Kusch, Kathrin

[["dc.bibliographiccitation.journal","Glia"],["dc.bibliographiccitation.volume","65"],["dc.contributor.author","Kusch, Kathrin"],["dc.contributor.author","Uecker, Martin"],["dc.contributor.author","Liepold, Thomas"],["dc.contributor.author","Möbius, Wiebke"],["dc.contributor.author","Werner, Hauke B."],["dc.contributor.author","Valerius, Oliver"],["dc.contributor.author","Jahn, Olaf"],["dc.contributor.author","Nave, Klaus-Armin"],["dc.date.accessioned","2018-11-07T10:23:03Z"],["dc.date.available","2018-11-07T10:23:03Z"],["dc.date.issued","2017"],["dc.identifier.isi","000403071700600"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42387"],["dc.language.iso","en"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Wiley"],["dc.publisher.place","Hoboken"],["dc.relation.conference","13th European Meeting on Glial Cells in Health and Disease"],["dc.relation.eventlocation","Edinburgh, Scotland"],["dc.title","SIRT2 as a genetic modifier of axonal degeneration in white matter tracts"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Proteomes"],["dc.bibliographiccitation.volume","5"],["dc.contributor.author","Kusch, Kathrin"],["dc.contributor.author","Uecker, Marina"],["dc.contributor.author","Liepold, Thomas"],["dc.contributor.author","Möbius, Wiebke"],["dc.contributor.author","Hoffmann, Christian"],["dc.contributor.author","Neumann, Heinz"],["dc.contributor.author","Werner, Hauke"],["dc.contributor.author","Jahn, Olaf"],["dc.date.accessioned","2020-12-10T18:47:19Z"],["dc.date.available","2020-12-10T18:47:19Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.3390/proteomes5010003"],["dc.identifier.eissn","2227-7382"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78723"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.publisher","MDPI"],["dc.relation.eissn","2227-7382"],["dc.rights","https://creativecommons.org/licenses/by/4.0/"],["dc.title","Partial Immunoblotting of 2D-Gels: A Novel Method to Identify Post-Translationally Modified Proteins Exemplified for the Myelin Acetylome"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","1163"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Nature Communications"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Meschkat, Martin"],["dc.contributor.author","Steyer, Anna M."],["dc.contributor.author","Weil, Marie-Theres"],["dc.contributor.author","Kusch, Kathrin"],["dc.contributor.author","Jahn, Olaf"],["dc.contributor.author","Piepkorn, Lars"],["dc.contributor.author","Agüi-Gonzalez, Paola"],["dc.contributor.author","Phan, Nhu Thi Ngoc"],["dc.contributor.author","Ruhwedel, Torben"],["dc.contributor.author","Sadowski, Boguslawa"],["dc.contributor.author","Möbius, Wiebke"],["dc.date.accessioned","2022-04-01T10:00:48Z"],["dc.date.available","2022-04-01T10:00:48Z"],["dc.date.issued","2022"],["dc.description.abstract","Abstract Myelin, the electrically insulating sheath on axons, undergoes dynamic changes over time. However, it is composed of proteins with long lifetimes. This raises the question how such a stable structure is renewed. Here, we study the integrity of myelinated tracts after experimentally preventing the formation of new myelin in the CNS of adult mice, using an inducible Mbp null allele. Oligodendrocytes survive recombination, continue to express myelin genes, but they fail to maintain compacted myelin sheaths. Using 3D electron microscopy and mass spectrometry imaging we visualize myelin-like membranes failing to incorporate adaxonally, most prominently at juxta-paranodes. Myelinoid body formation indicates degradation of existing myelin at the abaxonal side and the inner tongue of the sheath. Thinning of compact myelin and shortening of internodes result in the loss of about 50% of myelin and axonal pathology within 20 weeks post recombination. In summary, our data suggest that functional axon-myelin units require the continuous incorporation of new myelin membranes."],["dc.identifier.doi","10.1038/s41467-022-28720-y"],["dc.identifier.pii","28720"],["dc.identifier.pmid","35246535"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/105516"],["dc.identifier.url","https://mbexc.uni-goettingen.de/literature/publications/458"],["dc.identifier.url","https://for2848.gwdguser.de/literature/publications/27"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-530"],["dc.relation","EXC 2067: Multiscale Bioimaging"],["dc.relation","FOR 2848: Architektur und Heterogenität der inneren mitochondrialen Membran auf der Nanoskala"],["dc.relation","FOR 2848 | P08: Strukturelle und funktionale Veränderungen der inneren mitochondrialen Membran axonaler Mitochondrien in vivo in einem dymyelinisierenden Mausmodell"],["dc.relation.eissn","2041-1723"],["dc.relation.workinggroup","RG Möbius"],["dc.relation.workinggroup","RG Rizzoli (Quantitative Synaptology in Space and Time)"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","White matter integrity in mice requires continuous myelin synthesis at the inner tongue"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","37"],["dc.bibliographiccitation.lastpage","63"],["dc.bibliographiccitation.seriesnr","1936"],["dc.contributor.author","Erwig, Michelle S."],["dc.contributor.author","Hesse, Dörte"],["dc.contributor.author","Jung, Ramona B."],["dc.contributor.author","Uecker, Marina"],["dc.contributor.author","Kusch, Kathrin"],["dc.contributor.author","Tenzer, Stefan"],["dc.contributor.author","Jahn, Olaf"],["dc.contributor.author","Werner, Hauke B."],["dc.contributor.editor","Lyons, David A."],["dc.contributor.editor","Kegel, Linde"],["dc.date.accessioned","2021-06-02T10:44:26Z"],["dc.date.available","2021-06-02T10:44:26Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1007/978-1-4939-9072-6_3"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/87040"],["dc.notes.intern","DOI-Import GROB-425"],["dc.publisher","Springer New York"],["dc.publisher.place","New York, NY"],["dc.relation.crisseries","Methods in Molecular Biology"],["dc.relation.eisbn","978-1-4939-9072-6"],["dc.relation.isbn","978-1-4939-9070-2"],["dc.relation.ispartof","Methods in Molecular Biology"],["dc.relation.ispartof","Oligodendrocytes : Methods and Protocols"],["dc.relation.ispartofseries","Methods in Molecular Biology; 1936"],["dc.title","Myelin: Methods for Purification and Proteome Analysis"],["dc.type","book_chapter"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","eLife"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Erwig, Michelle S."],["dc.contributor.author","Patzig, Julia"],["dc.contributor.author","Steyer, Anna M."],["dc.contributor.author","Dibaj, Payam"],["dc.contributor.author","Heilmann, Mareike"],["dc.contributor.author","Heilmann, Ingo"],["dc.contributor.author","Jung, Ramona B."],["dc.contributor.author","Kusch, Kathrin"],["dc.contributor.author","Möbius, Wiebke"],["dc.contributor.author","Jahn, Olaf"],["dc.contributor.author","Nave, Klaus-Armin"],["dc.contributor.author","Werner, Hauke B."],["dc.date.accessioned","2019-08-02T06:29:41Z"],["dc.date.available","2019-08-02T06:29:41Z"],["dc.date.issued","2019"],["dc.description.abstract","Myelin serves as an axonal insulator that facilitates rapid nerve conduction along axons. By transmission electron microscopy, a healthy myelin sheath comprises compacted membrane layers spiraling around the cross-sectioned axon. Previously we identified the assembly of septin filaments in the innermost non-compacted myelin layer as one of the latest steps of myelin maturation in the central nervous system (CNS) (Patzig et al., 2016). Here we show that loss of the cytoskeletal adaptor protein anillin (ANLN) from oligodendrocytes disrupts myelin septin assembly, thereby causing the emergence of pathological myelin outfoldings. Since myelin outfoldings are a poorly understood hallmark of myelin disease and brain aging we assessed axon/myelin-units in Anln-mutant mice by focused ion beam-scanning electron microscopy (FIB-SEM); myelin outfoldings were three-dimensionally reconstructed as large sheets of multiple compact membrane layers. We suggest that anillin-dependent assembly of septin filaments scaffolds mature myelin sheaths, facilitating rapid nerve conduction in the healthy CNS."],["dc.identifier.doi","10.7554/eLife.43888"],["dc.identifier.pmid","30672734"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15932"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/62262"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.relation.eissn","2050-084X"],["dc.relation.issn","2050-084X"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Anillin facilitates septin assembly to prevent pathological outfoldings of central nervous system myelin"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","eLife"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Siems, Sophie B"],["dc.contributor.author","Jahn, Olaf"],["dc.contributor.author","Eichel, Maria A"],["dc.contributor.author","Kannaiyan, Nirmal"],["dc.contributor.author","Wu, Lai Man N"],["dc.contributor.author","Sherman, Diane L"],["dc.contributor.author","Kusch, Kathrin"],["dc.contributor.author","Hesse, Dörte"],["dc.contributor.author","Jung, Ramona B"],["dc.contributor.author","Fledrich, Robert"],["dc.contributor.author","Sereda, Michael W"],["dc.contributor.author","Rossner, Moritz J"],["dc.contributor.author","Brophy, Peter J"],["dc.contributor.author","Werner, Hauke B"],["dc.date.accessioned","2021-04-14T08:26:58Z"],["dc.date.available","2021-04-14T08:26:58Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.7554/eLife.51406"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/82127"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","2050-084X"],["dc.title","Proteome profile of peripheral myelin in healthy mice and in a neuropathy model"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]