Amador de Lara, Gabriel

[["dc.bibliographiccitation.firstpage","509"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Brain Stimulation"],["dc.bibliographiccitation.lastpage","517"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","de Lara, Gabriel Amador"],["dc.contributor.author","Alekseichuk, Ivan"],["dc.contributor.author","Turi, Zsolt"],["dc.contributor.author","Lehr, Albert"],["dc.contributor.author","Antal, Andrea"],["dc.contributor.author","Paulus, Walter"],["dc.date.accessioned","2018-10-10T10:23:09Z"],["dc.date.available","2018-10-10T10:23:09Z"],["dc.date.issued","2018"],["dc.description.abstract","Phase-amplitude cross-frequency coupling (PAC) is characterized by the modulation of the power of a fast brain oscillation (e.g., gamma) by the phase of a slow rhythm (e.g., theta). PAC in different sub- and neocortical regions is known to underlie effective neural communication and correlates with successful long-term memory formation."],["dc.identifier.doi","10.1016/j.brs.2017.12.007"],["dc.identifier.pmid","29317186"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15940"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.issn","1876-4754"],["dc.relation.issn","1935-861X"],["dc.title","Perturbation of theta-gamma coupling at the temporal lobe hinders verbal declarative memory"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Frontiers in Psychiatry"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Prillinger, Karin"],["dc.contributor.author","Radev, Stefan T."],["dc.contributor.author","Amador de Lara, Gabriel"],["dc.contributor.author","Klöbl, Manfred"],["dc.contributor.author","Lanzenberger, Rupert"],["dc.contributor.author","Plener, Paul L."],["dc.contributor.author","Poustka, Luise"],["dc.contributor.author","Konicar, Lilian"],["dc.date.accessioned","2021-10-01T09:58:20Z"],["dc.date.available","2021-10-01T09:58:20Z"],["dc.date.issued","2021"],["dc.description.abstract","Background: Social–emotional difficulties are a core symptom of autism spectrum disorder (ASD). Accordingly, individuals with ASD have problems with social cognition such as recognizing emotions from other peoples' faces. Various results from functional magnetic resonance imaging and electroencephalography studies as well as eye-tracking data reveal a neurophysiological basis of these deficits by linking them to abnormal brain activity. Thus, an intervention targeting the neural origin of ASD impairments seems warranted. A safe method able to influence neural activity is transcranial direct current stimulation (tDCS). This non-invasive brain stimulation method has already demonstrated promising results in several neuropsychiatric disorders in adults and children. The aim of this project is to investigate the effects of tDCS on ASD symptoms and their neural correlates in children and adolescents with ASD. Method: This study is designed as a double-blind, randomized, and sham-controlled trial with a target sample size of 20 male participants (aged 12–17 years) diagnosed with ASD. Before randomization, the participants will be stratified into comorbid depression, comorbid ADHS/conduct disorder, or no-comorbidity groups. The intervention phase comprises 10 sessions of anodal or sham tDCS applied over the left prefrontal cortex within 2 consecutive weeks. To engage the targeted brain regions, participants will perform a social cognition training during the stimulation. TDCS-induced effects on ASD symptoms and involved neural circuits will be investigated through psychological, neurophysiological, imaging, and behavioral data at pre- and post-measurements. Tolerability will be evaluated using a standardized questionnaire. Follow-up assessments 1 and 6 months after the intervention will examine long-lasting effects. Discussion: The results of this study will provide insights into the changeability of social impairments in ASD by investigating social and emotional abilities on different modalities following repeated sessions of anodal tDCS with an intra-simulation training. Furthermore, this trial will elucidate the tolerability and the potential of tDCS as a new treatment approach for ASD in adolescents. Clinical Trial Registration: The study is ongoing and has been registered in the German Registry of Clinical Trials (DRKS00017505) on 02/07/2019."],["dc.description.abstract","Background: Social–emotional difficulties are a core symptom of autism spectrum disorder (ASD). Accordingly, individuals with ASD have problems with social cognition such as recognizing emotions from other peoples' faces. Various results from functional magnetic resonance imaging and electroencephalography studies as well as eye-tracking data reveal a neurophysiological basis of these deficits by linking them to abnormal brain activity. Thus, an intervention targeting the neural origin of ASD impairments seems warranted. A safe method able to influence neural activity is transcranial direct current stimulation (tDCS). This non-invasive brain stimulation method has already demonstrated promising results in several neuropsychiatric disorders in adults and children. The aim of this project is to investigate the effects of tDCS on ASD symptoms and their neural correlates in children and adolescents with ASD. Method: This study is designed as a double-blind, randomized, and sham-controlled trial with a target sample size of 20 male participants (aged 12–17 years) diagnosed with ASD. Before randomization, the participants will be stratified into comorbid depression, comorbid ADHS/conduct disorder, or no-comorbidity groups. The intervention phase comprises 10 sessions of anodal or sham tDCS applied over the left prefrontal cortex within 2 consecutive weeks. To engage the targeted brain regions, participants will perform a social cognition training during the stimulation. TDCS-induced effects on ASD symptoms and involved neural circuits will be investigated through psychological, neurophysiological, imaging, and behavioral data at pre- and post-measurements. Tolerability will be evaluated using a standardized questionnaire. Follow-up assessments 1 and 6 months after the intervention will examine long-lasting effects. Discussion: The results of this study will provide insights into the changeability of social impairments in ASD by investigating social and emotional abilities on different modalities following repeated sessions of anodal tDCS with an intra-simulation training. Furthermore, this trial will elucidate the tolerability and the potential of tDCS as a new treatment approach for ASD in adolescents. Clinical Trial Registration: The study is ongoing and has been registered in the German Registry of Clinical Trials (DRKS00017505) on 02/07/2019."],["dc.identifier.doi","10.3389/fpsyt.2021.680525"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/90042"],["dc.notes.intern","DOI Import GROB-469"],["dc.relation.eissn","1664-0640"],["dc.title","Repeated Sessions of Transcranial Direct Current Stimulation on Adolescents With Autism Spectrum Disorder: Study Protocol for a Randomized, Double-Blind, and Sham-Controlled Clinical Trial"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1513"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Current Biology"],["dc.bibliographiccitation.lastpage","1521"],["dc.bibliographiccitation.volume","26"],["dc.contributor.author","Alekseichuk, Ivan"],["dc.contributor.author","Turi, Zsolt"],["dc.contributor.author","Amador de Lara, Gabriel"],["dc.contributor.author","Antal, Andrea"],["dc.contributor.author","Paulus, Walter J."],["dc.date.accessioned","2018-11-07T10:12:41Z"],["dc.date.available","2018-11-07T10:12:41Z"],["dc.date.issued","2016"],["dc.description.abstract","Previous, albeit correlative, findings have shown that the neural mechanisms underlying working memory critically require cross-structural and cross-frequency coupling mechanisms between theta and gamma neural oscillations. However, the direct causality between cross-frequency coupling and working memory performance remains to be demonstrated. Here we externally modulated the interaction of theta and gamma rhythms in the prefrontal cortex using novel cross-frequency protocols of transcranial alternating current stimulation to affect spatial working memory performance in humans. Enhancement of working memory performance and increase of global neocortical connectivity were observed when bursts of high gamma oscillations (80-100 Hz) coincided with the peaks of the theta waves, whereas superimposition on the trough of the theta wave and low gamma frequency protocols were ineffective. Thus, our results demonstrate the sensitivity of working memory performance and global neocortical connectivity to the phase and rhythm of the externally driven theta gamma cross-frequency synchronization."],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft [SPP 1665]"],["dc.identifier.doi","10.1016/j.cub.2016.04.035"],["dc.identifier.isi","000378661800014"],["dc.identifier.pmid","27238283"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40288"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.notes.submitter","Najko"],["dc.relation.issn","1879-0445"],["dc.relation.issn","0960-9822"],["dc.title","Spatial Working Memory in Humans Depends on Theta and High Gamma Synchronization in the Prefrontal Cortex"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]