Löwel, Siegrid

[["dc.bibliographiccitation.firstpage","16"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","The Journal of Neuroscience"],["dc.bibliographiccitation.lastpage","32"],["dc.bibliographiccitation.volume","42"],["dc.contributor.author","Akol, Ipek"],["dc.contributor.author","Kalogeraki, Evgenia"],["dc.contributor.author","Pielecka-Fortuna, Justyna"],["dc.contributor.author","Fricke, Merle"],["dc.contributor.author","Löwel, Siegrid"],["dc.date.accessioned","2022-02-01T10:31:36Z"],["dc.date.available","2022-02-01T10:31:36Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1523/JNEUROSCI.0902-21.2021"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/98900"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-517"],["dc.relation.eissn","1529-2401"],["dc.relation.issn","0270-6474"],["dc.title","MMP2 and MMP9 Activity Is Crucial for Adult Visual Cortex Plasticity in Healthy and Stroke-Affected Mice"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","15476"],["dc.bibliographiccitation.issue","46"],["dc.bibliographiccitation.journal","Journal of Neuroscience"],["dc.bibliographiccitation.lastpage","15481"],["dc.bibliographiccitation.volume","34"],["dc.contributor.author","Kalogeraki, Evgenia"],["dc.contributor.author","Greifzu, Franziska"],["dc.contributor.author","Haack, Franziska"],["dc.contributor.author","Loewel, Siegrid"],["dc.date.accessioned","2018-11-07T09:32:40Z"],["dc.date.available","2018-11-07T09:32:40Z"],["dc.date.issued","2014"],["dc.description.abstract","Ocular dominance (OD) plasticity in the mouse primary visual cortex (V1) declines during aging and is absent beyond postnatal day (P) 110 when mice are raised in standard cages (SCs; Lehmann and Lowel, 2008). In contrast, raising mice in an enriched environment (EE) preserved a juvenile-like OD plasticity into late adulthood (Greifzu et al., 2014). EE raising provides the mice with more social interactions, voluntary physical exercise, and cognitive stimulation compared with SC, raising the question whether all components are needed or whether one of them is already sufficient to prolong plasticity. To test whether voluntary physical exercise alone already prolongs the sensitive phase for OD plasticity, we raised mice from 7 d before birth to adulthood in slightly larger than normal SCs with or without a running wheel (RW). When the mice were older than P135, we visualized V1 activity before and after monocular deprivation (MD) using intrinsic signal optical imaging. Adult RW-raised mice continued to show an OD shift toward the open eye after 7 d of MD, while age-matched SC mice without a RW did not show OD plasticity. Notably, running just during the 7 d MD period restored OD plasticity in adult SC-raised mice. In addition, the OD shift of the RW mice was mediated by a decrease of deprived-eye responses in V1, a signature of \"juvenile-like\" plasticity. We conclude that voluntary physical exercise alone is sufficient to promote plasticity in adult mouse V1."],["dc.identifier.doi","10.1523/JNEUROSCI.2678-14.2014"],["dc.identifier.isi","000345220900035"],["dc.identifier.pmid","25392514"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/31799"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Soc Neuroscience"],["dc.relation.issn","0270-6474"],["dc.title","Voluntary Physical Exercise Promotes Ocular Dominance Plasticity in Adult Mouse Primary Visual Cortex"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1150"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Proceedings of the National Academy of Sciences of the United States of America"],["dc.bibliographiccitation.lastpage","1155"],["dc.bibliographiccitation.volume","111"],["dc.contributor.author","Greifzu, Franziska"],["dc.contributor.author","Pielecka-Fortuna, Justyna"],["dc.contributor.author","Kalogeraki, Evgenia"],["dc.contributor.author","Krempler, Katja"],["dc.contributor.author","Favaro, Plinio D."],["dc.contributor.author","Schlueter, Oliver M."],["dc.contributor.author","Loewel, Siegrid"],["dc.date.accessioned","2018-11-07T09:45:04Z"],["dc.date.available","2018-11-07T09:45:04Z"],["dc.date.issued","2014"],["dc.description.abstract","Ocular dominance (OD) plasticity in mouse primary visual cortex (V1) declines during postnatal development and is absent beyond postnatal day 110 if mice are raised in standard cages (SCs). An enriched environment (EE) promotes OD plasticity in adult rats. Here, we explored cellular mechanisms of EE in mouse V1 and the therapeutic potential of EE to prevent impairments of plasticity after a cortical stroke. Using in vivo optical imaging, we observed that monocular deprivation in adult EE mice (i) caused a very strong OD plasticity previously only observed in 4-wk-old animals, (ii) restored already lost OD plasticity in adult SC-raised mice, and (iii) preserved OD plasticity after a stroke in the primary somatosensory cortex. Using patch-clamp electrophysiology in vitro, we also show that (iv) local inhibition was significantly reduced in V1 slices of adult EE mice and (v) the GABA/AMPA ratio was like that in 4-wk-old SC-raised animals. These observations were corroborated by in vivo analyses showing that diazepam treatment significantly reduced the OD shift of EE mice after monocular deprivation. Taken together, EE extended the sensitive phase for OD plasticity into late adulthood, rejuvenated V1 after 4 mo of SC-rearing, and protected adult mice from stroke-induced impairments of cortical plasticity. The EE effect was mediated most likely by preserving low juvenile levels of inhibition into adulthood, which potentially promoted adaptive changes in cortical circuits."],["dc.identifier.doi","10.1073/pnas.1313385111"],["dc.identifier.isi","000329928400065"],["dc.identifier.pmid","24395770"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/34536"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Natl Acad Sciences"],["dc.relation.issn","0027-8424"],["dc.title","Environmental enrichment extends ocular dominance plasticity into adulthood and protects from stroke-induced impairments of plasticity"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","130"],["dc.bibliographiccitation.journal","Neurobiology of Aging"],["dc.bibliographiccitation.lastpage","137"],["dc.bibliographiccitation.volume","41"],["dc.contributor.author","Greifzu, Franziska"],["dc.contributor.author","Kalogeraki, Evgenia"],["dc.contributor.author","Loewel, Siegrid"],["dc.date.accessioned","2018-11-07T10:15:13Z"],["dc.date.available","2018-11-07T10:15:13Z"],["dc.date.issued","2016"],["dc.description.abstract","In standard cage (SC)-raised mice, ocular dominance (OD) plasticity of the primary visual cortex (V1) induced by monocular deprivation (MD) is maximal in juveniles, declines in adults, and is absent beyond postnatal day (PD) 110. Raising mice in an enriched environment (EE) preserved a juvenile-like OD plasticity after 7 days of MD until at least PD196, mediated by reductions of deprived eye responses in V1. Whether the sensitive phase for OD plasticity can be prolonged into older age and whether long-term EE modifies visual abilities was not yet known. Here, we demonstrate that EE raising enables lifelong OD plasticity. In contrast to PD200 EE-mice, the preserved OD shift in both >PD400 and >PD700 EE-mice was mediated by increases in open eye responses in V1 (adult OD plasticity). When SC-mice were transferred to EE after PD110, OD plasticity was restored until PD922. Moreover, visual abilities tested by both optomotry and the visual water task and interindividual variability were not different between PD700 SC- and EE-mice. Taken together, EE raising enabled a lifelong OD plasticity but did not affect basic visual performance. (C) 2016 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.neurobiolaging.2016.02.014"],["dc.identifier.isi","000375129400014"],["dc.identifier.pmid","27103526"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40766"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.relation.issn","1558-1497"],["dc.relation.issn","0197-4580"],["dc.title","Environmental enrichment preserved lifelong ocular dominance plasticity, but did not improve visual abilities"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]