Hallier, Ernst

[["dc.bibliographiccitation.firstpage","150"],["dc.bibliographiccitation.issue","1-3"],["dc.bibliographiccitation.journal","Toxicology"],["dc.bibliographiccitation.lastpage","151"],["dc.bibliographiccitation.volume","164"],["dc.contributor.author","Schulz, Thomas G."],["dc.contributor.author","Ruhnau, P."],["dc.contributor.author","Mueller, M."],["dc.contributor.author","Bunger, J."],["dc.contributor.author","Ellie-hausen, H. J."],["dc.contributor.author","Hallier, Ernst"],["dc.date.accessioned","2018-11-07T08:52:57Z"],["dc.date.available","2018-11-07T08:52:57Z"],["dc.date.issued","2001"],["dc.identifier.isi","000169888500479"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22289"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Sci Ireland Ltd"],["dc.publisher.place","Clare"],["dc.relation.issn","0300-483X"],["dc.title","Lack of correlation between CYP2A6 genotype and smoking habits"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","R128"],["dc.bibliographiccitation.journal","Naunyn-Schmiedeberg s Archives of Pharmacology"],["dc.bibliographiccitation.lastpage","R129"],["dc.bibliographiccitation.volume","371"],["dc.contributor.author","Mueller, M."],["dc.contributor.author","Schettgen, T."],["dc.contributor.author","Bunger, J."],["dc.contributor.author","Hallier, Ernst"],["dc.contributor.author","Angerer, J."],["dc.date.accessioned","2018-11-07T08:29:33Z"],["dc.date.available","2018-11-07T08:29:33Z"],["dc.date.issued","2005"],["dc.identifier.isi","000229046800536"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/16680"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","New york"],["dc.relation.conference","46th Spring Meeting of the Deutsche-Gesellschaft-fur-Experimentelle-und-Klinische-Pharmakologie-und Toxikologie"],["dc.relation.eventlocation","Mainz, GERMANY"],["dc.relation.issn","0028-1298"],["dc.title","The human glutathione S-transferase T1 activity influences the N-2-methylvaline adduct levels after high occupational exposure to dimethyl sulphate"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Naunyn-Schmiedeberg s Archives of Pharmacology"],["dc.bibliographiccitation.volume","369"],["dc.contributor.author","Mueller, M."],["dc.contributor.author","Schettgen, T."],["dc.contributor.author","Bunger, J."],["dc.contributor.author","Hallier, Ernst"],["dc.contributor.author","Angerer, J."],["dc.date.accessioned","2018-11-07T10:50:53Z"],["dc.date.available","2018-11-07T10:50:53Z"],["dc.date.issued","2004"],["dc.format.extent","R140"],["dc.identifier.isi","000220592800559"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/48754"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","New york"],["dc.relation.conference","45th Spring Meeting of the German-Society-for-Experimental-and-Clinical-Pharmacology-and-Toxicology"],["dc.relation.eventlocation","Mainz, GERMANY"],["dc.relation.issn","0028-1298"],["dc.title","Influence of the human glutathione S-transferase T1 activity on the N-2-hydroxyethylvaline adduct levels in non-smokers and smokers"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Naunyn-Schmiedeberg s Archives of Pharmacology"],["dc.bibliographiccitation.volume","372"],["dc.contributor.author","Handrich, Claudia"],["dc.contributor.author","Bunger, J."],["dc.contributor.author","Westphal, G."],["dc.contributor.author","Hallier, Ernst"],["dc.contributor.author","Mueller, M."],["dc.date.accessioned","2018-11-07T10:14:57Z"],["dc.date.available","2018-11-07T10:14:57Z"],["dc.date.issued","2006"],["dc.format.extent","109"],["dc.identifier.isi","000237126800420"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40725"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","New york"],["dc.relation.conference","47th Spring Meeting of the Deutsche-Gesellschaft-fur-Experimentelle-und-Klinische-Pharmakologie-und Toxikologie"],["dc.relation.eventlocation","Mainz, GERMANY"],["dc.relation.issn","0028-1298"],["dc.title","Development of a structure-activity method to identify unknown toxic mycotoxins in Aspergillus nidulans"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Naunyn-Schmiedeberg s Archives of Pharmacology"],["dc.bibliographiccitation.volume","369"],["dc.contributor.author","Bunger, J."],["dc.contributor.author","Krahl, H."],["dc.contributor.author","Stein, Harald"],["dc.contributor.author","Schroder, O."],["dc.contributor.author","Mueller, M."],["dc.contributor.author","Westphal, G."],["dc.contributor.author","Schulze, L."],["dc.contributor.author","Tschoke, L."],["dc.contributor.author","Munack, A."],["dc.contributor.author","Hallier, Ernst"],["dc.date.accessioned","2018-11-07T10:50:52Z"],["dc.date.available","2018-11-07T10:50:52Z"],["dc.date.issued","2004"],["dc.format.extent","R145"],["dc.identifier.isi","000220592800580"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/48750"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","New york"],["dc.relation.conference","45th Spring Meeting of the German-Society-for-Experimental-and-Clinical-Pharmacology-and-Toxicology"],["dc.relation.eventlocation","Mainz, GERMANY"],["dc.relation.issn","0028-1298"],["dc.title","Particle filters reduce emission and mutagenicity of diesel exhaust in regular operation but can cause an increase during the regeneration phase"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","490"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Archives of Toxicology"],["dc.bibliographiccitation.lastpage","498"],["dc.bibliographiccitation.volume","74"],["dc.contributor.author","Bunger, J."],["dc.contributor.author","Krahl, Juergen"],["dc.contributor.author","Baum, K."],["dc.contributor.author","Schroder, O."],["dc.contributor.author","Mueller, M."],["dc.contributor.author","Westphal, G."],["dc.contributor.author","Ruhnau, P."],["dc.contributor.author","Schulz, Thomas G."],["dc.contributor.author","Hallier, Ernst"],["dc.date.accessioned","2018-11-07T09:20:34Z"],["dc.date.available","2018-11-07T09:20:34Z"],["dc.date.issued","2000"],["dc.description.abstract","Diesel engine exhaust particles (DEP) contribute substantially to ambient air pollution. They cause acute and chronic adverse health effects in humans. Biodiesel (rapeseed oil methyl ester, RME) is used as a \"green fuel\" in several countries. For a preliminary assessment of environmental and health effects of RME, the particulate-associated emissions from the DEP of RME and common fossil diesel fuel (DF) and their in vitro cytotoxic and mutagenic effects were compared. A test tractor was fuelled with RME and DF and driven in a European standard test cycle (ECE R49) on an engine dynamometer. Particle numbers and size distributions of the exhausts were determined at the load modes \"idling\" and \"rated power\". Filter-sampled particles were extracted and their cytotoxic properties tested using the neutral red assay, Mutagenicity was tested using the Salmonella typhimurium/microsome assay. Despite higher total particle emissions, solid particulate matter (soot) in the emissions from RME was lower than in the emissions from DF. While the size distributions and the numbers of emitted particles at \"rated power\" were nearly identical for the two fuels, at \"idling\" DF emitted substantially higher numbers of smaller particles than RME. The RME extracts caused fourfold stronger toxic effects on mouse fibroblasts at \"idling' but not at \"rated power\" than DF extracts. The extracts at both load modes were significantly mutagenic in TA98 and TA100. However, extracts of DF showed a fourfold higher mutagenic effect in TA98 land twofold in TA100) than extracts of RME. These results indicate benefits as well as disadvantages for humans and the environment from the use of RME as a fuel for tractors. The lower mutagenic potency of DEP from RME compared to DEP from DF is probably due to lower emissions of polycyclic aromatic compounds. The higher toxicity is probably caused by carbonyl compounds and unburned fuel, and reduces the benefits of the lower emissions of solid particulate matter and mutagens from RME."],["dc.identifier.doi","10.1007/s002040000155"],["dc.identifier.isi","000165130900011"],["dc.identifier.pmid","11097388"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28912"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0340-5761"],["dc.title","Cytotoxic and mutagenic effects, particle size and concentration analysis of diesel engine emissions using biodiesel and petrol diesel as fuel"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Naunyn-Schmiedeberg s Archives of Pharmacology"],["dc.bibliographiccitation.volume","372"],["dc.contributor.author","Mueller, M."],["dc.contributor.author","Belov, V."],["dc.contributor.author","de Meijere, Armin"],["dc.contributor.author","Handrich, Claudia"],["dc.contributor.author","Hallier, Ernst"],["dc.contributor.author","Bunger, J."],["dc.date.accessioned","2018-11-07T10:15:14Z"],["dc.date.available","2018-11-07T10:15:14Z"],["dc.date.issued","2006"],["dc.format.extent","132"],["dc.identifier.isi","000237126800518"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40769"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","New york"],["dc.relation.conference","47th Spring Meeting of the Deutsche-Gesellschaft-fur-Experimentelle-und-Klinische-Pharmakologie-und Toxikologie"],["dc.relation.eventlocation","Mainz, GERMANY"],["dc.relation.issn","0028-1298"],["dc.title","Biological monitoring after epichlorohydrin exposure: Development of a new method to determine the hemoglobin adduct N-(2,3-dihydroxypropyl)valine"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","50"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Archives of Toxicology"],["dc.bibliographiccitation.lastpage","55"],["dc.bibliographiccitation.volume","77"],["dc.contributor.author","Westphal, Goetz Alexander"],["dc.contributor.author","Asgari, S."],["dc.contributor.author","Schutz, T. G."],["dc.contributor.author","Bunger, J."],["dc.contributor.author","Mueller, M."],["dc.contributor.author","Hallier, Ernst"],["dc.date.accessioned","2018-11-07T10:41:55Z"],["dc.date.available","2018-11-07T10:41:55Z"],["dc.date.issued","2003"],["dc.description.abstract","Thimerosal is a widely used preservative in health care products, especially in vaccines. Due to possible adverse health effects, investigations on its metabolism and toxicity are urgently needed. An in vivo study on chronic toxicity of thimerosal in rats was inconclusive and reports on genotoxic effects in various in vitro systems were contradictory. Therefore, we reinvestigated thimerosal in the cytochalasin B block micronucleus test. Glutathione S-transferases were proposed to be involved in the detoxification of thimerosal or its decomposition products. Since the outcome of genotoxicity studies can be dependent on the metabolic competence of the cells used, we were additionally interested whether polymorphisms of glutathione S-transferases (GSTM1, GSTT1, or GSTP1) may influence the results of the micronucleus test with primary human lymphocytes. Blood samples of six healthy donors of different glutathione S-transferase genotypes were included in the study. At least two independent experiments were performed for each blood donor. Significant induction of micronuclei was seen at concentrations between 0.05-0.5 mug/ml in 14 out of 16 experiments. Thus, genotoxic effects were seen even at concentrations which can occur at the injection site. Toxicity and toxicity-related elevation of micronuclei was seen at and above 0.6 mug/ml thimerosal. Marked individual and intraindividual variations in the in vitro response to thimerosal among the different blood donors occurred. However, there was no association observed with any of the glutathione S-transferase polymorphism investigated. In conclusion, thimerosal is genotoxic in the cytochalasin B block micronucleus test with human lymphocytes. These data raise some concern on the widespread use of thimerosal."],["dc.identifier.doi","10.1007/s00204-002-0405-z"],["dc.identifier.isi","000180851000011"],["dc.identifier.pmid","12491041"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/46656"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0340-5761"],["dc.title","Thimerosal induces micronuclei in the cytochalasin B block micronucleus test with human lymphocytes"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Naunyn-Schmiedeberg s Archives of Pharmacology"],["dc.bibliographiccitation.volume","367"],["dc.contributor.author","Mueller, M."],["dc.contributor.author","Podgorski, A."],["dc.contributor.author","Bunger, J."],["dc.contributor.author","Hallier, Ernst"],["dc.date.accessioned","2018-11-07T10:40:43Z"],["dc.date.available","2018-11-07T10:40:43Z"],["dc.date.issued","2003"],["dc.format.extent","R127"],["dc.identifier.isi","000182435500502"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/46369"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","New york"],["dc.relation.conference","44th Meeting of the Deutsche-Gesellschaft-fur-Experimentelle-und-Klinische-Pharmakologie-und Toxikologie/20th Gesellschaft-fur-Umwelt-Mutationsforschung"],["dc.relation.eventlocation","MAINZ, GERMANY"],["dc.relation.issn","0028-1298"],["dc.title","Formation of S-ethyl- and S-propylglutathione from ethyl- and propylmonohalides by the hGSTT1-1 in vitro"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","760"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Archives of Toxicology"],["dc.bibliographiccitation.lastpage","767"],["dc.bibliographiccitation.volume","74"],["dc.contributor.author","Mueller, M."],["dc.contributor.author","Voss, M."],["dc.contributor.author","Heise, C."],["dc.contributor.author","Schulz, T."],["dc.contributor.author","Bunger, J."],["dc.contributor.author","Hallier, Ernst"],["dc.date.accessioned","2018-11-07T09:23:09Z"],["dc.date.available","2018-11-07T09:23:09Z"],["dc.date.issued","2001"],["dc.description.abstract","Glutathione-S-transferase T1 (GSTT1-1) is a major isoenzyme for the biotransformation of halomethanes. The enzyme activity is located, among other places, in human liver and erythrocytes and is subject to a genetic polymorphism. Metabolism of the halomethanes via GSTT1-1 yields S-methylglutathione (MeSG). A new HPLC assay for the enzymatic formation of MeSG was developed. The glutathione conjugate was derivatized with 9-fluorenylmethyl chloroformate, followed by reverse-phase HPLC with gradient elution and fluorescence detection. The limit of detection was as low as about 39 pmol MeSG on-column. Including derivatization and HPLC analysis, samples could be run at 42-min intervals, thus enabling a high sample throughput. The entire method was validated for analyte recovery (78.2%) and for variations in detector response with replicated injections (11.8%) and with analyses on each of 11 consecutive days (15.2%) with erythrocyte lysate incubations as the matrix. The time-, protein-, and substrate-dependences of the enzymatic catalysis with the model substrates methyl bromide (MeBr) and methyl chloride (MeCl) were studied. Due to its strong electrophilic character, MeBr caused a high level of spontaneous MeSG formation from glutathione in a protein-free medium and a substrate-trapping side reaction in the presence of proteins. Therefore, enzymatic MeSG formation rates may only be determined with MeBr concentrations of at least 3000 ppm in the presence of limited amounts of protein (e.g. 100 mul erythrocyte lysate). In contrast, MeCl showed a lower alkylating potential allowing enzymatic catalysis to be the dominant reaction in incubations with 10,000 ppm MeCl and 2 ml erythrocyte lysate."],["dc.identifier.doi","10.1007/s002040000201"],["dc.identifier.isi","000167523000004"],["dc.identifier.pmid","11305778"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/29516"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0340-5761"],["dc.title","High-performance liquid chromatography/fluorescence detection of S-methylglutathione formed by glutathione-S-transferase T1 in vitro"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]