Löwel, Siegrid

[["dc.bibliographiccitation.artnumber","212"],["dc.bibliographiccitation.journal","Frontiers in Aging Neuroscience"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Kalogeraki, Evgenia"],["dc.contributor.author","Pielecka-Fortuna, Justyna"],["dc.contributor.author","Hueppe, Janika M."],["dc.contributor.author","Loewel, Siegrid"],["dc.date.accessioned","2018-11-07T10:08:26Z"],["dc.date.available","2018-11-07T10:08:26Z"],["dc.date.issued","2016"],["dc.description.abstract","The primary visual cortex (V1) is widely used to study brain plasticity, which is not only crucial for normal brain function, such as learning and memory, but also for recovery after brain injuries such as stroke. In standard cage (SC) raised mice, experience dependent ocular dominance (OD) plasticity in V1 declines with age and is compromised by a lesion in adjacent and distant cortical regions. In contrast, mice raised in an enriched environment (EE), exhibit lifelong OD plasticity and are protected from losing OD plasticity after a stroke-lesion in the somatosensory cortex. Since SC mice with an access to a running wheel (RW) displayed preserved OD plasticity during aging, we investigated whether physical exercise might also provide a plasticity promoting effect after a cortical stroke. To this end, we tested if adult RW-raised mice preserved OD plasticity after stroke and also if short-term running after stroke restored OD plasticity to SC mice. Indeed, unlike mice without a RW, adult RW mice continued to show OD plasticity even after stroke, and a 2 weeks RW experience after stroke already restored lost OD plasticity. Additionally, the experience-enabled increase of the spatial frequency and contrast threshold of the optomotor reflex of the open eye, normally lost after a stroke, was restored in both groups of RW mice. Our data suggest that physical exercise alone can not only preserve visual plasticity into old age, but also restore it after a cortical stroke."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2016"],["dc.identifier.doi","10.3389/fnagi.2016.00212"],["dc.identifier.isi","000383725600001"],["dc.identifier.pmid","27708575"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13775"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39461"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Frontiers Media S.A."],["dc.relation.eissn","1663-4365"],["dc.relation.issn","1663-4365"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Physical Exercise Preserves Adult Visual Plasticity in Mice and Restores it after a Stroke in the Somatosensory Cortex"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e11290"],["dc.bibliographiccitation.journal","eLife"],["dc.bibliographiccitation.volume","4"],["dc.contributor.author","Pielecka-Fortuna, Justyna"],["dc.contributor.author","Kalogeraki, Evgenia"],["dc.contributor.author","Fortuna, Michal G."],["dc.contributor.author","Loewel, Siegrid"],["dc.date.accessioned","2018-11-07T09:48:46Z"],["dc.date.available","2018-11-07T09:48:46Z"],["dc.date.issued","2015"],["dc.description.abstract","The ability of the adult brain to undergo plastic changes is of particular interest in medicine, especially regarding recovery from injuries or improving learning and cognition. Matrix metalloproteinases (MMPs) have been associated with juvenile experience-dependent primary visual cortex (V1) plasticity, yet little is known about their role in this process in the adult V1. Activation of MMPs is a crucial step facilitating structural changes in a healthy brain; however, upon brain injury, upregulated MMPs promote the spread of a lesion and impair recovery. To clarify these seemingly opposing outcomes of MMP-activation, we examined the effects of MMP-inhibition on experience-induced plasticity in healthy and stoke-affected adult mice. In healthy animals, 7-day application of MMP-inhibitor prevented visual plasticity. Additionally, treatment with MMP-inhibitor once but not twice following stroke rescued plasticity, normally lost under these conditions. Our data imply that an optimal level of MMP-activity is crucial for adult visual plasticity to occur."],["dc.identifier.doi","10.7554/eLife.11290"],["dc.identifier.isi","000372259000001"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13199"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35375"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elife Sciences Publications Ltd"],["dc.relation.issn","2050-084X"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Optimal level activity of matrix metalloproteinases is critical for adult visual plasticity in the healthy and stroke-affected brain"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e0186999"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","PloS one"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Kalogeraki, Evgenia"],["dc.contributor.author","Pielecka-Fortuna, Justyna"],["dc.contributor.author","Löwel, Siegrid"],["dc.date.accessioned","2019-07-09T11:44:41Z"],["dc.date.available","2019-07-09T11:44:41Z"],["dc.date.issued","2017"],["dc.description.abstract","In standard cage (SC) raised mice, experience-dependent ocular dominance (OD) plasticity in the primary visual cortex (V1) rapidly declines with age: in postnatal day 25-35 (critical period) mice, 4 days of monocular deprivation (MD) are sufficient to induce OD-shifts towards the open eye; thereafter, 7 days of MD are needed. Beyond postnatal day 110, even 14 days of MD failed to induce OD-plasticity in mouse V1. In contrast, mice raised in a so-called \"enriched environment\" (EE), exhibit lifelong OD-plasticity. EE-mice have more voluntary physical exercise (running wheels), and experience more social interactions (bigger housing groups) and more cognitive stimulation (regularly changed labyrinths or toys). Whether experience-dependent shifts of V1-activation happen faster in EE-mice and how long the plasticity promoting effect would persist after transferring EE-mice back to SCs has not yet been investigated. To this end, we used intrinsic signal optical imaging to visualize V1-activation i) before and after MD in EE-mice of different age groups (from 1-9 months), and ii) after transferring mice back to SCs after postnatal day 130. Already after 2 days of MD, and thus much faster than in SC-mice, EE-mice of all tested age groups displayed a significant OD-shift towards the open eye. Transfer of EE-mice to SCs immediately abolished OD-plasticity: already after 1 week of SC-housing and MD, OD-shifts could no longer be visualized. In an attempt to rescue abolished OD-plasticity of these mice, we either administered the anti-depressant fluoxetine (in drinking water) or supplied a running wheel in the SCs. OD-plasticity was only rescued for the running wheel- mice. Altogether our results show that raising mice in less deprived environments like large EE-cages strongly accelerates experience-dependent changes in V1-activation compared to the impoverished SC-raising. Furthermore, preventing voluntary physical exercise of EE-mice in adulthood immediately precludes OD-shifts in V1."],["dc.identifier.doi","10.1371/journal.pone.0186999"],["dc.identifier.pmid","29073219"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14867"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59067"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1932-6203"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","570"],["dc.subject.mesh","Aging"],["dc.subject.mesh","Animal Husbandry"],["dc.subject.mesh","Animals"],["dc.subject.mesh","Dominance, Ocular"],["dc.subject.mesh","Environment"],["dc.subject.mesh","Female"],["dc.subject.mesh","Fluoxetine"],["dc.subject.mesh","Mice"],["dc.subject.mesh","Mice, Inbred C57BL"],["dc.subject.mesh","Neuronal Plasticity"],["dc.subject.mesh","Serotonin Uptake Inhibitors"],["dc.subject.mesh","Time Factors"],["dc.subject.mesh","Visual Cortex"],["dc.title","Environmental enrichment accelerates ocular dominance plasticity in mouse visual cortex whereas transfer to standard cages resulted in a rapid loss of increased plasticity."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","16"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","The Journal of Neuroscience"],["dc.bibliographiccitation.lastpage","32"],["dc.bibliographiccitation.volume","42"],["dc.contributor.author","Akol, Ipek"],["dc.contributor.author","Kalogeraki, Evgenia"],["dc.contributor.author","Pielecka-Fortuna, Justyna"],["dc.contributor.author","Fricke, Merle"],["dc.contributor.author","Löwel, Siegrid"],["dc.date.accessioned","2022-02-01T10:31:36Z"],["dc.date.available","2022-02-01T10:31:36Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1523/JNEUROSCI.0902-21.2021"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/98900"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-517"],["dc.relation.eissn","1529-2401"],["dc.relation.issn","0270-6474"],["dc.title","MMP2 and MMP9 Activity Is Crucial for Adult Visual Cortex Plasticity in Healthy and Stroke-Affected Mice"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e0137961"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","PLoS ONE"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Pielecka-Fortuna, Justyna"],["dc.contributor.author","Kalogeraki, Evgenia"],["dc.contributor.author","Greifzu, Franziska"],["dc.contributor.author","Loewel, Siegrid"],["dc.date.accessioned","2018-11-07T09:51:41Z"],["dc.date.available","2018-11-07T09:51:41Z"],["dc.date.issued","2015"],["dc.description.abstract","It was previously shown that a small lesion in the primary somatosensory cortex (S1) prevented both cortical plasticity and sensory learning in the adult mouse visual system: While 3-month-old control mice continued to show ocular dominance (OD) plasticity in their primary visual cortex (V1) after monocular deprivation (MD), age-matched mice with a small photothrombotically induced (PT) stroke lesion in S1, positioned at least 1 mm anterior to the anterior border of V1, no longer expressed OD-plasticity. In addition, in the S1-lesioned mice, neither the experience-dependent increase of the spatial frequency threshold (\"visual acuity\") nor of the contrast threshold (\"contrast sensitivity\") of the optomotor reflex through the open eye was present. To assess whether these plasticity impairments can also occur if a lesion is placed more distant from V1, we tested the effect of a PT-lesion in the secondary motor cortex (M2). We observed that mice with a small M2-lesion restricted to the superficial cortical layers no longer expressed an OD-shift towards the open eye after 7 days of MD in V1 of the lesioned hemisphere. Consistent with previous findings about the consequences of an S1-lesion, OD-plasticity in V1 of the nonlesioned hemisphere of the M2-lesioned mice was still present. In addition, the experience-dependent improvements of both visual acuity and contrast sensitivity of the open eye were severely reduced. In contrast, sham-lesioned mice displayed both an OD-shift and improvements of visual capabilities of their open eye. To summarize, our data indicate that even a very small lesion restricted to the superficial cortical layers and more than 3mm anterior to the anterior border of V1 compromised V1-plasticity and impaired learning-induced visual improvements in adult mice. Thus both plasticity phenomena cannot only depend on modality-specific and local nerve cell networks but are clearly influenced by long-range interactions even from distant brain regions."],["dc.description.sponsorship","Open-Access Publikationsfonds 2015"],["dc.identifier.doi","10.1371/journal.pone.0137961"],["dc.identifier.isi","000361601100185"],["dc.identifier.pmid","26368569"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/12168"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35965"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Public Library Science"],["dc.relation.issn","1932-6203"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","A Small Motor Cortex Lesion Abolished Ocular Dominance Plasticity in the Adult Mouse Primary Visual Cortex and Impaired Experience-Dependent Visual Improvements"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3449"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Brain Structure and Function"],["dc.bibliographiccitation.lastpage","3467"],["dc.bibliographiccitation.volume","220"],["dc.contributor.author","Pielecka-Fortuna, Justyna"],["dc.contributor.author","Wagener, Robin Jan"],["dc.contributor.author","Martens, Ann-Kristin"],["dc.contributor.author","Goetze, Bianka"],["dc.contributor.author","Schmidt, Karl-Friedrich"],["dc.contributor.author","Staiger, Jochen F."],["dc.contributor.author","Loewel, Siegrid"],["dc.date.accessioned","2018-11-07T09:49:57Z"],["dc.date.available","2018-11-07T09:49:57Z"],["dc.date.issued","2015"],["dc.description.abstract","A hallmark of neocortical circuits is the segregation of processing streams into six distinct layers. The importance of this layered organization for cortical processing and plasticity is little understood. We investigated the structure, function and plasticity of primary visual cortex (V1) of adult mice deficient for the glycoprotein reelin and their wild-type littermates. In V1 of rl-/- mice, cells with different laminar fates are present at all cortical depths. Surprisingly, the (vertically) disorganized cortex maintains a precise retinotopic (horizontal) organization. Rl-/- mice have normal basic visual capabilities, but are compromised in more challenging perceptual tasks, such as orientation discrimination. Additionally, rl-/- animals learn and memorize a visual task as well as their wild-type littermates. Interestingly, reelin deficiency enhances visual cortical plasticity: juvenile-like ocular dominance plasticity is preserved into late adulthood. The present data offer an important insight into the capabilities of a disorganized cortical system to maintain basic functional properties."],["dc.identifier.doi","10.1007/s00429-014-0866-x"],["dc.identifier.isi","000361566000023"],["dc.identifier.pmid","25119525"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10852"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35606"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Heidelberg"],["dc.relation.issn","1863-2661"],["dc.relation.issn","1863-2653"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","The disorganized visual cortex in reelin-deficient mice is functional and allows for enhanced plasticity"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1150"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Proceedings of the National Academy of Sciences of the United States of America"],["dc.bibliographiccitation.lastpage","1155"],["dc.bibliographiccitation.volume","111"],["dc.contributor.author","Greifzu, Franziska"],["dc.contributor.author","Pielecka-Fortuna, Justyna"],["dc.contributor.author","Kalogeraki, Evgenia"],["dc.contributor.author","Krempler, Katja"],["dc.contributor.author","Favaro, Plinio D."],["dc.contributor.author","Schlueter, Oliver M."],["dc.contributor.author","Loewel, Siegrid"],["dc.date.accessioned","2018-11-07T09:45:04Z"],["dc.date.available","2018-11-07T09:45:04Z"],["dc.date.issued","2014"],["dc.description.abstract","Ocular dominance (OD) plasticity in mouse primary visual cortex (V1) declines during postnatal development and is absent beyond postnatal day 110 if mice are raised in standard cages (SCs). An enriched environment (EE) promotes OD plasticity in adult rats. Here, we explored cellular mechanisms of EE in mouse V1 and the therapeutic potential of EE to prevent impairments of plasticity after a cortical stroke. Using in vivo optical imaging, we observed that monocular deprivation in adult EE mice (i) caused a very strong OD plasticity previously only observed in 4-wk-old animals, (ii) restored already lost OD plasticity in adult SC-raised mice, and (iii) preserved OD plasticity after a stroke in the primary somatosensory cortex. Using patch-clamp electrophysiology in vitro, we also show that (iv) local inhibition was significantly reduced in V1 slices of adult EE mice and (v) the GABA/AMPA ratio was like that in 4-wk-old SC-raised animals. These observations were corroborated by in vivo analyses showing that diazepam treatment significantly reduced the OD shift of EE mice after monocular deprivation. Taken together, EE extended the sensitive phase for OD plasticity into late adulthood, rejuvenated V1 after 4 mo of SC-rearing, and protected adult mice from stroke-induced impairments of cortical plasticity. The EE effect was mediated most likely by preserving low juvenile levels of inhibition into adulthood, which potentially promoted adaptive changes in cortical circuits."],["dc.identifier.doi","10.1073/pnas.1313385111"],["dc.identifier.isi","000329928400065"],["dc.identifier.pmid","24395770"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/34536"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Natl Acad Sciences"],["dc.relation.issn","0027-8424"],["dc.title","Environmental enrichment extends ocular dominance plasticity into adulthood and protects from stroke-induced impairments of plasticity"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e1002143"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","PLoS Biology"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","van Wyk, Michiel"],["dc.contributor.author","Pielecka-Fortuna, Justyna"],["dc.contributor.author","Loewel, Siegrid"],["dc.contributor.author","Kleinlogel, Sonja"],["dc.date.accessioned","2018-11-07T09:57:41Z"],["dc.date.available","2018-11-07T09:57:41Z"],["dc.date.issued","2015"],["dc.description.abstract","Photoreceptor degeneration is one of the most prevalent causes of blindness. Despite photoreceptor loss, the inner retina and central visual pathways remain intact over an extended time period, which has led to creative optogenetic approaches to restore light sensitivity in the surviving inner retina. The major drawbacks of all optogenetic tools recently developed and tested in mouse models are their low light sensitivity and lack of physiological compatibility. Here we introduce a next-generation optogenetic tool, Opto-mGluR6, designed for retinal ON-bipolar cells, which overcomes these limitations. We show that Opto-mGluR6, a chimeric protein consisting of the intracellular domains of the ON-bipolar cell-specific metabotropic glutamate receptor mGluR6 and the light-sensing domains of melanopsin, reliably recovers vision at the retinal, cortical, and behavioral levels under moderate daylight illumination."],["dc.identifier.doi","10.1371/journal.pbio.1002143"],["dc.identifier.isi","000355305600003"],["dc.identifier.pmid","25950461"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/12062"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37215"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Public Library Science"],["dc.relation.issn","1545-7885"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Restoring the ON Switch in Blind Retinas: Opto-mGluR6, a Next-Generation, Cell-Tailored Optogenetic Tool"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]