Schröder-Schetelig, Johannes

[["dc.bibliographiccitation.artnumber","337"],["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.journal","Frontiers in Physiology"],["dc.bibliographiccitation.lastpage","7"],["dc.bibliographiccitation.volume","5"],["dc.contributor.author","Dura, Miroslav"],["dc.contributor.author","Schröder-Schetelig, Johannes"],["dc.contributor.author","Luther, Stefan"],["dc.contributor.author","Lehnart, Stephan Elmar"],["dc.date.accessioned","2018-05-07T12:40:50Z"],["dc.date.available","2018-05-07T12:40:50Z"],["dc.date.issued","2014"],["dc.description.abstract","To investigate the dynamics and propensity for arrhythmias in intact transgenic hearts comprehensively, optical strategies for panoramic fluorescence imaging of action potential (AP) propagation are essential. In particular, mechanism-oriented molecular studies usually depend on transgenic mouse hearts of only a few millimeters in size. Furthermore, the temporal scales of the mouse heart remain a challenge for panoramic fluorescence imaging with heart rates ranging from 200 min(-1) (e.g., depressed sinus node function) to over 1200 min(-1) during fast arrhythmias. To meet these challenging demands, we and others developed physiologically relevant mouse models and characterized their hearts with planar AP mapping. Here, we summarize the progress toward panoramic fluorescence imaging and its prospects for the mouse heart. In general, several high-resolution cameras are synchronized and geometrically arranged for panoramic voltage mapping and the surface and blood vessel anatomy documented through image segmentation and heart surface reconstruction. We expect that panoramic voltage imaging will lead to novel insights about molecular arrhythmia mechanisms through quantitative strategies and organ-representative analysis of intact mouse hearts."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2014"],["dc.identifier.doi","10.3389/fphys.2014.00337"],["dc.identifier.pmid","25249982"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10964"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/14628"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.publisher","Frontiers Media S.A."],["dc.relation.doi","10.3389/fphys.2014.00337"],["dc.relation.eissn","1664-042X"],["dc.rights","CC BY 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/3.0"],["dc.title","Toward panoramic in situ mapping of action potential propagation in transgenic hearts to investigate initiation and therapeutic control of arrhythmias"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","357"],["dc.bibliographiccitation.issue","3-4"],["dc.bibliographiccitation.journal","Autonomous Robots"],["dc.bibliographiccitation.lastpage","366"],["dc.bibliographiccitation.volume","29"],["dc.contributor.author","Schroeder-Schetelig, Johannes"],["dc.contributor.author","Manoonpong, Poramate"],["dc.contributor.author","Woergoetter, Florentin"],["dc.date.accessioned","2018-11-07T08:37:21Z"],["dc.date.available","2018-11-07T08:37:21Z"],["dc.date.issued","2010"],["dc.description.abstract","To behave properly in an unknown environment, animals or robots must distinguish external from self-generated stimuli on their sensors. The biologically inspired concepts of efference copy and internal model have been successfully applied to a number of robot control problems. Here we present an application of this for our dynamic walking robot RunBot. We use efference copies of the motor commands with a simple forward internal model to predict the expected self-generated acceleration during walking. The difference to the actually measured acceleration is then used to stabilize the walking on terrains with changing slopes through its upper body component controller. As a consequence, the controller drives the upper body component (UBC) to lean forwards/backwards as soon as an error occurs resulting in dynamical stable walking. We have evaluated the performance of the system on four different track configurations. Furthermore we believe that the experimental studies pursued here will sharpen our understanding of how the efference copies influence dynamic locomotion control to the benefit of modern neural control strategies in robots."],["dc.identifier.doi","10.1007/s10514-010-9199-7"],["dc.identifier.isi","000282783600006"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/11196"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18511"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1573-7527"],["dc.relation.issn","0929-5593"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Using efference copy and a forward internal model for adaptive biped walking"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","150"],["dc.bibliographiccitation.journal","Progress in Biophysics and Molecular Biology"],["dc.bibliographiccitation.lastpage","169"],["dc.bibliographiccitation.volume","130"],["dc.contributor.author","Christoph, J."],["dc.contributor.author","Schröder-Schetelig, J."],["dc.contributor.author","Luther, Stefan"],["dc.date.accessioned","2019-02-20T14:58:52Z"],["dc.date.available","2019-02-20T14:58:52Z"],["dc.date.issued","2017"],["dc.description.abstract","Optical mapping is a widely used imaging technique for investigating cardiac electrophysiology in intact, Langendorff-perfused hearts. Mechanical contraction of cardiac tissue, however, may result in severe motion artifacts and significant distortion of the fluorescence signals. Therefore, pharmacological uncoupling is widely used to reduce tissue motion. Recently, various image processing algorithms have been proposed to reduce motion artifacts. We will review these technological developments. Furthermore, we will present a novel approach for the three-dimensional, marker-free reconstruction of contracting Langendorff-perfused intact hearts under physiological conditions. The algorithm allows disentangling the fluorescence signals (e.g. membrane voltage or intracellular calcium) from the mechanical motion (e.g. tissue strain). We will discuss the algorithms reconstruction accuracy, resolution, and robustness using experimental data from Langendorff-perfused rabbit hearts."],["dc.identifier.doi","10.1016/j.pbiomolbio.2017.09.015"],["dc.identifier.pmid","28947080"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/57607"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/189"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | C03: Erholung nach Herzinsuffizienz: Analyse der transmuralen mechano-elektrischen Funktionsstörung"],["dc.relation.issn","0079-6107"],["dc.relation.workinggroup","RG Luther (Biomedical Physics)"],["dc.rights","CC BY-NC-ND 4.0"],["dc.title","Electromechanical optical mapping"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]