Guy, Julien

[["dc.bibliographiccitation.firstpage","1427"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Cerebral Cortex"],["dc.bibliographiccitation.lastpage","1443"],["dc.bibliographiccitation.volume","31"],["dc.contributor.author","Hafner, Georg"],["dc.contributor.author","Guy, Julien"],["dc.contributor.author","Witte, Mirko"],["dc.contributor.author","Truschow, Pavel"],["dc.contributor.author","Rüppel, Alina"],["dc.contributor.author","Sirmpilatze, Nikoloz"],["dc.contributor.author","Dadarwal, Rakshit"],["dc.contributor.author","Boretius, Susann"],["dc.contributor.author","Staiger, Jochen F"],["dc.date.accessioned","2021-06-01T09:41:52Z"],["dc.date.available","2021-06-01T09:41:52Z"],["dc.date.issued","2020"],["dc.description.abstract","Abstract The neocortex is composed of layers. Whether layers constitute an essential framework for the formation of functional circuits is not well understood. We investigated the brain-wide input connectivity of vasoactive intestinal polypeptide (VIP) expressing neurons in the reeler mouse. This mutant is characterized by a migration deficit of cortical neurons so that no layers are formed. Still, neurons retain their properties and reeler mice show little cognitive impairment. We focused on VIP neurons because they are known to receive strong long-range inputs and have a typical laminar bias toward upper layers. In reeler, these neurons are more dispersed across the cortex. We mapped the brain-wide inputs of VIP neurons in barrel cortex of wild-type and reeler mice with rabies virus tracing. Innervation by subcortical inputs was not altered in reeler, in contrast to the cortical circuitry. Numbers of long-range ipsilateral cortical inputs were reduced in reeler, while contralateral inputs were strongly increased. Reeler mice had more callosal projection neurons. Hence, the corpus callosum was larger in reeler as shown by structural imaging. We argue that, in the absence of cortical layers, circuits with subcortical structures are maintained but cortical neurons establish a different network that largely preserves cognitive functions."],["dc.identifier.doi","10.1093/cercor/bhaa280"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85068"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","1460-2199"],["dc.relation.issn","1047-3211"],["dc.title","Increased Callosal Connectivity in Reeler Mice Revealed by Brain-Wide Input Mapping of VIP Neurons in Barrel Cortex"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Cerebral Cortex"],["dc.contributor.author","Guy, Julien"],["dc.contributor.author","Sachkova, Alexandra"],["dc.contributor.author","Möck, Martin"],["dc.contributor.author","Witte, Mirko"],["dc.contributor.author","Wagener, Robin J."],["dc.contributor.author","Staiger, Jochen F."],["dc.date.accessioned","2020-12-10T18:18:32Z"],["dc.date.available","2020-12-10T18:18:32Z"],["dc.date.issued","2016"],["dc.identifier.doi","10.1093/cercor/bhw281"],["dc.identifier.eissn","1460-2199"],["dc.identifier.issn","1047-3211"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/75088"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Intracortical Network Effects Preserve Thalamocortical Input Efficacy in a Cortex Without Layers"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","81"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Biomedical Microdevices"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Hassler, Christina"],["dc.contributor.author","Guy, Julien"],["dc.contributor.author","Nietzschmann, Max"],["dc.contributor.author","Plachta, Dennis T. T."],["dc.contributor.author","Staiger, Jochen F."],["dc.contributor.author","Stieglitz, Thomas"],["dc.date.accessioned","2018-11-07T10:07:31Z"],["dc.date.available","2018-11-07T10:07:31Z"],["dc.date.issued","2016"],["dc.description.abstract","Polyimide based shaft electrodes were coated with a bioresorbable layer to stiffen them for intracortical insertion and to reduce the mechanical mismatch between the target tissue and the implanted device after degradation of the coating. Molten saccharose was used as coating material. In a proof-of-concept study, the electrodes were implanted into the cortex of Wistar rats and the insertion forces during implantation were recorded. Electrochemical impedance spectroscopy was performed immediately after implantation and up to 13 weeks after implantation to monitor the tissue response to the implanted electrodes. The recorded spectra were modeled with an equivalent circuit to differentiate the influence of the single components. In one rat, a peak in the encapsulation resistance was observable after two weeks of implantation, indicating the peak of the acute inflammatory response. In another rat, the lowest resistances were observed after four weeks, indicating the termination of the acute inflammatory response. Multiunit activity was recorded with an adequate signal to noise ratio to allow spike sorting. Histology was performed after 7, 45 and 201 days of implantation. The results showed the highest tissue reaction after 45 days and confirmed impedance data that acute inflammatory reactions terminate over time."],["dc.description.sponsorship","German Federal Ministry of Education and Research (BMBF) [01GQ0830]"],["dc.identifier.doi","10.1007/s10544-016-0106-7"],["dc.identifier.isi","000386555500007"],["dc.identifier.pmid","27534649"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39298"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1572-8781"],["dc.relation.issn","1387-2176"],["dc.title","Intracortical polyimide electrodes with a bioresorbable coating"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]