Tetens, Jens

[["dc.bibliographiccitation.journal","Frontiers in Genetics"],["dc.bibliographiccitation.volume","13"],["dc.contributor.affiliation","Mott, Alexander Charles; \r\n1\r\nDepartment of Animal Sciences, Georg-August-University, Göttingen, Germany"],["dc.contributor.affiliation","Mott, Andrea; \r\n1\r\nDepartment of Animal Sciences, Georg-August-University, Göttingen, Germany"],["dc.contributor.affiliation","Preuß, Siegfried; \r\n2\r\nInstitute of Animal Science, University of Hohenheim, Stuttgart, Germany"],["dc.contributor.affiliation","Bennewitz, Jörn; \r\n2\r\nInstitute of Animal Science, University of Hohenheim, Stuttgart, Germany"],["dc.contributor.affiliation","Tetens, Jens; \r\n1\r\nDepartment of Animal Sciences, Georg-August-University, Göttingen, Germany"],["dc.contributor.affiliation","Falker-Gieske, Clemens; \r\n1\r\nDepartment of Animal Sciences, Georg-August-University, Göttingen, Germany"],["dc.contributor.author","Mott, Alexander Charles"],["dc.contributor.author","Mott, Andrea"],["dc.contributor.author","Preuß, Siegfried"],["dc.contributor.author","Bennewitz, Jörn"],["dc.contributor.author","Tetens, Jens"],["dc.contributor.author","Falker-Gieske, Clemens"],["dc.date.accessioned","2022-08-31T11:11:52Z"],["dc.date.available","2022-08-31T11:11:52Z"],["dc.date.issued","2022-08-17"],["dc.date.updated","2022-08-31T09:11:03Z"],["dc.description.abstract","Feather pecking in chickens is a damaging behavior, seriously impacting animal welfare and leading to economic losses. Feather pecking is a complex trait, which is partly under genetic control. Different hypotheses have been proposed to explain the etiology of feather pecking and notably, several studies have identified similarities between feather pecking and human mental disorders such as obsessive-compulsive disorder and schizophrenia. This study uses transcriptomic and phenotypic data from 167 chickens to map expression quantitative trait loci and to identify regulatory genes with a significant effect on this behavioral disorder using an association weight matrix approach. From 70 of the analyzed differentially expressed genes, 11,790 genome wide significantly associated variants were detected, of which 23 showed multiple associations (≥15). These were located in proximity to a number of genes, which are transcription regulators involved in chromatin binding, nucleic acid metabolism, protein translation and putative regulatory RNAs. The association weight matrix identified 36 genes and the two transcription factors: SP6 (synonym: KLF14) and ENSGALG00000042129 (synonym: CHTOP) as the most significant, with an enrichment of KLF14 binding sites being detectable in 40 differentially expressed genes. This indicates that differential expression between animals showing high and low levels of feather pecking was significantly associated with a genetic variant in proximity to KLF14. This multiallelic variant was located 652 bp downstream of KLF14 and is a deletion of 1-3 bp. We propose that a deletion downstream of the transcription factor KLF14 has a negative impact on the level of T cells in the developing brain of high feather pecking chickens, which leads to developmental and behavioral abnormalities. The lack of CD4 T cells and gamma-Aminobutyric acid (GABA) receptors are important factors for the increased propensity of laying hens to perform feather pecking. As such, KLF14 is a clear candidate regulator for the expression of genes involved in the pathogenic development. By further elucidating the regulatory pathways involved in feather pecking we hope to take significant steps forward in explaining and understanding other mental disorders, not just in chickens."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2022"],["dc.identifier.doi","10.3389/fgene.2022.969752"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/113333"],["dc.language.iso","en"],["dc.relation.eissn","1664-8021"],["dc.rights","CC BY 4.0"],["dc.rights.uri","http://creativecommons.org/licenses/by/4.0/"],["dc.title","eQTL analysis of laying hens divergently selected for feather pecking identifies KLF14 as a potential key regulator for this behavioral disorder"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Scientific Reports"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Falker-Gieske, Clemens"],["dc.contributor.author","Knorr, Christoph"],["dc.contributor.author","Tetens, Jens"],["dc.date.accessioned","2020-12-10T18:11:09Z"],["dc.date.available","2020-12-10T18:11:09Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1038/s41598-019-53901-z"],["dc.identifier.eissn","2045-2322"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16737"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/73908"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Blood transcriptome analysis in a buck-ewe hybrid and its parents"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","49"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Genetics Selection Evolution"],["dc.bibliographiccitation.volume","54"],["dc.contributor.author","Reich, Paula"],["dc.contributor.author","Falker-Gieske, Clemens"],["dc.contributor.author","Pook, Torsten"],["dc.contributor.author","Tetens, Jens"],["dc.date.accessioned","2022-08-04T12:06:22Z"],["dc.date.available","2022-08-04T12:06:22Z"],["dc.date.issued","2022-07-04"],["dc.date.updated","2022-07-25T11:18:58Z"],["dc.description.abstract","Background Genotype imputation is a cost-effective method to generate sequence-level genotypes for a large number of animals. Its application can improve the power of genomic studies, provided that the accuracy of imputation is sufficiently high. The purpose of this study was to develop an optimal strategy for genotype imputation from genotyping array data to sequence level in German warmblood horses, and to investigate the effect of different factors on the accuracy of imputation. Publicly available whole-genome sequence data from 317 horses of 46 breeds was used to conduct the analyses. Results Depending on the size and composition of the reference panel, the accuracy of imputation from medium marker density (60K) to sequence level using the software Beagle 5.1 ranged from 0.64 to 0.70 for horse chromosome 3. Generally, imputation accuracy increased as the size of the reference panel increased, but if genetically distant individuals were included in the panel, the accuracy dropped. Imputation was most precise when using a reference panel of multiple but related breeds and the software Beagle 5.1, which outperformed the other two tested computer programs, Impute 5 and Minimac 4. Genome-wide imputation for this scenario resulted in a mean accuracy of 0.66. Stepwise imputation from 60K to 670K markers and subsequently to sequence level did not improve the accuracy of imputation. However, imputation from higher density (670K) was considerably more accurate (about 0.90) than from medium density. Likewise, imputation in genomic regions with a low marker coverage resulted in a reduced accuracy of imputation. Conclusions The accuracy of imputation in horses was influenced by the size and composition of the reference panel, the marker density of the genotyping array, and the imputation software. Genotype imputation can be used to extend the limited amount of available sequence-level data from horses in order to boost the power of downstream analyses, such as genome-wide association studies, or the detection of embryonic lethal variants."],["dc.identifier.citation","Genetics Selection Evolution. 2022 Jul 04;54(1):49"],["dc.identifier.doi","10.1186/s12711-022-00740-8"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112649"],["dc.language.iso","en"],["dc.rights","CC BY 4.0"],["dc.rights.holder","The Author(s)"],["dc.title","Development and validation of a horse reference panel for genotype imputation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Genomics"],["dc.bibliographiccitation.volume","21"],["dc.contributor.author","Falker-Gieske, Clemens"],["dc.contributor.author","Mott, Andrea"],["dc.contributor.author","Preuß, Siegfried"],["dc.contributor.author","Franzenburg, Sören"],["dc.contributor.author","Bessei, Werner"],["dc.contributor.author","Bennewitz, Jörn"],["dc.contributor.author","Tetens, Jens"],["dc.date.accessioned","2021-04-14T08:23:58Z"],["dc.date.available","2021-04-14T08:23:58Z"],["dc.date.issued","2020"],["dc.description.sponsorship","Open-Access-Publikationsfonds 2021"],["dc.identifier.doi","10.1186/s12864-020-07002-1"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17529"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81113"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1471-2164"],["dc.relation.orgunit","Department für Nutztierwissenschaften"],["dc.rights","CC BY 4.0"],["dc.rights.holder","The Author(s)"],["dc.title","Analysis of the brain transcriptome in lines of laying hens divergently selected for feather pecking"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Molecular Biology Reports"],["dc.contributor.author","Falker-Gieske, Clemens"],["dc.contributor.author","Bennewitz, Jörn"],["dc.contributor.author","Tetens, Jens"],["dc.date.accessioned","2022-01-11T14:08:05Z"],["dc.date.available","2022-01-11T14:08:05Z"],["dc.date.issued","2021"],["dc.description.abstract","Abstract Background Feather pecking is a serious behavioral disorder in chickens that has a considerable impact on animal welfare and poses an economic burden for poultry farming. To study the underlying genetics of feather pecking animals were divergently selected for feather pecking over 15 generations based on estimated breeding values for the behavior. Methods and results By characterizing the transcriptomes of whole brains isolated from high and low feather pecking chickens in response to light stimulation we discovered a putative dysregulation of micro RNA processing caused by a lack of Dicer1 . This results in a prominent downregulation of the GABRB2 gene and other GABA receptor transcripts, which might cause a constant high level of excitation in the brains of high feather pecking chickens. Moreover, our results point towards an increase in immune system-related transcripts that may be caused by higher interferon concentrations due to Dicer1 downregulation. Conclusion Based on our results, we conclude that feather pecking in chickens and schizophrenia in humans have numerous common features. For instance, a Dicer1 dependent disruption of miRNA biogenesis and the lack of GABRB2 expression have been linked to schizophrenia pathogenesis. Furthermore, disturbed circadian rhythms and dysregulation of genes involved in the immune system are common features of both conditions."],["dc.description.abstract","Abstract Background Feather pecking is a serious behavioral disorder in chickens that has a considerable impact on animal welfare and poses an economic burden for poultry farming. To study the underlying genetics of feather pecking animals were divergently selected for feather pecking over 15 generations based on estimated breeding values for the behavior. Methods and results By characterizing the transcriptomes of whole brains isolated from high and low feather pecking chickens in response to light stimulation we discovered a putative dysregulation of micro RNA processing caused by a lack of Dicer1 . This results in a prominent downregulation of the GABRB2 gene and other GABA receptor transcripts, which might cause a constant high level of excitation in the brains of high feather pecking chickens. Moreover, our results point towards an increase in immune system-related transcripts that may be caused by higher interferon concentrations due to Dicer1 downregulation. Conclusion Based on our results, we conclude that feather pecking in chickens and schizophrenia in humans have numerous common features. For instance, a Dicer1 dependent disruption of miRNA biogenesis and the lack of GABRB2 expression have been linked to schizophrenia pathogenesis. Furthermore, disturbed circadian rhythms and dysregulation of genes involved in the immune system are common features of both conditions."],["dc.identifier.doi","10.1007/s11033-021-07111-4"],["dc.identifier.pii","7111"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/97930"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-507"],["dc.relation.eissn","1573-4978"],["dc.relation.issn","0301-4851"],["dc.title","The light response in chickens divergently selected for feather pecking behavior reveals mechanistic insights towards psychiatric disorders"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Journal of Applied Genetics"],["dc.contributor.author","Vosgerau, Sarah"],["dc.contributor.author","Krattenmacher, Nina"],["dc.contributor.author","Falker-Gieske, Clemens"],["dc.contributor.author","Seidel, Anita"],["dc.contributor.author","Tetens, Jens"],["dc.contributor.author","Stock, Kathrin F."],["dc.contributor.author","Nolte, Wietje"],["dc.contributor.author","Wobbe, Mirell"],["dc.contributor.author","Blaj, Iulia"],["dc.contributor.author","Reents, Reinhard"],["dc.contributor.author","Thaller, Georg"],["dc.date.accessioned","2022-02-01T10:32:00Z"],["dc.date.available","2022-02-01T10:32:00Z"],["dc.date.issued","2022"],["dc.description.abstract","Abstract   Reliability of genomic predictions is influenced by the size and genetic composition of the reference population. For German Warmblood horses, compilation of a reference population has been enabled through the cooperation of five German breeding associations. In this study, preliminary data from this joint reference population were used to genetically and genomically characterize withers height and to apply single-step methodology for estimating genomic breeding values for withers height. Using data on 2113 mares and their genomic information considering about 62,000 single nucleotide polymorphisms (SNPs), analysis of the genomic relationship revealed substructures reflecting breed origin and different breeding goals of the contributing breeding associations. A genome-wide association study confirmed a known quantitative trait locus (QTL) for withers height on equine chromosome (ECA) 3 close to LCORL and identified a further significant peak on ECA 1. Using a single-step approach with a combined relationship matrix, the estimated heritability for withers height was 0.31 (SE = 0.08) and the corresponding genomic breeding values ranged from − 2.94 to 2.96 cm. A mean reliability of 0.38 was realized for these breeding values. The analyses of withers height showed that compiling a reference population across breeds is a suitable strategy for German Warmblood horses. The single-step method is an appealing approach for practical genomic prediction in horses, because not many genotypes are available yet and animals without genotypes can by this way directly contribute to the estimation system."],["dc.description.abstract","Abstract   Reliability of genomic predictions is influenced by the size and genetic composition of the reference population. For German Warmblood horses, compilation of a reference population has been enabled through the cooperation of five German breeding associations. In this study, preliminary data from this joint reference population were used to genetically and genomically characterize withers height and to apply single-step methodology for estimating genomic breeding values for withers height. Using data on 2113 mares and their genomic information considering about 62,000 single nucleotide polymorphisms (SNPs), analysis of the genomic relationship revealed substructures reflecting breed origin and different breeding goals of the contributing breeding associations. A genome-wide association study confirmed a known quantitative trait locus (QTL) for withers height on equine chromosome (ECA) 3 close to LCORL and identified a further significant peak on ECA 1. Using a single-step approach with a combined relationship matrix, the estimated heritability for withers height was 0.31 (SE = 0.08) and the corresponding genomic breeding values ranged from − 2.94 to 2.96 cm. A mean reliability of 0.38 was realized for these breeding values. The analyses of withers height showed that compiling a reference population across breeds is a suitable strategy for German Warmblood horses. The single-step method is an appealing approach for practical genomic prediction in horses, because not many genotypes are available yet and animals without genotypes can by this way directly contribute to the estimation system."],["dc.identifier.doi","10.1007/s13353-021-00681-w"],["dc.identifier.pii","681"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/99000"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-517"],["dc.relation.eissn","2190-3883"],["dc.relation.issn","1234-1983"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Genetic and genomic characterization followed by single-step genomic evaluation of withers height in German Warmblood horses"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","341"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Genomics"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Hosseini, Shahrbanou"],["dc.contributor.author","Ngoc-Thuy Ha, Ngoc-Thuy Ha"],["dc.contributor.author","Simianer, Henner"],["dc.contributor.author","Falker-Gieske, Clemens"],["dc.contributor.author","Brenig, Bertram B."],["dc.contributor.author","Franke, Andre"],["dc.contributor.author","Hörstgen-Schwark, Gabriele"],["dc.contributor.author","Tetens, Jens"],["dc.contributor.author","Herzog, Sebastian"],["dc.contributor.author","Sharifi, Ahmad R."],["dc.date.accessioned","2019-07-09T11:51:19Z"],["dc.date.available","2019-07-09T11:51:19Z"],["dc.date.issued","2019"],["dc.description.abstract","Abstract Background Elevated water temperature, as is expected through climate change, leads to masculinization in fish species with sexual plasticity, resulting in changes in population dynamics. These changes are one important ecological consequence, contributing to the risk of extinction in small and inbred fish populations under natural conditions, due to male-biased sex ratio. Here we investigated the effect of elevated water temperature during embryogenesis on sex ratio and sex-biased gene expression profiles between two different tissues, namely gonad and caudal fin of adult zebrafish males and females, to gain new insights into the molecular mechanisms underlying sex determination (SD) and colour patterning related to sexual attractiveness. Results Our study demonstrated sex ratio imbalances with 25.5% more males under high-temperature condition, resulting from gonadal masculinization. The result of transcriptome analysis showed a significantly upregulated expression of male SD genes (e.g. dmrt1, amh, cyp11c1 and sept8b) and downregulation of female SD genes (e.g. zp2.1, vtg1, cyp19a1a and bmp15) in male gonads compared to female gonads. Contrary to expectations, we found highly differential expression of colour pattern (CP) genes in the gonads, suggesting the ‘neofunctionalisation’ of those genes in the zebrafish reproduction system. However, in the caudal fin, no differential expression of CP genes was identified, suggesting the observed differences in colouration between males and females in adult fish may be due to post-transcriptional regulation of key enzymes involved in pigment synthesis and distribution. Conclusions Our study demonstrates male-biased sex ratio under high temperature condition and support a polygenic SD (PSD) system in laboratory zebrafish. We identify a subset of pathways (tight junction, gap junction and apoptosis), enriched for SD and CP genes, which appear to be co-regulated in the same pathway, providing evidence for involvement of those genes in the regulation of phenotypic sexual dimorphism in zebrafish."],["dc.identifier.doi","10.1186/s12864-019-5722-1"],["dc.identifier.pmid","31060508"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16103"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59925"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Genetic mechanism underlying sexual plasticity and its association with colour patterning in zebrafish (Danio rerio)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1002"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Animals"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Kilic, Isabel"],["dc.contributor.author","Stehr, Manuel"],["dc.contributor.author","Hennies, Mark"],["dc.contributor.author","Metges, Cornelia C."],["dc.contributor.author","Franzenburg, Sören"],["dc.contributor.author","Falker-Gieske, Clemens"],["dc.contributor.author","Tetens, Jens"],["dc.contributor.author","Daş, Gürbüz"],["dc.date.accessioned","2021-06-01T09:42:30Z"],["dc.date.available","2021-06-01T09:42:30Z"],["dc.date.issued","2021"],["dc.description.abstract","Here, we describe the first transcriptomic investigation of the peripheral blood of chickens exposed to Ascaridia galli and Heterakis gallinarum infections. We investigated differentially expressed gene (DEG) patterns in two chicken genotypes with either a higher (Lohmann Brown Plus, LB) or lower (Lohmann Dual, LD) laying performance level. The hens were experimentally coinfected with A. galli and H. gallinarum, and their worm burdens and infection parameters were determined six weeks post infection. Based on most representative infection parameters, the hens were clustered into lower- and higher-infection intensity classes. We identified a total of 78 DEGs contributing to infection-related phenotypic variation in the two genotypes. Our data showed significant upregulation of Guanylate Binding Protein 7 (GBP7) in LD hens, making it a promising candidate for tolerance to ascarid infections in chickens. Gene ontology analysis revealed higher transcriptome activity related to biological processes such as “response to external stimulus” in LB hens, implying a higher stress response in this genotype. In contrast, LD hens showed higher transcriptomic expression of genes related to ontology classes that are possibly associated with a higher tolerance to infections. These findings may help explain why lower-performing genotypes (i.e., LD) are less sensitive to infections in terms of maintaining their performance."],["dc.description.sponsorship","Bundesanstalt für Landwirtschaft und Ernährung"],["dc.description.sponsorship","Open Access Fund of the Leibniz Institute for Farm Animal Biology"],["dc.identifier.doi","10.3390/ani11041002"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85268"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.publisher","MDPI"],["dc.relation.eissn","2076-2615"],["dc.rights","https://creativecommons.org/licenses/by/4.0/"],["dc.title","Differentially Expressed Gene Patterns in Ascarid-Infected Chickens of Higher- or Lower-Performing Genotypes"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","146"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Genomics"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Falker-Gieske, Clemens"],["dc.contributor.author","Mott, Andrea"],["dc.contributor.author","Franzenburg, Sören"],["dc.contributor.author","Tetens, Jens"],["dc.date.accessioned","2021-04-14T08:28:09Z"],["dc.date.accessioned","2022-08-18T12:34:01Z"],["dc.date.available","2021-04-14T08:28:09Z"],["dc.date.available","2022-08-18T12:34:01Z"],["dc.date.issued","2021-03-02"],["dc.date.updated","2022-07-29T12:06:59Z"],["dc.description.abstract","Abstract\r\n \r\n Background\r\n Retinol (RO) and its active metabolite retinoic acid (RA) are major regulators of gene expression in vertebrates and influence various processes like organ development, cell differentiation, and immune response. To characterize a general transcriptomic response to RA-exposure in vertebrates, independent of species- and tissue-specific effects, four publicly available RNA-Seq datasets from Homo sapiens, Mus musculus, and Xenopus laevis were analyzed. To increase species and cell-type diversity we generated RNA-seq data with chicken hepatocellular carcinoma (LMH) cells. Additionally, we compared the response of LMH cells to RA and RO at different time points.\r\n \r\n \r\n Results\r\n By conducting a transcriptome meta-analysis, we identified three retinoic acid response core clusters (RARCCs) consisting of 27 interacting proteins, seven of which have not been associated with retinoids yet. Comparison of the transcriptional response of LMH cells to RO and RA exposure at different time points led to the identification of non-coding RNAs (ncRNAs) that are only differentially expressed (DE) during the early response.\r\n \r\n \r\n Conclusions\r\n We propose that these RARCCs stand on top of a common regulatory RA hierarchy among vertebrates. Based on the protein sets included in these clusters we were able to identify an RA-response cluster, a control center type cluster, and a cluster that directs cell proliferation. Concerning the comparison of the cellular response to RA and RO we conclude that ncRNAs play an underestimated role in retinoid-mediated gene regulation."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2021"],["dc.identifier.citation","BMC Genomics. 2021 Mar 02;22(1):146"],["dc.identifier.doi","10.1186/s12864-021-07451-2"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17740"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/82518"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112925"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.notes.intern","Merged from goescholar"],["dc.publisher","BioMed Central"],["dc.relation.eissn","1471-2164"],["dc.rights","CC BY 4.0"],["dc.rights.holder","The Author(s)"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0/"],["dc.subject","Retinoids"],["dc.subject","Retinoic acid"],["dc.subject","Retinol"],["dc.subject","RNA-seq"],["dc.subject","Meta-analysis"],["dc.subject","Transcriptomics"],["dc.title","Multi-species transcriptome meta-analysis of the response to retinoic acid in vertebrates and comparative analysis of the effects of retinol and retinoic acid on gene expression in LMH cells"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1039"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Genes"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Bögeholz, Anke"],["dc.contributor.author","Falker-Gieske, Clemens"],["dc.contributor.author","Guélat, Monika"],["dc.contributor.author","Gurtner, Corinne"],["dc.contributor.author","Hunziker, Sibylle"],["dc.contributor.author","Oevermann, Anna"],["dc.contributor.author","Thaller, Georg"],["dc.contributor.author","Drögemüller, Cord"],["dc.contributor.author","Tetens, Jens"],["dc.date.accessioned","2021-08-12T07:45:57Z"],["dc.date.available","2021-08-12T07:45:57Z"],["dc.date.issued","2021"],["dc.description.abstract","Bilateral convergent strabismus with exophthalmos (BCSE) is a malformation of the eyes and is recognized as a mild but progressive disorder that affects cattle in the first two years of life. This most likely inherited disorder is rarely described in cattle resembling autosomal dominantly inherited forms of human progressive external ophthalmoplegia (PEO). In German Braunvieh cattle, two linked genome regions were found that could be responsible for the development and/or progression of BCSE. The goal of this study was to phenotypically characterize BCSE in Holstein cattle from Germany and Switzerland as well as to identify associated genome regions by GWAS. The clinicopathological phenotype of 52 BCSE-affected Holstein cattle was in accordance with the phenotype described in German Braunvieh cattle, but in addition, signs of degeneration and cellular infiltration in the eye muscles were found. By using imputed sequence level genotype data, three genome-wide significant GWAS hits were revealed on different chromosomes that were not detected by initial GWAS based on high density SNP array data highlighting the usefulness of this approach for mapping studies. The associated genome regions include the ABCC4 gene as well as markers adjacent to the NCOR2 and DNAJC3 genes all illustrating possible functional candidate genes. Our results challenge a monogenic mode of inheritance and indicate a more complex inheritance of BCSE in Holstein cattle. Furthermore, in comparison to previous results from German Braunvieh cattle, it illustrates an obvious genetic heterogeneity causing BSCE in cattle. Subsequent whole genome sequencing (WGS)-based analyses might elucidate pathogenic variants in the future."],["dc.description.abstract","Bilateral convergent strabismus with exophthalmos (BCSE) is a malformation of the eyes and is recognized as a mild but progressive disorder that affects cattle in the first two years of life. This most likely inherited disorder is rarely described in cattle resembling autosomal dominantly inherited forms of human progressive external ophthalmoplegia (PEO). In German Braunvieh cattle, two linked genome regions were found that could be responsible for the development and/or progression of BCSE. The goal of this study was to phenotypically characterize BCSE in Holstein cattle from Germany and Switzerland as well as to identify associated genome regions by GWAS. The clinicopathological phenotype of 52 BCSE-affected Holstein cattle was in accordance with the phenotype described in German Braunvieh cattle, but in addition, signs of degeneration and cellular infiltration in the eye muscles were found. By using imputed sequence level genotype data, three genome-wide significant GWAS hits were revealed on different chromosomes that were not detected by initial GWAS based on high density SNP array data highlighting the usefulness of this approach for mapping studies. The associated genome regions include the ABCC4 gene as well as markers adjacent to the NCOR2 and DNAJC3 genes all illustrating possible functional candidate genes. Our results challenge a monogenic mode of inheritance and indicate a more complex inheritance of BCSE in Holstein cattle. Furthermore, in comparison to previous results from German Braunvieh cattle, it illustrates an obvious genetic heterogeneity causing BSCE in cattle. Subsequent whole genome sequencing (WGS)-based analyses might elucidate pathogenic variants in the future."],["dc.description.sponsorship","H. Wilhelm Schaumann Stiftung"],["dc.description.sponsorship","Open-Access-Publikationsfonds 2021"],["dc.identifier.doi","10.3390/genes12071039"],["dc.identifier.pii","genes12071039"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/88582"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-448"],["dc.relation.eissn","2073-4425"],["dc.rights","CC BY 4.0"],["dc.title","GWAS Hits for Bilateral Convergent Strabismus with Exophthalmos in Holstein Cattle Using Imputed Sequence Level Genotypes"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]