Pieler, Tomas

[["dc.bibliographiccitation.artnumber","36"],["dc.bibliographiccitation.journal","BMC Developmental Biology"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Nieber, Frank"],["dc.contributor.author","Hedderich, Marie"],["dc.contributor.author","Jahn, Olaf"],["dc.contributor.author","Pieler, Tomas"],["dc.contributor.author","Henningfeld, Kristine A."],["dc.date.accessioned","2018-11-07T09:18:40Z"],["dc.date.available","2018-11-07T09:18:40Z"],["dc.date.issued","2013"],["dc.description.abstract","Background: Members of the vertebrate Numb family of cell fate determinants serve multiple functions throughout early embryogenesis, including an essential role in the development of the nervous system. The Numb proteins interact with various partner proteins and correspondingly participate in multiple cellular activities, including inhibition of the Notch pathway. Results: Here, we describe the expression characteristics of Numb and Numblike (NumbL) during Xenopus development and characterize the function of NumbL during primary neurogenesis. NumbL, in contrast to Numb, is expressed in the territories of primary neurogenesis and is positively regulated by the Neurogenin family of proneural transcription factors. Knockdown of NumbL afforded a complete loss of primary neurons and did not lead to an increase in Notch signaling in the open neural plate. Furthermore, we provide evidence that interaction of NumbL with the AP-2 complex is required for NumbL function during primary neurogenesis. Conclusion: We demonstrate an essential role of NumbL during Xenopus primary neurogenesis and provide evidence for a Notch-independent function of NumbL in this context."],["dc.identifier.doi","10.1186/1471-213X-13-36"],["dc.identifier.isi","000325803700001"],["dc.identifier.pmid","24125469"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10415"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28454"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1471-213X"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","NumbL is essential for Xenopus primary neurogenesis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2347"],["dc.bibliographiccitation.issue","17"],["dc.bibliographiccitation.journal","Genes & Development"],["dc.bibliographiccitation.lastpage","2352"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Souopgui, Jacob"],["dc.contributor.author","Rust, Barbara"],["dc.contributor.author","Vanhomwegen, Jessica"],["dc.contributor.author","Heasman, Janet"],["dc.contributor.author","Henningfeld, Kristine A."],["dc.contributor.author","Bellefroid, Eric J."],["dc.contributor.author","Pieler, Tomas"],["dc.date.accessioned","2018-11-07T11:11:28Z"],["dc.date.available","2018-11-07T11:11:28Z"],["dc.date.issued","2008"],["dc.description.abstract","VegT represents a localized maternal determinant essentially required for endoderm formation in Xenopus. Here, we report on the identification of the RNA-binding protein XSeb4R as a positive regulator of VegT. XSeb4R interacts directly with the 3'-untranslated region of VegT mRNA, stabilizes it, and stimulates translation. Ablation of XSeb4R activity results in impairment of endoderm and mesoderm formation, while ectopic expression of XSeb4R in ectodermal cells induces endodermal and mesodermal gene expression. These observations unravel a novel mode of VegT regulation at the post-transcriptional level that is essential for germ layer formation in Xenopus."],["dc.identifier.doi","10.1101/gad.479808"],["dc.identifier.isi","000258878100006"],["dc.identifier.pmid","18765788"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6117"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53443"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Cold Spring Harbor Lab Press, Publications Dept"],["dc.relation.issn","0890-9369"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","The RNA-binding protein XSeb4R: a positive regulator of VegT mRNA stability and translation that is required for germ layer formation in Xenopus"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.issue","110"],["dc.bibliographiccitation.journal","BMC developmental biology"],["dc.bibliographiccitation.lastpage","14"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Dullin, Jean-Philippe"],["dc.contributor.author","Locker, Morgane"],["dc.contributor.author","Robach, Mélodie"],["dc.contributor.author","Henningfeld, Kristine A."],["dc.contributor.author","Parain, Karine"],["dc.contributor.author","Afelik, Solomon"],["dc.contributor.author","Pieler, Tomas"],["dc.date.accessioned","2019-07-10T08:13:01Z"],["dc.date.available","2019-07-10T08:13:01Z"],["dc.date.issued","2007"],["dc.description.abstract","Background: In recent years, considerable knowledge has been gained on the molecular mechanisms underlying retinal cell fate specification. However, hitherto studies focused primarily on the six major retinal cell classes (five types of neurons of one type of glial cell), and paid little attention to the specification of different neuronal subtypes within the same cell class. In particular, the molecular machinery governing the specification of the two most abundant neurotransmitter phenotypes in the retina, GABAergic and glutamatergic, is largely unknown. In the spinal cord and cerebellum, the transcription factor Ptf1a is essential for GABAergic neuron production. In the mouse retina, Ptf1a has been shown to be involved in horizontal and most amacrine neurons differentiation.Results: In this study, we examined the distribution of neurotransmitter subtypes following Ptf1a gain and loss of function in the Xenopus retina. We found cell-autonomous dramatic switches between GABAergic and glutamatergic neuron production, concomitant with profound defects in the genesis of amacrine and horizontal cells, which are mainly GABAergic. Therefore, we investigated whether Ptf1a promotes the fate of these two cell types or acts directly as a GABAergic subtype determination factor. In ectodermal explant assays ... Conclusion: Altogether, our results reveal for the first time in the retina a major player in the GABAergic versus glutamatergic cell specification genetic pathway."],["dc.identifier.fs","87121"],["dc.identifier.ppn","559806469"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/4372"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/61102"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.orgunit","Universitätsmedizin Göttingen"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.ddc","610"],["dc.subject.ddc","573.8"],["dc.subject.ddc","612"],["dc.subject.ddc","612.8"],["dc.title","Ptf1a triggers GABAergic neuronal cell fates in the retina"],["dc.title.alternative","Research article"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]