Löwel, Siegrid

[["dc.bibliographiccitation.artnumber","e0186999"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","PloS one"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Kalogeraki, Evgenia"],["dc.contributor.author","Pielecka-Fortuna, Justyna"],["dc.contributor.author","Löwel, Siegrid"],["dc.date.accessioned","2019-07-09T11:44:41Z"],["dc.date.available","2019-07-09T11:44:41Z"],["dc.date.issued","2017"],["dc.description.abstract","In standard cage (SC) raised mice, experience-dependent ocular dominance (OD) plasticity in the primary visual cortex (V1) rapidly declines with age: in postnatal day 25-35 (critical period) mice, 4 days of monocular deprivation (MD) are sufficient to induce OD-shifts towards the open eye; thereafter, 7 days of MD are needed. Beyond postnatal day 110, even 14 days of MD failed to induce OD-plasticity in mouse V1. In contrast, mice raised in a so-called \"enriched environment\" (EE), exhibit lifelong OD-plasticity. EE-mice have more voluntary physical exercise (running wheels), and experience more social interactions (bigger housing groups) and more cognitive stimulation (regularly changed labyrinths or toys). Whether experience-dependent shifts of V1-activation happen faster in EE-mice and how long the plasticity promoting effect would persist after transferring EE-mice back to SCs has not yet been investigated. To this end, we used intrinsic signal optical imaging to visualize V1-activation i) before and after MD in EE-mice of different age groups (from 1-9 months), and ii) after transferring mice back to SCs after postnatal day 130. Already after 2 days of MD, and thus much faster than in SC-mice, EE-mice of all tested age groups displayed a significant OD-shift towards the open eye. Transfer of EE-mice to SCs immediately abolished OD-plasticity: already after 1 week of SC-housing and MD, OD-shifts could no longer be visualized. In an attempt to rescue abolished OD-plasticity of these mice, we either administered the anti-depressant fluoxetine (in drinking water) or supplied a running wheel in the SCs. OD-plasticity was only rescued for the running wheel- mice. Altogether our results show that raising mice in less deprived environments like large EE-cages strongly accelerates experience-dependent changes in V1-activation compared to the impoverished SC-raising. Furthermore, preventing voluntary physical exercise of EE-mice in adulthood immediately precludes OD-shifts in V1."],["dc.identifier.doi","10.1371/journal.pone.0186999"],["dc.identifier.pmid","29073219"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14867"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59067"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1932-6203"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","570"],["dc.subject.mesh","Aging"],["dc.subject.mesh","Animal Husbandry"],["dc.subject.mesh","Animals"],["dc.subject.mesh","Dominance, Ocular"],["dc.subject.mesh","Environment"],["dc.subject.mesh","Female"],["dc.subject.mesh","Fluoxetine"],["dc.subject.mesh","Mice"],["dc.subject.mesh","Mice, Inbred C57BL"],["dc.subject.mesh","Neuronal Plasticity"],["dc.subject.mesh","Serotonin Uptake Inhibitors"],["dc.subject.mesh","Time Factors"],["dc.subject.mesh","Visual Cortex"],["dc.title","Environmental enrichment accelerates ocular dominance plasticity in mouse visual cortex whereas transfer to standard cages resulted in a rapid loss of increased plasticity."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]