Wilke, Melanie

[["dc.bibliographiccitation.firstpage","94"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Human Brain Mapping"],["dc.bibliographiccitation.lastpage","121"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Cabral-Calderin, Yuranny"],["dc.contributor.author","Weinrich, Christiane Anne"],["dc.contributor.author","Schmidt-Samoa, Carsten"],["dc.contributor.author","Poland, Eva"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Bähr, Mathias"],["dc.contributor.author","Wilke, Melanie"],["dc.date.accessioned","2017-09-07T11:54:45Z"],["dc.date.available","2017-09-07T11:54:45Z"],["dc.date.issued","2016"],["dc.description.abstract","Transcranial alternating current stimulation (tACS) has emerged as a promising tool for manipulating ongoing brain oscillations. While previous studies demonstrated frequency-specific effects of tACS on diverse cognitive functions, its effect on neural activity remains poorly understood. Here we asked how tACS modulates regional fMRI blood oxygenation level dependent (BOLD) signal as a function of frequency, current strength, and task condition. TACS was applied over the posterior cortex of healthy human subjects while the BOLD signal was measured during rest or task conditions (visual perception, passive video viewing and motor task). TACS was applied in a blockwise manner at different frequencies (10, 16, 60 and 80 Hz). The strongest tACS effects on BOLD activity were observed with stimulation at alpha (10 Hz) and beta (16 Hz) frequency bands, while effects of tACS at the gamma range were rather modest. Specifically, we found that tACS at 16 Hz induced BOLD activity increase in fronto-parietal areas. Overall, tACS effects varied as a function of frequency and task, and were predominantly seen in regions that were not activated by the task. Also, the modulated regions were poorly predicted by current density modeling studies. Taken together, our results suggest that tACS does not necessarily exert its strongest effects in regions below the electrodes and that region specificity might be achieved with tACS due to varying susceptibility of brain regions to entrain to a given frequency. (C) 2015 The Authors. Human Brain Mapping Published by Wiley Periodicals, Inc."],["dc.identifier.doi","10.1002/hbm.23016"],["dc.identifier.fs","618728"],["dc.identifier.gro","3141752"],["dc.identifier.isi","000369150500007"],["dc.identifier.pmid","26503692"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14044"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/680"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-03-10 / Funder: Hermann and Lilly Schilling Foundation"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.eissn","1097-0193"],["dc.relation.issn","1065-9471"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/4.0"],["dc.title","Transcranial Alternating Current Stimulation Affects the BOLD Signal in a Frequency and Task-dependent Manner"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","123"],["dc.bibliographiccitation.issue","Part A"],["dc.bibliographiccitation.journal","Neuropsychologia"],["dc.bibliographiccitation.lastpage","137"],["dc.bibliographiccitation.volume","79"],["dc.contributor.author","Paschke, Kerstin"],["dc.contributor.author","Kagan, Igor"],["dc.contributor.author","Wüstenberg, Torsten"],["dc.contributor.author","Bähr, Mathias"],["dc.contributor.author","Wilke, Melanie"],["dc.date.accessioned","2017-09-07T11:47:55Z"],["dc.date.available","2017-09-07T11:47:55Z"],["dc.date.issued","2015"],["dc.description.abstract","Manipulation of the trunk midline has been shown to improve visuospatial performance in patients with unilateral visual neglect. The goal of the present study was to disentangle motor and perceptual components of egocentric midline manipulations and to investigate the contribution of individual hand preference. Two versions of visual temporal order judgment (TOJ) tasks were tested in healthy right- and left-handed subjects while trunk rotation was varied. In the congruent version, subjects were required to execute a saccade to the first of two horizontal stimuli presented with different stimulus onset asynchronies (SOA). In the incongruent version, subjects were required to perform a vertical saccade to a pre-learned color target, thereby dissociating motor response from the perceptual stimulus location. The main findings of this study are a trunk rotation and response direction specific impact on temporal judgments in form of a prior entry bias for right hemifield stimuli during rightward trunk rotation, but only in the congruent task. This trunk rotation-induced spatial bias was most pronounced in left-handed participants but had the same sign in the right-handed group. Results suggest that egocentric midline shifts in healthy subjects induce a spatially-specific motor, but not a perceptual, bias and underline the importance of taking individual differences in functional laterality such as handedness and mode of perceptual report into account when evaluating effects of trunk rotation in either healthy subjects or neurological patients."],["dc.identifier.doi","10.1016/j.neuropsychologia.2015.10.031"],["dc.identifier.gro","3150766"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7555"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.notes.submitter","chake"],["dc.relation.issn","0028-3932"],["dc.title","Trunk rotation affects temporal order judgments with direct saccades: Influence of handedness"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Frontiers in Physiology"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Kottlarz, Inga"],["dc.contributor.author","Berg, Sebastian"],["dc.contributor.author","Toscano-Tejeida, Diana"],["dc.contributor.author","Steinmann, Iris"],["dc.contributor.author","Bähr, Mathias"],["dc.contributor.author","Luther, Stefan"],["dc.contributor.author","Wilke, Melanie"],["dc.contributor.author","Parlitz, Ulrich"],["dc.contributor.author","Schlemmer, Alexander"],["dc.date.accessioned","2021-04-14T08:29:50Z"],["dc.date.available","2021-04-14T08:29:50Z"],["dc.date.issued","2021"],["dc.description.abstract","In this study, ordinal pattern analysis and classical frequency-based EEG analysis methods are used to differentiate between EEGs of different age groups as well as individuals. As characteristic features, functional connectivity as well as single-channel measures in both the time and frequency domain are considered. We compare the separation power of each feature set after nonlinear dimensionality reduction using t-distributed stochastic neighbor embedding and demonstrate that ordinal pattern-based measures yield results comparable to frequency-based measures applied to preprocessed data, and outperform them if applied to raw data. Our analysis yields no significant differences in performance between single-channel features and functional connectivity features regarding the question of age group separation."],["dc.identifier.doi","10.3389/fphys.2020.614565"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/82999"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.publisher","Frontiers Media S.A."],["dc.relation.eissn","1664-042X"],["dc.rights","http://creativecommons.org/licenses/by/4.0/"],["dc.title","Extracting Robust Biomarkers From Multichannel EEG Time Series Using Nonlinear Dimensionality Reduction Applied to Ordinal Pattern Statistics and Spectral Quantities"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","135"],["dc.bibliographiccitation.journal","Cortex"],["dc.bibliographiccitation.lastpage","149"],["dc.bibliographiccitation.volume","99"],["dc.contributor.author","Wilke, Melanie"],["dc.contributor.author","Schneider, Lukas"],["dc.contributor.author","Dominguez-Vargas, Adan-Ulises"],["dc.contributor.author","Schmidt-Samoa, Carsten"],["dc.contributor.author","Miloserdov, Kristina"],["dc.contributor.author","Nazzal, Ahmad"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Cabral-Calderin, Yuranny"],["dc.contributor.author","Scherberger, Hansjörg"],["dc.contributor.author","Kagan, Igor"],["dc.contributor.author","Bähr, Mathias"],["dc.date.accessioned","2018-02-08T10:49:56Z"],["dc.date.available","2018-02-08T10:49:56Z"],["dc.date.issued","2018-02"],["dc.description.abstract","Expansion of the dorsal pulvinar in humans and its anatomical connectivity suggests its involvement in higher-order cognitive and visuomotor functions. We investigated visuomotor performance in a 31 year old patient (M.B.) with a lesion centered on the medial portion of the dorsal pulvinar (left > right) due to an atypical Sarcoidosis manifestation. Unlike lesions with a vascular etiology, the lesion of M.B. did not include primary sensory or motor thalamic nuclei. Thus, this patient gave us the exceedingly rare opportunity to study the contribution of the dorsal pulvinar to visuomotor behavior in a human without confounding losses in primary sensory or motor domains. We investigated reaching, saccade and visual decision making performance. Patient data in each task was compared to at least seven age matched healthy controls. While saccades were hypometric towards both hemifields, the patient did not show any spatial choice bias or perceptual deficits. At the same time, he exhibited reach and grasp difficulties, which shared features with both, parietal and cerebellar damage. In particular, he had problems to form a precision grip and exhibited reach deficits expressed in decreased accuracy, delayed initiation and prolonged movement durations. Reach deficits were similar in foveal and extrafoveal viewing conditions and in both visual hemifields but were stronger with the right hand. These results suggest that dorsal pulvinar function in humans goes beyond its subscribed role in visual cognition and is critical for the programming of voluntary actions with the hands."],["dc.identifier.doi","10.1016/j.cortex.2017.10.011"],["dc.identifier.pmid","29216478"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/12057"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.doi","10.1016/j.cortex.2017.10.011"],["dc.relation.eissn","1973-8102"],["dc.relation.issn","1973-8102"],["dc.title","Reach and grasp deficits following damage to the dorsal pulvinar"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","898"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Movement Disorders Clinical Practice"],["dc.bibliographiccitation.lastpage","900"],["dc.bibliographiccitation.volume","4"],["dc.contributor.author","Wilke, Melanie"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Bähr, Mathias"],["dc.date.accessioned","2018-04-23T11:48:57Z"],["dc.date.available","2018-04-23T11:48:57Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1002/mdc3.12544"],["dc.identifier.gro","3142066"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/13610"],["dc.language.iso","en"],["dc.notes.intern","lifescience updates Crossref Import"],["dc.notes.status","final"],["dc.relation.issn","2330-1619"],["dc.title","Sarcoidosis Manifestion Centered on the Thalamic Pulvinar Leading to Persistent Astasia"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","102076"],["dc.bibliographiccitation.journal","NeuroImage: Clinical"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Miloserdov, Kristina"],["dc.contributor.author","Schmidt-Samoa, Carsten"],["dc.contributor.author","Williams, Kathleen"],["dc.contributor.author","Weinrich, Christiane Anne"],["dc.contributor.author","Kagan, Igor"],["dc.contributor.author","Bürk, Katrin"],["dc.contributor.author","Trenkwalder, Claudia"],["dc.contributor.author","Bähr, Mathias"],["dc.contributor.author","Wilke, Melanie"],["dc.date.accessioned","2020-12-10T15:20:31Z"],["dc.date.available","2020-12-10T15:20:31Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1016/j.nicl.2019.102076"],["dc.identifier.issn","2213-1582"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16784"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/72695"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/4.0"],["dc.title","Aberrant functional connectivity of resting state networks related to misperceptions and intra-individual variability in Parkinson‘s disease"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","101898"],["dc.bibliographiccitation.journal","NeuroImage: Clinical"],["dc.bibliographiccitation.volume","23"],["dc.contributor.author","Paschke, Kerstin"],["dc.contributor.author","Bähr, Mathias"],["dc.contributor.author","Wüstenberg, Torsten"],["dc.contributor.author","Wilke, Melanie"],["dc.date.accessioned","2019-07-30T07:47:17Z"],["dc.date.available","2019-07-30T07:47:17Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1016/j.nicl.2019.101898"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16804"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/62177"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","2213-1582"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/4.0"],["dc.title","Trunk rotation and handedness modulate cortical activation in neglect-associated regions during temporal order judgments"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]