Bayerlová, Michaela

[["dc.bibliographiccitation.firstpage","3182"],["dc.bibliographiccitation.issue","17"],["dc.bibliographiccitation.journal","Development"],["dc.bibliographiccitation.lastpage","3194"],["dc.bibliographiccitation.volume","143"],["dc.contributor.author","Schille, Carolin"],["dc.contributor.author","Bayerlova, Michaela"],["dc.contributor.author","Bleckmann, Annalen"],["dc.contributor.author","Schambony, Alexandra"],["dc.date.accessioned","2018-11-07T10:08:51Z"],["dc.date.available","2018-11-07T10:08:51Z"],["dc.date.issued","2016"],["dc.description.abstract","The receptor tyrosine kinase Ror2 is a major Wnt receptor that activates beta-catenin-independent signaling and plays a conserved role in the regulation of convergent extension movements and planar cell polarity in vertebrates. Mutations in the ROR2 gene cause recessive Robinow syndrome in humans, a short-limbed dwarfism associated with craniofacial malformations. Here, we show that Ror2 is required for local upregulation of gdf6 at the neural plate border in Xenopus embryos. Ror2 morphant embryos fail to upregulate neural plate border genes and show defects in the induction of neural crest cell fate. These embryos lack the spatially restricted activation of BMP signaling at the neural plate border at early neurula stages, which is required for neural crest induction. Ror2-dependent planar cell polarity signaling is required in the dorsolateral marginal zone during gastrulation indirectly to upregulate the BMP ligand Gdf6 at the neural plate border and Gdf6 is sufficient to rescue neural plate border specification in Ror2 morphant embryos. Thereby, Ror2 links Wnt/planar cell polarity signaling to BMP signaling in neural plate border specification and neural crest induction."],["dc.identifier.doi","10.1242/dev.135426"],["dc.identifier.isi","000393450600015"],["dc.identifier.pmid","27578181"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39549"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Company Of Biologists Ltd"],["dc.relation.issn","1477-9129"],["dc.relation.issn","0950-1991"],["dc.title","Ror2 signaling is required for local upregulation of GDF6 and activation of BMP signaling at the neural plate border"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Onkologie"],["dc.bibliographiccitation.volume","35"],["dc.contributor.author","Bleckmann, Annalen"],["dc.contributor.author","Bayerlova, M."],["dc.contributor.author","Kramer, Franz-Josef"],["dc.contributor.author","Klemm, Florian"],["dc.contributor.author","Binder, Claudia"],["dc.contributor.author","Pukrop, Tobias"],["dc.contributor.author","Beißbarth, Tim"],["dc.date.accessioned","2018-11-07T09:04:54Z"],["dc.date.available","2018-11-07T09:04:54Z"],["dc.date.issued","2012"],["dc.format.extent","65"],["dc.identifier.isi","000310766700159"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25203"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.publisher.place","Basel"],["dc.relation.issn","0378-584X"],["dc.title","Analyzing breast-cancer gene expression data using a newly developed graph-based WNT model in breast cancer"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Glia"],["dc.bibliographiccitation.volume","61"],["dc.contributor.author","Chuang, H.-N."],["dc.contributor.author","vanRossum, D. V."],["dc.contributor.author","Sieger, Dirk"],["dc.contributor.author","Siam, Laila"],["dc.contributor.author","Klemm, Florian"],["dc.contributor.author","Bleckmann, Annalen"],["dc.contributor.author","Bayerlova, M."],["dc.contributor.author","Wenske, Britta"],["dc.contributor.author","Farhat, Katja"],["dc.contributor.author","Scheffel, Joerg"],["dc.contributor.author","Schulz, M."],["dc.contributor.author","Dehghani, Faramarz"],["dc.contributor.author","Stadelmann, Christine"],["dc.contributor.author","Hanisch, U.-K."],["dc.contributor.author","Binder, Claudia"],["dc.contributor.author","Pukrop, Tobias"],["dc.date.accessioned","2018-11-07T09:23:22Z"],["dc.date.available","2018-11-07T09:23:22Z"],["dc.date.issued","2013"],["dc.format.extent","S216"],["dc.identifier.isi","000320408400701"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/29559"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.eventlocation","Berlin, GERMANY"],["dc.relation.issn","0894-1491"],["dc.title","CARCINOMA CELLS MISUSE THE HOST TISSUE DANGER RESPONSE TO INVADE THE BRAIN"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","520"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Bioinformatics"],["dc.bibliographiccitation.lastpage","522"],["dc.bibliographiccitation.volume","29"],["dc.contributor.author","Kramer, Frank"],["dc.contributor.author","Bayerlová, Michaela"],["dc.contributor.author","Klemm, Florian"],["dc.contributor.author","Bleckmann, Annalen"],["dc.contributor.author","Beißbarth, Tim"],["dc.date.accessioned","2018-11-07T09:28:07Z"],["dc.date.available","2018-11-07T09:28:07Z"],["dc.date.issued","2013"],["dc.description.abstract","Motivation: Biological pathway data, stored in structured databases, is a useful source of knowledge for a wide range of bioinformatics algorithms and tools. The Biological Pathway Exchange (BioPAX) language has been established as a standard to store and annotate pathway information. However, use of these data within statistical analyses can be tedious. On the other hand, the statistical computing environment R has become the standard for bioinformatics analysis of large-scale genomics data. With this package, we hope to enable R users to work with BioPAX data and make use of the always increasing amount of biological pathway knowledge within data analysis methods. Results: rBiopaxParser is a software package that provides a comprehensive set of functions for parsing, viewing and modifying BioPAX pathway data within R. These functions enable the user to access and modify specific parts of the BioPAX model. Furthermore, it allows to generate and layout regulatory graphs of controlling interactions and to visualize BioPAX pathways."],["dc.identifier.doi","10.1093/bioinformatics/bts710"],["dc.identifier.isi","000315158500022"],["dc.identifier.pmid","23274212"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/30697"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.relation.issn","1460-2059"],["dc.relation.issn","1367-4803"],["dc.title","rBiopaxParser-an R package to parse, modify and visualize BioPAX data"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]