Becker, Anja

[["dc.bibliographiccitation.firstpage","1183"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Neuroscience"],["dc.bibliographiccitation.lastpage","1191"],["dc.bibliographiccitation.volume","167"],["dc.contributor.author","Roessner, Veit"],["dc.contributor.author","Sagvolden, T."],["dc.contributor.author","DasBanerjee, T."],["dc.contributor.author","Middleton, Frank A."],["dc.contributor.author","Faraone, Steven V."],["dc.contributor.author","Walaas, S. I."],["dc.contributor.author","Becker, A."],["dc.contributor.author","Rothenberger, A."],["dc.contributor.author","Bock, Nathalie"],["dc.date.accessioned","2018-11-07T08:42:20Z"],["dc.date.available","2018-11-07T08:42:20Z"],["dc.date.issued","2010"],["dc.description.abstract","The spontaneously hypertensive rat (SHR/NCrI) is a validated model of attention-deficit/hyperactivity disorder (ADHD) combined subtype, whereas a recently identified sub-strain of the Wistar Kyoto rat (WKY/NCrI) is a model of ADHD inattentive subtype. In this study, we first examined the expression of genes involved in dopamine signaling and metabolism in the dorsal striatum and ventral mesencephalon of these two rat strains, as well as three reference control strains (WKY/NHsd, WK/HanTac, and SD/NTac) using quantitative real time RT-PCR. Next, striatal dopamine transporter (DAT) density was determined by ligand binding assay in the two ADHD-like strains at different developmental stages and after methylphenidate treatment. In adult rats, the mRNA expression of DAT and tyrosine hydroxylase was elevated in SHR/NCrI and WKY/NCrI rats compared to control strains, with differences between SHR/NCrI and WKY/NCrI rats also evident. During normal development, changes of striatal DAT densities occurred in both strains with lower densities in WKY/NCrI compared to SHR/NCrI after day 25. Two-weeks methylphenidate treatment during different developmental stages was associated with decreased striatal DAT density in both rat strains compared to the non-treated rats with more pronounced effects followed prepubertal treatment. These results suggest differences in the pathophysiology of the combined versus the predominantly inattentive animal model of ADHD. Finally, treatment with methylphenidate might reduce elevated DAT levels more effectively in the combined subtype especially when applied before puberty. (C) 2010 IBRO. Published by Elsevier Ltd. All rights reserved."],["dc.identifier.doi","10.1016/j.neuroscience.2010.02.073"],["dc.identifier.isi","000277434800022"],["dc.identifier.pmid","20211696"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6332"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19675"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Pergamon-elsevier Science Ltd"],["dc.relation.issn","0306-4522"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","METHYLPHENIDATE NORMALIZES ELEVATED DOPAMINE TRANSPORTER DENSITIES IN AN ANIMAL MODEL OF THE ATTENTION-DEFICIT/HYPERACTIVITY DISORDER COMBINED TYPE, BUT NOT TO THE SAME EXTENT IN ONE OF THE ATTENTION-DEFICIT/HYPERACTIVITY DISORDER INATTENTIVE TYPE"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","69"],["dc.bibliographiccitation.lastpage","99"],["dc.contributor.author","Roessner, Veit"],["dc.contributor.author","Becker, A."],["dc.contributor.author","Banaschewski, Tobias"],["dc.contributor.author","Rothenberger, A."],["dc.contributor.editor","Fleischhacker, W. W."],["dc.date.accessioned","2018-11-07T08:42:24Z"],["dc.date.available","2018-11-07T08:42:24Z"],["dc.date.issued","2005"],["dc.description.abstract","Over the last years evidence on the overlap between tic-disorders (TD) and obsessive compulsive behavior/disorder (OCB/OCD) has increased. The main focus of research have been the phenomenological and epidemiological similarities and differences in samples of different age, primary diagnosis (TD vs. OCD) including the co-occurrence of both. Unfortunately, only a minority of studies included all three groups (TD, TD + OCD, OCD). Nevertheless, new insight concerning possible subtypes for both TD and OCD has been gained. While some authors concentrated on OCD with/without tics we will summarize the field of TD and OCB/OCD from the viewpoint of tics, since OCB plays an important role in patients with TD. Thereby we will not only sharpen the clinicans' awareness of known differences in phenomenology, epidemiology, genetics and neurobiology, aimed to improve their diagnoses and treatment but also highlight the gaps of knowledge and discuss possibilities for further research in this field."],["dc.identifier.isi","000233962600006"],["dc.identifier.pmid","16355604"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19691"],["dc.language.iso","en"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Wien"],["dc.relation.isbn","3-211-26292-X"],["dc.relation.isbn","978-3-211-26292-4"],["dc.relation.ispartof","Neurodevelopmental disorders"],["dc.relation.issn","0303-6995"],["dc.title","Tic disorders and obsessive compulsive disorder: where is the link?"],["dc.type","book_chapter"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]