Hallier, Ernst

[["dc.bibliographiccitation.firstpage","150"],["dc.bibliographiccitation.issue","1-3"],["dc.bibliographiccitation.journal","Toxicology"],["dc.bibliographiccitation.lastpage","151"],["dc.bibliographiccitation.volume","164"],["dc.contributor.author","Schulz, Thomas G."],["dc.contributor.author","Ruhnau, P."],["dc.contributor.author","Mueller, M."],["dc.contributor.author","Bunger, J."],["dc.contributor.author","Ellie-hausen, H. J."],["dc.contributor.author","Hallier, Ernst"],["dc.date.accessioned","2018-11-07T08:52:57Z"],["dc.date.available","2018-11-07T08:52:57Z"],["dc.date.issued","2001"],["dc.identifier.isi","000169888500479"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22289"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Sci Ireland Ltd"],["dc.publisher.place","Clare"],["dc.relation.issn","0300-483X"],["dc.title","Lack of correlation between CYP2A6 genotype and smoking habits"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","213"],["dc.bibliographiccitation.lastpage","215"],["dc.bibliographiccitation.seriesnr","500"],["dc.contributor.author","Schulz, Thomas G."],["dc.contributor.author","Ruhnau, P."],["dc.contributor.author","Hallier, Ernst"],["dc.contributor.editor","Dansette, Patrick M."],["dc.date.accessioned","2018-11-07T09:30:00Z"],["dc.date.available","2018-11-07T09:30:00Z"],["dc.date.issued","2001"],["dc.identifier.isi","000173071900029"],["dc.identifier.pmid","11764938"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/31194"],["dc.language.iso","en"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Kluwer Academic/Plenum Publishers"],["dc.publisher.place","New York"],["dc.relation.conference","6th International Symposium on Biological Reactive Intermediates"],["dc.relation.crisseries","Advances in Experimental Medicine and Biology"],["dc.relation.eventend","2000-07-20"],["dc.relation.eventlocation","Paris"],["dc.relation.eventstart","2000-07-16"],["dc.relation.isbn","0-306-46659-7"],["dc.relation.ispartof","Biological reactive intermediates VI: Chemical and biological mechanisms in susceptibility to and prevention of environmental diseases"],["dc.relation.ispartofseries","Advances in experimental medicine and biology; 500"],["dc.relation.issn","0065-2598"],["dc.title","Lack of correlation between CYP2A6 genotype and smoking habits"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","490"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Archives of Toxicology"],["dc.bibliographiccitation.lastpage","498"],["dc.bibliographiccitation.volume","74"],["dc.contributor.author","Bunger, J."],["dc.contributor.author","Krahl, Juergen"],["dc.contributor.author","Baum, K."],["dc.contributor.author","Schroder, O."],["dc.contributor.author","Mueller, M."],["dc.contributor.author","Westphal, G."],["dc.contributor.author","Ruhnau, P."],["dc.contributor.author","Schulz, Thomas G."],["dc.contributor.author","Hallier, Ernst"],["dc.date.accessioned","2018-11-07T09:20:34Z"],["dc.date.available","2018-11-07T09:20:34Z"],["dc.date.issued","2000"],["dc.description.abstract","Diesel engine exhaust particles (DEP) contribute substantially to ambient air pollution. They cause acute and chronic adverse health effects in humans. Biodiesel (rapeseed oil methyl ester, RME) is used as a \"green fuel\" in several countries. For a preliminary assessment of environmental and health effects of RME, the particulate-associated emissions from the DEP of RME and common fossil diesel fuel (DF) and their in vitro cytotoxic and mutagenic effects were compared. A test tractor was fuelled with RME and DF and driven in a European standard test cycle (ECE R49) on an engine dynamometer. Particle numbers and size distributions of the exhausts were determined at the load modes \"idling\" and \"rated power\". Filter-sampled particles were extracted and their cytotoxic properties tested using the neutral red assay, Mutagenicity was tested using the Salmonella typhimurium/microsome assay. Despite higher total particle emissions, solid particulate matter (soot) in the emissions from RME was lower than in the emissions from DF. While the size distributions and the numbers of emitted particles at \"rated power\" were nearly identical for the two fuels, at \"idling\" DF emitted substantially higher numbers of smaller particles than RME. The RME extracts caused fourfold stronger toxic effects on mouse fibroblasts at \"idling' but not at \"rated power\" than DF extracts. The extracts at both load modes were significantly mutagenic in TA98 and TA100. However, extracts of DF showed a fourfold higher mutagenic effect in TA98 land twofold in TA100) than extracts of RME. These results indicate benefits as well as disadvantages for humans and the environment from the use of RME as a fuel for tractors. The lower mutagenic potency of DEP from RME compared to DEP from DF is probably due to lower emissions of polycyclic aromatic compounds. The higher toxicity is probably caused by carbonyl compounds and unburned fuel, and reduces the benefits of the lower emissions of solid particulate matter and mutagens from RME."],["dc.identifier.doi","10.1007/s002040000155"],["dc.identifier.isi","000165130900011"],["dc.identifier.pmid","11097388"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28912"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0340-5761"],["dc.title","Cytotoxic and mutagenic effects, particle size and concentration analysis of diesel engine emissions using biodiesel and petrol diesel as fuel"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Journal of Investigative Dermatology"],["dc.bibliographiccitation.volume","115"],["dc.contributor.author","Reich, Kristian"],["dc.contributor.author","Westphal, G."],["dc.contributor.author","Hallier, Ernst"],["dc.contributor.author","Ruhnau, P."],["dc.contributor.author","Kranke, B."],["dc.contributor.author","Schnuch, Axel"],["dc.contributor.author","Neumann, C."],["dc.date.accessioned","2018-11-07T10:31:10Z"],["dc.date.available","2018-11-07T10:31:10Z"],["dc.date.issued","2000"],["dc.format.extent","577"],["dc.identifier.isi","000089100300394"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/44041"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Science Inc"],["dc.publisher.place","Malden"],["dc.relation.issn","0022-202X"],["dc.title","Association between contact allergy and polymorphisms of the interleukin-1 gene family"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","458"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Occupational and Environmental Medicine"],["dc.bibliographiccitation.lastpage","464"],["dc.bibliographiccitation.volume","57"],["dc.contributor.author","Bunger, J."],["dc.contributor.author","Antlauf-Lammers, M."],["dc.contributor.author","Schulz, Thomas G."],["dc.contributor.author","Westphal, Goetz Alexander"],["dc.contributor.author","Mueller, M. M."],["dc.contributor.author","Ruhnau, P."],["dc.contributor.author","Hallier, Ernst"],["dc.date.accessioned","2018-11-07T10:42:26Z"],["dc.date.available","2018-11-07T10:42:26Z"],["dc.date.issued","2000"],["dc.description.abstract","Objectives-In a cross sectional study, work related health complaints and diseases of 58 compost workers and 53 biowaste collectors were investigated and compared with 40 control subjects. Levels of specific IgG antibodies to moulds and bacteria were measured as immunological markers of exposure to bioaerosols. Methods-With a standardised protocol, the participants of the study were interview ed for work related symptoms, conditions of exposure to bioaerosols at their workplaces, exposure to bioaerosols from other sources, atopic diseases, and smoking habits. They were clinically examined by physicians specialised in occupational medicine. Also, concentrations of specific IgG antibodies against antigens of moulds and actinomycetes occurring regularly at these workplaces were measured and compared with the health complaints of the workers. Results-Compost workers had significantly more symptoms and diseases of the airways (p=0.003) and the skin (p=0.02) than the control subjects. Health complaints of biowaste collectors did not differ significantly from those of the control group. Subjects with atopic diseases were underrepresented in the compost workers (p=0.003). Significantly increased antibody concentrations against fungi and actinomycetes were measured in workers at composting plants. The concentrations in biowaste collectors did not differ significantly from those in the control subjects. A significant association between the diseases and increased antibody concentrations were found in the compost workers. Conclusion-The high exposure to bioaerosols of compost workers is significantly associated with a higher frequency of health complaints and diseases as well as higher concentrations of specific antibodies against moulds and actinomycetes. A healthy worker effect is indicated by the underrepresentation of atopic diseases among the compost workers compared with biowaste collectors and the control group."],["dc.identifier.doi","10.1136/oem.57.7.458"],["dc.identifier.isi","000087830700005"],["dc.identifier.pmid","10854498"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/46796"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","British Med Journal Publ Group"],["dc.relation.issn","1351-0711"],["dc.title","Health complaints and immunological markers of exposure to bioaerosols among biowaste collectors and compost workers"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Naunyn-Schmiedeberg s Archives of Pharmacology"],["dc.bibliographiccitation.volume","363"],["dc.contributor.author","Schulz, Thomas G."],["dc.contributor.author","Ruhnau, P."],["dc.contributor.author","Mueller, M."],["dc.contributor.author","Bunger, J."],["dc.contributor.author","Elliehausen, H. J."],["dc.contributor.author","Hallier, Ernst"],["dc.date.accessioned","2018-11-07T09:14:30Z"],["dc.date.available","2018-11-07T09:14:30Z"],["dc.date.issued","2001"],["dc.format.extent","R168"],["dc.identifier.isi","000167682100668"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/27429"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","New york"],["dc.relation.issn","0028-1298"],["dc.title","Lack of correlation between CYP2A6 genotype and smoking habits"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","634"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Archives of Toxicology"],["dc.bibliographiccitation.lastpage","642"],["dc.bibliographiccitation.volume","76"],["dc.contributor.author","Mueller, M."],["dc.contributor.author","Bunger, J."],["dc.contributor.author","Voss, M."],["dc.contributor.author","Westphal, G."],["dc.contributor.author","Ruhnau, P."],["dc.contributor.author","Hallier, Ernst"],["dc.date.accessioned","2018-11-07T09:51:06Z"],["dc.date.available","2018-11-07T09:51:06Z"],["dc.date.issued","2002"],["dc.description.abstract","The human glutathione S-transferase hGSTT1-1 is characterized by a polymorphism displaying three phenotypes: the \"non-conjugator\" (NC) phenotype expresses no or only a residual activity due to a homozygous deletion of the hGSTT1 gene, a medium hGSTT1-1 activity can be demonstrated for the \"low conjugator\" (LC) phenotype as the heterozygous bearer of one hGSTT1 allele, and a high hGSTT1-1 activity is detected for the \"high conjugator\" (HC) phenotype as the homozygous bearer of two hGSTT1 alleles. We have developed a routine ex vivo photometric phenotyping procedure based on the determination of bromide release rates from the hGSTT1-1-catalyzed glutathione conjugation of the substrate methyl bromide in EDTA blood samples under standard conditions (1,000 ppm methyl bromide, 10 min incubation). The bromide release rates were standardized to the hemoglobin (Hb) value. Twenty-six individuals were phenotyped following the new procedure. Four individuals were classified as NCs (24-33 pmol Br-/mg Hb per min), 21 individuals were regarded as LCs (107-206 pmol Br-/mg Hb per min) and one person of the study group was designated HC (236 pmol Br-/mg Hb per min). The results were validated by qualitative hGSTT1 genotyping and demonstrated a 100% match for conjugators and non-conjugators. A second HPLC phenotyping routine procedure based on the-formation of S-methylglutathione from methyl chloride in erythrocyte lysate incubations (Muller et al. 2001, Arch Toxicol 74:760-767) was established and validated by genotyping. The phenotyping results obtained with both methods were correlated, resulting in a good correlation with R-2 = 0.64 (y = 0.8997x + 51.535). Three distinct phenotype clusters for NCs, LCs and HCs, consistent with the proposed genetics, were demonstrated. Assay-dependent storage experiments revealed an excellent stability of the hGSTT1-1 activity. In conclusion, the evaluated methods provide powerful tools for determination of hGSTTI-I activity as a clinical parameter."],["dc.identifier.doi","10.1007/s00204-002-0391-1"],["dc.identifier.isi","000179695300004"],["dc.identifier.pmid","12415426"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35843"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0340-5761"],["dc.title","Phenotyping of human glutathione S-transferase hGSTT1-1: a comparison of two ex vivo routine procedures"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]