Opitz, Lennart

[["dc.bibliographiccitation.firstpage","753"],["dc.bibliographiccitation.issue","5979"],["dc.bibliographiccitation.journal","Science"],["dc.bibliographiccitation.lastpage","756"],["dc.bibliographiccitation.volume","328"],["dc.contributor.author","Peleg, Shahaf"],["dc.contributor.author","Sananbenesi, Farahnaz"],["dc.contributor.author","Zovoilis, Athanasios"],["dc.contributor.author","Burkhardt, Susanne"],["dc.contributor.author","Bahari-Javan, Sanaz"],["dc.contributor.author","Agis-Balboa, Roberto Carlos"],["dc.contributor.author","Cota, Perla"],["dc.contributor.author","Wittnam, Jessica"],["dc.contributor.author","Opitz, Lennart"],["dc.contributor.author","Salinas-Riester, Gabriela"],["dc.contributor.author","Dettenhofer, Markus"],["dc.contributor.author","Kang, Hui"],["dc.contributor.author","Farinelli, Laurent"],["dc.contributor.author","Chen, Wei"],["dc.contributor.author","Fischer, Andre"],["dc.contributor.author","Doering, Aaron"],["dc.date.accessioned","2017-09-07T11:46:04Z"],["dc.date.available","2017-09-07T11:46:04Z"],["dc.date.issued","2010"],["dc.description.abstract","As the human life span increases, the number of people suffering from cognitive decline is rising dramatically. The mechanisms underlying age-associated memory impairment are, however, not understood. Here we show that memory disturbances in the aging brain of the mouse are associated with altered hippocampal chromatin plasticity. During learning, aged mice display a specific deregulation of histone H4 lysine 12 (H4K12) acetylation and fail to initiate a hippocampal gene expression program associated with memory consolidation. Restoration of physiological H4K12 acetylation reinstates the expression of learning-induced genes and leads to the recovery of cognitive abilities. Our data suggest that deregulated H4K12 acetylation may represent an early biomarker of an impaired genome-environment interaction in the aging mouse brain."],["dc.identifier.doi","10.1126/science.1186088"],["dc.identifier.gro","3142928"],["dc.identifier.isi","000277357100040"],["dc.identifier.pmid","20448184"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/386"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","0036-8075"],["dc.title","Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","4071"],["dc.bibliographiccitation.issue","19"],["dc.bibliographiccitation.journal","EMBO Journal"],["dc.bibliographiccitation.lastpage","4083"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","Agis-Balboa, Roberto Carlos"],["dc.contributor.author","Arcos-Diaz, Dario"],["dc.contributor.author","Wittnam, Jessica"],["dc.contributor.author","Govindarajan, Nambirajan"],["dc.contributor.author","Blom, Kim"],["dc.contributor.author","Burkhardt, Susanne"],["dc.contributor.author","Haladyniak, Ulla"],["dc.contributor.author","Agbemenyah, Hope Yao"],["dc.contributor.author","Zovoilis, Athanasios"],["dc.contributor.author","Salinas-Riester, Gabriela"],["dc.contributor.author","Opitz, Lennart"],["dc.contributor.author","Sananbenesi, Farahnaz"],["dc.contributor.author","Fischer, Andre"],["dc.date.accessioned","2017-09-07T11:43:23Z"],["dc.date.available","2017-09-07T11:43:23Z"],["dc.date.issued","2011"],["dc.description.abstract","Extinction learning refers to the phenomenon that a previously learned response to an environmental stimulus, for example, the expression of an aversive behaviour upon exposure to a specific context, is reduced when the stimulus is repeatedly presented in the absence of a previously paired aversive event. Extinction of fear memories has been implicated with the treatment of anxiety disease but the molecular processes that underlie fear extinction are only beginning to emerge. Here, we show that fear extinction initiates upregulation of hippocampal insulin-growth factor 2 (Igf2) and downregulation of insulin-growth factor binding protein 7 (Igfbp7). In line with this observation, we demonstrate that IGF2 facilitates fear extinction, while IGFBP7 impairs fear extinction in an IGF2-dependent manner. Furthermore, we identify one cellular substrate of altered IGF2 signalling during fear extinction. To this end, we show that fear extinctioninduced IGF2/IGFBP7 signalling promotes the survival of 17-19-day-old newborn hippocampal neurons. In conclusion, our data suggest that therapeutic strategies that enhance IGF2 signalling and adult neurogenesis might be suitable to treat disease linked to excessive fear memory."],["dc.identifier.doi","10.1038/emboj.2011.293"],["dc.identifier.gro","3142650"],["dc.identifier.isi","000295967300019"],["dc.identifier.pmid","21873981"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","0261-4189"],["dc.title","A hippocampal insulin-growth factor 2 pathway regulates the extinction of fear memories"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]