Hallier, Ernst

[["dc.bibliographiccitation.firstpage","599"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Archives of Toxicology"],["dc.bibliographiccitation.lastpage","603"],["dc.bibliographiccitation.volume","81"],["dc.contributor.author","Buenger, Juergen"],["dc.contributor.author","Krahl, Juergen"],["dc.contributor.author","Munack, Axel"],["dc.contributor.author","Ruschel, Yvonne"],["dc.contributor.author","Schroeder, Olaf"],["dc.contributor.author","Emmert, Birgit"],["dc.contributor.author","West, Goetz"],["dc.contributor.author","Mueller, Michael"],["dc.contributor.author","Hallier, Ernst"],["dc.contributor.author","Bruening, Thomas"],["dc.date.accessioned","2018-11-07T10:59:47Z"],["dc.date.available","2018-11-07T10:59:47Z"],["dc.date.issued","2007"],["dc.description.abstract","Diesel engine emissions (DEE) are classified as probably carcinogenic to humans. In recent years every effort was made to reduce DEE and their content of carcinogenic and mutagenic polycyclic aromatic compounds. Since 1995 we observed an appreciable reduction of mutagenicity of DEE driven by reformulated or newly designed fuels in several studies. Recently, the use of rapeseed oil as fuel for diesel engines is rapidly growing among German transportation businesses and agriculture due to economic reasons. We compared the mutagenic effects of DEE from two different batches of rapeseed oil (RSO) with rapeseed methyl ester (RME, biodiesel), natural gas derived synthetic fuel (gas-to-liquid, GTL), and a reference diesel fuel (DF). The test engine was a heavy-duty truck diesel running the European Stationary Cycle. Particulate matter from the exhaust was sampled onto PTFE-coated glass fibre filters and extracted with dichloromethane in a soxhlet apparatus. The gas phase constituents were sampled as condensates. The mutagenicity of the particle extracts and the condensates was tested using the Salmonella typhimurium/mammalian microsome assay with tester strains TA98 and TA100. Compared to DF the two RSO qualities significantly increased the mutagenic effects of the particle extracts by factors of 9.7 up to 59 in tester strain TA98 and of 5.4 up to 22.3 in tester strain TA100, respectively. The condensates of the RSO fuels caused an up to factor 13.5 stronger mutagenicity than the reference fuel. RME extracts had a moderate but significant higher mutagenic response in assays of TA98 with metabolic activation and TA100 without metabolic activation. GTL samples did not differ significantly from DF. In conclusion, the strong increase of mutagenicity using RSO as diesel fuel compared to the reference DF and other fuels causes deep concern on future usage of this biologic resource as a replacement of established diesel fuels."],["dc.identifier.doi","10.1007/s00204-007-0196-3"],["dc.identifier.isi","000248109400008"],["dc.identifier.pmid","17375286"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50777"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0340-5761"],["dc.title","Strong mutagenic effects of diesel engine emissions using vegetable oil as fuel"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Naunyn-Schmiedeberg s Archives of Pharmacology"],["dc.bibliographiccitation.volume","367"],["dc.contributor.author","Westphal, Goetz Alexander"],["dc.contributor.author","Asgari, S."],["dc.contributor.author","Schulz, T."],["dc.contributor.author","Hallier, Ernst"],["dc.date.accessioned","2018-11-07T10:40:45Z"],["dc.date.available","2018-11-07T10:40:45Z"],["dc.date.issued","2003"],["dc.format.extent","R135"],["dc.identifier.isi","000182435500535"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/46377"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","New york"],["dc.relation.conference","44th Meeting of the Deutsche-Gesellschaft-fur-Experimentelle-und-Klinische-Pharmakologie-und Toxikologie/20th Gesellschaft-fur-Umwelt-Mutationsforschung"],["dc.relation.eventlocation","MAINZ, GERMANY"],["dc.relation.issn","0028-1298"],["dc.title","Thimerosal induces micronuclei in primary human lymphocytes"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","384"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","International Archives of Occupational and Environmental Health"],["dc.bibliographiccitation.lastpage","388"],["dc.bibliographiccitation.volume","73"],["dc.contributor.author","Westphal, Goetz Alexander"],["dc.contributor.author","Schnuch, Axel"],["dc.contributor.author","Schulz, Thomas G."],["dc.contributor.author","Reich, Kristian"],["dc.contributor.author","Aberer, Werner"],["dc.contributor.author","Brasch, Jochen"],["dc.contributor.author","Koch, P."],["dc.contributor.author","Wessbecher, R."],["dc.contributor.author","Szliska, Christiane"],["dc.contributor.author","Bauer, A."],["dc.contributor.author","Hallier, Ernst"],["dc.date.accessioned","2018-11-07T10:37:14Z"],["dc.date.available","2018-11-07T10:37:14Z"],["dc.date.issued","2000"],["dc.description.abstract","Objective: Thimerosal is an important preservative in vaccines and ophthalmologic preparations. The substance is known to be a type IV sensitizing agent. High sensitization rates were observed in contact-allergic patients and in health care workers who had been exposed to thimerosal-preserved vaccines. There is evidence for the involvement of the glutathione system in the metabolism of thimerosal or its decomposition products (organomercury alkyl compounds). Thus detoxification by polymorphically expressed glutathione S-transferases such as GSTT1 and GSTM1 might have a protective effect against sensitization by these substances. Methods: To address this question, a case control study was conducted, including 91 Central European individuals with a positive patch-test reaction to thimerosal. This population was compared with 169 healthy controls and additionally with 114 individuals affected by an allergy against para-substituted aryl compounds. The latter population was included in order to test whether possible associations were due to substance-specific effects, or were a general feature connected with type IV immunological diseases. Homozygous deletions of GSTT1 and GSTM1 were determined by polymerase chain reaction. Results: Glutathione S-transferase M1 deficiency was significantly more frequent among patients sensitized to thimerosal (65.9%, P = 0.013) compared with the healthy control group (49.1%) and the \"para-compound\" group (48%, P = 0.034). Glutathione S-transferase T1 deficiency in the thimerosal/mercury group (19.8%) was barely elevated versus healthy controls (16.0%) and the \"para-compound\" group (14.0%). The combined deletion (GSTT1-/GSTM1-) was markedly more frequent among thimerosal-sensitized patients than in healthy controls (17.6% vs. 6.5%, P = 0.0093) and in the \"para-compound\" group (17.6% vs. 6.1%; P = 0.014), revealing a synergistic effect of these enzyme deficiencies (healthy controls vs. thimerosal GSTM1 negative individuals, OR = 2.0 [CI = 1.2-3.4], GSTT1-, OR = 1.2 [CI = 0.70-2.1], GSTM1/T1-, OR = 3.1 [CI = 1.4-6.5]). Conclusions: Since the glutathione-dependent system was repeatedly shown to be involved in the metabolism of thimerosal decomposition products, the observed association may be of functional relevance."],["dc.identifier.doi","10.1007/s004200000159"],["dc.identifier.isi","000089088300005"],["dc.identifier.pmid","11007341"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/45516"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0340-0131"],["dc.title","Homozygous gene deletions of the glutathione S-transferases M1, and T1 are associated with thimerosal sensitization"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","161"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Zeitschrift für Geburtshilfe und Neonatologie"],["dc.bibliographiccitation.lastpage","166"],["dc.bibliographiccitation.volume","214"],["dc.contributor.author","Voigt, M."],["dc.contributor.author","Briese, Volker"],["dc.contributor.author","Carstensen, M."],["dc.contributor.author","Wolterdorf, F."],["dc.contributor.author","Hallier, Ernst"],["dc.contributor.author","Straube, Sebastian"],["dc.date.accessioned","2018-11-07T08:41:15Z"],["dc.date.available","2018-11-07T08:41:15Z"],["dc.date.issued","2010"],["dc.description.abstract","Aim: A description of preterm birth rates - specified according to maternal age - after the exclusion of anamnestic risk factors. Material and Methods: Data for this study were taken from the German Perinatal Survey of 1998-2000. We analysed data from 492 576 single ton pregnancies and determined preterm birth rates according to maternal age after a stepwise exclusion of anamnestic risk factors. Results: There was a U-shaped dependence of preterm birth rates on maternal age. The low est preterm birth rate (without excluding women with anamnestic risk factors) was 5.6 % at a maternal age of 29 years. The prevalence of some anamnestic risk factors for preterm birth, such as previous stillbirths, spontaneous and induced abortions, and ectopic pregnancies, increased with maternal age. Excluding women with anam nestic risk factors lowered the preterm birth rates substantially. The lowest preterm birth rates were found in women with one previous live birth, without any anamnestic risk factors, and with a body mass index (BMI) of 25.00-29.99. With these restrictions, we found preterm birth rates of under 2 % for women aged 24-31 years. Conclusions: The magnitude and age-dependence of the preterm birth rate can to some extent be explained with the age-dependent prevalence of anamnestic risk factors for preterm birth. Excluding women with anamnestic risk factors from our study population lowered the preterm birth rates substantially."],["dc.identifier.doi","10.1055/s-0030-1254140"],["dc.identifier.isi","000208514200005"],["dc.identifier.pmid","20806151"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19425"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","0948-2393"],["dc.title","Age-Specific Preterm Birth Rates after Exclusion of Risk Factors - An Analysis of the German Perinatal Survey"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","150"],["dc.bibliographiccitation.issue","1-3"],["dc.bibliographiccitation.journal","Toxicology"],["dc.bibliographiccitation.lastpage","151"],["dc.bibliographiccitation.volume","164"],["dc.contributor.author","Schulz, Thomas G."],["dc.contributor.author","Ruhnau, P."],["dc.contributor.author","Mueller, M."],["dc.contributor.author","Bunger, J."],["dc.contributor.author","Ellie-hausen, H. J."],["dc.contributor.author","Hallier, Ernst"],["dc.date.accessioned","2018-11-07T08:52:57Z"],["dc.date.available","2018-11-07T08:52:57Z"],["dc.date.issued","2001"],["dc.identifier.isi","000169888500479"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22289"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Sci Ireland Ltd"],["dc.publisher.place","Clare"],["dc.relation.issn","0300-483X"],["dc.title","Lack of correlation between CYP2A6 genotype and smoking habits"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Naunyn-Schmiedeberg s Archives of Pharmacology"],["dc.bibliographiccitation.volume","379"],["dc.contributor.author","Westphal, Goetz Alexander"],["dc.contributor.author","Buenger, J."],["dc.contributor.author","Lichey, Nadine"],["dc.contributor.author","Taeger, Dirk"],["dc.contributor.author","Hallier, Ernst"],["dc.date.accessioned","2018-11-07T08:31:19Z"],["dc.date.available","2018-11-07T08:31:19Z"],["dc.date.issued","2009"],["dc.format.extent","78"],["dc.identifier.isi","000266563200387"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17096"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","New york"],["dc.relation.conference","50th Annual Meeting of the Deutsche-Gesellschaft-fur-Experimentelle-und-Klinische-Pharmakologie-und Toxikologie"],["dc.relation.eventlocation","Mainz, GERMANY"],["dc.relation.issn","0028-1298"],["dc.title","Myeloeperoxidase mediated cytotoxcity of p-benzoquinone"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Toxicology Letters"],["dc.bibliographiccitation.volume","189"],["dc.contributor.author","Mueller, Michael"],["dc.contributor.author","Handrich, Claudia"],["dc.contributor.author","Quitschau, Melanie"],["dc.contributor.author","Buenger, Juergen"],["dc.contributor.author","Westphal, Goetz"],["dc.contributor.author","Hallier, Ernst"],["dc.contributor.author","Grond, Stephanie"],["dc.date.accessioned","2018-11-07T11:24:19Z"],["dc.date.available","2018-11-07T11:24:19Z"],["dc.date.issued","2009"],["dc.format.extent","S80"],["dc.identifier.doi","10.1016/j.toxlet.2009.06.241"],["dc.identifier.isi","000269778800233"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56375"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Ireland Ltd"],["dc.publisher.place","Clare"],["dc.relation.conference","46th Congress of the European-Societies-of-Toxicology"],["dc.relation.eventlocation","Dreden, GERMANY"],["dc.relation.issn","0378-4274"],["dc.title","Identification of a cycloisoemericellin derivative as a novel mycotoxin in Aspergillus nidulans"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","229"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Zeitschrift für Geburtshilfe und Neonatologie"],["dc.bibliographiccitation.lastpage","233"],["dc.bibliographiccitation.volume","214"],["dc.contributor.author","Voigt, M."],["dc.contributor.author","Straube, Sebastian"],["dc.contributor.author","Gulashvili, A."],["dc.contributor.author","Schild, R. L."],["dc.contributor.author","Hallier, Ernst"],["dc.contributor.author","Briese, Volker"],["dc.date.accessioned","2018-11-07T08:36:36Z"],["dc.date.available","2018-11-07T08:36:36Z"],["dc.date.issued","2010"],["dc.description.abstract","Aim: The aim of this study was to compare neonatal outcomes in primiparous women with and without previous extrauterine pregnancies. Material and Methods: We analysed data from 207 171 singleton pregnancies in primiparous women from the German Perinatal Survey of 1998-2000. To minimise confounding factors, we only included women without previous miscarriages or terminations of pregnancy and performed comparisons separately for 3 maternal age groups as well as for all cases together. Results: Women with and without previous extrauterine pregnancies were of comparable height and weight but women with previous extrauterine pregnancies were on average older (29.2 vs. 26.6 years). The preterm birth rate was higher in women with previous extrauterine pregnancies (9.4 % vs. 6.8 %, odds ratio 1.42 [95 % confidence interval 1.18-1.69], p < 0.001; analysing all cases together) as was the rate of neonates with a low birth weight <= 2 499 g (7.9 % vs. 5.7 %, odds ratio 1.43 [95 % confidence interval 1.17-1.72], p > 0.001; analysing all cases together). The proportions of neonates classified as small, appropriate, or large for gestational age were rather similar in women with and without previous extrauterine pregnancies; likewise Apgar scores differed only slightly, although for some comparisons statistical significance was reached in spite of the small magnitude of differences. Conclusions: Previous extrauterine pregnancies are associated with higher rates of preterm birth and infants of low birth weight in subsequent pregnancies."],["dc.identifier.doi","10.1055/s-0030-1255026"],["dc.identifier.isi","000208514500002"],["dc.identifier.pmid","21207322"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18352"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","0948-2393"],["dc.title","Previous Extrauterine Pregnancies and Neonatal Outcomes in Primiparous Women - An Analysis of the German Perinatal Survey"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","R128"],["dc.bibliographiccitation.journal","Naunyn-Schmiedeberg s Archives of Pharmacology"],["dc.bibliographiccitation.lastpage","R129"],["dc.bibliographiccitation.volume","371"],["dc.contributor.author","Mueller, M."],["dc.contributor.author","Schettgen, T."],["dc.contributor.author","Bunger, J."],["dc.contributor.author","Hallier, Ernst"],["dc.contributor.author","Angerer, J."],["dc.date.accessioned","2018-11-07T08:29:33Z"],["dc.date.available","2018-11-07T08:29:33Z"],["dc.date.issued","2005"],["dc.identifier.isi","000229046800536"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/16680"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","New york"],["dc.relation.conference","46th Spring Meeting of the Deutsche-Gesellschaft-fur-Experimentelle-und-Klinische-Pharmakologie-und Toxikologie"],["dc.relation.eventlocation","Mainz, GERMANY"],["dc.relation.issn","0028-1298"],["dc.title","The human glutathione S-transferase T1 activity influences the N-2-methylvaline adduct levels after high occupational exposure to dimethyl sulphate"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Naunyn-Schmiedeberg s Archives of Pharmacology"],["dc.bibliographiccitation.volume","369"],["dc.contributor.author","Mueller, M."],["dc.contributor.author","Schettgen, T."],["dc.contributor.author","Bunger, J."],["dc.contributor.author","Hallier, Ernst"],["dc.contributor.author","Angerer, J."],["dc.date.accessioned","2018-11-07T10:50:53Z"],["dc.date.available","2018-11-07T10:50:53Z"],["dc.date.issued","2004"],["dc.format.extent","R140"],["dc.identifier.isi","000220592800559"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/48754"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","New york"],["dc.relation.conference","45th Spring Meeting of the German-Society-for-Experimental-and-Clinical-Pharmacology-and-Toxicology"],["dc.relation.eventlocation","Mainz, GERMANY"],["dc.relation.issn","0028-1298"],["dc.title","Influence of the human glutathione S-transferase T1 activity on the N-2-hydroxyethylvaline adduct levels in non-smokers and smokers"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]