Battle, Christopher

[["dc.bibliographiccitation.firstpage","237"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Nano Letters"],["dc.bibliographiccitation.lastpage","242"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Chizhik, Anna M."],["dc.contributor.author","Stein, Simon"],["dc.contributor.author","Dekaliuk, Mariia O."],["dc.contributor.author","Battle, Christopher"],["dc.contributor.author","Li, Weixing"],["dc.contributor.author","Huss, Anja"],["dc.contributor.author","Platen, Mitja"],["dc.contributor.author","Schaap, Iwan A. T."],["dc.contributor.author","Gregor, Ingo"],["dc.contributor.author","Demchenko, Alexander P."],["dc.contributor.author","Schmidt, Christoph F."],["dc.contributor.author","Enderlein, Jörg"],["dc.contributor.author","Chizhik, Alexey"],["dc.date.accessioned","2017-09-07T11:54:46Z"],["dc.date.available","2017-09-07T11:54:46Z"],["dc.date.issued","2016"],["dc.description.abstract","Success in super-resolution imaging relies on a proper choice of fluorescent probes. Here, we suggest novel easily produced and biocompatible nanoparticles-carbon nanodots-for super-resolution optical fluctuation bioimaging (SOFT). The particles revealed an intrinsic dual-color fluorescence, which corresponds to two subpopulations of particles of different electric charges. The neutral nanoparticles localize to cellular nuclei suggesting their potential use as an inexpensive, easily produced nucleus-specific label. The single particle study revealed that the carbon nanodots possess a unique hybrid combination of fluorescence properties exhibiting characteristics of both dye molecules and semiconductor nanocrystals. The results suggest that charge trapping and redistribution on the surface of the particles triggers their transitions between emissive and dark states. These findings open up new possibilities for the utilization of carbon nanodots in the various super-resolution microscopy methods based on stochastic optical switching."],["dc.identifier.doi","10.1021/acs.nanolett.5b03609"],["dc.identifier.gro","3141754"],["dc.identifier.isi","000368322700038"],["dc.identifier.pmid","26605640"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/702"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.eissn","1530-6992"],["dc.relation.issn","1530-6984"],["dc.title","Super-Resolution Optical Fluctuation Bio-Imaging with Dual-Color Carbon Nanodots"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","053703"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Review of Scientific Instruments"],["dc.bibliographiccitation.volume","84"],["dc.contributor.author","Battle, Christopher"],["dc.contributor.author","Lautscham, L."],["dc.contributor.author","Schmidt, Christoph"],["dc.date.accessioned","2017-09-07T11:47:42Z"],["dc.date.available","2017-09-07T11:47:42Z"],["dc.date.issued","2013"],["dc.description.abstract","Differential interference contrast (DIC) microscopy is a common mode of biological light microscopy used to achieve maximal resolution and contrast with label-free, weakly absorbing specimens such as cells. Maintaining the polarization state of the illuminating light is essential for the technique, and this requirement can conflict with optical trapping. We describe how to optimize DIC imaging using a light-emitting diode illumination source in a microscope while integrating a dual optical trap into the set up. Every time a polarized light beam reflects off or transmits through a dichroic mirror in the beam path, its polarization state will change if it is not polarized exactly parallel (p) or perpendicular (s) to the plane of incidence. We observe wavelength-dependent optical rotation and depolarization effects in our illumination light upon reflection from/transmission through dichroic mirrors in the beam path, resulting in significant degradation of image quality. We describe a method to compensate for these effects by introducing quarter-waveplates and a laser clean-up filter into the imaging pathway. We show that this approach achieves a full recovery of image quality. (C) 2013 AIP Publishing LLC."],["dc.identifier.doi","10.1063/1.4804597"],["dc.identifier.gro","3142352"],["dc.identifier.isi","000319999300030"],["dc.identifier.pmid","23742554"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7330"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Amer Inst Physics"],["dc.relation.eissn","1089-7623"],["dc.relation.issn","0034-6748"],["dc.title","Differential interference contrast microscopy using light-emitting diode illumination in conjunction with dual optical traps"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","604"],["dc.bibliographiccitation.issue","6285"],["dc.bibliographiccitation.journal","Science"],["dc.bibliographiccitation.lastpage","607"],["dc.bibliographiccitation.volume","352"],["dc.contributor.author","Battle, Christopher"],["dc.contributor.author","Broedersz, Chase P."],["dc.contributor.author","Fakhri, Nikta"],["dc.contributor.author","Geyer, Veikko F."],["dc.contributor.author","Howard, Jonathon"],["dc.contributor.author","Schmidt, Christoph"],["dc.contributor.author","MacKintosh, Fred C."],["dc.date.accessioned","2017-09-07T11:54:33Z"],["dc.date.available","2017-09-07T11:54:33Z"],["dc.date.issued","2016"],["dc.description.abstract","Systems in thermodynamic equilibrium are not only characterized by time-independent macroscopic properties, but also satisfy the principle of detailed balance in the transitions between microscopic configurations. Living systems function out of equilibrium and are characterized by directed fluxes through chemical states, which violate detailed balance at the molecular scale. Here we introduce a method to probe for broken detailed balance and demonstrate how such nonequilibrium dynamics are manifest at the mesosopic scale. The periodic beating of an isolated flagellum from Chlamydomonas reinhardtii exhibits probability flux in the phase space of shapes. With a model, we show how the breaking of detailed balance can also be quantified in stationary, nonequilibrium stochastic systems in the absence of periodic motion. We further demonstrate such broken detailed balance in the nonperiodic fluctuations of primary cilia of epithelial cells. Our analysis provides a general tool to identify nonequilibrium dynamics in cells and tissues."],["dc.identifier.doi","10.1126/science.aac8167"],["dc.identifier.gro","3141695"],["dc.identifier.isi","000374998600049"],["dc.identifier.pmid","27126047"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/47"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Amer Assoc Advancement Science"],["dc.relation.eissn","1095-9203"],["dc.relation.issn","0036-8075"],["dc.title","Broken detailed balance at mesoscopic scales in active biological systems"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1410"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Proceedings of the National Academy of Sciences"],["dc.bibliographiccitation.lastpage","1415"],["dc.bibliographiccitation.volume","112"],["dc.contributor.author","Battle, Christopher"],["dc.contributor.author","Ott, Carolyn M."],["dc.contributor.author","Burnette, Dylan T."],["dc.contributor.author","Lippincott-Schwartz, Jennifer"],["dc.contributor.author","Schmidt, Christoph"],["dc.date.accessioned","2017-09-07T11:44:36Z"],["dc.date.available","2017-09-07T11:44:36Z"],["dc.date.issued","2015"],["dc.description.abstract","Primary cilia are ubiquitous, microtubule-based organelles that play diverse roles in sensory transduction in many eukaryotic cells. They interrogate the cellular environment through chemosensing, osmosensing, and mechanosensing using receptors and ion channels in the ciliary membrane. Little is known about the mechanical and structural properties of the cilium and how these properties contribute to ciliary perception. We probed the mechanical responses of primary cilia from kidney epithelial cells [Madin-Darby canine kidney-II (MDCK-II)], which sense fluid flow in renal ducts. We found that, on manipulation with an optical trap, cilia deflect by bending along their length and pivoting around an effective hinge located below the basal body. The calculated bending rigidity indicates weak microtubule doublet coupling. Primary cilia of MDCK cells lack interdoublet dynein motors. Nevertheless, we found that the organelles display active motility. 3D tracking showed correlated fluctuations of the cilium and basal body. These angular movements seemed random but were dependent on ATP and cytoplasmic myosin-II in the cell cortex. We conclude that force generation by the actin cytoskeleton surrounding the basal body results in active ciliary movement. We speculate that actin-driven ciliary movement might tune and calibrate ciliary sensory functions."],["dc.identifier.doi","10.1073/pnas.1421845112"],["dc.identifier.gro","3141960"],["dc.identifier.isi","000349087700052"],["dc.identifier.pmid","25605896"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/2990"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Natl Acad Sciences"],["dc.relation.issn","0027-8424"],["dc.title","Intracellular and extracellular forces drive primary cilia movement"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Molecular Biology of the Cell"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Ott, C. M."],["dc.contributor.author","Battle, C."],["dc.contributor.author","Lippincott-Schwartz, Jennifer"],["dc.contributor.author","Schmidt, C. F."],["dc.date.accessioned","2018-11-07T09:31:34Z"],["dc.date.available","2018-11-07T09:31:34Z"],["dc.date.issued","2014"],["dc.identifier.isi","000352094104229"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/31560"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Soc Cell Biology"],["dc.publisher.place","Bethesda"],["dc.relation.conference","Joint Annual Meeting of the American-Society-for-Cell-Biology (ASCB) / International-Federation-for-Cell-Biology (IFCB)"],["dc.relation.eventlocation","Philadelphia, PA"],["dc.relation.issn","1939-4586"],["dc.relation.issn","1059-1524"],["dc.title","Primary cilia bend and pivot in response to intracellular and extracellular forces."],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]