Löwel, Siegrid

[["dc.bibliographiccitation.artnumber","e0186999"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","PloS one"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Kalogeraki, Evgenia"],["dc.contributor.author","Pielecka-Fortuna, Justyna"],["dc.contributor.author","Löwel, Siegrid"],["dc.date.accessioned","2019-07-09T11:44:41Z"],["dc.date.available","2019-07-09T11:44:41Z"],["dc.date.issued","2017"],["dc.description.abstract","In standard cage (SC) raised mice, experience-dependent ocular dominance (OD) plasticity in the primary visual cortex (V1) rapidly declines with age: in postnatal day 25-35 (critical period) mice, 4 days of monocular deprivation (MD) are sufficient to induce OD-shifts towards the open eye; thereafter, 7 days of MD are needed. Beyond postnatal day 110, even 14 days of MD failed to induce OD-plasticity in mouse V1. In contrast, mice raised in a so-called \"enriched environment\" (EE), exhibit lifelong OD-plasticity. EE-mice have more voluntary physical exercise (running wheels), and experience more social interactions (bigger housing groups) and more cognitive stimulation (regularly changed labyrinths or toys). Whether experience-dependent shifts of V1-activation happen faster in EE-mice and how long the plasticity promoting effect would persist after transferring EE-mice back to SCs has not yet been investigated. To this end, we used intrinsic signal optical imaging to visualize V1-activation i) before and after MD in EE-mice of different age groups (from 1-9 months), and ii) after transferring mice back to SCs after postnatal day 130. Already after 2 days of MD, and thus much faster than in SC-mice, EE-mice of all tested age groups displayed a significant OD-shift towards the open eye. Transfer of EE-mice to SCs immediately abolished OD-plasticity: already after 1 week of SC-housing and MD, OD-shifts could no longer be visualized. In an attempt to rescue abolished OD-plasticity of these mice, we either administered the anti-depressant fluoxetine (in drinking water) or supplied a running wheel in the SCs. OD-plasticity was only rescued for the running wheel- mice. Altogether our results show that raising mice in less deprived environments like large EE-cages strongly accelerates experience-dependent changes in V1-activation compared to the impoverished SC-raising. Furthermore, preventing voluntary physical exercise of EE-mice in adulthood immediately precludes OD-shifts in V1."],["dc.identifier.doi","10.1371/journal.pone.0186999"],["dc.identifier.pmid","29073219"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14867"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59067"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1932-6203"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","570"],["dc.subject.mesh","Aging"],["dc.subject.mesh","Animal Husbandry"],["dc.subject.mesh","Animals"],["dc.subject.mesh","Dominance, Ocular"],["dc.subject.mesh","Environment"],["dc.subject.mesh","Female"],["dc.subject.mesh","Fluoxetine"],["dc.subject.mesh","Mice"],["dc.subject.mesh","Mice, Inbred C57BL"],["dc.subject.mesh","Neuronal Plasticity"],["dc.subject.mesh","Serotonin Uptake Inhibitors"],["dc.subject.mesh","Time Factors"],["dc.subject.mesh","Visual Cortex"],["dc.title","Environmental enrichment accelerates ocular dominance plasticity in mouse visual cortex whereas transfer to standard cages resulted in a rapid loss of increased plasticity."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e11912"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","PloS one"],["dc.bibliographiccitation.lastpage","e11912"],["dc.bibliographiccitation.volume","5"],["dc.contributor.author","Keary, Nina"],["dc.contributor.author","Voss, Joe"],["dc.contributor.author","Lehmann, Konrad"],["dc.contributor.author","Bischof, Hans-Joachim"],["dc.contributor.author","Löwel, Siegrid"],["dc.date.accessioned","2019-07-09T11:53:19Z"],["dc.date.available","2019-07-09T11:53:19Z"],["dc.date.issued","2010"],["dc.description.abstract","BACKGROUND: The primary visual cortex of mammals is characterised by a retinotopic representation of the visual field. It has therefore been speculated that the visual wulst, the avian homologue of the visual cortex, also contains such a retinotopic map. We examined this for the first time by optical imaging of intrinsic signals in zebra finches, a small songbird with laterally placed eyes. In addition to the visual wulst, we visualised the retinotopic map of the optic tectum which is homologue to the superior colliculus in mammals. METHODOLOGY/PRINCIPAL FINDINGS: For the optic tectum, our results confirmed previous accounts of topography based on anatomical studies and conventional electrophysiology. Within the visual wulst, the retinotopy revealed by our experiments has not been illustrated convincingly before. The frontal part of the visual field (0 degrees +/-30 degrees azimuth) was not represented in the retinotopic map. The visual field from 30 degrees -60 degrees azimuth showed stronger magnification compared with more lateral regions. Only stimuli within elevations between about 20 degrees and 40 degrees above the horizon elicited neuronal activation. Activation from other elevations was masked by activation of the preferred region. Most interestingly, we observed more than one retinotopic representation of visual space within the visual wulst, which indicates that the avian wulst, like the visual cortex in mammals, may show some compartmentation parallel to the surface in addition to its layered structure. CONCLUSION/SIGNIFICANCE: Our results show the applicability of the optical imaging method also for small songbirds. We obtained a more detailed picture of retinotopic maps in birds, especially on the functional neuronal organisation of the visual wulst. Our findings support the notion of homology of visual wulst and visual cortex by showing that there is a functional correspondence between the two areas but also raise questions based on considerable differences between avian and mammalian retinotopic representations."],["dc.identifier.doi","10.1371/journal.pone.0011912"],["dc.identifier.fs","582119"],["dc.identifier.pmid","20694137"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/7274"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/60396"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1932-6203"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.mesh","Animals"],["dc.subject.mesh","Female"],["dc.subject.mesh","Male"],["dc.subject.mesh","Molecular Imaging"],["dc.subject.mesh","Optical Processes"],["dc.subject.mesh","Photic Stimulation"],["dc.subject.mesh","Songbirds"],["dc.subject.mesh","Superior Colliculi"],["dc.subject.mesh","Visual Cortex"],["dc.title","Optical imaging of retinotopic maps in a small songbird, the zebra finch."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]