Romitti, Federica

[["dc.bibliographiccitation.firstpage","2187"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Intensive Care Medicine"],["dc.bibliographiccitation.lastpage","2196"],["dc.bibliographiccitation.volume","46"],["dc.contributor.author","Chiumello, Davide"],["dc.contributor.author","Busana, Mattia"],["dc.contributor.author","Coppola, Silvia"],["dc.contributor.author","Romitti, Federica"],["dc.contributor.author","Formenti, Paolo"],["dc.contributor.author","Bonifazi, Matteo"],["dc.contributor.author","Pozzi, Tommaso"],["dc.contributor.author","Palumbo, Maria Michela"],["dc.contributor.author","Cressoni, Massimo"],["dc.contributor.author","Herrmann, Peter"],["dc.contributor.author","Meissner, Konrad"],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Camporota, Luigi"],["dc.contributor.author","Marini, John J."],["dc.contributor.author","Gattinoni, Luciano"],["dc.date.accessioned","2021-04-14T08:32:14Z"],["dc.date.available","2021-04-14T08:32:14Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1007/s00134-020-06281-2"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83854"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1432-1238"],["dc.relation.issn","0342-4642"],["dc.title","Physiological and quantitative CT-scan characterization of COVID-19 and typical ARDS: a matched cohort study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","675"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Shock"],["dc.bibliographiccitation.lastpage","680"],["dc.bibliographiccitation.volume","54"],["dc.contributor.author","Vassalli, Francesco"],["dc.contributor.author","Masson, Serge"],["dc.contributor.author","Meessen, Jennifer"],["dc.contributor.author","Pasticci, Iacopo"],["dc.contributor.author","Bonifazi, Matteo"],["dc.contributor.author","Vivona, Luigi"],["dc.contributor.author","Caironi, Pietro"],["dc.contributor.author","Busana, Mattia"],["dc.contributor.author","Giosa, Lorenzo"],["dc.contributor.author","Macrì, Matteo Maria"],["dc.contributor.author","Romitti, Federica"],["dc.contributor.author","Novelli, Deborah"],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Latini, Roberto"],["dc.contributor.author","Gattinoni, Luciano"],["dc.date.accessioned","2021-04-14T08:31:36Z"],["dc.date.available","2021-04-14T08:31:36Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1097/SHK.0000000000001543"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83651"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1540-0514"],["dc.relation.issn","1073-2322"],["dc.title","Pentraxin-3, Troponin T, N-Terminal Pro-B-Type Natriuretic Peptide in Septic Patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1498"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Intensive Care Medicine"],["dc.bibliographiccitation.lastpage","1499"],["dc.bibliographiccitation.volume","46"],["dc.contributor.author","Camporota, Luigi"],["dc.contributor.author","Chiumello, Davide"],["dc.contributor.author","Busana, Mattia"],["dc.contributor.author","Romitti, Federica"],["dc.contributor.author","Gattinoni, Luciano"],["dc.date.accessioned","2021-04-14T08:26:12Z"],["dc.date.available","2021-04-14T08:26:12Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1007/s00134-020-06124-0"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81865"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1432-1238"],["dc.relation.issn","0342-4642"],["dc.title","From phenotypes to black holes… and back"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","japplphysiol.00426.2022"],["dc.bibliographiccitation.journal","Journal of Applied Physiology"],["dc.contributor.author","Busana, Mattia"],["dc.contributor.author","Zinnato, Carmelo"],["dc.contributor.author","Romitti, Federica"],["dc.contributor.author","Palumbo, Michela"],["dc.contributor.author","Gattarello, Simone"],["dc.contributor.author","Sonzogni, Aurelio"],["dc.contributor.author","Gersmann, Ann-Kathrin"],["dc.contributor.author","Richter, Annika"],["dc.contributor.author","Herrmann, Peter"],["dc.contributor.author","Hahn, Günter"],["dc.contributor.author","Gattinoni, Luciano"],["dc.date.accessioned","2022-10-04T10:21:51Z"],["dc.date.available","2022-10-04T10:21:51Z"],["dc.date.issued","2022"],["dc.description.abstract","The amount of energy delivered to the respiratory system is recognized as a cause of Ventilator Induced Lung Injury (VILI). How energy dissipation within the lung causes damage is still a matter of debate. Expiratory flow control has been proposed as a strategy to reduce the energy dissipated into the respiratory system during expiration and, possibly, VILI. We studied 22 healthy pigs (29±2 kg), which were randomized into a control (n=11) and a valve group (n=11), where the expiratory flow was controlled through a variable resistor. Both groups were ventilated with the same tidal volume, PEEP and inspiratory flow. Electric impedance tomography was continuously acquired. At completion, lung weight, wet to dry ratios and histology were evaluated. The total mechanical power was similar in the control and valve groups (8.54±0.83 J min\n -1\n and 8.42±0.54 J min\n -\n 1\n respectively, p=0.552). The total energy dissipated within the whole system (circuit + respiratory system) was remarkably different (4.34±0.66 vs 2.62±0.31 J/min, p<0.001). However, most of this energy was dissipated across the endotracheal tube (2.87±0.3 vs 1.88±0.2 J/min, p<0.001). The amount dissipated into the respiratory system averaged 1.45±0.5 in controls vs 0.73±0.16 J min\n -1\n in the valve group, p<0.001. Although respiratory mechanics, gas exchange, hemodynamics, wet to dry ratios and histology were similar in the two groups, the decrease of end-expiratory lung impedance was significantly greater in the control group (p=0.02). We conclude that with our experimental conditions, the reduction of energy dissipated in the respiratory system did not lead to appreciable differences in VILI."],["dc.identifier.doi","10.1152/japplphysiol.00426.2022"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/114520"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-600"],["dc.relation.eissn","1522-1601"],["dc.relation.issn","8750-7587"],["dc.title","Energy dissipation during expiration and Ventilator Induced Lung Injury: an experimental animal study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Intensive Care Medicine"],["dc.contributor.author","Coppola, Silvia"],["dc.contributor.author","Chiumello, Davide"],["dc.contributor.author","Busana, Mattia"],["dc.contributor.author","Giola, Emanuele"],["dc.contributor.author","Palermo, Paola"],["dc.contributor.author","Pozzi, Tommaso"],["dc.contributor.author","Steinberg, Irene"],["dc.contributor.author","Roli, Stefano"],["dc.contributor.author","Romitti, Federica"],["dc.contributor.author","Lazzari, Stefano"],["dc.contributor.author","Gattinoni, Luciano"],["dc.date.accessioned","2021-10-01T09:58:50Z"],["dc.date.available","2021-10-01T09:58:50Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1007/s00134-021-06519-7"],["dc.identifier.pii","6519"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/90156"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-469"],["dc.relation.eissn","1432-1238"],["dc.relation.haserratum","/handle/2/97655"],["dc.relation.issn","0342-4642"],["dc.title","Role of total lung stress on the progression of early COVID-19 pneumonia"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","210138"],["dc.bibliographiccitation.issue","162"],["dc.bibliographiccitation.journal","European Respiratory Review"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","Gattinoni, Luciano"],["dc.contributor.author","Gattarello, Simone"],["dc.contributor.author","Steinberg, Irene"],["dc.contributor.author","Busana, Mattia"],["dc.contributor.author","Palermo, Paola"],["dc.contributor.author","Lazzari, Stefano"],["dc.contributor.author","Romitti, Federica"],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Meissner, Konrad"],["dc.contributor.author","Marini, John J."],["dc.contributor.author","Camporota, Luigi"],["dc.date.accessioned","2022-04-01T10:02:45Z"],["dc.date.available","2022-04-01T10:02:45Z"],["dc.date.issued","2021"],["dc.description.abstract","Coronavirus disease 2019 (COVID-19) pneumonia is an evolving disease. We will focus on the development of its pathophysiologic characteristics over time, and how these time-related changes determine modifications in treatment. In the emergency department: the peculiar characteristic is the coexistence, in a significant fraction of patients, of severe hypoxaemia, near-normal lung computed tomography imaging, lung gas volume and respiratory mechanics. Despite high respiratory drive, dyspnoea and respiratory rate are often normal. The underlying mechanism is primarily altered lung perfusion. The anatomical prerequisites for PEEP (positive end-expiratory pressure) to work (lung oedema, atelectasis, and therefore recruitability) are lacking. In the high-dependency unit: the disease starts to worsen either because of its natural evolution or additional patient self-inflicted lung injury (P-SILI). Oedema and atelectasis may develop, increasing recruitability. Noninvasive supports are indicated if they result in a reversal of hypoxaemia and a decreased inspiratory effort. Otherwise, mechanical ventilation should be considered to avert P-SILI. In the intensive care unit: the primary characteristic of the advance of unresolved COVID-19 disease is a progressive shift from oedema or atelectasis to less reversible structural lung alterations to lung fibrosis. These later characteristics are associated with notable impairment of respiratory mechanics, increased arterial carbon dioxide tension ( P aCO 2 ), decreased recruitability and lack of response to PEEP and prone positioning."],["dc.identifier.doi","10.1183/16000617.0138-2021"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/105996"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-530"],["dc.relation.eissn","1600-0617"],["dc.relation.issn","0905-9180"],["dc.rights.uri","http://creativecommons.org/licenses/by-nc/4.0/"],["dc.title","COVID-19 pneumonia: pathophysiology and management"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Critical Care Medicine"],["dc.contributor.author","Steinberg, Irene"],["dc.contributor.author","Pasticci, Iacopo"],["dc.contributor.author","Busana, Mattia"],["dc.contributor.author","Costamagna, Andrea"],["dc.contributor.author","Hahn, Günter"],["dc.contributor.author","Gattarello, Simone"],["dc.contributor.author","Palermo, Paola"],["dc.contributor.author","Lazzari, Stefano"],["dc.contributor.author","Romitti, Federica"],["dc.contributor.author","Herrmann, Peter"],["dc.contributor.author","Gattinoni, Luciano"],["dc.date.accessioned","2022-04-01T10:02:54Z"],["dc.date.available","2022-04-01T10:02:54Z"],["dc.date.issued","2022"],["dc.identifier.doi","10.1097/CCM.0000000000005479"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/106031"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-530"],["dc.relation.issn","0090-3493"],["dc.title","Lung Ultrasound and Electrical Impedance Tomography During Ventilator-Induced Lung Injury"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1126"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Anesthesiology"],["dc.bibliographiccitation.lastpage","1137"],["dc.bibliographiccitation.volume","132"],["dc.contributor.author","Vassalli, Francesco"],["dc.contributor.author","Pasticci, Iacopo"],["dc.contributor.author","Romitti, Federica"],["dc.contributor.author","Duscio, Eleonora"],["dc.contributor.author","Aßmann, David Jerome"],["dc.contributor.author","Grünhagen, Hannah"],["dc.contributor.author","Vasques, Francesco"],["dc.contributor.author","Bonifazi, Matteo"],["dc.contributor.author","Busana, Mattia"],["dc.contributor.author","Macrì, Matteo Maria"],["dc.contributor.author","Giosa, Lorenzo"],["dc.contributor.author","Reupke, Verena"],["dc.contributor.author","Herrmann, Peter"],["dc.contributor.author","Hahn, Günter"],["dc.contributor.author","Leopardi, Orazio"],["dc.contributor.author","Moerer, Onnen"],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Marini, John J."],["dc.contributor.author","Gattinoni, Luciano"],["dc.date.accessioned","2020-12-10T18:19:48Z"],["dc.date.available","2020-12-10T18:19:48Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1097/ALN.0000000000003189"],["dc.identifier.issn","0003-3022"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/75386"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Does Iso-mechanical Power Lead to Iso-lung Damage?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","56"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Intensive Care Medicine"],["dc.bibliographiccitation.lastpage","66"],["dc.bibliographiccitation.volume","48"],["dc.contributor.author","Rossi, Sandra"],["dc.contributor.author","Palumbo, Maria Michela"],["dc.contributor.author","Sverzellati, Nicola"],["dc.contributor.author","Busana, Mattia"],["dc.contributor.author","Malchiodi, Laura"],["dc.contributor.author","Bresciani, Paolo"],["dc.contributor.author","Ceccarelli, Patrizia"],["dc.contributor.author","Sani, Emanuele"],["dc.contributor.author","Romitti, Federica"],["dc.contributor.author","Bonifazi, Matteo"],["dc.contributor.author","Gattinoni, Luciano"],["dc.date.accessioned","2022-01-11T14:05:23Z"],["dc.date.available","2022-01-11T14:05:23Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1007/s00134-021-06562-4"],["dc.identifier.pii","6562"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/97654"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-507"],["dc.relation.eissn","1432-1238"],["dc.relation.issn","0342-4642"],["dc.title","Mechanisms of oxygenation responses to proning and recruitment in COVID-19 pneumonia"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Frontiers in Physiology"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Gattarello, Simone"],["dc.contributor.author","Pasticci, Iacopo"],["dc.contributor.author","Busana, Mattia"],["dc.contributor.author","Lazzari, Stefano"],["dc.contributor.author","Palermo, Paola"],["dc.contributor.author","Palumbo, Maria Michela"],["dc.contributor.author","Romitti, Federica"],["dc.contributor.author","Steinberg, Irene"],["dc.contributor.author","Collino, Francesca"],["dc.contributor.author","Vassalli, Francesco"],["dc.contributor.author","Gattinoni, Luciano"],["dc.date.accessioned","2022-04-01T10:00:42Z"],["dc.date.available","2022-04-01T10:00:42Z"],["dc.date.issued","2021"],["dc.description.abstract","Background: Ventilator-induced lung injury (VILI) via respiratory mechanics is deeply interwoven with hemodynamic, kidney and fluid/electrolyte changes. We aimed to assess the role of positive fluid balance in the framework of ventilation-induced lung injury. Methods: Post-hoc analysis of seventy-eight pigs invasively ventilated for 48 h with mechanical power ranging from 18 to 137 J/min and divided into two groups: high vs. low pleural pressure (10.0 ± 2.8 vs. 4.4 ± 1.5 cmH 2 O; p < 0.01). Respiratory mechanics, hemodynamics, fluid, sodium and osmotic balances, were assessed at 0, 6, 12, 24, 48 h. Sodium distribution between intracellular, extracellular and non-osmotic sodium storage compartments was estimated assuming osmotic equilibrium. Lung weight, wet-to-dry ratios of lung, kidney, liver, bowel and muscle were measured at the end of the experiment. Results: High pleural pressure group had significant higher cardiac output (2.96 ± 0.92 vs. 3.41 ± 1.68 L/min; p < 0.01), use of norepinephrine/epinephrine (1.76 ± 3.31 vs. 5.79 ± 9.69 mcg/kg; p < 0.01) and total fluid infusions (3.06 ± 2.32 vs. 4.04 ± 3.04 L; p < 0.01). This hemodynamic status was associated with significantly increased sodium and fluid retention (at 48 h, respectively, 601.3 ± 334.7 vs. 1073.2 ± 525.9 mmol, p < 0.01; and 2.99 ± 2.54 vs. 6.66 ± 3.87 L, p < 0.01). Ten percent of the infused sodium was stored in an osmotically inactive compartment. Increasing fluid and sodium retention was positively associated with lung-weight ( R 2 = 0.43, p < 0.01; R 2 = 0.48, p < 0.01) and with wet-to-dry ratio of the lungs ( R 2 = 0.14, p < 0.01; R 2 = 0.18, p < 0.01) and kidneys ( R 2 = 0.11, p = 0.02; R 2 = 0.12, p = 0.01). Conclusion: Increased mechanical power and pleural pressures dictated an increase in hemodynamic support resulting in proportionally increased sodium and fluid retention and pulmonary edema."],["dc.description.sponsorship","Georg-August-Universität Göttingen"],["dc.identifier.doi","10.3389/fphys.2021.743153"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/105492"],["dc.notes.intern","DOI-Import GROB-530"],["dc.relation.eissn","1664-042X"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0/"],["dc.title","Role of Fluid and Sodium Retention in Experimental Ventilator-Induced Lung Injury"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]