Now showing 1 - 7 of 7
  • 2021Journal Article
    [["dc.bibliographiccitation.journal","International Urology and Nephrology"],["dc.contributor.author","Wenzel, Mike"],["dc.contributor.author","Yu, Hang"],["dc.contributor.author","Uhlig, Annemarie"],["dc.contributor.author","Würnschimmel, Christoph"],["dc.contributor.author","Wallbach, Manuel"],["dc.contributor.author","Becker, Andreas"],["dc.contributor.author","Fisch, Margit"],["dc.contributor.author","Chun, Felix K. H."],["dc.contributor.author","Meyer, Christian P."],["dc.contributor.author","Leitsmann, Marianne"],["dc.date.accessioned","2021-08-12T07:46:14Z"],["dc.date.available","2021-08-12T07:46:14Z"],["dc.date.issued","2021"],["dc.description.abstract","Abstract Purpose To test the value of preoperative and postoperative cystatin C (CysC) as a predictor on kidney function after partial (PN) or radical nephrectomy (RN) in renal cell carcinoma (RCC) patients with normal preoperative renal function. Methods From 01/2011 to 12/2014, 195 consecutive RCC patients with a preoperative estimated glomerular filtration rate (eGFR) > 60 ml/min/1.73m 2 underwent surgical RCC treatment with either PN or RN. Logistic and linear regression models tested for the effect of CysC as a predictor of new-onset chronic kidney disease in follow-up (eGFR < 60 ml/min/1.73m 2 ). Moreover, postoperative CysC and creatinine values were compared for kidney function estimation. Results Of 195 patients, 129 (66.2%) underwent PN. In postoperative and in follow-up setting (median 14 months, IQR 10–20), rates of eGFR < 60 ml/min/1.73m 2 were 55.9 and 30.2%. In multivariable logistic regression models, preoperative CysC [odds ratio (OR): 18.3] and RN (OR: 13.5) were independent predictors for a reduced eGFR < 60 ml/min/1.73m 2 in follow-up (both p  < 0.01), while creatinine was not. In multivariable linear regression models, a difference of the preoperative CysC level of 0.1 mg/dl estimated an eGFR decline in follow-up of about 5.8 ml/min/1.73m 2 . Finally, we observed a plateau of postoperative creatinine values in the range of 1.2–1.3 mg/dl, when graphically depicted vs. postoperative CysC values (‘creatinine blind area’). Conclusion Preoperative CysC predicts renal function impairment following RCC surgery. Furthermore, CysC might be superior to creatinine for renal function monitoring in the early postoperative setting."],["dc.description.abstract","Abstract Purpose To test the value of preoperative and postoperative cystatin C (CysC) as a predictor on kidney function after partial (PN) or radical nephrectomy (RN) in renal cell carcinoma (RCC) patients with normal preoperative renal function. Methods From 01/2011 to 12/2014, 195 consecutive RCC patients with a preoperative estimated glomerular filtration rate (eGFR) > 60 ml/min/1.73m 2 underwent surgical RCC treatment with either PN or RN. Logistic and linear regression models tested for the effect of CysC as a predictor of new-onset chronic kidney disease in follow-up (eGFR < 60 ml/min/1.73m 2 ). Moreover, postoperative CysC and creatinine values were compared for kidney function estimation. Results Of 195 patients, 129 (66.2%) underwent PN. In postoperative and in follow-up setting (median 14 months, IQR 10–20), rates of eGFR < 60 ml/min/1.73m 2 were 55.9 and 30.2%. In multivariable logistic regression models, preoperative CysC [odds ratio (OR): 18.3] and RN (OR: 13.5) were independent predictors for a reduced eGFR < 60 ml/min/1.73m 2 in follow-up (both p  < 0.01), while creatinine was not. In multivariable linear regression models, a difference of the preoperative CysC level of 0.1 mg/dl estimated an eGFR decline in follow-up of about 5.8 ml/min/1.73m 2 . Finally, we observed a plateau of postoperative creatinine values in the range of 1.2–1.3 mg/dl, when graphically depicted vs. postoperative CysC values (‘creatinine blind area’). Conclusion Preoperative CysC predicts renal function impairment following RCC surgery. Furthermore, CysC might be superior to creatinine for renal function monitoring in the early postoperative setting."],["dc.identifier.doi","10.1007/s11255-021-02957-w"],["dc.identifier.pii","2957"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/88653"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-448"],["dc.relation.eissn","1573-2584"],["dc.relation.issn","0301-1623"],["dc.title","Cystatin C predicts renal function impairment after partial or radical tumor nephrectomy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]
    Details DOI
  • 2022Journal Article
    [["dc.bibliographiccitation.artnumber","end.2022.0396"],["dc.bibliographiccitation.journal","Journal of Endourology"],["dc.contributor.author","Gild, Philipp"],["dc.contributor.author","Vetterlein, Malte Wolfram"],["dc.contributor.author","Daoud, Ihab"],["dc.contributor.author","Ludwig, Tim Alexander"],["dc.contributor.author","Soave, Armin"],["dc.contributor.author","Marks, Phillip"],["dc.contributor.author","Chun, Felix"],["dc.contributor.author","Ahyai, Sascha A"],["dc.contributor.author","Dahlem, Roland"],["dc.contributor.author","Fisch, Margit"],["dc.contributor.author","Becker, Andreas"],["dc.date.accessioned","2022-12-01T08:31:06Z"],["dc.date.available","2022-12-01T08:31:06Z"],["dc.date.issued","2022"],["dc.identifier.doi","10.1089/end.2022.0396"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/118072"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-621"],["dc.relation.eissn","1557-900X"],["dc.relation.issn","0892-7790"],["dc.title","Which Men do or do not Achieve Longterm Symptom Relief after Holmium Laser Enucleation of the Prostate (Holep) – 11 Years of Holep Experience"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]
    Details DOI
  • 2017Journal Article
    [["dc.bibliographiccitation.firstpage","1319"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Journal of Cancer Research and Clinical Oncology"],["dc.bibliographiccitation.lastpage","1325"],["dc.bibliographiccitation.volume","143"],["dc.contributor.author","Dulz, Simon"],["dc.contributor.author","Asselborn, Niels H."],["dc.contributor.author","Dieckmann, Klaus-Peter"],["dc.contributor.author","Matthies, Cord"],["dc.contributor.author","Wagner, Walter"],["dc.contributor.author","Weidmann, Jens"],["dc.contributor.author","Seidel, Christoph"],["dc.contributor.author","Oing, Christoph"],["dc.contributor.author","Berger, Lars A."],["dc.contributor.author","Alsdorf, Winfried"],["dc.contributor.author","Mankichian, Blanche"],["dc.contributor.author","Meyer, Christian"],["dc.contributor.author","Vetterlein, Malte W."],["dc.contributor.author","Gild, Philipp"],["dc.contributor.author","Ludwig, Tim A."],["dc.contributor.author","Soave, Armin"],["dc.contributor.author","Schriefer, Philipp"],["dc.contributor.author","Becker, Andreas"],["dc.contributor.author","Ahyai, Sascha A."],["dc.contributor.author","Oechsle, Karin"],["dc.contributor.author","Bokemeyer, Carsten"],["dc.contributor.author","Wagenfeld, Lars"],["dc.contributor.author","Fisch, Margit"],["dc.contributor.author","Hartmann, Michael"],["dc.contributor.author","Chun, Felix K-H."],["dc.contributor.author","Kluth, Luis A."],["dc.date.accessioned","2018-11-07T10:22:05Z"],["dc.date.available","2018-11-07T10:22:05Z"],["dc.date.issued","2017"],["dc.description.abstract","Visual impairment represents an infrequent form of cisplatin-induced neurotoxicity; however, visual deterioration has been reported in several studies. To evaluate potential morphological and functional retinal alterations in patients with germ cell cancer (GCC) treated with cisplatin-based chemotherapy (CBC). Multi-disciplinary and multi-institutional study design. Examination of 28 eyes of 14 male GCC patients, who had received at least one cycle of CBC. A matched control group of healthy, untreated patients were included in this study. Subjects underwent a retinal nerve fiber thickness (RNFL) measurement, color vision, visual acuity testing, full-field electroretinograms (ff-ERG). To assess a correlation between cumulative cisplatin dose and measured RNFL and ff-ERG Pearson correlation coefficient analysis was performed. Both study groups (CBC recipients vs. healthy controls) consisted each of 14 participants with a median patient age of 30 years (interquartile range (IQR) 26-37 years). Tumor histology was seminoma in 6 of 14 patients (43%), and non-seminomatous GCC in 8 of 14 patients (57%). Median cumulative cisplatin dosis at examination was 627 mg/m(2) (IQR 413-1013 mg/m(2)). Morphological assessment revealed reduced RNFL in 11 of 14 patients (78.6%). Reduction in RNFL was significantly correlated to the cumulative CBC dose received (rho = + 0.70; p = 0.004). ff-ERG showed significant differences between CBC recipients and the control group in 2 of 5 tested categories (all p values < 0.001). This study represents first evidence of chronic subclinical retinal toxicity due to cisplatin-based chemotherapy in patients with GCC. The reduction of RNFL might become clinically relevant in upcoming age-related chronic degenerative disorders such as glaucoma."],["dc.identifier.doi","10.1007/s00432-017-2384-8"],["dc.identifier.isi","000404235900022"],["dc.identifier.pmid","28281024"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42216"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Springer"],["dc.relation.issn","1432-1335"],["dc.relation.issn","0171-5216"],["dc.title","Retinal toxicity after cisplatin-based chemotherapy in patients with germ cell cancer"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]
    Details DOI PMID PMC WOS
  • 2021Journal Article
    [["dc.bibliographiccitation.journal","Journal of Endourology"],["dc.contributor.author","Gild, Philipp"],["dc.contributor.author","Lenke, Lukas"],["dc.contributor.author","Pompe, Raisa S."],["dc.contributor.author","Vetterlein, Malte W."],["dc.contributor.author","Ludwig, Tim A."],["dc.contributor.author","Soave, Armin"],["dc.contributor.author","Chun, Felix K.-H."],["dc.contributor.author","Ahyai, Sascha"],["dc.contributor.author","Dahlem, Roland"],["dc.contributor.author","Fisch, Margit"],["dc.contributor.author","Rink, Michael"],["dc.contributor.author","Meyer, Christian P."],["dc.contributor.author","Becker, Andreas"],["dc.date.accessioned","2021-04-14T08:30:10Z"],["dc.date.available","2021-04-14T08:30:10Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1089/end.2020.0605"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83133"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1557-900X"],["dc.relation.issn","0892-7790"],["dc.title","Assessing the Outcome of Holmium Laser Enucleation of the Prostate by Age, Prostate Volume, and a History of Blood Thinning Agents: Report from a Single-Center Series of >1800 Consecutive Cases"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]
    Details DOI
  • 2020Journal Article
    [["dc.bibliographiccitation.firstpage","3207"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","World Journal of Urology"],["dc.bibliographiccitation.lastpage","3217"],["dc.bibliographiccitation.volume","38"],["dc.contributor.author","Ahyai, Sascha A."],["dc.contributor.author","Marik, Irina"],["dc.contributor.author","Ludwig, Tim A."],["dc.contributor.author","Becker, Andreas"],["dc.contributor.author","Asdjodi, Saman"],["dc.contributor.author","Kluth, Luis"],["dc.contributor.author","Chun, Felix"],["dc.contributor.author","Fisch, Margit"],["dc.contributor.author","Schmid, Marianne"],["dc.date.accessioned","2020-12-10T14:10:14Z"],["dc.date.available","2020-12-10T14:10:14Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1007/s00345-020-03126-x"],["dc.identifier.eissn","1433-8726"],["dc.identifier.issn","0724-4983"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70691"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Super early detailed assessment of lower urinary tract symptoms after holmium laser enucleation of the prostate (HoLEP): a prospective study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]
    Details DOI
  • 2021Journal Article
    [["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.journal","Scandinavian Journal of Urology"],["dc.bibliographiccitation.lastpage","6"],["dc.contributor.author","Wenzel, Mike"],["dc.contributor.author","Kleimaker, Alexander"],["dc.contributor.author","Uhlig, Annemarie"],["dc.contributor.author","Würnschimmel, Christoph"],["dc.contributor.author","Becker, Andreas"],["dc.contributor.author","Yu, Hang"],["dc.contributor.author","Meyer, Christian P."],["dc.contributor.author","Fisch, Margit"],["dc.contributor.author","Chun, Felix K. H."],["dc.contributor.author","Leitsmann, Marianne"],["dc.date.accessioned","2021-10-01T09:57:53Z"],["dc.date.available","2021-10-01T09:57:53Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1080/21681805.2021.1948916"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/89935"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-469"],["dc.relation.eissn","2168-1813"],["dc.relation.issn","2168-1805"],["dc.title","Impact of comorbidities on acute kidney injury and renal function impairment after partial and radical tumor nephrectomy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]
    Details DOI
  • 2020Journal Article
    [["dc.bibliographiccitation.firstpage","1779"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Andrology"],["dc.bibliographiccitation.lastpage","1786"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Gild, Philipp"],["dc.contributor.author","Dahlem, Roland"],["dc.contributor.author","Pompe, Raisa S."],["dc.contributor.author","Soave, Armin"],["dc.contributor.author","Vetterlein, Malte W."],["dc.contributor.author","Ludwig, Tim A."],["dc.contributor.author","Maurer, Valentin"],["dc.contributor.author","Marks, Phillip"],["dc.contributor.author","Ahyai, Sascha A."],["dc.contributor.author","Chun, Felix K.‐H."],["dc.contributor.author","Lenke, Lukas"],["dc.contributor.author","Ernst, Tabea"],["dc.contributor.author","Fisch, Margit"],["dc.contributor.author","Rink, Michael"],["dc.contributor.author","Meyer, Christian P."],["dc.contributor.author","Becker, Andreas"],["dc.date.accessioned","2021-04-14T08:22:57Z"],["dc.date.available","2021-04-14T08:22:57Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1111/andr.12887"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/80747"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","2047-2927"],["dc.relation.issn","2047-2919"],["dc.title","Retrograde ejaculation after holmium laser enucleation of the prostate (HoLEP)—Impact on sexual function and evaluation of patient bother using validated questionnaires"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]
    Details DOI