Erpenbeck, Luise

[["dc.bibliographiccitation.firstpage","E54"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Experimental Dermatology"],["dc.bibliographiccitation.lastpage","E55"],["dc.bibliographiccitation.volume","26"],["dc.contributor.author","Senger-Sander, S. N."],["dc.contributor.author","Grandke, J."],["dc.contributor.author","Neubert, E."],["dc.contributor.author","Erdelt, S."],["dc.contributor.author","Manzke, V. S."],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Erpenbeck, Luise"],["dc.date.accessioned","2018-11-07T10:26:27Z"],["dc.date.available","2018-11-07T10:26:27Z"],["dc.date.issued","2017"],["dc.identifier.isi","000397284200129"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43048"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Wiley"],["dc.publisher.place","Hoboken"],["dc.relation.conference","44th Annual Meeting of the Arbeitsgemeinschaft-Dermatologische-Forschung (ADF)"],["dc.relation.eventlocation","Gottingen, GERMANY"],["dc.relation.issn","1600-0625"],["dc.relation.issn","0906-6705"],["dc.title","In vitro formation of neutrophil extracellular traps (NETs) is inhibited by the presence of serum and serum albumin in culture media"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","121"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Experimental Dermatology"],["dc.bibliographiccitation.lastpage","128"],["dc.bibliographiccitation.volume","28"],["dc.contributor.author","Priebe, Marie K."],["dc.contributor.author","Dewert, Nadin"],["dc.contributor.author","Amschler, Katharina"],["dc.contributor.author","Erpenbeck, Luise"],["dc.contributor.author","Heinzerling, Lucie"],["dc.contributor.author","Schön, Michael P."],["dc.contributor.author","Seitz, Cornelia S."],["dc.contributor.author","Lorenz, Verena N."],["dc.date.accessioned","2020-12-10T18:28:40Z"],["dc.date.available","2020-12-10T18:28:40Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1111/exd.13848"],["dc.identifier.issn","0906-6705"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/76375"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","c-Rel is a cell cycle modulator in human melanoma cells"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","528"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Molecular Cancer Research"],["dc.bibliographiccitation.lastpage","542"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Amschler, Katharina"],["dc.contributor.author","Kossmann, Eugen"],["dc.contributor.author","Erpenbeck, Luise"],["dc.contributor.author","Kruss, Sebastian"],["dc.contributor.author","Schill, Tillmann"],["dc.contributor.author","Schön, Margarete"],["dc.contributor.author","Möckel, Sigrid M.C."],["dc.contributor.author","Spatz, Joachim P."],["dc.contributor.author","Schön, Michael P."],["dc.date.accessioned","2020-12-10T18:37:47Z"],["dc.date.available","2020-12-10T18:37:47Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1158/1541-7786.MCR-17-0272"],["dc.identifier.eissn","1557-3125"],["dc.identifier.issn","1541-7786"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77091"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Nanoscale Tuning of VCAM-1 Determines VLA-4–Dependent Melanoma Cell Plasticity on RGD Motifs"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","795"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Journal der Deutschen Dermatologischen Gesellschaft"],["dc.bibliographiccitation.lastpage","807"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Schön, Michael P."],["dc.contributor.author","Berking, Carola"],["dc.contributor.author","Biedermann, Tilo"],["dc.contributor.author","Buhl, Timo"],["dc.contributor.author","Erpenbeck, Luise"],["dc.contributor.author","Eyerich, Kilian"],["dc.contributor.author","Eyerich, Stefanie"],["dc.contributor.author","Ghoreschi, Kamran"],["dc.contributor.author","Goebeler, Matthias"],["dc.contributor.author","Ludwig, Ralf J."],["dc.contributor.author","Schäkel, Knut"],["dc.contributor.author","Schilling, Bastian"],["dc.contributor.author","Schlapbach, Christoph"],["dc.contributor.author","Stary, Georg"],["dc.contributor.author","Stebut, Esther"],["dc.contributor.author","Steinbrink, Kerstin"],["dc.date.accessioned","2021-04-14T08:24:09Z"],["dc.date.available","2021-04-14T08:24:09Z"],["dc.date.issued","2020"],["dc.description.abstract","Summary The COVID‐19 pandemic caused by SARS‐CoV‐2 has far‐reaching direct and indirect medical consequences. These include both the course and treatment of diseases. It is becoming increasingly clear that infections with SARS‐CoV‐2 can cause considerable immunological alterations, which particularly also affect pathogenetically and/or therapeutically relevant factors. Against this background we summarize here the current state of knowledge on the interaction of SARS‐CoV‐2/COVID‐19 with mediators of the acute phase of inflammation (TNF, IL‐1, IL‐6), type 1 and type 17 immune responses (IL‐12, IL‐23, IL‐17, IL‐36), type 2 immune reactions (IL‐4, IL‐13, IL‐5, IL‐31, IgE), B‐cell immunity, checkpoint regulators (PD‐1, PD‐L1, CTLA4), and orally druggable signaling pathways (JAK, PDE4, calcineurin). In addition, we discuss in this context non‐specific immune modulation by glucocorticosteroids, methotrexate, antimalarial drugs, azathioprine, dapsone, mycophenolate mofetil and fumaric acid esters, as well as neutrophil granulocyte‐mediated innate immune mechanisms. From these recent findings we derive possible implications for the therapeutic modulation of said immunological mechanisms in connection with SARS‐CoV‐2/COVID‐19. Although, of course, the greatest care should be taken with patients with immunologically mediated diseases or immunomodulating therapies, it appears that many treatments can also be carried out during the COVID‐19 pandemic; some even appear to alleviate COVID‐19."],["dc.identifier.doi","10.1111/ddg.14169"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81179"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1610-0387"],["dc.relation.issn","1610-0379"],["dc.rights","This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes."],["dc.title","COVID‐19 and immunological regulations – from basic and translational aspects to clinical implications"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Experimental Dermatology"],["dc.bibliographiccitation.volume","23"],["dc.contributor.author","Erpenbeck, Luise"],["dc.contributor.author","Kruss, Sebastian"],["dc.contributor.author","Amschler, Katharina"],["dc.contributor.author","Spear, Stephen F."],["dc.contributor.author","Schoen, Michael Peter"],["dc.date.accessioned","2018-11-07T09:43:01Z"],["dc.date.available","2018-11-07T09:43:01Z"],["dc.date.issued","2014"],["dc.format.extent","E11"],["dc.identifier.isi","000332335500079"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/34086"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.conference","41st Annual Meeting of the Arbeitsgemeinschaft-Dermatologische-Forschung (ADF)"],["dc.relation.eventlocation","Cologne, GERMANY"],["dc.relation.issn","1600-0625"],["dc.relation.issn","0906-6705"],["dc.title","Adhesion maturation of neutrophils on nanoscopically presented integrin ligands"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Experimental Dermatology"],["dc.bibliographiccitation.volume","23"],["dc.contributor.author","Amschler, Katharina"],["dc.contributor.author","Kossmann, E."],["dc.contributor.author","Erpenbeck, Luise"],["dc.contributor.author","Spear, Stephen F."],["dc.contributor.author","Kruss, Sebastian"],["dc.contributor.author","Schoen, Michael Peter"],["dc.date.accessioned","2018-11-07T09:43:00Z"],["dc.date.available","2018-11-07T09:43:00Z"],["dc.date.issued","2014"],["dc.format.extent","E46"],["dc.identifier.isi","000332335500287"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/34084"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.conference","41st Annual Meeting of the Arbeitsgemeinschaft-Dermatologische-Forschung (ADF)"],["dc.relation.eventlocation","Cologne, GERMANY"],["dc.relation.issn","1600-0625"],["dc.relation.issn","0906-6705"],["dc.title","Melanoma cell function regulated by VCAM-1 presented on tunable nano-structured surfaces"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","857"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Thrombosis and Haemostasis"],["dc.bibliographiccitation.lastpage","859"],["dc.bibliographiccitation.volume","103"],["dc.contributor.author","Erpenbeck, Luise"],["dc.contributor.author","Rubant, Simone"],["dc.contributor.author","Hardt, Katja"],["dc.contributor.author","Santoso, Sentot"],["dc.contributor.author","Boehncke, Wolf-Henning"],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Ludwig, Ralf J."],["dc.date.accessioned","2018-11-07T08:44:57Z"],["dc.date.available","2018-11-07T08:44:57Z"],["dc.date.issued","2010"],["dc.identifier.doi","10.1160/TH09-08-0572"],["dc.identifier.isi","000277031700025"],["dc.identifier.pmid","20135068"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20316"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Schattauer Gmbh-verlag Medizin Naturwissenschaften"],["dc.relation.issn","0340-6245"],["dc.title","Constitutive and functionally relevant expression of JAM-C on platelets"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","576"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Investigative Dermatology"],["dc.bibliographiccitation.lastpage","586"],["dc.bibliographiccitation.volume","130"],["dc.contributor.author","Erpenbeck, Luise"],["dc.contributor.author","Nieswandt, Bernhard"],["dc.contributor.author","Schoen, Margarete"],["dc.contributor.author","Pozgajova, Miroslava"],["dc.contributor.author","Schoen, Michael Peter"],["dc.date.accessioned","2018-11-07T08:46:21Z"],["dc.date.available","2018-11-07T08:46:21Z"],["dc.date.issued","2010"],["dc.description.abstract","Platelet glycoprotein Iba (GPIb alpha) is part of the receptor complex GPIb-V-IX, which has a critical role in hemostasis, especially through interactions with the subendothelial von Willebrand factor. As there is accumulating evidence for a contribution of platelet receptors to hematogenous tumor metastasis, GPIba is an interesting molecule to study in this context. We have investigated the effect of GPIba inhibition by monovalent Fab fragments on experimental pulmonary metastasis in a syngeneic mouse model using C57BL/6 mice and B16F10 melanoma cells. The early fate of green fluorescent protein (GFP)-transfected melanoma cells under GPIba blockade was also assessed, as was the effect of GPIba inhibition on pulmonary metastasis in mice lacking P-selectin. Surprisingly and, to our knowledge previously unreported, GPIba inhibition led to a significant increase in pulmonary metastasis, and assessment of the early fate of circulating GFP-labeled B16F10 showed improved survival and pulmonary arrest of tumor cells shortly after GPIba inhibition, indicating that inhibition of a platelet protein can, in some cases, promote metastasis of a malignant tumor. In contrast, GPIba blockade in P-selectin-deficient mice had no enhancing effect on metastasis, suggesting the involvement of GPIba in the initial, P-selectin-dependent steps of metastasis. These findings suggest that GPIba contributes to the control of tumor metastasis, in addition to its role in hemostasis."],["dc.identifier.doi","10.1038/jid.2009.278"],["dc.identifier.isi","000273841300034"],["dc.identifier.pmid","19727118"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20670"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","0022-202X"],["dc.title","Inhibition of Platelet GPIb alpha and Promotion of Melanoma Metastasis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","12"],["dc.bibliographiccitation.journal","Frontiers in Immunology"],["dc.bibliographiccitation.volume","10"],["dc.contributor.affiliation","Neubert, Elsa; 1Department of Dermatology, Venereology and Allergology, University Medical Center Göttingen, Göttingen, Germany"],["dc.contributor.affiliation","Senger-Sander, Susanne N.; 1Department of Dermatology, Venereology and Allergology, University Medical Center Göttingen, Göttingen, Germany"],["dc.contributor.affiliation","Manzke, Veit S.; 1Department of Dermatology, Venereology and Allergology, University Medical Center Göttingen, Göttingen, Germany"],["dc.contributor.affiliation","Busse, Julia; 1Department of Dermatology, Venereology and Allergology, University Medical Center Göttingen, Göttingen, Germany"],["dc.contributor.affiliation","Polo, Elena; 2Institute of Physical Chemistry, University of Göttingen, Göttingen, Germany"],["dc.contributor.affiliation","Scheidmann, Sophie E. F.; 1Department of Dermatology, Venereology and Allergology, University Medical Center Göttingen, Göttingen, Germany"],["dc.contributor.affiliation","Schön, Michael P.; 1Department of Dermatology, Venereology and Allergology, University Medical Center Göttingen, Göttingen, Germany"],["dc.contributor.affiliation","Kruss, Sebastian; 2Institute of Physical Chemistry, University of Göttingen, Göttingen, Germany"],["dc.contributor.affiliation","Erpenbeck, Luise; 1Department of Dermatology, Venereology and Allergology, University Medical Center Göttingen, Göttingen, Germany"],["dc.contributor.author","Neubert, Elsa"],["dc.contributor.author","Senger-Sander, Susanne N."],["dc.contributor.author","Manzke, Veit S."],["dc.contributor.author","Busse, Julia"],["dc.contributor.author","Polo, Elena"],["dc.contributor.author","Scheidmann, Sophie E. F."],["dc.contributor.author","Schön, Michael P."],["dc.contributor.author","Kruss, Sebastian"],["dc.contributor.author","Erpenbeck, Luise"],["dc.date.accessioned","2019-07-09T11:50:03Z"],["dc.date.available","2019-07-09T11:50:03Z"],["dc.date.issued","2019"],["dc.date.updated","2022-02-09T13:23:16Z"],["dc.description.abstract","The formation of neutrophil extracellular traps (NETs) is an immune defense mechanism of neutrophilic granulocytes. Moreover, it is also involved in the pathogenesis of autoimmune, inflammatory, and neoplastic diseases. For that reason, the process of NET formation (NETosis) is subject of intense ongoing research. In vitro approaches to quantify NET formation are commonly used and involve neutrophil stimulation with various activators such as phorbol 12-myristate 13-acetate (PMA), lipopolysaccharides (LPS), or calcium ionophores (CaI). However, the experimental conditions of these experiments, particularly the media and media supplements employed by different research groups, vary considerably, rendering comparisons of results difficult. Here, we present the first standardized investigation of the influence of different media supplements on NET formation in vitro. The addition of heat-inactivated (hi) fetal calf serum (FCS), 0.5% human serum albumin (HSA), or 0.5% bovine serum albumin (BSA) efficiently prevented NET formation of human neutrophils following stimulation with LPS and CaI, but not after stimulation with PMA. Thus, serum components such as HSA, BSA and hiFCS (at concentrations typically found in the literature) inhibit NET formation to different degrees, depending on the NETosis inducer used. In contrast, in murine neutrophils, NETosis was inhibited by FCS and BSA, regardless of the inducer employed. This shows that mouse and human neutrophils have different susceptibilities toward the inhibition of NETosis by albumin or serum components. Furthermore, we provide experimental evidence that albumin inhibits NETosis by scavenging activators such as LPS. We also put our results into the context of media supplements most commonly used in NET research. In experiments with human neutrophils, either FCS (0.5-10%), heat-inactivated (hiFCS, 0.1-10%) or human serum albumin (HSA, 0.05-2%) was commonly added to the medium. For murine neutrophils, serum-free medium was used in most cases for stimulation with LPS and CaI, reflecting the different sensitivities of human and murine neutrophils to media supplements. Thus, the choice of media supplements greatly determines the outcome of experiments on NET-formation, which must be taken into account in NETosis research."],["dc.identifier.doi","10.3389/fimmu.2019.00012"],["dc.identifier.eissn","1664-3224"],["dc.identifier.pmid","30733715"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15847"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59691"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.publisher","Frontiers Media S.A."],["dc.relation.eissn","1664-3224"],["dc.relation.issn","1664-3224"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","610"],["dc.title","Serum and Serum Albumin Inhibit in vitro Formation of Neutrophil Extracellular Traps (NETs)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","9984"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","ACS Nano"],["dc.bibliographiccitation.lastpage","9996"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Kruss, Sebastian"],["dc.contributor.author","Erpenbeck, Luise"],["dc.contributor.author","Amschler, Katharina"],["dc.contributor.author","Mundinger, Tabea A."],["dc.contributor.author","Boehm, Heike"],["dc.contributor.author","Helms, Hans-Joachim"],["dc.contributor.author","Friede, Tim"],["dc.contributor.author","Andrews, Robert K."],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Spatz, Joachim P."],["dc.date.accessioned","2021-08-17T14:20:35Z"],["dc.date.available","2021-08-17T14:20:35Z"],["dc.date.issued","2013"],["dc.description.abstract","Neutrophilic granulocytes play a fundamental role in cardiovascular disease. They interact with platelet aggregates via the integrin Mac-1 and the platelet receptor glycoprotein Ibα (GPIbα). In vivo, GPIbα presentation is highly variable under different physiological and pathophysiological conditions. Here, we quantitatively determined the conditions for neutrophil adhesion in a biomimetic in vitro system, which allowed precise adjustment of the spacings between human GPIbα presented on the nanoscale from 60 to 200 nm. Unlike most conventional nanopatterning approaches, this method provided control over the local receptor density (spacing) rather than just the global receptor density. Under physiological flow conditions, neutrophils required a minimum spacing of GPIbα molecules to successfully adhere. In contrast, under low-flow conditions, neutrophils adhered on all tested spacings with subtle but nonlinear differences in cell response, including spreading area, spreading kinetics, adhesion maturation, and mobility. Surprisingly, Mac-1-dependent neutrophil adhesion was very robust to GPIbα density variations up to 1 order of magnitude. This complex response map indicates that neutrophil adhesion under flow and adhesion maturation are differentially regulated by GPIbα density. Our study reveals how Mac-1/GPIbα interactions govern cell adhesion and how neutrophils process the number of available surface receptors on the nanoscale. In the future, such in vitro studies can be useful to determine optimum therapeutic ranges for targeting this interaction."],["dc.identifier.doi","10.1021/nn403923h"],["dc.identifier.isi","000327752200047"],["dc.identifier.pmid","24093566"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/88782"],["dc.language.iso","en"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Chemical Soc"],["dc.relation.eissn","1936-086X"],["dc.relation.issn","1936-0851"],["dc.relation.issn","1936-086X"],["dc.title","Adhesion maturation of neutrophils on nanoscopically presented platelet glycoprotein Ibα"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]