Guy, Julien

[["dc.bibliographiccitation.artnumber","13664"],["dc.bibliographiccitation.journal","Nature Communications"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Walker, F."],["dc.contributor.author","Moeck, Martin"],["dc.contributor.author","Feyerabend, M."],["dc.contributor.author","Guy, Julien"],["dc.contributor.author","Wagener, Robin Jan"],["dc.contributor.author","Schubert, D."],["dc.contributor.author","Staiger, Jochen F."],["dc.contributor.author","Witte, M."],["dc.date.accessioned","2018-11-07T10:05:39Z"],["dc.date.available","2018-11-07T10:05:39Z"],["dc.date.issued","2016"],["dc.description.abstract","Disinhibition of cortical excitatory cell gate information flow through and between cortical columns. The major contribution of Martinotti cells (MC) is providing dendritic inhibition to excitatory neurons and therefore they are a main component of disinhibitory connections. Here we show by means of optogenetics that MC in layers II/III of the mouse primary somatosensory cortex are inhibited by both parvalbumin (PV)- and vasoactive intestinal polypeptide (VIP)-expressing cells. Paired recordings revealed stronger synaptic input onto MC from PV cells than from VIP cells. Moreover, PV cell input showed frequency-independent depression, whereas VIP cell input facilitated at high frequencies. These differences in the properties of the two unitary connections enable disinhibition with distinct temporal features."],["dc.identifier.doi","10.1038/ncomms13664"],["dc.identifier.isi","000388661600001"],["dc.identifier.pmid","27897179"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14059"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38939"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","2041-1723"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Parvalbumin- and vasoactive intestinal polypeptide-expressing neocortical interneurons impose differential inhibition on Martinotti cells"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2517"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Cerebral Cortex"],["dc.bibliographiccitation.lastpage","2528"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Guy, Julien"],["dc.contributor.author","Wagener, Robin Jan"],["dc.contributor.author","Moeck, Martin"],["dc.contributor.author","Staiger, Jochen F."],["dc.date.accessioned","2018-11-07T09:52:22Z"],["dc.date.available","2018-11-07T09:52:22Z"],["dc.date.issued","2015"],["dc.description.abstract","In rodents, layer IV of the primary somatosensory cortex contains the barrel field, where individual, large facial whiskers are represented as a dense cluster of cells. In the reeler mouse, a model of disturbed cortical development characterized by a loss of cortical lamination, the barrel field exists in a distorted manner. Little is known about the consequences of such a highly disturbed lamination on cortical function in this model. We used in vivo intrinsic signal optical imaging together with piezo-controlled whisker stimulation to explore sensory map organization and stimulus representation in the barrel field. We found that the loss of cortical layers in reeler mice had surprisingly little incidence on these properties. The overall topological order of whisker representations is highly preserved and the functional activation of individual whisker representations is similar in size and strength to wild-type controls. Because intrinsic imaging measures hemodynamic signals, we furthermore investigated the cortical blood vessel pattern of both genotypes, where we also did not detect major differences. In summary, the loss of the reelin protein results in a widespread disturbance of cortical development which compromises neither the establishment nor the function of an ordered, somatotopic map of the facial whiskers."],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft (DFG) via CRC [889]"],["dc.identifier.doi","10.1093/cercor/bhu052"],["dc.identifier.isi","000361464000016"],["dc.identifier.pmid","24759695"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/12149"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36113"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press Inc"],["dc.relation.issn","1460-2199"],["dc.relation.issn","1047-3211"],["dc.rights","CC BY-NC 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc/3.0"],["dc.title","Persistence of Functional Sensory Maps in the Absence of Cortical Layers in the Somsatosensory Cortex of Reeler Mice"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","820"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Cerebral Cortex"],["dc.bibliographiccitation.lastpage","837"],["dc.bibliographiccitation.volume","26"],["dc.contributor.author","Wagener, Robin Jan"],["dc.contributor.author","Witte, Mirko"],["dc.contributor.author","Guy, Julien"],["dc.contributor.author","Mingo-Moreno, Nieves"],["dc.contributor.author","Kuegler, Sebastian"],["dc.contributor.author","Staiger, Jochen F."],["dc.date.accessioned","2018-11-07T10:18:31Z"],["dc.date.available","2018-11-07T10:18:31Z"],["dc.date.issued","2016"],["dc.description.abstract","Neuronal wiring is key to proper neural information processing. Tactile information from the rodent's whiskers reaches the cortex via distinct anatomical pathways. The lemniscal pathway relays whisking and touch information from the ventral posteromedial thalamic nucleus to layer IV of the primary somatosensory \"barrel\" cortex. The disorganized neocortex of the reeler mouse is a model system that should severely compromise the ingrowth of thalamocortical axons (TCAs) into the cortex. Moreover, it could disrupt intracortical wiring. We found that neuronal intermingling within the reeler barrel cortex substantially exceeded previous descriptions, leading to the loss of layers. However, viral tracing revealed that TCAs still specifically targeted transgenically labeled spiny layer IV neurons. Slice electrophysiology and optogenetics proved that these connections represent functional synapses. In addition, we assessed intracortical activation via immediate-early-gene expression resulting from a behavioral exploration task. The cellular composition of activated neuronal ensembles suggests extensive similarities in intracolumnar information processing in the wild-type and reeler brains. We conclude that extensive ectopic positioning of neuronal partners can be compensated for by cell-autonomous mechanisms that allow for the establishment of proper connectivity. Thus, genetic neuronal fate seems to be of greater importance for correct cortical wiring than radial neuronal position."],["dc.identifier.doi","10.1093/cercor/bhv257"],["dc.identifier.isi","000371522500030"],["dc.identifier.pmid","26564256"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14147"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/41460"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press Inc"],["dc.relation.issn","1460-2199"],["dc.relation.issn","1047-3211"],["dc.rights","CC BY-NC 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc/4.0"],["dc.title","Thalamocortical Connections Drive Intracortical Activation of Functional Columns in the Mislaminated Reeler Somatosensory Cortex"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]