Leonov, Andrei

[["dc.bibliographiccitation.firstpage","E4971"],["dc.bibliographiccitation.issue","25"],["dc.bibliographiccitation.journal","Proceedings of the National Academy of Sciences of the United States of America"],["dc.bibliographiccitation.lastpage","E4977"],["dc.bibliographiccitation.volume","114"],["dc.contributor.author","Turriani, Elisa"],["dc.contributor.author","Lázaro, Diana F."],["dc.contributor.author","Ryazanov, Sergey"],["dc.contributor.author","Leonov, Andrei"],["dc.contributor.author","Giese, Armin"],["dc.contributor.author","Schön, Margarete"],["dc.contributor.author","Schön, Michael P."],["dc.contributor.author","Griesinger, Christian"],["dc.contributor.author","Outeiro, Tiago F."],["dc.contributor.author","Arndt-Jovin, Donna J."],["dc.contributor.author","Becker, Dorothea"],["dc.date.accessioned","2018-04-23T11:47:36Z"],["dc.date.available","2018-04-23T11:47:36Z"],["dc.date.issued","2017"],["dc.description.abstract","Recent epidemiological and clinical studies have reported a significantly increased risk for melanoma in people with Parkinson’s disease. Because no evidence could be obtained that genetic factors are the reason for the association between these two diseases, we hypothesized that of the three major Parkinson’s disease-related proteins—α-synuclein, LRRK2, and Parkin—α-synuclein might be a major link. Our data, presented here, demonstrate that α-synuclein promotes the survival of primary and metastatic melanoma cells, which is the exact opposite of the effect that α-synuclein has on dopaminergic neurons, where its accumulation causes neuronal dysfunction and death. Because this detrimental effect of α-synuclein on neurons can be rescued by the small molecule anle138b, we explored its effect on melanoma cells. We found that treatment with anle138b leads to massive melanoma cell death due to a major dysregulation of autophagy, suggesting that α-synuclein is highly beneficial to advanced melanoma because it ensures that autophagy is maintained at a homeostatic level that promotes and ensures the cell’s survival."],["dc.identifier.doi","10.1073/pnas.1700200114"],["dc.identifier.gro","3142238"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/13362"],["dc.language.iso","en"],["dc.notes.intern","lifescience updates Crossref Import"],["dc.notes.status","final"],["dc.relation.issn","0027-8424"],["dc.title","Treatment with diphenyl–pyrazole compound anle138b/c reveals that α-synuclein protects melanoma cells from autophagic cell death"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","S38"],["dc.bibliographiccitation.journal","Magnetic Resonance in Chemistry"],["dc.bibliographiccitation.lastpage","S44"],["dc.bibliographiccitation.volume","50"],["dc.contributor.author","Schmidt, Manuel"],["dc.contributor.author","Sun, Han"],["dc.contributor.author","Leonov, Andrei"],["dc.contributor.author","Griesinger, Christian"],["dc.contributor.author","Reinscheid, Uwe M."],["dc.date.accessioned","2017-09-07T11:48:20Z"],["dc.date.available","2017-09-07T11:48:20Z"],["dc.date.issued","2012"],["dc.description.abstract","A new chiral alignment medium for dimethyl sulfoxide, methanol, and water as solvents was developed. Because both enantiomers of the gel are available, it is possible to enantiodiscriminate natural products such as strychnine HCl that naturally occurs as single enantiomer. With the two methods of achieving anisotropy, namely stretching and confinement, the degree of alignment can be adjusted, and the director changed from horizontal to vertical. This increases the applicability. Three compounds were enantiodiscriminated on the basis of residual dipolar coupling data: mefloquine HCl, strychnine HCl, and menthylamine HCl. Copyright (C) 2012 John Wiley & Sons, Ltd."],["dc.identifier.doi","10.1002/mrc.3886"],["dc.identifier.gro","3142431"],["dc.identifier.isi","000319964200007"],["dc.identifier.pmid","23280659"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/8207"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","0749-1581"],["dc.title","Chiral discrimination of amines by anisotropic NMR parameters using chiral polyacrylamide-based gels"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","779"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Acta Neuropathologica"],["dc.bibliographiccitation.lastpage","780"],["dc.bibliographiccitation.volume","127"],["dc.contributor.author","Levin, Johannes"],["dc.contributor.author","Schmidt, Felix"],["dc.contributor.author","Boehm, Cathrin"],["dc.contributor.author","Prix, Catharina"],["dc.contributor.author","Boetzel, Kai"],["dc.contributor.author","Ryazanov, Sergey"],["dc.contributor.author","Leonov, Andrei"],["dc.contributor.author","Griesinger, Christian"],["dc.contributor.author","Giese, Armin"],["dc.date.accessioned","2017-09-07T11:46:17Z"],["dc.date.available","2017-09-07T11:46:17Z"],["dc.date.issued","2014"],["dc.identifier.doi","10.1007/s00401-014-1265-3"],["dc.identifier.gro","3142137"],["dc.identifier.isi","000334426300011"],["dc.identifier.pmid","24615514"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/12109"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/4955"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Springer"],["dc.relation.eissn","1432-0533"],["dc.relation.issn","0001-6322"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","The oligomer modulator anle138b inhibits disease progression in a Parkinson mouse model even with treatment started after disease onset"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","letter_note"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3752"],["dc.bibliographiccitation.issue","19"],["dc.bibliographiccitation.journal","The Journal of Neuroscience"],["dc.bibliographiccitation.lastpage","3769"],["dc.bibliographiccitation.volume","39"],["dc.contributor.author","Gong, Jing"],["dc.contributor.author","Szego, Éva M."],["dc.contributor.author","Leonov, Andrei"],["dc.contributor.author","Benito, Eva"],["dc.contributor.author","Becker, Stefan"],["dc.contributor.author","Fischer, Andre"],["dc.contributor.author","Zweckstetter, Markus"],["dc.contributor.author","Outeiro, Tiago"],["dc.contributor.author","Schneider, Anja"],["dc.date.accessioned","2020-12-10T18:42:35Z"],["dc.date.available","2020-12-10T18:42:35Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1523/JNEUROSCI.2070-18.2019"],["dc.identifier.pmid","30796158"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78015"],["dc.identifier.url","https://sfb1286.uni-goettingen.de/literature/publications/13"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.relation","SFB 1286: Quantitative Synaptologie"],["dc.relation","SFB 1286 | B06: Die Rolle von RNA in Synapsenphysiologie und Neurodegeneration"],["dc.relation.workinggroup","RG A. Fischer (Epigenetics and Systems Medicine in Neurodegenerative Diseases)"],["dc.relation.workinggroup","RG Outeiro (Experimental Neurodegeneration)"],["dc.title","Translocator Protein Ligand Protects against Neurodegeneration in the MPTP Mouse Model of Parkinsonism"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","575"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Acta Neuropathologica"],["dc.bibliographiccitation.lastpage","595"],["dc.bibliographiccitation.volume","138"],["dc.contributor.author","Wegrzynowicz, Michal"],["dc.contributor.author","Bar-On, Dana"],["dc.contributor.author","Calo’, Laura"],["dc.contributor.author","Anichtchik, Oleg"],["dc.contributor.author","Iovino, Mariangela"],["dc.contributor.author","Xia, Jing"],["dc.contributor.author","Ryazanov, Sergey"],["dc.contributor.author","Leonov, Andrei"],["dc.contributor.author","Giese, Armin"],["dc.contributor.author","Dalley, Jeffrey W."],["dc.contributor.author","Griesinger, Christian"],["dc.contributor.author","Ashery, Uri"],["dc.contributor.author","Spillantini, Maria Grazia"],["dc.date.accessioned","2020-12-10T14:10:27Z"],["dc.date.available","2020-12-10T14:10:27Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1007/s00401-019-02023-x"],["dc.identifier.pmid","31165254"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16591"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70765"],["dc.identifier.url","https://mbexc.uni-goettingen.de/literature/publications/28"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.relation","EXC 2067: Multiscale Bioimaging"],["dc.relation.workinggroup","RG Griesinger"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Depopulation of dense α-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson’s disease model"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","4421"],["dc.bibliographiccitation.issue","19"],["dc.bibliographiccitation.journal","The Journal of Physical Chemistry A"],["dc.bibliographiccitation.lastpage","4428"],["dc.bibliographiccitation.volume","104"],["dc.contributor.author","Leonov, A."],["dc.contributor.author","Marstokk, K. M."],["dc.contributor.author","de Meijere, Armin"],["dc.contributor.author","Mollendahl, H."],["dc.date.accessioned","2018-11-07T10:50:48Z"],["dc.date.available","2018-11-07T10:50:48Z"],["dc.date.issued","2000"],["dc.description.abstract","The microwave spectra of 1-ethenylcyclopropan-1-ol, (CH2)(2)C(OH)C=CH2, and one deuterated species, (CH2)(2)C(OD)C=CH2, have been investigated in the 11.0-60.0 GHz region. The (ac,ap)- and (ac,ac1)-conformers denoted Syn 1 and Skew 1 were assigned. Each of these two forms is stabilized with an intramolecular hydrogen bond formed between the hydrogen atom of the hydroxyl group and the pi electrons of the double bond. In the Syn 1 rotamer the C=C-C-O chain of atoms takes a syn conformation (dihedral angle = -2.6 degrees) and the H-O-C-C= link of atoms is gauche (dihedral angle = -67.2 degrees from syn). The C=C-C-O link of atoms takes a skew conformation (dihedral angle = 132.1 degrees from syn) in the Skew 1 rotamer, while the H-O-C-C= dihedral angle is -67.1 degrees. Syn 1 is preferred by 4.9(6) kJ mol(-1) relative to Skew 1. Syn 1 is virtually a hybrid of the most stable conformer of unsubstituted ethenylcyclopropane, and unsubstituted cyclopropanol, Skew 1, is the corresponding hybrid of the second rotamer of ethenylcyclopropane and the most stable one of cyclopropanol. The spectrum of Syn 1 is perturbed by tunneling of the hydroxyl group. An analysis yielded 2280.184(60) MHz for the tunneling frequency and 39.82(19) MHz for the Coriolis coupling term mu(ca) for the normal species. The corresponding values were 72.401(27) and 5.2(10) MHz, respectively, for the deuterated species. A potential function for the tunneling motion consisting of three cosine terms was found to have the following potential constants: V-1 -918.2, V-2 = -900.0, and V-3 = 418.0 cm(-1). This double-minimum function yields a barrier of 16.6(50) kJ mol(-1) at the anti position and 10.6(30) kJ mol(-1) at syn. The microwave work has been assisted by ab initio computations at the MP2/cc-pVTZ level of theory as well as density functional theory calculations at the B3LYP/6-31G level. These calculations indicate that there are only three stable rotameric forms of the molecule. The gas-phase IR spectrum in the O-H stretching region revealed a broad and complex band red-shifted by roughly 50 cm(-1) presumably as a result of internal hydrogen bonding."],["dc.identifier.doi","10.1021/jp9940755"],["dc.identifier.isi","000087003200011"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/48739"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Chemical Soc"],["dc.relation.issn","1089-5639"],["dc.title","Microwave spectrum, conformational equilibrium, intramolecular hydrogen bonding, tunneling, and quantum chemical calculations for 1-ethenylcyclopropan-1-ol"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","European Journal of Nuclear Medicine and Molecular Imaging"],["dc.contributor.author","Kuebler, Laura"],["dc.contributor.author","Buss, Sabrina"],["dc.contributor.author","Leonov, Andrei"],["dc.contributor.author","Ryazanov, Sergey"],["dc.contributor.author","Schmidt, Felix"],["dc.contributor.author","Maurer, Andreas"],["dc.contributor.author","Weckbecker, Daniel"],["dc.contributor.author","Landau, Anne M."],["dc.contributor.author","Lillethorup, Thea P."],["dc.contributor.author","Bleher, Daniel"],["dc.contributor.author","Saw, Ran Sing"],["dc.contributor.author","Pichler, Bernd J."],["dc.contributor.author","Griesinger, Christian"],["dc.contributor.author","Giese, Armin"],["dc.contributor.author","Herfert, Kristina"],["dc.date.accessioned","2021-04-14T08:30:50Z"],["dc.date.available","2021-04-14T08:30:50Z"],["dc.date.issued","2020"],["dc.description.abstract","Purpose\r\n\r\nDeposition of misfolded alpha-synuclein (αSYN) aggregates in the human brain is one of the major hallmarks of synucleinopathies. However, a target-specific tracer to detect pathological aggregates of αSYN remains lacking. Here, we report the development of a positron emission tomography (PET) tracer based on anle138b, a compound shown to have therapeutic activity in animal models of neurodegenerative diseases.\r\nMethods\r\n\r\nSpecificity and selectivity of [3H]MODAG-001 were tested in in vitro binding assays using recombinant fibrils. After carbon-11 radiolabeling, the pharmacokinetic and metabolic profile was determined in mice. Specific binding was quantified in rats, inoculated with αSYN fibrils and using in vitro autoradiography in human brain sections of Lewy body dementia (LBD) cases provided by the Neurobiobank Munich (NBM).\r\nResults\r\n\r\n[3H]MODAG-001 revealed a very high affinity towards pure αSYN fibrils (Kd = 0.6 ± 0.1 nM) and only a moderate affinity to hTau46 fibrils (Kd = 19 ± 6.4 nM) as well as amyloid-β1–42 fibrils (Kd = 20 ± 10 nM). [11C]MODAG-001 showed an excellent ability to penetrate the mouse brain. Metabolic degradation was present, but the stability of the parent compound improved after selective deuteration of the precursor. (d3)-[11C]MODAG-001 binding was confirmed in fibril-inoculated rat striata using in vivo PET imaging. In vitro autoradiography showed no detectable binding to aggregated αSYN in human brain sections of LBD cases, most likely, because of the low abundance of aggregated αSYN against background protein.\r\nConclusion\r\n\r\nMODAG-001 provides a promising lead structure for future compound development as it combines a high affinity and good selectivity in fibril-binding assays with suitable pharmacokinetics and biodistribution properties."],["dc.identifier.doi","10.1007/s00259-020-05133-x"],["dc.identifier.pmid","33369690"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83387"],["dc.identifier.url","https://mbexc.uni-goettingen.de/literature/publications/101"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation","EXC 2067: Multiscale Bioimaging"],["dc.relation.eissn","1619-7089"],["dc.relation.issn","1619-7070"],["dc.relation.workinggroup","RG Griesinger"],["dc.rights","CC BY 4.0"],["dc.title","[11C]MODAG-001—towards a PET tracer targeting α-synuclein aggregates"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","14893"],["dc.bibliographiccitation.journal","Nature Communications"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Jaipuria, Garima"],["dc.contributor.author","Leonov, Andrei"],["dc.contributor.author","Giller, Karin"],["dc.contributor.author","Vasa, Suresh Kumar"],["dc.contributor.author","Jaremko, Lukasz"],["dc.contributor.author","Jaremko, Mariusz"],["dc.contributor.author","Linser, Rasmus"],["dc.contributor.author","Becker, Stefan"],["dc.contributor.author","Zweckstetter, Markus"],["dc.date.accessioned","2018-11-07T10:26:01Z"],["dc.date.available","2018-11-07T10:26:01Z"],["dc.date.issued","2017"],["dc.description.abstract","Cholesterol is an important regulator of membrane protein function. However, the exact mechanisms involved in this process are still not fully understood. Here we study how the tertiary and quaternary structure of the mitochondrial translocator protein TSPO, which binds cholesterol with nanomolar affinity, is affected by this sterol. Residue-specific analysis of TSPO by solid-state NMR spectroscopy reveals a dynamic monomer-dimer equilibrium of TSPO in the membrane. Binding of cholesterol to TSPO's cholesterol-recognition motif leads to structural changes across the protein that shifts the dynamic equilibrium towards the translocator monomer. Consistent with an allosteric mechanism, a mutation within the oligomerization interface perturbs transmembrane regions located up to 35 angstrom away from the interface, reaching TSPO's cholesterol-binding motif. The lower structural stability of the intervening transmembrane regions provides a mechanistic basis for signal transmission. Our study thus reveals an allosteric signal pathway that connects membrane protein tertiary and quaternary structure with cholesterol binding."],["dc.identifier.doi","10.1038/ncomms14893"],["dc.identifier.isi","000397799000001"],["dc.identifier.pmid","28358007"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14416"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42959"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","2041-1723"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Cholesterol-mediated allosteric regulation of the mitochondrial translocator protein structure"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","15114"],["dc.bibliographiccitation.issue","49"],["dc.bibliographiccitation.journal","Journal of the American Chemical Society"],["dc.bibliographiccitation.lastpage","+"],["dc.bibliographiccitation.volume","129"],["dc.contributor.author","Schuetz, Anne"],["dc.contributor.author","Junker, Jochen"],["dc.contributor.author","Leonov, Andrei"],["dc.contributor.author","Lange, Oliver F."],["dc.contributor.author","Molinski, Tadeusz F."],["dc.contributor.author","Griesinger, Christian"],["dc.date.accessioned","2017-09-07T11:49:21Z"],["dc.date.available","2017-09-07T11:49:21Z"],["dc.date.issued","2007"],["dc.description.abstract","Sagittamide A is a long-chain acyclic M,CO-dicarboxylic acid with eight stereocenters, The central hexahydroxyhexane moiety carries six of them. For this moiety, two different relative stereochemical assignments were published in 2006. In this communication, one relative configuration is clearly singled out based on NOEs, J - and residual dipolar couplings despite conformational averaging that is present in this moiety. The proposed NMR method relies on the measurement of dipolar couplings in recently introduced alignment media that are compatible with organic solvents, and cross validating the NMR determined ensemble of conformations against the residual dipolar couplings. The method is easily applicable to many other stereochemical problems."],["dc.identifier.doi","10.1021/ja075876l"],["dc.identifier.gro","3143398"],["dc.identifier.isi","000251477400012"],["dc.identifier.pmid","17999506"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/908"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Amer Chemical Soc"],["dc.relation.issn","0002-7863"],["dc.title","Stereochemistry of sagittamide a from residual dipolar coupling enhanced NMR"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","924"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Journal of Neuropathology and Experimental Neurology"],["dc.bibliographiccitation.lastpage","933"],["dc.bibliographiccitation.volume","74"],["dc.contributor.author","Shi, Song"],["dc.contributor.author","Wagner, Jens"],["dc.contributor.author","Mitteregger-Kretzschmar, Gerda"],["dc.contributor.author","Ryazanov, Sergey"],["dc.contributor.author","Leonov, Andrei"],["dc.contributor.author","Griesinger, Christian"],["dc.contributor.author","Giese, Armin"],["dc.date.accessioned","2017-09-07T11:43:35Z"],["dc.date.available","2017-09-07T11:43:35Z"],["dc.date.issued","2015"],["dc.description.abstract","Prion diseases are fatal neurodegenerative diseases characterized by accumulation of the pathogenic prion protein PrPSc in the brain. We established quantitative real-time quaking-induced conversion for the measurement of minute amounts of PrPSc in body fluids such as urine. Using this approach, we monitored the efficacy of antiprion therapy by quantifying the seeding activity of PrPSc from the brain and urine of mice after prion infection. We found that the aggregation inhibitor anle138b decreased the levels of PrPSc in the brain and urine. Importantly, variations of PrPSc levels in the urine closely corresponded to those in the brain. Our findings indicate that quantification of urinary PrPSc enables measurement of prion disease progression in body fluids and can substitute for immunodetection in brain tissue. We expect PrPSc quantification biologic fluids (such as urine and cerebrospinal fluid) with quantitative real-time quaking-induced conversion to emerge as a valuable noninvasive diagnostic tool for monitoring disease progression and the efficacy of therapeutic approaches in animal studies and human clinical trials of prion diseases. Moreover, highly sensitive methods for quantifying pathologic aggregate seeds might provide novel molecular biomarkers for other neurodegenerative diseases that may involve prion-like mechanisms (protein aggregation and spreading), such as Alzheimer disease and Parkinson disease."],["dc.identifier.doi","10.1097/NEN.0000000000000233"],["dc.identifier.gro","3141840"],["dc.identifier.isi","000360142900007"],["dc.identifier.pmid","26247395"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/1656"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","0022-3069"],["dc.title","Quantitative Real-Time Quaking-Induced Conversion Allows Monitoring of Disease-Modifying Therapy in the Urine of Prion-Infected Mice"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]