Pieler, Tomas

[["dc.bibliographiccitation.firstpage","3777"],["dc.bibliographiccitation.issue","21"],["dc.bibliographiccitation.journal","Molecular Biology of the Cell"],["dc.bibliographiccitation.lastpage","3787"],["dc.bibliographiccitation.volume","26"],["dc.contributor.author","Claussen, Maike"],["dc.contributor.author","Lingner, Thomas"],["dc.contributor.author","Pommerenke, Claudia"],["dc.contributor.author","Opitz, Lennart"],["dc.contributor.author","Salinas, Gabriela"],["dc.contributor.author","Pieler, Tomas"],["dc.date.accessioned","2018-11-07T09:49:18Z"],["dc.date.available","2018-11-07T09:49:18Z"],["dc.date.issued","2015"],["dc.description.abstract","RNAs that localize to the vegetal cortex during Xenopus laevis oogenesis have been reported to function in germ layer patterning, axis determination, and development of the primordial germ cells. Here we report on the genome-wide, comparative analysis of differentially localizing RNAs in Xenopus laevis and Xenopus tropicalis oocytes, revealing a surprisingly weak degree of conservation in respect to the identity of animally as well as vegetally enriched transcripts in these closely related species. Heterologous RNA injections and protein binding studies indicate that the different RNA localization patterns in these two species are due to gain/loss of cis-acting localization signals rather than to differences in the RNA-localizing machinery."],["dc.identifier.doi","10.1091/mbc.E15-02-0115"],["dc.identifier.isi","000366322200015"],["dc.identifier.pmid","26337391"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/12732"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35480"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Soc Cell Biology"],["dc.relation.issn","1939-4586"],["dc.relation.issn","1059-1524"],["dc.rights","CC BY-NC-SA 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-sa/3.0"],["dc.title","Global analysis of asymmetric RNA enrichment in oocytes reveals low conservation between closely related Xenopus species"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Frontiers in Cell and Developmental Biology"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Hahn, Anne"],["dc.contributor.author","Pensold, Daniel"],["dc.contributor.author","Bayer, Cathrin"],["dc.contributor.author","Tittelmeier, Jessica"],["dc.contributor.author","González-Bermúdez, Lourdes"],["dc.contributor.author","Marx-Blümel, Lisa"],["dc.contributor.author","Linde, Jenice"],["dc.contributor.author","Groß, Jonas"],["dc.contributor.author","Salinas-Riester, Gabriela"],["dc.contributor.author","Lingner, Thomas"],["dc.contributor.author","von Maltzahn, Julia"],["dc.contributor.author","Spehr, Marc"],["dc.contributor.author","Pieler, Tomas"],["dc.contributor.author","Urbach, Anja"],["dc.contributor.author","Zimmer-Bensch, Geraldine"],["dc.date.accessioned","2021-04-14T08:23:52Z"],["dc.date.available","2021-04-14T08:23:52Z"],["dc.date.issued","2020"],["dc.description.abstract","Increased life expectancy in modern society comes at the cost of age-associated disabilities and diseases. Aged brains not only show reduced excitability and plasticity, but also a decline in inhibition. Age-associated defects in inhibitory circuits likely contribute to cognitive decline and age-related disorders. Molecular mechanisms that exert epigenetic control of gene expression contribute to age-associated neuronal impairments. Both DNA methylation, mediated by DNA methyltransferases (DNMTs), and histone modifications maintain neuronal function throughout lifespan. Here we provide evidence that DNMT1 function is implicated in the age-related loss of cortical inhibitory interneurons. Dnmt1 deletion in parvalbumin-positive interneurons attenuates their age-related decline in the cerebral cortex. Moreover, conditional Dnmt1-deficient mice show improved somatomotor performance and reduced aging-associated transcriptional changes. A decline in the proteostasis network, responsible for the proper degradation and removal of defective proteins, is implicated in age- and disease-related neurodegeneration. Our data suggest that DNMT1 acts indirectly on interneuron survival in aged mice by modulating the proteostasis network during life-time."],["dc.identifier.doi","10.3389/fcell.2020.00639"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81079"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.publisher","Frontiers Media S.A."],["dc.relation.eissn","2296-634X"],["dc.rights","http://creativecommons.org/licenses/by/4.0/"],["dc.title","DNA Methyltransferase 1 (DNMT1) Function Is Implicated in the Age-Related Loss of Cortical Interneurons"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]