Steiner, Wolfgang

[["dc.bibliographiccitation.firstpage","2719"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","European Archives of Oto-Rhino-Laryngology"],["dc.bibliographiccitation.lastpage","2727"],["dc.bibliographiccitation.volume","270"],["dc.contributor.author","Canis, Martin"],["dc.contributor.author","Ihler, Friedrich"],["dc.contributor.author","Martin, Alexios"],["dc.contributor.author","Wolff, Hendrik Andreas"],["dc.contributor.author","Matthias, Christoph"],["dc.contributor.author","Steiner, Wolfgang"],["dc.date.accessioned","2018-11-07T09:20:45Z"],["dc.date.available","2018-11-07T09:20:45Z"],["dc.date.issued","2013"],["dc.description.abstract","The main objective of this study is to assess the feasibility of transoral laser microsurgery (TLM) in the treatment of T4a laryngeal cancer and to report the oncological and functional outcomes. This is a retrospective case-series study, held in a single-institute, academic tertiary referral center. Seventy-nine patients with previously untreated T4a glottic (n = 31, 39 %) or supraglottic laryngeal carcinoma (n = 48, 61 %) were included in this study. Five patients (6 %) were treated exclusively by TLM, 16 (20 %) had TLM and unilateral neck dissection, 27 (35 %) had TLM and bilateral neck dissection. Adjuvant (chemo)radiotherapy was additionally administered in 26 (33 %) cases following TLM and neck dissection, and in 5 (6 %) cases after TLM without neck dissection. The main outcome measures included organ preservation, local control, functional outcome, overall, recurrence-free, and disease-specific survival. The median follow-up period was 49 months, 5 year organ preservation rate and local control rate were 80.0 and 67.2 %, 5 year overall, recurrence-free and disease-specific survival were 55.8, 61.9 and 71.8 %. The 5 year overall survival rates were 62.5 % in pN0 cases and 57.2 % in cases with pN-positive neck disease. With respect to survival, these results are comparable to total laryngectomy, while being superior to primary (chemo)radiotherapy. TLM results in a low morbidity, rapid recovery and good function and can be a valid option for organ preserving surgery of pT4a glottic and supraglottic cancer."],["dc.identifier.doi","10.1007/s00405-013-2382-7"],["dc.identifier.isi","000323739100020"],["dc.identifier.pmid","23408021"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10308"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28952"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0937-4477"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Organ preservation in T4a laryngeal cancer: is transoral laser microsurgery an option?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2315"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","European Archives of Oto-Rhino-Laryngology"],["dc.bibliographiccitation.lastpage","2326"],["dc.bibliographiccitation.volume","270"],["dc.contributor.author","Canis, Martin"],["dc.contributor.author","Martin, Alexios"],["dc.contributor.author","Ihler, Friedrich"],["dc.contributor.author","Wolff, Hendrik Andreas"],["dc.contributor.author","Kron, Martina"],["dc.contributor.author","Matthias, Christoph"],["dc.contributor.author","Steiner, Wolfgang"],["dc.date.accessioned","2018-11-07T09:22:08Z"],["dc.date.available","2018-11-07T09:22:08Z"],["dc.date.issued","2013"],["dc.description.abstract","The objective of the study was to evaluate the oncological and functional results of transoral laser microsurgery (TLM) in patients with supraglottic laryngeal squamous cell carcinoma. Between June 1980 and December 2006, 277 patients with squamous cell supraglottic carcinoma of all stages were treated by primary carbon dioxide laser microsurgery. All treatments were performed with curative intention. The goal was the complete tumor removal with preservation of functionally important structures of the larynx. The administered treatment was exclusively TLM with or without selective or modified radical neck dissection in 215 cases (78 %); TLM with postoperative radiotherapy was performed in 62 cases (22 %). Data were analyzed using the Kaplan-Meier method. The median follow-up was 65 months. We achieved a 5-year local control rate of 85 % for pT1/pT2, 82 % for pT3, and 76 % for pT4. The 5-year overall, recurrence-free and disease-specific survival rates for stages I and II were 76, 81, and 92 %, for stages III and IVa 59, 65, and 81 %, respectively. With respect to local control and survival, these results are comparable with the results achieved by conventional partial and total resection of the larynx, while being superior to primary (chemo)radiotherapy. Transoral laser microsurgery results in a low morbidity, rapid recovery, and superior function compared with standard therapy."],["dc.identifier.doi","10.1007/s00405-012-2327-6"],["dc.identifier.isi","000321286600020"],["dc.identifier.pmid","23306348"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10307"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/29270"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0937-4477"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Results of transoral laser microsurgery for supraglottic carcinoma in 277 patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2299"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","European Archives of Oto-Rhino-Laryngology"],["dc.bibliographiccitation.lastpage","2306"],["dc.bibliographiccitation.volume","270"],["dc.contributor.author","Canis, Martin"],["dc.contributor.author","Martin, Alexios"],["dc.contributor.author","Kron, Martina"],["dc.contributor.author","Konstantinou, Alexandra"],["dc.contributor.author","Ihler, Friedrich"],["dc.contributor.author","Wolff, Hendrik Andreas"],["dc.contributor.author","Matthias, Christoph"],["dc.contributor.author","Steiner, Wolfgang"],["dc.date.accessioned","2018-11-07T09:22:07Z"],["dc.date.available","2018-11-07T09:22:07Z"],["dc.date.issued","2013"],["dc.description.abstract","The objective of this study is to assess the feasibility of transoral laser microsurgery (TLM) in the treatment of squamous cell cancer of the tonsil and to report the oncological and functional outcomes, using retrospective chart review in the setting of single-institute, academic tertiary referral center. Between October 1987 and December 2006, 102 patients were eligible for this study, mostly suffering from advanced disease: 13 % presented with stage I and II (UICC/AJCC 2002) tumors and 87 % with stages III and IVa. The median follow-up was 63 months. All patients were treated by TLM with (or without) neck dissection (95 %) and with (66 %) postoperative radiotherapy. Overall survival, recurrence-free survival, disease-free survival, local control and loco-regional control were analyzed as end points. Rate of tracheotomies, postoperative complications and swallowing function were also analyzed. 5-year Kaplan-Meier local and loco-regional control was 78 % for pT1 and pT2 and 75 % for pT3 and pT4a tumors. 5-year Kaplan-Meier disease-free survival, recurrence-free survival, and overall survival and was 74, 64 and 59 % for stage I and II, 68, 60 and 56 % for stage III and IVa, respectively. Our data supports the conclusion, that TLM should be considered as a therapeutic option for the treatment of cancer of the tonsil. The oncological and functional results are comparable to any other treatment regimen, while the morbidity and complications tend to be lower."],["dc.identifier.doi","10.1007/s00405-012-2335-6"],["dc.identifier.isi","000321286600018"],["dc.identifier.pmid","23274878"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10306"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/29267"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0937-4477"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Results of transoral laser microsurgery in 102 patients with squamous cell carcinoma of the tonsil"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]