Tetens, Jens

[["dc.bibliographiccitation.journal","Frontiers in Genetics"],["dc.bibliographiccitation.volume","13"],["dc.contributor.affiliation","Mott, Alexander Charles; \r\n1\r\nDepartment of Animal Sciences, Georg-August-University, Göttingen, Germany"],["dc.contributor.affiliation","Mott, Andrea; \r\n1\r\nDepartment of Animal Sciences, Georg-August-University, Göttingen, Germany"],["dc.contributor.affiliation","Preuß, Siegfried; \r\n2\r\nInstitute of Animal Science, University of Hohenheim, Stuttgart, Germany"],["dc.contributor.affiliation","Bennewitz, Jörn; \r\n2\r\nInstitute of Animal Science, University of Hohenheim, Stuttgart, Germany"],["dc.contributor.affiliation","Tetens, Jens; \r\n1\r\nDepartment of Animal Sciences, Georg-August-University, Göttingen, Germany"],["dc.contributor.affiliation","Falker-Gieske, Clemens; \r\n1\r\nDepartment of Animal Sciences, Georg-August-University, Göttingen, Germany"],["dc.contributor.author","Mott, Alexander Charles"],["dc.contributor.author","Mott, Andrea"],["dc.contributor.author","Preuß, Siegfried"],["dc.contributor.author","Bennewitz, Jörn"],["dc.contributor.author","Tetens, Jens"],["dc.contributor.author","Falker-Gieske, Clemens"],["dc.date.accessioned","2022-08-31T11:11:52Z"],["dc.date.available","2022-08-31T11:11:52Z"],["dc.date.issued","2022-08-17"],["dc.date.updated","2022-08-31T09:11:03Z"],["dc.description.abstract","Feather pecking in chickens is a damaging behavior, seriously impacting animal welfare and leading to economic losses. Feather pecking is a complex trait, which is partly under genetic control. Different hypotheses have been proposed to explain the etiology of feather pecking and notably, several studies have identified similarities between feather pecking and human mental disorders such as obsessive-compulsive disorder and schizophrenia. This study uses transcriptomic and phenotypic data from 167 chickens to map expression quantitative trait loci and to identify regulatory genes with a significant effect on this behavioral disorder using an association weight matrix approach. From 70 of the analyzed differentially expressed genes, 11,790 genome wide significantly associated variants were detected, of which 23 showed multiple associations (≥15). These were located in proximity to a number of genes, which are transcription regulators involved in chromatin binding, nucleic acid metabolism, protein translation and putative regulatory RNAs. The association weight matrix identified 36 genes and the two transcription factors: SP6 (synonym: KLF14) and ENSGALG00000042129 (synonym: CHTOP) as the most significant, with an enrichment of KLF14 binding sites being detectable in 40 differentially expressed genes. This indicates that differential expression between animals showing high and low levels of feather pecking was significantly associated with a genetic variant in proximity to KLF14. This multiallelic variant was located 652 bp downstream of KLF14 and is a deletion of 1-3 bp. We propose that a deletion downstream of the transcription factor KLF14 has a negative impact on the level of T cells in the developing brain of high feather pecking chickens, which leads to developmental and behavioral abnormalities. The lack of CD4 T cells and gamma-Aminobutyric acid (GABA) receptors are important factors for the increased propensity of laying hens to perform feather pecking. As such, KLF14 is a clear candidate regulator for the expression of genes involved in the pathogenic development. By further elucidating the regulatory pathways involved in feather pecking we hope to take significant steps forward in explaining and understanding other mental disorders, not just in chickens."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2022"],["dc.identifier.doi","10.3389/fgene.2022.969752"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/113333"],["dc.language.iso","en"],["dc.relation.eissn","1664-8021"],["dc.rights","CC BY 4.0"],["dc.rights.uri","http://creativecommons.org/licenses/by/4.0/"],["dc.title","eQTL analysis of laying hens divergently selected for feather pecking identifies KLF14 as a potential key regulator for this behavioral disorder"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Genomics"],["dc.bibliographiccitation.volume","21"],["dc.contributor.author","Falker-Gieske, Clemens"],["dc.contributor.author","Mott, Andrea"],["dc.contributor.author","Preuß, Siegfried"],["dc.contributor.author","Franzenburg, Sören"],["dc.contributor.author","Bessei, Werner"],["dc.contributor.author","Bennewitz, Jörn"],["dc.contributor.author","Tetens, Jens"],["dc.date.accessioned","2021-04-14T08:23:58Z"],["dc.date.available","2021-04-14T08:23:58Z"],["dc.date.issued","2020"],["dc.description.sponsorship","Open-Access-Publikationsfonds 2021"],["dc.identifier.doi","10.1186/s12864-020-07002-1"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17529"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81113"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1471-2164"],["dc.relation.orgunit","Department für Nutztierwissenschaften"],["dc.rights","CC BY 4.0"],["dc.rights.holder","The Author(s)"],["dc.title","Analysis of the brain transcriptome in lines of laying hens divergently selected for feather pecking"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

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[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Genetics"],["dc.bibliographiccitation.volume","21"],["dc.contributor.author","Falker-Gieske, Clemens"],["dc.contributor.author","Iffland, Hanna"],["dc.contributor.author","Preuß, Siegfried"],["dc.contributor.author","Bessei, Werner"],["dc.contributor.author","Drögemüller, Cord"],["dc.contributor.author","Bennewitz, Jörn"],["dc.contributor.author","Tetens, Jens"],["dc.date.accessioned","2021-04-14T08:32:47Z"],["dc.date.available","2021-04-14T08:32:47Z"],["dc.date.issued","2020"],["dc.description.sponsorship","Open-Access-Publikationsfonds 2021"],["dc.identifier.doi","10.1186/s12863-020-00920-9"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17586"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/84015"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.notes.intern","Merged from goescholar"],["dc.relation.eissn","1471-2156"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0/"],["dc.title","Meta-analyses of genome wide association studies in lines of laying hens divergently selected for feather pecking using imputed sequence level genotypes"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]