Jackson, Daniel John

[["dc.bibliographiccitation.firstpage","408"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Autophagy"],["dc.bibliographiccitation.lastpage","415"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Jackson, Daniel John"],["dc.contributor.author","Woerheide, Gert"],["dc.date.accessioned","2018-11-07T09:43:18Z"],["dc.date.available","2018-11-07T09:43:18Z"],["dc.date.issued","2014"],["dc.identifier.doi","10.4161/auto.27319"],["dc.identifier.isi","000332164400003"],["dc.identifier.pmid","24343243"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/34152"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Landes Bioscience"],["dc.relation.issn","1554-8635"],["dc.relation.issn","1554-8627"],["dc.title","Symbiophagy and biomineralization in the \" living fossil\" Astrosclera willeyana"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1893"],["dc.bibliographiccitation.issue","5833"],["dc.bibliographiccitation.journal","Science"],["dc.bibliographiccitation.lastpage","1895"],["dc.bibliographiccitation.volume","316"],["dc.contributor.author","Jackson, Daniel John"],["dc.contributor.author","Macis, Luciana"],["dc.contributor.author","Reitner, Joachim"],["dc.contributor.author","Degnan, Bernard M."],["dc.contributor.author","Wörheide, Gert"],["dc.date.accessioned","2018-11-07T11:01:22Z"],["dc.date.available","2018-11-07T11:01:22Z"],["dc.date.issued","2007"],["dc.description.abstract","Sponges (phylum Porifera) were prolific reef-building organisms during the Paleozoic and Mesozoic similar to 542 to 65 million years ago. These ancient animals inherited components of the first multicellular skeletogenic toolkit from the last common ancestor of the Metazoa. Using a paleogenomics approach, including gene- and protein-expression techniques and phylogenetic reconstruction, we show that a molecular component of this toolkit was the precursor to the alpha-carbonic anhydrases (alpha-CAs), a gene family used by extant animals in a variety of fundamental physiological processes. We used the coralline demosponge Astrosclera willeyana, a \"living fossil\" that has survived from the Mesozoic, to provide insight into the evolution of the ability to biocalcify, and show that the alpha-CA family expanded from a single ancestral gene through several independent gene- duplication events in sponges and eumetazoans."],["dc.identifier.doi","10.1126/science.1141560"],["dc.identifier.isi","000247602700038"],["dc.identifier.pmid","17540861"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/51136"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","0036-8075"],["dc.title","Sponge paleogenomics reveals an ancient role for carbonic anhydrase in skeletogenesis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e0140100"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","PLoS One"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Germer, Juliane"],["dc.contributor.author","Mann, Karlheinz"],["dc.contributor.author","Wörheide, Gert"],["dc.contributor.author","Jackson, Daniel John"],["dc.date.accessioned","2018-11-07T09:49:05Z"],["dc.date.available","2018-11-07T09:49:05Z"],["dc.date.issued","2015"],["dc.description.abstract","The ability to construct a mineralized skeleton was a major innovation for the Metazoa during their evolution in the late Precambrian/early Cambrian. Porifera (sponges) hold an informative position for efforts aimed at unraveling the origins of this ability because they are widely regarded to be the earliest branching metazoans, and are among the first multi-cellular animals to display the ability to biomineralize in the fossil record. Very few biomineralization associated proteins have been identified in sponges so far, with no transcriptome or proteome scale surveys yet available. In order to understand what genetic repertoire may have been present in the last common ancestor of the Metazoa (LCAM), and that may have contributed to the evolution of the ability to biocalcify, we have studied the skeletal proteome of the coralline demosponge Vaceletia sp. and compare this to other metazoan biomineralizing proteomes. We bring some spatial resolution to this analysis by dividing Vaceletia's aragonitic calcium carbonate skeleton into \"head\" and \"stalk\" regions. With our approach we were able to identify 40 proteins from both the head and stalk regions, with many of these sharing some similarity to previously identified gene products from other organisms. Among these proteins are known biomineralization compounds, such as carbonic anhydrase, spherulin, extracellular matrix proteins and very acidic proteins. This report provides the first proteome scale analysis of a calcified poriferan skeletal proteome, and its composition clearly demonstrates that the LCAM contributed several key enzymes and matrix proteins to its descendants that supported the metazoan ability to biocalcify. However, lineage specific evolution is also likely to have contributed significantly to the ability of disparate metazoan lineages to biocalcify."],["dc.description.sponsorship","Open-Access Publikationsfonds 2015"],["dc.identifier.doi","10.1371/journal.pone.0140100"],["dc.identifier.isi","000364298400016"],["dc.identifier.pmid","26536128"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/12559"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35436"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","1932-6203"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0/"],["dc.title","The Skeleton Forming Proteome of an Early Branching Metazoan: A Molecular Survey of the Biomineralization Components Employed by the Coralline Sponge Vaceletia Sp."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1983"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Molecular Biology and Evolution"],["dc.bibliographiccitation.lastpage","1987"],["dc.bibliographiccitation.volume","27"],["dc.contributor.author","Pick, Kerstin"],["dc.contributor.author","Philippe, Herve"],["dc.contributor.author","Schreiber, F."],["dc.contributor.author","Erpenbeck, D."],["dc.contributor.author","Jackson, Daniel John"],["dc.contributor.author","Wrede, P."],["dc.contributor.author","Wiens, M."],["dc.contributor.author","Alie, A."],["dc.contributor.author","Morgenstern, Burkhard"],["dc.contributor.author","Manuel, Michael"],["dc.contributor.author","Woerheide, Gert"],["dc.date.accessioned","2018-11-07T08:39:58Z"],["dc.date.available","2018-11-07T08:39:58Z"],["dc.date.issued","2010"],["dc.description.abstract","Despite expanding data sets and advances in phylogenomic methods, deep-level metazoan relationships remain highly controversial. Recent phylogenomic analyses depart from classical concepts in recovering ctenophores as the earliest branching metazoan taxon and propose a sister-group relationship between sponges and cnidarians (e.g., Dunn CW, Hejnol A, Matus DQ, et al. (18 co-authors). 2008. Broad phylogenomic sampling improves resolution of the animal tree of life. Nature 452:745-749). Here, we argue that these results are artifacts stemming from insufficient taxon sampling and long-branch attraction (LBA). By increasing taxon sampling from previously unsampled nonbilaterians and using an identical gene set to that reported by Dunn et al., we recover monophyletic Porifera as the sister group to all other Metazoa. This suggests that the basal position of the fast-evolving Ctenophora proposed by Dunn et al. was due to LBA and that broad taxon sampling is of fundamental importance to metazoan phylogenomic analyses. Additionally, saturation in the Dunn et al. character set is comparatively high, possibly contributing to the poor support for some nonbilaterian nodes."],["dc.identifier.doi","10.1093/molbev/msq089"],["dc.identifier.isi","000281184100002"],["dc.identifier.pmid","20378579"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19123"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.relation.issn","1537-1719"],["dc.relation.issn","0737-4038"],["dc.title","Improved Phylogenomic Taxon Sampling Noticeably Affects Nonbilaterian Relationships"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1403"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Bioorganic & Medicinal Chemistry"],["dc.bibliographiccitation.lastpage","1410"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Ohradanova, Anna"],["dc.contributor.author","Vullo, Daniela"],["dc.contributor.author","Pastorekova, Silvia"],["dc.contributor.author","Pastorek, Jaromir"],["dc.contributor.author","Jackson, Daniel John"],["dc.contributor.author","Woerheide, Gert"],["dc.contributor.author","Supuran, Claudiu T."],["dc.date.accessioned","2018-11-07T09:13:26Z"],["dc.date.available","2018-11-07T09:13:26Z"],["dc.date.issued","2012"],["dc.description.abstract","The alpha-carbonic anhydrase (CA, EC 4.2.1.1) Astrosclerin-3 previously isolated from the living fossil sponge Astrosclera willeyana (Jackson et al., Science 2007, 316, 1893), was cloned, kinetically characterized and investigated for its inhibition properties with sulfonamides and sulfamates. Astrosclerin-3 has a high catalytic activity for the CO2 hydration reaction to bicarbonate and protons (k(cat) of 9.0 x 10(5) s (1) and k(cat)/K-m of 1.1 x 10(8) M (1) x s (1)), and is inhibited by various aromatic/heterocyclic sulfonamides and sulfamates with inhibition constants in the range of 2.9 nM-8.85 mu M. Astrosclerin, and the human isoform CA II, display similar kinetic properties and affinities for sulfonamide inhibitors, despite more than 550 million years of independent evolution. Because Astrosclerin-3 is involved in biocalcification, the inhibitors characterized here may be used to gain insights into such processes in other metazoans. (C) 2012 Elsevier Ltd. All rights reserved."],["dc.identifier.doi","10.1016/j.bmc.2012.01.007"],["dc.identifier.isi","000300391200005"],["dc.identifier.pmid","22285172"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/27175"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Pergamon-elsevier Science Ltd"],["dc.relation.issn","0968-0896"],["dc.title","Cloning, characterization and sulfonamide inhibition studies of an alpha-carbonic anhydrase from the living fossil sponge Astrosclera willeyana"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.issue","160"],["dc.bibliographiccitation.journal","BMC evolutionary biology"],["dc.bibliographiccitation.lastpage","17"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Jackson, Daniel J."],["dc.contributor.author","Wörheide, Gert"],["dc.contributor.author","Degnan, Bernard M."],["dc.date.accessioned","2019-07-10T08:13:01Z"],["dc.date.available","2019-07-10T08:13:01Z"],["dc.date.issued","2007"],["dc.description.abstract","Background: The Mollusca constitute one of the most morphologically and ecologically diverse metazoan phyla, occupying a wide range of marine, terrestrial and freshwater habitats. The evolutionary success of the molluscs can in part be attributed to the evolvability of the external shell. Typically, the shell first forms during embryonic and larval development, changing dramatically in shape, colour and mineralogical composition as development and maturation proceeds. Major developmental transitions in shell morphology often correlate with ecological transitions (e.g. from a planktonic to benthic existence at metamorphosis). While the genes involved in molluscan biomineralisation are beginning to be identified, there is little understanding of how these are developmentally regulated, or if the same genes are operational at different stages of the mollusc's life. Results: Here we relate the developmental expression of nine genes in the tissue responsible for shell production the mantle to ecological transitions that occur during the lifetime of the tropical abalone Haliotis asinina (Vetigastropoda). Four of these genes encode evolutionarily ancient proteins, while four others encode secreted proteins with little or no identity to known proteins. Another gene has been previously described from the mantle of another haliotid vetigastropod. All nine genes display dynamic spatial and temporal expression profiles within the larval shell field and juvenile mantle. Conclusion: These expression data reflect the regulatory complexity that underlies molluscan shell construction from larval stages to adulthood, and serves to highlight the different ecological demands placed on each stage. The use of both ancient and novel genes in all stages of shell construction also suggest that a core set of shell-making genes was provided by a shared metazoan ancestor, which has been elaborated upon to produce the range of molluscan shell types we see today."],["dc.format.mimetype","application/pdf"],["dc.identifier.ppn","55980959X"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/4371"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/61101"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.rights","Goescholar"],["dc.rights.access","openAccess"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.ddc","576"],["dc.title","Dynamic expression of ancient and novel molluscan shell genes during ecological transitions"],["dc.title.alternative","Research article"],["dc.title.subtitle","Research article"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1314"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Bioorganic & Medicinal Chemistry Letters"],["dc.bibliographiccitation.lastpage","1316"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Ohradanova, Anna"],["dc.contributor.author","Vullo, Daniela"],["dc.contributor.author","Pastorekova, Silvia"],["dc.contributor.author","Pastorek, Jaromir"],["dc.contributor.author","Jackson, Daniel John"],["dc.contributor.author","Woerheide, Gert"],["dc.contributor.author","Supuran, Claudiu T."],["dc.date.accessioned","2018-11-07T09:13:45Z"],["dc.date.available","2018-11-07T09:13:45Z"],["dc.date.issued","2012"],["dc.description.abstract","An alpha-carbonic anhydrase (CA, EC 4.2.1.1) isolated from the living fossil sponge Astrosclera willeyana, Astrosclerin, was investigated for its inhibition profile with simple inorganic anions, complex anions and other small molecules known to interact with these zinc enzymes. Astrosclerin is a catalytically highly efficient enzyme, and is inhibited in the low micromolar range by sulfamide, sulfamic acid, phenylboronic acid and phenylarsonic acid, and in the submillimolar range by a variety of anions including fluoride, chloride, cyanate, thiocyanate, cyanide, hydrogen sulfide, bisulfate, stannate, perosmate, divana-date, perrhenate, perruthenate, selenocyanide, trithiocarbonate, diethyldithiocarbamate and iminodisulfonate. Less efficient Astrosclerin inhibitors were sulfate, bromide, iodide, azide, bicarbonate, carbonate, tetraborate and perchlorate (K(I)s of 5.11-30.6 mM) whereas tetrafluoroborate was not at all inhibitory. Because Astrosclerin is involved in calcification processes in vivo, its anion inhibition profile may be important for future studies designed to shed light on the physiologic functions of alpha-CAs in marine organisms. (C) 2011 Elsevier Ltd. All rights reserved."],["dc.identifier.doi","10.1016/j.bmcl.2011.12.085"],["dc.identifier.isi","000300404200003"],["dc.identifier.pmid","22227210"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/27242"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Pergamon-elsevier Science Ltd"],["dc.relation.issn","0960-894X"],["dc.title","Anion inhibition studies of an alpha-carbonic anhydrase from the living fossil Astrosclera willeyana"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","238"],["dc.bibliographiccitation.journal","BMC Evolutionary Biology"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Jackson, Daniel John"],["dc.contributor.author","Macis, Luciana"],["dc.contributor.author","Reitner, Joachim"],["dc.contributor.author","Wörheide, Gert"],["dc.date.accessioned","2018-11-07T08:53:15Z"],["dc.date.available","2018-11-07T08:53:15Z"],["dc.date.issued","2011"],["dc.description.abstract","Background: The synchronous and widespread adoption of the ability to biomineralize was a defining event for metazoan evolution during the late Precambrian/early Cambrian 545 million years ago. However our understanding on the molecular level of how animals first evolved this capacity is poor. Because sponges are the earliest branching phylum of biomineralizing metazoans, we have been studying how biocalcification occurs in the coralline demosponge Astrosclera willeyana. Results: We have isolated and characterized a novel protein directly from the calcified spherulites of A. willeyana. Using three independent lines of evidence (genomic architecture of the gene in A. willeyana, spatial expression of the gene product in A. willeyana and genomic architecture of the gene in the related demosponge Amphimedon queenslandica), we show that the gene that encodes this protein was horizontally acquired from a bacterium, and is now highly and exclusively expressed in spherulite forming cells. Conclusions: Our findings highlight the ancient and close association that exists between sponges and bacteria, and provide support for the notion that horizontal gene transfer may have been an important mechanism that supported the evolution of this early metazoan biomineralisation strategy."],["dc.identifier.doi","10.1186/1471-2148-11-238"],["dc.identifier.isi","000294423500001"],["dc.identifier.pmid","21838889"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6875"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22364"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","1471-2148"],["dc.rights","CC BY 2.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.0"],["dc.title","A horizontal gene transfer supported the evolution of an early metazoan biomineralization strategy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","706"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Current Biology"],["dc.bibliographiccitation.lastpage","712"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Philippe, Herve"],["dc.contributor.author","Derelle, Romain"],["dc.contributor.author","Lopez, Philippe"],["dc.contributor.author","Pick, Kerstin"],["dc.contributor.author","Borchiellini, Carole"],["dc.contributor.author","Boury-Esnault, Nicole"],["dc.contributor.author","Vacelet, Jean"],["dc.contributor.author","Renard, Emmanuelle"],["dc.contributor.author","Houliston, Evelyn"],["dc.contributor.author","Queinnec, Eric"],["dc.contributor.author","Da Silva, Corinne"],["dc.contributor.author","Wincker, Patrick"],["dc.contributor.author","Le Guyader, Herve"],["dc.contributor.author","Leys, Sally"],["dc.contributor.author","Jackson, Daniel John"],["dc.contributor.author","Schreiber, Fabian"],["dc.contributor.author","Erpenbeck, Dirk"],["dc.contributor.author","Morgenstern, Burkhard"],["dc.contributor.author","Woerheide, Gert"],["dc.contributor.author","Manuel, Michael"],["dc.date.accessioned","2018-11-07T08:30:40Z"],["dc.date.available","2018-11-07T08:30:40Z"],["dc.date.issued","2009"],["dc.description.abstract","The origin of many of the defining features of animal body plans, such as symmetry, nervous system, and the mesoderm, remains shrouded in mystery because of major uncertainty regarding the emergence order of the early branching taxa: the sponge groups, ctenophores, placozoans, cnidarians, and bilaterians. The \"phylogenomic\" approach [1] has recently provided a robust picture for intrabilaterian relationships [2, 3] but not yet for more early branching metazoan clades. We have assembled a comprehensive 128 gene data set including newly generated sequence data from ctenophores, cnidarians, and all four main sponge groups. The resulting phylogeny yields two significant conclusions reviving old views that have been challenged in the molecular era: (1) that the sponges (Porifera) are monophyletic and not paraphyletic as repeatedly proposed [4-9], thus undermining the idea that ancestral metazoans had a sponge-like body plan; (2) that the most likely position for the ctenophores is together with the cnidarians in a \"coelenterate\" clade. The Porifera and the Placozoa branch basally with respect to a moderately supported \"eumetazoan\" clade containing the three taxa with nervous system and muscle cells (Cnidaria, Ctenophora, and Bilateria). This new phylogeny provides a stimulating framework for exploring the important changes that shaped the body plans of the early diverging phyla."],["dc.identifier.doi","10.1016/j.cub.2009.02.052"],["dc.identifier.isi","000265718300035"],["dc.identifier.pmid","19345102"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/16944"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Cell Press"],["dc.relation.issn","1879-0445"],["dc.relation.issn","0960-9822"],["dc.title","Phylogenomics Revives Traditional Views on Deep Animal Relationships"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","40"],["dc.bibliographiccitation.journal","BMC Biology"],["dc.bibliographiccitation.volume","4"],["dc.contributor.author","Jackson, Daniel John"],["dc.contributor.author","McDougall, Carmel"],["dc.contributor.author","Green, Kathryn"],["dc.contributor.author","Simpson, Fiona"],["dc.contributor.author","Woerheide, Gert"],["dc.contributor.author","Degnan, Bernard M."],["dc.date.accessioned","2018-11-07T08:57:07Z"],["dc.date.available","2018-11-07T08:57:07Z"],["dc.date.issued","2006"],["dc.description.abstract","Background: Instructions to fabricate mineralized structures with distinct nanoscale architectures, such as seashells and coral and vertebrate skeletons, are encoded in the genomes of a wide variety of animals. In mollusks, the mantle is responsible for the extracellular production of the shell, directing the ordered biomineralization of CaCO3 and the deposition of architectural and color patterns. The evolutionary origins of the ability to synthesize calcified structures across various metazoan taxa remain obscure, with only a small number of protein families identified from molluskan shells. The recent sequencing of a wide range of metazoan genomes coupled with the analysis of gene expression in non-model animals has allowed us to investigate the evolution and process of biomineralization in gastropod mollusks. Results: Here we show that over 25% of the genes expressed in the mantle of the vetigastropod Haliotis asinina encode secreted proteins, indicating that hundreds of proteins are likely to be contributing to shell fabrication and patterning. Almost 85% of the secretome encodes novel proteins; remarkably, only 19% of these have identifiable homologues in the full genome of the patellogastropod Lottia scutum. The spatial expression profiles of mantle genes that belong to the secretome is restricted to discrete mantle zones, with each zone responsible for the fabrication of one of the structural layers of the shell. Patterned expression of a subset of genes along the length of the mantle is indicative of roles in shell ornamentation. For example, Has-sometsuke maps precisely to pigmentation patterns in the shell, providing the first case of a gene product to be involved in molluskan shell pigmentation. We also describe the expression of two novel genes involved in nacre (mother of pearl) deposition. Conclusion: The unexpected complexity and evolvability of this secretome and the modular design of the molluskan mantle enables diversification of shell strength and design, and as such must contribute to the variety of adaptive architectures and colors found in mollusk shells. The composition of this novel mantle-specific secretome suggests that there are significant molecular differences in the ways in which gastropods synthesize their shells."],["dc.identifier.doi","10.1186/1741-7007-4-40"],["dc.identifier.isi","000243654800001"],["dc.identifier.pmid","17121673"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?goescholar/2204"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23313"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1741-7007"],["dc.relation.orgunit","Fakultät für Geowissenschaften und Geographie"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","A rapidly evolving secretome builds and patterns a sea shell"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]