Tetens, Jens

[["dc.bibliographiccitation.journal","Frontiers in Genetics"],["dc.bibliographiccitation.volume","13"],["dc.contributor.affiliation","Mott, Alexander Charles; \r\n1\r\nDepartment of Animal Sciences, Georg-August-University, Göttingen, Germany"],["dc.contributor.affiliation","Mott, Andrea; \r\n1\r\nDepartment of Animal Sciences, Georg-August-University, Göttingen, Germany"],["dc.contributor.affiliation","Preuß, Siegfried; \r\n2\r\nInstitute of Animal Science, University of Hohenheim, Stuttgart, Germany"],["dc.contributor.affiliation","Bennewitz, Jörn; \r\n2\r\nInstitute of Animal Science, University of Hohenheim, Stuttgart, Germany"],["dc.contributor.affiliation","Tetens, Jens; \r\n1\r\nDepartment of Animal Sciences, Georg-August-University, Göttingen, Germany"],["dc.contributor.affiliation","Falker-Gieske, Clemens; \r\n1\r\nDepartment of Animal Sciences, Georg-August-University, Göttingen, Germany"],["dc.contributor.author","Mott, Alexander Charles"],["dc.contributor.author","Mott, Andrea"],["dc.contributor.author","Preuß, Siegfried"],["dc.contributor.author","Bennewitz, Jörn"],["dc.contributor.author","Tetens, Jens"],["dc.contributor.author","Falker-Gieske, Clemens"],["dc.date.accessioned","2022-08-31T11:11:52Z"],["dc.date.available","2022-08-31T11:11:52Z"],["dc.date.issued","2022-08-17"],["dc.date.updated","2022-08-31T09:11:03Z"],["dc.description.abstract","Feather pecking in chickens is a damaging behavior, seriously impacting animal welfare and leading to economic losses. Feather pecking is a complex trait, which is partly under genetic control. Different hypotheses have been proposed to explain the etiology of feather pecking and notably, several studies have identified similarities between feather pecking and human mental disorders such as obsessive-compulsive disorder and schizophrenia. This study uses transcriptomic and phenotypic data from 167 chickens to map expression quantitative trait loci and to identify regulatory genes with a significant effect on this behavioral disorder using an association weight matrix approach. From 70 of the analyzed differentially expressed genes, 11,790 genome wide significantly associated variants were detected, of which 23 showed multiple associations (≥15). These were located in proximity to a number of genes, which are transcription regulators involved in chromatin binding, nucleic acid metabolism, protein translation and putative regulatory RNAs. The association weight matrix identified 36 genes and the two transcription factors: SP6 (synonym: KLF14) and ENSGALG00000042129 (synonym: CHTOP) as the most significant, with an enrichment of KLF14 binding sites being detectable in 40 differentially expressed genes. This indicates that differential expression between animals showing high and low levels of feather pecking was significantly associated with a genetic variant in proximity to KLF14. This multiallelic variant was located 652 bp downstream of KLF14 and is a deletion of 1-3 bp. We propose that a deletion downstream of the transcription factor KLF14 has a negative impact on the level of T cells in the developing brain of high feather pecking chickens, which leads to developmental and behavioral abnormalities. The lack of CD4 T cells and gamma-Aminobutyric acid (GABA) receptors are important factors for the increased propensity of laying hens to perform feather pecking. As such, KLF14 is a clear candidate regulator for the expression of genes involved in the pathogenic development. By further elucidating the regulatory pathways involved in feather pecking we hope to take significant steps forward in explaining and understanding other mental disorders, not just in chickens."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2022"],["dc.identifier.doi","10.3389/fgene.2022.969752"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/113333"],["dc.language.iso","en"],["dc.relation.eissn","1664-8021"],["dc.rights","CC BY 4.0"],["dc.rights.uri","http://creativecommons.org/licenses/by/4.0/"],["dc.title","eQTL analysis of laying hens divergently selected for feather pecking identifies KLF14 as a potential key regulator for this behavioral disorder"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","235"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Life"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Borda-Molina, Daniel"],["dc.contributor.author","Iffland, Hanna"],["dc.contributor.author","Schmid, Markus"],["dc.contributor.author","Müller, Regina"],["dc.contributor.author","Schad, Svenja"],["dc.contributor.author","Seifert, Jana"],["dc.contributor.author","Tetens, Jens"],["dc.contributor.author","Bessei, Werner"],["dc.contributor.author","Bennewitz, Jörn"],["dc.contributor.author","Camarinha-Silva, Amélia"],["dc.date.accessioned","2021-06-01T09:42:38Z"],["dc.date.available","2021-06-01T09:42:38Z"],["dc.date.issued","2021"],["dc.description.abstract","Background: Feather pecking is a well-known problem in layer flocks that causes animal welfare restrictions and contributes to economic losses. Birds’ gut microbiota has been linked to feather pecking. This study aims to characterize the microbial communities of two laying hen lines divergently selected for high (HFP) and low (LFP) feather pecking and investigates if the microbiota is associated with feather pecking or agonistic behavior. Methods: Besides phenotyping for the behavioral traits, microbial communities from the digesta and mucosa of the ileum and caeca were investigated using target amplicon sequencing and functional predictions. Microbiability was estimated with a microbial mixed linear model. Results: Ileum digesta showed an increase in the abundance of the genus Lactobacillus in LFP, while Escherichia was abundant in HFP hens. In the caeca digesta and mucosa of the LFP line were more abundant Faecalibacterium and Blautia. Tryptophan metabolism and lysine degradation were higher in both digesta and mucosa of the HFP hens. Linear models revealed that the two lines differ significantly in all behavior traits. Microbiabilities were close to zero and not significant in both lines and for all traits. Conclusions: Trait variation was not affected by the gut microbial composition in both selection lines."],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft"],["dc.identifier.doi","10.3390/life11030235"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85309"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.publisher","MDPI"],["dc.relation.eissn","2075-1729"],["dc.rights","https://creativecommons.org/licenses/by/4.0/"],["dc.title","Gut Microbial Composition and Predicted Functions Are Not Associated with Feather Pecking and Antagonistic Behavior in Laying Hens"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","108"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Animals"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","van der Sluis, Malou"],["dc.contributor.author","Siegford, Janice"],["dc.contributor.author","Guzhva, Oleksiy"],["dc.contributor.author","Bennewitz, Jörn"],["dc.contributor.author","Norton, Tomas"],["dc.contributor.author","Piette, Deborah"],["dc.contributor.author","Tetens, Jens"],["dc.contributor.author","de Klerk, Britt"],["dc.contributor.author","Visser, Bram"],["dc.contributor.author","Ellen, Esther D."],["dc.contributor.author","Toscano, Michael J."],["dc.contributor.author","van der Zande, Lisette E."],["dc.contributor.author","van der Eijk, Jerine A. J."],["dc.contributor.author","de Haas, Elske N."],["dc.contributor.author","Rodenburg, T. Bas"],["dc.date.accessioned","2020-12-10T18:46:55Z"],["dc.date.available","2020-12-10T18:46:55Z"],["dc.date.issued","2019"],["dc.description.sponsorship","European Cooperation in Science and Technology"],["dc.description.sponsorship","Ministerie van Economische Zaken"],["dc.description.sponsorship","National Institute of Food and Agriculture"],["dc.identifier.doi","10.3390/ani9030108"],["dc.identifier.eissn","2076-2615"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78589"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.publisher","MDPI"],["dc.relation.eissn","2076-2615"],["dc.relation.isreplacedby","hdl:2/78589"],["dc.rights","https://creativecommons.org/licenses/by/4.0/"],["dc.title","Review of Sensor Technologies in Animal Breeding: Phenotyping Behaviors of Laying Hens to Select Against Feather Pecking"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Genomics"],["dc.bibliographiccitation.volume","21"],["dc.contributor.author","Falker-Gieske, Clemens"],["dc.contributor.author","Mott, Andrea"],["dc.contributor.author","Preuß, Siegfried"],["dc.contributor.author","Franzenburg, Sören"],["dc.contributor.author","Bessei, Werner"],["dc.contributor.author","Bennewitz, Jörn"],["dc.contributor.author","Tetens, Jens"],["dc.date.accessioned","2021-04-14T08:23:58Z"],["dc.date.available","2021-04-14T08:23:58Z"],["dc.date.issued","2020"],["dc.description.sponsorship","Open-Access-Publikationsfonds 2021"],["dc.identifier.doi","10.1186/s12864-020-07002-1"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17529"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81113"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1471-2164"],["dc.relation.orgunit","Department für Nutztierwissenschaften"],["dc.rights","CC BY 4.0"],["dc.rights.holder","The Author(s)"],["dc.title","Analysis of the brain transcriptome in lines of laying hens divergently selected for feather pecking"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","262"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Animals"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Iffland, Hanna"],["dc.contributor.author","Wellmann, Robin"],["dc.contributor.author","Schmid, Markus"],["dc.contributor.author","Preuß, Siegfried"],["dc.contributor.author","Tetens, Jens"],["dc.contributor.author","Bessei, Werner"],["dc.contributor.author","Bennewitz, Jörn"],["dc.date.accessioned","2020-12-10T18:46:54Z"],["dc.date.available","2020-12-10T18:46:54Z"],["dc.date.issued","2020"],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft"],["dc.identifier.doi","10.3390/ani10020262"],["dc.identifier.eissn","2076-2615"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78583"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.publisher","MDPI"],["dc.relation.eissn","2076-2615"],["dc.rights","https://creativecommons.org/licenses/by/4.0/"],["dc.title","Genomewide Mapping of Selection Signatures and Genes for Extreme Feather Pecking in Two Divergently Selected Laying Hen Lines"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","e0205576"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","PLoS One"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Blaj, Iulia"],["dc.contributor.author","Tetens, Jens"],["dc.contributor.author","Preuß, Siegfried"],["dc.contributor.author","Bennewitz, Jörn"],["dc.contributor.author","Thaller, Georg"],["dc.contributor.editor","Óvilo, Cristina"],["dc.date.accessioned","2020-12-10T18:42:09Z"],["dc.date.available","2020-12-10T18:42:09Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1371/journal.pone.0205576"],["dc.identifier.eissn","1932-6203"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15706"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77827"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.relation.orgunit","Fakultät für Agrarwissenschaften"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Genome-wide association studies and meta-analysis uncovers new candidate genes for growth and carcass traits in pigs"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2823"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","G3: Genes, Genomes, Genetics"],["dc.bibliographiccitation.lastpage","2834"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Falker-Gieske, Clemens"],["dc.contributor.author","Blaj, Iulia"],["dc.contributor.author","Preuß, Siegfried"],["dc.contributor.author","Bennewitz, Jörn"],["dc.contributor.author","Thaller, Georg"],["dc.contributor.author","Tetens, Jens"],["dc.date.accessioned","2020-12-10T18:42:41Z"],["dc.date.available","2020-12-10T18:42:41Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1534/g3.119.400452"],["dc.identifier.eissn","2160-1836"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16481"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78045"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","GWAS for Meat and Carcass Traits Using Imputed Sequence Level Genotypes in Pooled F2-Designs in Pigs"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","631"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Genomics"],["dc.bibliographiccitation.volume","23"],["dc.contributor.author","Blaj, Iulia"],["dc.contributor.author","Tetens, Jens"],["dc.contributor.author","Bennewitz, Jörn"],["dc.contributor.author","Thaller, Georg"],["dc.contributor.author","Falker-Gieske, Clemens"],["dc.date.accessioned","2022-09-05T09:03:00Z"],["dc.date.available","2022-09-05T09:03:00Z"],["dc.date.issued","2022-09-03"],["dc.date.updated","2022-09-04T03:12:20Z"],["dc.description.abstract","Abstract\r\n \r\n Background\r\n Structural variants and tandem repeats are relevant sources of genomic variation that are not routinely analyzed in genome wide association studies mainly due to challenging identification and genotyping. Here, we profiled these variants via state-of-the-art strategies in the founder animals of four F2 pig crosses using whole-genome sequence data (20x coverage). The variants were compared at a founder level with the commonly screened SNPs and small indels. At the F2 level, we carried out an association study using imputed structural variants and tandem repeats with four growth and carcass traits followed by a comparison with a previously conducted SNPs and small indels based association study.\r\n \r\n \r\n Results\r\n A total of 13,201 high confidence structural variants and 103,730 polymorphic tandem repeats (with a repeat length of 2-20 bp) were profiled in the founders. We observed a moderate to high (r from 0.48 to 0.57) level of co-localization between SNPs or small indels and structural variants or tandem repeats. In the association step 56.56% of the significant variants were not in high LD with significantly associated SNPs and small indels identified for the same traits in the earlier study and thus presumably not tagged in case of a standard association study. For the four growth and carcass traits investigated, many of the already proposed candidate genes in our previous studies were confirmed and additional ones were identified. Interestingly, a common pattern on how structural variants or tandem repeats regulate the phenotypic traits emerged. Many of the significant variants were embedded or nearby long non-coding RNAs drawing attention to their functional importance. Through which specific mechanisms the identified long non-coding RNAs and their associated structural variants or tandem repeats contribute to quantitative trait variation will need further investigation.\r\n \r\n \r\n Conclusions\r\n The current study provides insights into the characteristics of structural variants and tandem repeats and their role in association studies. A systematic incorporation of these variants into genome wide association studies is advised. While not of immediate interest for genomic prediction purposes, this will be particularly beneficial for elucidating biological mechanisms driving the complex trait variation."],["dc.identifier.citation","BMC Genomics. 2022 Sep 03;23(1):631"],["dc.identifier.doi","10.1186/s12864-022-08716-0"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/114071"],["dc.language.iso","en"],["dc.rights","CC BY 4.0"],["dc.rights.holder","The Author(s)"],["dc.subject","Structural variants"],["dc.subject","Tandem repeats"],["dc.subject","Genome wide association studies"],["dc.subject","Imputation"],["dc.subject","Pig"],["dc.subject","Whole-genome sequencing"],["dc.subject","lncRNA"],["dc.title","Structural variants and tandem repeats in the founder individuals of four F2 pig crosses and implications to F2 GWAS results"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Genetics"],["dc.bibliographiccitation.volume","21"],["dc.contributor.author","Falker-Gieske, Clemens"],["dc.contributor.author","Iffland, Hanna"],["dc.contributor.author","Preuß, Siegfried"],["dc.contributor.author","Bessei, Werner"],["dc.contributor.author","Drögemüller, Cord"],["dc.contributor.author","Bennewitz, Jörn"],["dc.contributor.author","Tetens, Jens"],["dc.date.accessioned","2021-04-14T08:32:47Z"],["dc.date.available","2021-04-14T08:32:47Z"],["dc.date.issued","2020"],["dc.description.sponsorship","Open-Access-Publikationsfonds 2021"],["dc.identifier.doi","10.1186/s12863-020-00920-9"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17586"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/84015"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.notes.intern","Merged from goescholar"],["dc.relation.eissn","1471-2156"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0/"],["dc.title","Meta-analyses of genome wide association studies in lines of laying hens divergently selected for feather pecking using imputed sequence level genotypes"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]