Bao, Guobin

[["dc.bibliographiccitation.firstpage","2985"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","European Journal of Neuroscience"],["dc.bibliographiccitation.lastpage","2995"],["dc.bibliographiccitation.volume","42"],["dc.contributor.author","Bao, Guobin"],["dc.contributor.author","de Jong, Danielle"],["dc.contributor.author","Alevra, Mihai"],["dc.contributor.author","Schild, Detlev"],["dc.date.accessioned","2018-11-07T09:48:00Z"],["dc.date.available","2018-11-07T09:48:00Z"],["dc.date.issued","2015"],["dc.description.abstract","Olfactory receptor neurons (ORNs) have high-voltage-gated Ca2+ channels whose physiological impact has remained enigmatic since the voltage-gated conductances in this cell type were first described in the 1980s. Here we show that in ORN somata of Xenopus laevis tadpoles these channels are clustered and co-expressed with large-conductance potassium (BK) channels. We found approximately five clusters per ORN and twelve Ca2+ channels per cluster. The action potential-triggered activation of BK channels accelerates the repolarization of action potentials and shortens interspike intervals during odour responses. This increases the sensitivity of individual ORNs to odorants. At the level of mitral cells of the olfactory bulb, odour qualities have been shown to be coded by first-spike-latency patterns. The system of Ca2+ and BK channels in ORNs appears to be important for correct odour coding because the blockage of BK channels not only affects ORN spiking patterns but also changes the latency pattern representation of odours in the olfactory bulb."],["dc.identifier.doi","10.1111/ejn.13095"],["dc.identifier.isi","000368243100011"],["dc.identifier.pmid","26452167"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35218"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1460-9568"],["dc.relation.issn","0953-816X"],["dc.title","Ca2+-BK channel clusters in olfactory receptor neurons and their role in odour coding"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e90500"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","PLoS ONE"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Bao, Guobin"],["dc.contributor.author","Schild, Detlev"],["dc.date.accessioned","2018-11-07T09:42:40Z"],["dc.date.available","2018-11-07T09:42:40Z"],["dc.date.issued","2014"],["dc.description.abstract","The parameters of experimentally obtained exponentials are usually found by least-squares fitting methods. Essentially, this is done by minimizing the mean squares sum of the differences between the data, most often a function of time, and a parameter-defined model function. Here we delineate a novel method where the noisy data are represented and analyzed in the space of Legendre polynomials. This is advantageous in several respects. First, parameter retrieval in the Legendre domain is typically two orders of magnitude faster than direct fitting in the time domain. Second, data fitting in a low-dimensional Legendre space yields estimates for amplitudes and time constants which are, on the average, more precise compared to least-squares-fitting with equal weights in the time domain. Third, the Legendre analysis of two exponentials gives satisfactory estimates in parameter ranges where least-squares-fitting in the time domain typically fails. Finally, filtering exponentials in the domain of Legendre polynomials leads to marked noise removal without the phase shift characteristic for conventional lowpass filters."],["dc.identifier.doi","10.1371/journal.pone.0090500"],["dc.identifier.isi","000332483600058"],["dc.identifier.pmid","24603904"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10017"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/34009"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Public Library Science"],["dc.relation.issn","1932-6203"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Fast and Accurate Fitting and Filtering of Noisy Exponentials in Legendre Space"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Nature Communications"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Zafeiriou, Maria-Patapia"],["dc.contributor.author","Bao, Guobin"],["dc.contributor.author","Hudson, James"],["dc.contributor.author","Halder, Rashi"],["dc.contributor.author","Blenkle, Alica"],["dc.contributor.author","Schreiber, Marie-Kristin"],["dc.contributor.author","Fischer, Andre"],["dc.contributor.author","Schild, Detlev"],["dc.contributor.author","Zimmermann, Wolfram-Hubertus"],["dc.date.accessioned","2021-04-14T08:24:29Z"],["dc.date.available","2021-04-14T08:24:29Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1038/s41467-020-17521-w"],["dc.identifier.pmid","32728089"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17472"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81301"],["dc.identifier.url","https://mbexc.uni-goettingen.de/literature/publications/66"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/365"],["dc.identifier.url","https://sfb1286.uni-goettingen.de/literature/publications/57"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.notes.intern","Merged from goescholar"],["dc.relation","EXC 2067: Multiscale Bioimaging"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | C04: Fibroblasten-Kardiomyozyten Interaktion im gesunden und erkrankten Herzen: Mechanismen und therapeutische Interventionen bei Kardiofibroblastopathien"],["dc.relation","SFB 1002 | D04: Bedeutung der Methylierung von RNA (m6A) und des Histons H3 (H3K4) in der Herzinsuffizienz"],["dc.relation","SFB 1002 | S01: In vivo und in vitro Krankheitsmodelle"],["dc.relation","SFB 1286: Quantitative Synaptologie"],["dc.relation","SFB 1286 | B06: Die Rolle von RNA in Synapsenphysiologie und Neurodegeneration"],["dc.relation.eissn","2041-1723"],["dc.relation.workinggroup","RG A. Fischer (Epigenetics and Systems Medicine in Neurodegenerative Diseases)"],["dc.relation.workinggroup","RG Zafeiriou (3D Electrically Excitable Cell Networks – Brain and Heart)"],["dc.relation.workinggroup","RG Zimmermann (Engineered Human Myocardium)"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Developmental GABA polarity switch and neuronal plasticity in Bioengineered Neuronal Organoids"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Chemical Senses"],["dc.bibliographiccitation.volume","40"],["dc.contributor.author","Bao, Guobin"],["dc.contributor.author","de Jong, Danille"],["dc.contributor.author","Alevra, Mihai"],["dc.contributor.author","Schild, Detlev"],["dc.date.accessioned","2018-11-07T10:00:24Z"],["dc.date.available","2018-11-07T10:00:24Z"],["dc.date.issued","2015"],["dc.format.extent","233"],["dc.identifier.isi","000351015600070"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37796"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.publisher.place","Oxford"],["dc.relation.eventlocation","Dijon, FRANCE"],["dc.relation.issn","1464-3553"],["dc.relation.issn","0379-864X"],["dc.title","Ca2+/BK channel clusters in olfactory neurons and odor coding"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]