Irniger, Stefan

[["dc.bibliographiccitation.artnumber","e1002816"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","PLOS Genetics"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Bayram, Ozgür"],["dc.contributor.author","Bayram, Özlem Sarikaya"],["dc.contributor.author","Ahmed, Yasar Luqman"],["dc.contributor.author","Maruyama, Jun-ichi"],["dc.contributor.author","Valerius, Oliver"],["dc.contributor.author","Rizzoli, Silvio"],["dc.contributor.author","Ficner, Ralf"],["dc.contributor.author","Irniger, Stefan"],["dc.contributor.author","Braus, Gerhard H."],["dc.date.accessioned","2017-09-07T11:48:50Z"],["dc.date.available","2017-09-07T11:48:50Z"],["dc.date.issued","2012"],["dc.description.abstract","The sexual Fus3 MAP kinase module of yeast is highly conserved in eukaryotes and transmits external signals from the plasma membrane to the nucleus. We show here that the module of the filamentous fungus Aspergillus nidulans ( An) consists of the AnFus3 MAP kinase, the upstream kinases AnSte7 and AnSte11, and the AnSte50 adaptor. The fungal MAPK module controls the coordination of fungal development and secondary metabolite production. It lacks the membrane docking yeast Ste5 scaffold homolog; but, similar to yeast, the entire MAPK module's proteins interact with each other at the plasma membrane. AnFus3 is the only subunit with the potential to enter the nucleus from the nuclear envelope. AnFus3 interacts with the conserved nuclear transcription factor AnSte12 to initiate sexual development and phosphorylates VeA, which is a major regulatory protein required for sexual development and coordinated secondary metabolite production. Our data suggest that not only Fus3, but even the entire MAPK module complex of four physically interacting proteins, can migrate from plasma membrane to nuclear envelope."],["dc.identifier.doi","10.1371/journal.pgen.1002816"],["dc.identifier.gro","3142498"],["dc.identifier.isi","000306840400030"],["dc.identifier.pmid","22829779"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/7871"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/8856"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","1553-7404"],["dc.rights","CC BY 2.5"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.5"],["dc.title","The Aspergillus nidulans MAPK Module AnSte11-Ste50-Ste7-Fus3 Controls Development and Secondary Metabolism"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e1001226"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","PLoS Genetics"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","Bayram, Oezlem Sarikaya"],["dc.contributor.author","Bayram, Oezguer"],["dc.contributor.author","Valerius, Oliver"],["dc.contributor.author","Park, Hee Soo"],["dc.contributor.author","Irniger, Stefan"],["dc.contributor.author","Gerke, Jennifer"],["dc.contributor.author","Ni, Min"],["dc.contributor.author","Han, Kap-Hoon"],["dc.contributor.author","Yu, Jae-Hyuk"],["dc.contributor.author","Braus, Gerhard H."],["dc.date.accessioned","2018-11-07T08:36:31Z"],["dc.date.available","2018-11-07T08:36:31Z"],["dc.date.issued","2010"],["dc.description.abstract","VeA is the founding member of the velvet superfamily of fungal regulatory proteins. This protein is involved in light response and coordinates sexual reproduction and secondary metabolism in Aspergillus nidulans. In the dark, VeA bridges VelB and LaeA to form the VelB-VeA-LaeA (velvet) complex. The VeA-like protein VelB is another developmental regulator, and LaeA has been known as global regulator of secondary metabolism. In this study, we show that VelB forms a second light-regulated developmental complex together with VosA, another member of the velvet family, which represses asexual development. LaeA plays a key role, not only in secondary metabolism, but also in directing formation of the VelB-VosA and VelB-VeA-LaeA complexes. LaeA controls VeA modification and protein levels and possesses additional developmental functions. The laeA null mutant results in constitutive sexual differentiation, indicating that LaeA plays a pivotal role in inhibiting sexual development in response to light. Moreover, the absence of LaeA results in the formation of significantly smaller fruiting bodies. This is due to the lack of a specific globose cell type (Hulle cells), which nurse the young fruiting body during development. This suggests that LaeA controls Hulle cells. In summary, LaeA plays a dynamic role in fungal morphological and chemical development, and it controls expression, interactions, and modification of the velvet regulators."],["dc.identifier.doi","10.1371/journal.pgen.1001226"],["dc.identifier.isi","000285578900004"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/7265"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18331"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Public Library Science"],["dc.relation.issn","1553-7404"],["dc.rights","CC BY 2.5"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.5"],["dc.title","LaeA Control of Velvet Family Regulatory Proteins for Light-Dependent Development and Fungal Cell-Type Specificity"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]