefit from investigating the degree to which psychopathology qualifies relations between prefrontal cortical structure and amygdalar reactivity."],["dc.identifier.doi","10.1371/journal.pone.0216152"],["dc.identifier.pmid","31048888"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16093"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59915"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation","info:eu-repo/grantAgreement/EC/H2020/695313/EU//STRATIFY"],["dc.relation","info:eu-repo/grantAgreement/EC/FP7/602450/EU//IMAGEMEND"],["dc.relation","info:eu-repo/grantAgreement/EC/FP7/603016/EU//MATRICS"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.ddc","610"],["dc.title","Amygdalar reactivity is associated with prefrontal cortical thickness in a large population-based sample of adolescents"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","53"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Psychopathology"],["dc.bibliographiccitation.lastpage","59"],["dc.bibliographiccitation.volume","44"],["dc.contributor.author","Holtmann, Martin"],["dc.contributor.author","Becker, Andreas"],["dc.contributor.author","Banaschewski, Tobias"],["dc.contributor.author","Rothenberger, Aribert"],["dc.contributor.author","Roessner, Veit"],["dc.date.accessioned","2018-11-07T09:01:59Z"],["dc.date.available","2018-11-07T09:01:59Z"],["dc.date.issued","2011"],["dc.description.abstract","Background: In many severely mentally disordered children, the clinical presentation is complicated by comorbid affective and behavioral dysregulation. Recently, a highly heritable behavioral phenotype of simultaneous deviance on the nanxious/depressed, attention problems, and aggressive behavior syndrome scales has been identified on the Child Behavior Checklist Dysregulation Profile (CBCL-DP). The aim of the present pilot study was to determine an equivalent to the CBCL-DP using the Strengths and Difficulties Questionnaire (SDQ). Sampling and Methods: We applied stepwise linear discriminant analyses and receiver operating characteristic (ROC) analysis to data from 543 consecutively referred children and adolescents, aged 5-17 years. The CBCL and the SDQ were completed by parents as part of the diagnostic routine. ICD-10 discharge diagnoses were established in consensus conferences. Results: A combination of five SDQ items (SDQ-Dysregulation Profile, SDQ-DP) yielded the best discrimination of children with and without CBCL-DP and classified 81.0% of the subjects correctly leading to an area under the curve of 0.93. The content of the five SDQ-DP items mirrors well the mixed behavioral phenotype of anxious-depressive, aggressive and attention problems captured by the CBCL-DP. SDQ-DP status was highly correlated with CBCL-DP status and was best defined by a SDQ-DP score >= 5. Conclusions: The psychometric properties of the SDQ-DP have been robustly tested and validated. Based on these results, clinicians may use the SDQ-DP as a useful and economical screening measure to improve the assessment, prevention, and treatment of severe dysregulation in childhood and adolescence. Future investigations should study the longitudinal stability, heritability, and genetic associations of this behavioral phenotype. Copyright (C) 2010 S. Karger AG, Basel"],["dc.identifier.doi","10.1159/000318164"],["dc.identifier.isi","000284157300008"],["dc.identifier.pmid","21072000"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8050"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24567"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.relation.issn","0254-4962"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Psychometric Validity of the Strengths and Difficulties Questionnaire-Dysregulation Profile"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]