Löwel, Siegrid

[["dc.bibliographiccitation.artnumber","212"],["dc.bibliographiccitation.journal","Frontiers in Aging Neuroscience"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Kalogeraki, Evgenia"],["dc.contributor.author","Pielecka-Fortuna, Justyna"],["dc.contributor.author","Hueppe, Janika M."],["dc.contributor.author","Loewel, Siegrid"],["dc.date.accessioned","2018-11-07T10:08:26Z"],["dc.date.available","2018-11-07T10:08:26Z"],["dc.date.issued","2016"],["dc.description.abstract","The primary visual cortex (V1) is widely used to study brain plasticity, which is not only crucial for normal brain function, such as learning and memory, but also for recovery after brain injuries such as stroke. In standard cage (SC) raised mice, experience dependent ocular dominance (OD) plasticity in V1 declines with age and is compromised by a lesion in adjacent and distant cortical regions. In contrast, mice raised in an enriched environment (EE), exhibit lifelong OD plasticity and are protected from losing OD plasticity after a stroke-lesion in the somatosensory cortex. Since SC mice with an access to a running wheel (RW) displayed preserved OD plasticity during aging, we investigated whether physical exercise might also provide a plasticity promoting effect after a cortical stroke. To this end, we tested if adult RW-raised mice preserved OD plasticity after stroke and also if short-term running after stroke restored OD plasticity to SC mice. Indeed, unlike mice without a RW, adult RW mice continued to show OD plasticity even after stroke, and a 2 weeks RW experience after stroke already restored lost OD plasticity. Additionally, the experience-enabled increase of the spatial frequency and contrast threshold of the optomotor reflex of the open eye, normally lost after a stroke, was restored in both groups of RW mice. Our data suggest that physical exercise alone can not only preserve visual plasticity into old age, but also restore it after a cortical stroke."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2016"],["dc.identifier.doi","10.3389/fnagi.2016.00212"],["dc.identifier.isi","000383725600001"],["dc.identifier.pmid","27708575"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13775"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39461"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Frontiers Media S.A."],["dc.relation.eissn","1663-4365"],["dc.relation.issn","1663-4365"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Physical Exercise Preserves Adult Visual Plasticity in Mice and Restores it after a Stroke in the Somatosensory Cortex"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e11290"],["dc.bibliographiccitation.journal","eLife"],["dc.bibliographiccitation.volume","4"],["dc.contributor.author","Pielecka-Fortuna, Justyna"],["dc.contributor.author","Kalogeraki, Evgenia"],["dc.contributor.author","Fortuna, Michal G."],["dc.contributor.author","Loewel, Siegrid"],["dc.date.accessioned","2018-11-07T09:48:46Z"],["dc.date.available","2018-11-07T09:48:46Z"],["dc.date.issued","2015"],["dc.description.abstract","The ability of the adult brain to undergo plastic changes is of particular interest in medicine, especially regarding recovery from injuries or improving learning and cognition. Matrix metalloproteinases (MMPs) have been associated with juvenile experience-dependent primary visual cortex (V1) plasticity, yet little is known about their role in this process in the adult V1. Activation of MMPs is a crucial step facilitating structural changes in a healthy brain; however, upon brain injury, upregulated MMPs promote the spread of a lesion and impair recovery. To clarify these seemingly opposing outcomes of MMP-activation, we examined the effects of MMP-inhibition on experience-induced plasticity in healthy and stoke-affected adult mice. In healthy animals, 7-day application of MMP-inhibitor prevented visual plasticity. Additionally, treatment with MMP-inhibitor once but not twice following stroke rescued plasticity, normally lost under these conditions. Our data imply that an optimal level of MMP-activity is crucial for adult visual plasticity to occur."],["dc.identifier.doi","10.7554/eLife.11290"],["dc.identifier.isi","000372259000001"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13199"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35375"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elife Sciences Publications Ltd"],["dc.relation.issn","2050-084X"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Optimal level activity of matrix metalloproteinases is critical for adult visual plasticity in the healthy and stroke-affected brain"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e0186999"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","PloS one"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Kalogeraki, Evgenia"],["dc.contributor.author","Pielecka-Fortuna, Justyna"],["dc.contributor.author","Löwel, Siegrid"],["dc.date.accessioned","2019-07-09T11:44:41Z"],["dc.date.available","2019-07-09T11:44:41Z"],["dc.date.issued","2017"],["dc.description.abstract","In standard cage (SC) raised mice, experience-dependent ocular dominance (OD) plasticity in the primary visual cortex (V1) rapidly declines with age: in postnatal day 25-35 (critical period) mice, 4 days of monocular deprivation (MD) are sufficient to induce OD-shifts towards the open eye; thereafter, 7 days of MD are needed. Beyond postnatal day 110, even 14 days of MD failed to induce OD-plasticity in mouse V1. In contrast, mice raised in a so-called \"enriched environment\" (EE), exhibit lifelong OD-plasticity. EE-mice have more voluntary physical exercise (running wheels), and experience more social interactions (bigger housing groups) and more cognitive stimulation (regularly changed labyrinths or toys). Whether experience-dependent shifts of V1-activation happen faster in EE-mice and how long the plasticity promoting effect would persist after transferring EE-mice back to SCs has not yet been investigated. To this end, we used intrinsic signal optical imaging to visualize V1-activation i) before and after MD in EE-mice of different age groups (from 1-9 months), and ii) after transferring mice back to SCs after postnatal day 130. Already after 2 days of MD, and thus much faster than in SC-mice, EE-mice of all tested age groups displayed a significant OD-shift towards the open eye. Transfer of EE-mice to SCs immediately abolished OD-plasticity: already after 1 week of SC-housing and MD, OD-shifts could no longer be visualized. In an attempt to rescue abolished OD-plasticity of these mice, we either administered the anti-depressant fluoxetine (in drinking water) or supplied a running wheel in the SCs. OD-plasticity was only rescued for the running wheel- mice. Altogether our results show that raising mice in less deprived environments like large EE-cages strongly accelerates experience-dependent changes in V1-activation compared to the impoverished SC-raising. Furthermore, preventing voluntary physical exercise of EE-mice in adulthood immediately precludes OD-shifts in V1."],["dc.identifier.doi","10.1371/journal.pone.0186999"],["dc.identifier.pmid","29073219"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14867"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59067"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1932-6203"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","570"],["dc.subject.mesh","Aging"],["dc.subject.mesh","Animal Husbandry"],["dc.subject.mesh","Animals"],["dc.subject.mesh","Dominance, Ocular"],["dc.subject.mesh","Environment"],["dc.subject.mesh","Female"],["dc.subject.mesh","Fluoxetine"],["dc.subject.mesh","Mice"],["dc.subject.mesh","Mice, Inbred C57BL"],["dc.subject.mesh","Neuronal Plasticity"],["dc.subject.mesh","Serotonin Uptake Inhibitors"],["dc.subject.mesh","Time Factors"],["dc.subject.mesh","Visual Cortex"],["dc.title","Environmental enrichment accelerates ocular dominance plasticity in mouse visual cortex whereas transfer to standard cages resulted in a rapid loss of increased plasticity."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","16"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","The Journal of Neuroscience"],["dc.bibliographiccitation.lastpage","32"],["dc.bibliographiccitation.volume","42"],["dc.contributor.author","Akol, Ipek"],["dc.contributor.author","Kalogeraki, Evgenia"],["dc.contributor.author","Pielecka-Fortuna, Justyna"],["dc.contributor.author","Fricke, Merle"],["dc.contributor.author","Löwel, Siegrid"],["dc.date.accessioned","2022-02-01T10:31:36Z"],["dc.date.available","2022-02-01T10:31:36Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1523/JNEUROSCI.0902-21.2021"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/98900"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-517"],["dc.relation.eissn","1529-2401"],["dc.relation.issn","0270-6474"],["dc.title","MMP2 and MMP9 Activity Is Crucial for Adult Visual Cortex Plasticity in Healthy and Stroke-Affected Mice"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","15476"],["dc.bibliographiccitation.issue","46"],["dc.bibliographiccitation.journal","Journal of Neuroscience"],["dc.bibliographiccitation.lastpage","15481"],["dc.bibliographiccitation.volume","34"],["dc.contributor.author","Kalogeraki, Evgenia"],["dc.contributor.author","Greifzu, Franziska"],["dc.contributor.author","Haack, Franziska"],["dc.contributor.author","Loewel, Siegrid"],["dc.date.accessioned","2018-11-07T09:32:40Z"],["dc.date.available","2018-11-07T09:32:40Z"],["dc.date.issued","2014"],["dc.description.abstract","Ocular dominance (OD) plasticity in the mouse primary visual cortex (V1) declines during aging and is absent beyond postnatal day (P) 110 when mice are raised in standard cages (SCs; Lehmann and Lowel, 2008). In contrast, raising mice in an enriched environment (EE) preserved a juvenile-like OD plasticity into late adulthood (Greifzu et al., 2014). EE raising provides the mice with more social interactions, voluntary physical exercise, and cognitive stimulation compared with SC, raising the question whether all components are needed or whether one of them is already sufficient to prolong plasticity. To test whether voluntary physical exercise alone already prolongs the sensitive phase for OD plasticity, we raised mice from 7 d before birth to adulthood in slightly larger than normal SCs with or without a running wheel (RW). When the mice were older than P135, we visualized V1 activity before and after monocular deprivation (MD) using intrinsic signal optical imaging. Adult RW-raised mice continued to show an OD shift toward the open eye after 7 d of MD, while age-matched SC mice without a RW did not show OD plasticity. Notably, running just during the 7 d MD period restored OD plasticity in adult SC-raised mice. In addition, the OD shift of the RW mice was mediated by a decrease of deprived-eye responses in V1, a signature of \"juvenile-like\" plasticity. We conclude that voluntary physical exercise alone is sufficient to promote plasticity in adult mouse V1."],["dc.identifier.doi","10.1523/JNEUROSCI.2678-14.2014"],["dc.identifier.isi","000345220900035"],["dc.identifier.pmid","25392514"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/31799"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Soc Neuroscience"],["dc.relation.issn","0270-6474"],["dc.title","Voluntary Physical Exercise Promotes Ocular Dominance Plasticity in Adult Mouse Primary Visual Cortex"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e0137961"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","PLoS ONE"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Pielecka-Fortuna, Justyna"],["dc.contributor.author","Kalogeraki, Evgenia"],["dc.contributor.author","Greifzu, Franziska"],["dc.contributor.author","Loewel, Siegrid"],["dc.date.accessioned","2018-11-07T09:51:41Z"],["dc.date.available","2018-11-07T09:51:41Z"],["dc.date.issued","2015"],["dc.description.abstract","It was previously shown that a small lesion in the primary somatosensory cortex (S1) prevented both cortical plasticity and sensory learning in the adult mouse visual system: While 3-month-old control mice continued to show ocular dominance (OD) plasticity in their primary visual cortex (V1) after monocular deprivation (MD), age-matched mice with a small photothrombotically induced (PT) stroke lesion in S1, positioned at least 1 mm anterior to the anterior border of V1, no longer expressed OD-plasticity. In addition, in the S1-lesioned mice, neither the experience-dependent increase of the spatial frequency threshold (\"visual acuity\") nor of the contrast threshold (\"contrast sensitivity\") of the optomotor reflex through the open eye was present. To assess whether these plasticity impairments can also occur if a lesion is placed more distant from V1, we tested the effect of a PT-lesion in the secondary motor cortex (M2). We observed that mice with a small M2-lesion restricted to the superficial cortical layers no longer expressed an OD-shift towards the open eye after 7 days of MD in V1 of the lesioned hemisphere. Consistent with previous findings about the consequences of an S1-lesion, OD-plasticity in V1 of the nonlesioned hemisphere of the M2-lesioned mice was still present. In addition, the experience-dependent improvements of both visual acuity and contrast sensitivity of the open eye were severely reduced. In contrast, sham-lesioned mice displayed both an OD-shift and improvements of visual capabilities of their open eye. To summarize, our data indicate that even a very small lesion restricted to the superficial cortical layers and more than 3mm anterior to the anterior border of V1 compromised V1-plasticity and impaired learning-induced visual improvements in adult mice. Thus both plasticity phenomena cannot only depend on modality-specific and local nerve cell networks but are clearly influenced by long-range interactions even from distant brain regions."],["dc.description.sponsorship","Open-Access Publikationsfonds 2015"],["dc.identifier.doi","10.1371/journal.pone.0137961"],["dc.identifier.isi","000361601100185"],["dc.identifier.pmid","26368569"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/12168"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35965"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Public Library Science"],["dc.relation.issn","1932-6203"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","A Small Motor Cortex Lesion Abolished Ocular Dominance Plasticity in the Adult Mouse Primary Visual Cortex and Impaired Experience-Dependent Visual Improvements"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","ENEURO.0252-18.2018"],["dc.bibliographiccitation.firstpage","ENEURO.0252-18.2018"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","eNeuro"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","Kalogeraki, Evgenia"],["dc.contributor.author","Yusifov, Rashad"],["dc.contributor.author","Löwel, Siegrid"],["dc.date.accessioned","2020-12-10T18:42:33Z"],["dc.date.available","2020-12-10T18:42:33Z"],["dc.date.issued","2019"],["dc.description.abstract","In recent years, evidence has accumulated that non-Mendelian transgenerational inheritance of qualities acquired through experience is possible. In particular, it has been shown that raising rodents in a so-called enriched environment (EE) can not only modify the animals' behavior and increase their susceptibility to activity-dependent neuronal network changes, but also influences both behavior and neuronal plasticity of the non-enriched offspring. Here, we tested whether such a transgenerational transmission can also be observed in the primary visual cortex (V1) using ocular dominance (OD) plasticity after monocular deprivation (MD) as a paradigm. Whereas OD plasticity after 7 d of MD is absent in standard-cage (SC) raised mice beyond postnatal day (P)110, it is present lifelong in EE-raised mice. Using intrinsic signal optical imaging to visualize cortical activity, we confirm these previous observations and additionally show that OD plasticity is not only preserved in adult EE mice but also in their adult non-enriched offspring: mice born to enriched parents, but raised in SCs at least until P110 displayed similar OD shifts toward the open eye after 7 d of MD as age-matched EE-raised animals. Furthermore, testing the offspring of EE-female versus EE-males with SC-mating partners revealed that only pups of EE-females, but not of EE-males, preserved OD plasticity into adulthood, suggesting that the life experiences of the mother have a greater impact on the continued V1 plasticity of the offspring. The OD plasticity of the non-enriched pups of EE-mothers was, however, mechanistically different from that of non-enriched pups of EE-parents or EE mice."],["dc.identifier.doi","10.1523/ENEURO.0252-18.2018"],["dc.identifier.eissn","2373-2822"],["dc.identifier.pmid","30805555"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15818"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78002"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.relation.eissn","2373-2822"],["dc.relation.issn","2373-2822"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Transgenerational Transmission of Enhanced Ocular Dominance Plasticity from Enriched Mice to Their Non-enriched Offspring"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1150"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Proceedings of the National Academy of Sciences of the United States of America"],["dc.bibliographiccitation.lastpage","1155"],["dc.bibliographiccitation.volume","111"],["dc.contributor.author","Greifzu, Franziska"],["dc.contributor.author","Pielecka-Fortuna, Justyna"],["dc.contributor.author","Kalogeraki, Evgenia"],["dc.contributor.author","Krempler, Katja"],["dc.contributor.author","Favaro, Plinio D."],["dc.contributor.author","Schlueter, Oliver M."],["dc.contributor.author","Loewel, Siegrid"],["dc.date.accessioned","2018-11-07T09:45:04Z"],["dc.date.available","2018-11-07T09:45:04Z"],["dc.date.issued","2014"],["dc.description.abstract","Ocular dominance (OD) plasticity in mouse primary visual cortex (V1) declines during postnatal development and is absent beyond postnatal day 110 if mice are raised in standard cages (SCs). An enriched environment (EE) promotes OD plasticity in adult rats. Here, we explored cellular mechanisms of EE in mouse V1 and the therapeutic potential of EE to prevent impairments of plasticity after a cortical stroke. Using in vivo optical imaging, we observed that monocular deprivation in adult EE mice (i) caused a very strong OD plasticity previously only observed in 4-wk-old animals, (ii) restored already lost OD plasticity in adult SC-raised mice, and (iii) preserved OD plasticity after a stroke in the primary somatosensory cortex. Using patch-clamp electrophysiology in vitro, we also show that (iv) local inhibition was significantly reduced in V1 slices of adult EE mice and (v) the GABA/AMPA ratio was like that in 4-wk-old SC-raised animals. These observations were corroborated by in vivo analyses showing that diazepam treatment significantly reduced the OD shift of EE mice after monocular deprivation. Taken together, EE extended the sensitive phase for OD plasticity into late adulthood, rejuvenated V1 after 4 mo of SC-rearing, and protected adult mice from stroke-induced impairments of cortical plasticity. The EE effect was mediated most likely by preserving low juvenile levels of inhibition into adulthood, which potentially promoted adaptive changes in cortical circuits."],["dc.identifier.doi","10.1073/pnas.1313385111"],["dc.identifier.isi","000329928400065"],["dc.identifier.pmid","24395770"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/34536"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Natl Acad Sciences"],["dc.relation.issn","0027-8424"],["dc.title","Environmental enrichment extends ocular dominance plasticity into adulthood and protects from stroke-induced impairments of plasticity"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","130"],["dc.bibliographiccitation.journal","Neurobiology of Aging"],["dc.bibliographiccitation.lastpage","137"],["dc.bibliographiccitation.volume","41"],["dc.contributor.author","Greifzu, Franziska"],["dc.contributor.author","Kalogeraki, Evgenia"],["dc.contributor.author","Loewel, Siegrid"],["dc.date.accessioned","2018-11-07T10:15:13Z"],["dc.date.available","2018-11-07T10:15:13Z"],["dc.date.issued","2016"],["dc.description.abstract","In standard cage (SC)-raised mice, ocular dominance (OD) plasticity of the primary visual cortex (V1) induced by monocular deprivation (MD) is maximal in juveniles, declines in adults, and is absent beyond postnatal day (PD) 110. Raising mice in an enriched environment (EE) preserved a juvenile-like OD plasticity after 7 days of MD until at least PD196, mediated by reductions of deprived eye responses in V1. Whether the sensitive phase for OD plasticity can be prolonged into older age and whether long-term EE modifies visual abilities was not yet known. Here, we demonstrate that EE raising enables lifelong OD plasticity. In contrast to PD200 EE-mice, the preserved OD shift in both >PD400 and >PD700 EE-mice was mediated by increases in open eye responses in V1 (adult OD plasticity). When SC-mice were transferred to EE after PD110, OD plasticity was restored until PD922. Moreover, visual abilities tested by both optomotry and the visual water task and interindividual variability were not different between PD700 SC- and EE-mice. Taken together, EE raising enabled a lifelong OD plasticity but did not affect basic visual performance. (C) 2016 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.neurobiolaging.2016.02.014"],["dc.identifier.isi","000375129400014"],["dc.identifier.pmid","27103526"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40766"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.relation.issn","1558-1497"],["dc.relation.issn","0197-4580"],["dc.title","Environmental enrichment preserved lifelong ocular dominance plasticity, but did not improve visual abilities"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]